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Chemical Name: | alpha/beta Thujone Mixture |
---|---|
CASRN: | ="76231-76-0" |
Study Number: | C99037B |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | GAV |
TDMS Number: | 9903798.ss |
Sex: | Female |
Strain and Species: | Fischer 344 Rats |
Clinical Chemistry Individual Animal Data | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (mg/kg) | Control Code | BUN (mg_dL) | Creat (U per L) | TP (g_dL) | ALB (g_dL) | Creat Kinase (IU_L) | ALT (IU_L) | SDH (IU_L) | ALP (IU_L) | TBA (umol per g) |
Day 4 | 0181 | 0 | 19.4 | 0.6 | 6.4 | 4.5 | 551 | 44 | 13.7 | 546 | 20.0 | |
Day 4 | 0182 | 0 | 17.8 | 0.5 | 6.2 | 4.5 | 828 | 49 | 7.9 | 547 | 23.9 | |
Day 4 | 0183 | 0 | 17.0 | 0.5 | 5.9 | 4.2 | 697 | 50 | 5.5 | 537 | 22.8 | |
Day 4 | 0184 | 0 | 14.2 | 0.6 | 5.8 | 4.2 | 702 | 56 | 8.4 | 622 | 26.8 | |
Day 4 | 0185 | 0 | 14.9 | 0.6 | 6.0 | 4.5 | 474 | 47 | 8.7 | 548 | 24.4 | |
Day 4 | 0186 | 0 | 14.0 | 0.3 | 5.8 | 4.2 | 370 | 45 | 7.6 | 572 | 14.4 | |
Day 4 | 0187 | 0 | 15.3 | 0.5 | 6.1 | 4.4 | 492 | 42 | 6.2 | 534 | 18.3 | |
Day 4 | 0188 | 0 | 13.2 | 0.5 | 6.0 | 4.3 | 638 | 49 | 2.1 | 585 | 21.3 | |
Day 4 | 0189 | 0 | 13.1 | 0.6 | 5.8 | 4.3 | 488 | 48 | 10.0 | 538 | 19.2 | |
Day 4 | 0190 | 0 | 13.7 | 0.5 | 6.0 | 4.3 | 937 | 47 | 0.7 | 507 | 20.8 | |
Day 4 | 0191 | 12.5 | 15.0 | 0.5 | 5.7 | 4.2 | 1073 | 47 | 3.6 | 496 | 23.5 | |
Day 4 | 0192 | 12.5 | 17.3 | 0.5 | 6.0 | 4.3 | 863 | 53 | 4.2 | 555 | 18.2 | |
Day 4 | 0193 | 12.5 | 14.9 | 0.5 | 6.2 | 4.5 | 512 | 48 | 8.2 | 537 | 15.0 | |
Day 4 | 0194 | 12.5 | 17.1 | 0.5 | 5.8 | 4.4 | 505 | 47 | 5.9 | 528 | 19.1 | |
Day 4 | 0195 | 12.5 | 17.5 | 0.5 | 6.4 | 4.6 | 371 | 53 | 12.3 | 600 | 28.1 | |
Day 4 | 0196 | 12.5 | 12.5 | 0.6 | 5.8 | 4.3 | 316 | 62 | 13.2 | 589 | 29.4 | |
Day 4 | 0197 | 12.5 | 14.5 | 0.6 | 6.0 | 4.4 | 434 | 49 | 9.4 | 490 | 14.2 | |
Day 4 | 0198 | 12.5 | 15.3 | 0.6 | 6.0 | 4.4 | 436 | 57 | 10.2 | 548 | 24.4 | |
Day 4 | 0199 | 12.5 | 15.8 | 0.5 | 5.7 | 4.3 | 550 | 51 | 8.6 | 520 | 20.6 | |
Day 4 | 0200 | 12.5 | 14.7 | 0.6 | 6.4 | 4.6 | 602 | 53 | 6.2 | 608 | 22.4 | |
Day 4 | 0201 | 25 | 16.2 | 0.5 | 6.1 | 4.4 | 584 | 50 | 4.0 | 553 | 22.6 | |
Day 4 | 0202 | 25 | 18.1 | 0.5 | 6.1 | 4.4 | 497 | 49 | 6.0 | 563 | 25.6 | |
Day 4 | 0203 | 25 | 16.5 | 0.5 | 6.0 | 4.2 | 588 | 56 | 7.9 | 612 | 26.0 | |
Day 4 | 0204 | 25 | 14.6 | 0.6 | 5.9 | 4.3 | 528 | 48 | 5.6 | 546 | 23.9 | |
Day 4 | 0205 | 25 | 16.4 | 0.5 | 6.0 | 4.5 | 734 | 55 | 4.2 | 562 | 25.0 | |
Day 4 | 0206 | 25 | 15.1 | 0.5 | 5.5 | 4.1 | 501 | 52 | 2.5 | 509 | 28.8 | |
Day 4 | 0207 | 25 | 13.8 | 0.5 | 6.3 | 4.5 | 307 | 51 | 10.9 | 528 | 25.8 | |
Day 4 | 0208 | 25 | 14.1 | 0.6 | 6.4 | 4.5 | 417 | 49 | 8.5 | 552 | 21.9 | |
Day 4 | 0209 | 25 | 16.9 | 0.6 | 6.1 | 4.4 | 784 | 53 | 4.2 | 568 | 19.2 | |
Day 4 | 0210 | 25 | 11.9 | 0.6 | 5.6 | 4.1 | 997 | 57 | 0.9 | 558 | 27.7 | |
Day 4 | 0211 | 50 | 16.8 | 0.5 | 6.2 | 4.4 | 614 | 54 | 8.2 | 617 | 23.6 | |
Day 4 | 0212 | 50 | 14.4 | 0.6 | 6.3 | 4.5 | 717 | 46 | 9.1 | 590 | 20.6 | |
Day 4 | 0213 | 50 | 15.2 | 0.6 | 6.2 | 4.4 | 1631 | 53 | 5.1 | 563 | 26.4 | |
Day 4 | 0214 | 50 | 15.5 | 0.5 | 6.2 | 4.4 | 638 | 56 | 9.0 | 604 | 28.1 | |
Day 4 | 0215 | 50 | 16.9 | 0.6 | 6.0 | 4.5 | 585 | 49 | 2.5 | 523 | 24.8 | |
Day 4 | 0216 | 50 | 14.7 | 0.5 | 6.0 | 4.4 | 652 | 46 | 0.5 | 492 | 15.7 | |
Day 4 | 0217 | 50 | 15.6 | 0.6 | 6.1 | 4.5 | 464 | 50 | 6.5 | 538 | 17.0 | |
Day 4 | 0218 | 50 | 11.8 | 0.6 | 5.6 | 4.2 | 347 | 47 | 10.9 | 516 | 19.6 | |
Day 4 | 0219 | 50 | 16.3 | 0.6 | 6.2 | 4.6 | 620 | 51 | 4.2 | 541 | 23.8 | |
Day 4 | 0220 | 50 | 13.1 | 0.6 | 5.8 | 4.3 | 596 | 55 | 6.6 | 532 | 16.8 | |
Day 4 | 0221 | 75 | 15.6 | 0.6 | 6.1 | 4.4 | 462 | 52 | 13.2 | 539 | 15.8 | |
Day 4 | 0222 | 75 | 16.8 | 0.6 | 6.0 | 4.4 | 744 | 62 | 6.8 | 628 | 22.5 | |
Day 4 | 0223 | 75 | 18.9 | 0.5 | 6.4 | 4.4 | 675 | 56 | 3.3 | 566 | 27.9 | |
Day 4 | 0224 | 75 | 16.5 | 0.5 | 6.1 | 4.3 | 992 | 51 | 5.3 | 571 | 32.1 | |
Day 4 | 0225 | 75 | 15.4 | 0.6 | 5.9 | 4.3 | 590 | 51 | 3.6 | 545 | 26.2 | |
Day 4 | 0226 | 75 | 16.3 | 0.6 | 6.1 | 4.4 | 463 | 54 | 6.5 | 574 | 19.8 | |
Day 4 | 0227 | 75 | 15.0 | 0.5 | 6.0 | 4.4 | 387 | 49 | 15.6 | 511 | 17.9 | |
Day 4 | 0228 | 75 | 13.8 | 0.6 | 6.3 | 4.5 | 385 | 55 | 12.2 | 525 | 24.0 | |
Day 4 | 0229 | 75 | 16.3 | 0.5 | 5.8 | 4.3 | 819 | 51 | 1.6 | 489 | 17.3 | |
Day 4 | 0230 | 75 | 13.0 | 0.6 | 6.4 | 4.5 | 642 | 60 | 10.6 | 608 | 30.6 | |
Day 4 | 0231 | 100 | 17.2 | 0.5 | 5.6 | 4.3 | 465 | 53 | 15.7 | 511 | 21.8 | |
Day 4 | 0232 | 100 | 17.6 | 0.6 | 6.0 | 4.3 | 789 | 47 | 3.7 | 538 | 17.0 | |
Day 4 | 0233 | 100 | 16.5 | 0.5 | 6.3 | 4.4 | 486 | 53 | 9.9 | 479 | 25.7 | |
Day 4 | 0234 | 100 | 14.7 | 0.5 | 6.1 | 4.2 | 534 | 57 | 5.4 | 551 | 31.0 | |
Day 4 | 0235 | 100 | 18.3 | 0.6 | 6.1 | 4.5 | 347 | 49 | 12.5 | 488 | 25.4 | |
Day 4 | 0236 | 100 | 14.5 | 0.6 | 5.8 | 4.2 | 678 | 52 | 0.1 | 535 | 20.6 | |
Day 4 | 0237 | 100 | 15.2 | 0.5 | 6.1 | 4.5 | 572 | 49 | 6.0 | 454 | 25.0 | |
Day 4 | 0238 | 100 | 12.4 | 0.6 | 5.7 | 4.3 | 398 | 52 | 10.2 | 546 | 27.5 | |
Day 4 | 0239 | 100 | 16.5 | 0.6 | 5.9 | 4.3 | 860 | 57 | 2.3 | 547 | 23.0 | |
Day 4 | 0240 | 100 | 14.6 | 0.6 | 6.2 | 4.4 | 819 | 54 | 3.9 | 482 | 25.4 | |
Day 25 | 0181 | 0 | 20.0 | 0.6 | 5.9 | 4.3 | 348 | 45 | 12.2 | 344 | 15.7 | |
Day 25 | 0182 | 0 | 17.1 | 0.5 | 6.2 | 4.6 | 442 | 39 | 7.1 | 289 | 13.6 | |
Day 25 | 0183 | 0 | 20.0 | 0.6 | 6.2 | 4.6 | 407 | 51 | 9.2 | 325 | 25.9 | |
Day 25 | 0184 | 0 | 16.9 | 0.5 | 5.9 | 4.3 | 417 | 44 | 9.1 | 318 | 19.5 | |
Day 25 | 0185 | 0 | 20.3 | 0.6 | 6.0 | 4.4 | 429 | 45 | 12.0 | 318 | 11.7 | |
Day 25 | 0186 | 0 | 18.3 | 0.5 | 6.1 | 4.3 | 157 | 37 | 14.1 | 292 | 19.0 | |
Day 25 | 0187 | 0 | 18.1 | 0.6 | 6.2 | 4.4 | 292 | 49 | 10.6 | 334 | 25.8 | |
Day 25 | 0188 | 0 | 19.9 | 0.5 | 6.2 | 4.4 | 288 | 44 | 7.8 | 342 | 16.8 | |
Day 25 | 0189 | 0 | 17.2 | 0.6 | 6.3 | 4.5 | 280 | 41 | 7.0 | 288 | 20.6 | |
Day 25 | 0190 | 0 | 18.0 | 0.5 | 6.3 | 4.4 | 335 | 48 | 4.4 | 351 | 25.8 | |
Day 25 | 0191 | 12.5 | 18.8 | 0.5 | 6.2 | 4.4 | 458 | 40 | 7.4 | 290 | 26.3 | |
Day 25 | 0192 | 12.5 | 18.8 | 0.5 | 5.7 | 4.3 | 311 | 46 | 10.8 | 330 | 13.5 | |
Day 25 | 0193 | 12.5 | 18.3 | 0.5 | 6.3 | 4.5 | 151 | 43 | 15.5 | 325 | 19.7 | |
Day 25 | 0194 | 12.5 | 19.2 | 0.5 | 5.8 | 4.3 | 264 | 43 | 11.1 | 319 | 28.8 | |
Day 25 | 0195 | 12.5 | 17.0 | 0.5 | 5.9 | 4.3 | 214 | 43 | 12.8 | 324 | 25.9 | |
Day 25 | 0196 | 12.5 | 14.9 | 0.5 | 5.8 | 4.1 | 460 | 33 | 10.2 | 321 | 14.0 | |
Day 25 | 0197 | 12.5 | 18.5 | 0.6 | 6.3 | 4.6 | 248 | 39 | 14.4 | 296 | 15.0 | |
Day 25 | 0198 | 12.5 | 15.0 | 0.6 | 6.3 | 4.5 | 294 | 36 | 10.9 | 341 | 18.1 | |
Day 25 | 0199 | 12.5 | 18.1 | 0.5 | 6.2 | 4.5 | 493 | 29 | 9.6 | 254 | 14.9 | |
Day 25 | 0200 | 12.5 | 17.3 | 0.6 | 6.2 | 4.5 | 432 | 37 | 6.4 | 319 | 13.4 | |
Day 25 | 0201 | 25 | 17.1 | 0.6 | 6.2 | 4.5 | 408 | 40 | 16.4 | 321 | 13.7 | |
Day 25 | 0202 | 25 | 19.1 | 0.6 | 6.4 | 4.6 | 277 | 47 | 17.6 | 349 | 17.1 | |
Day 25 | 0203 | 25 | 19.0 | 0.5 | 6.0 | 4.5 | 351 | 43 | 7.9 | 301 | 21.2 | |
Day 25 | 0204 | 25 | 17.7 | 0.7 | 6.2 | 4.5 | 301 | 41 | 11.9 | 345 | 20.1 | |
Day 25 | 0205 | 25 | 18.6 | 0.6 | 6.2 | 4.5 | 223 | 43 | 15.3 | 330 | 19.0 | |
Day 25 | 0206 | 25 | 17.2 | 0.5 | 5.9 | 4.2 | 258 | 40 | 9.8 | 306 | 26.4 | |
Day 25 | 0207 | 25 | 18.8 | 0.6 | 6.3 | 4.4 | 176 | 48 | 13.1 | 339 | 20.2 | |
Day 25 | 0208 | 25 | 19.0 | 0.6 | 6.3 | 4.4 | 300 | 44 | 9.5 | 305 | 19.8 | |
Day 25 | 0209 | 25 | 19.0 | 0.6 | 6.6 | 4.6 | 345 | 44 | 8.1 | 353 | 21.8 | |
Day 25 | 0210 | 25 | 18.7 | 0.6 | 6.1 | 4.3 | 267 | 44 | 10.9 | 323 | 26.6 | |
Day 25 | 0211 | 50 | 16.1 | 0.5 | 6.2 | 4.5 | 300 | 37 | 15.9 | 323 | 26.1 | |
Day 25 | 0212 | 50 | 16.7 | 0.5 | 6.1 | 4.4 | 419 | 39 | 7.1 | 293 | 19.6 | |
Day 25 | 0213 | 50 | 18.6 | 0.6 | 6.0 | 4.4 | 341 | 46 | 7.3 | 287 | 24.5 | |
Day 25 | 0214 | 50 | 16.8 | 0.5 | 6.2 | 4.4 | 326 | 45 | 7.5 | 343 | 31.4 | |
Day 25 | 0215 | 50 | 16.6 | 0.6 | 6.0 | 4.5 | 261 | 43 | 14.3 | 307 | 15.0 | |
Day 25 | 0216 | 50 | 18.2 | 0.6 | 6.5 | 4.6 | 153 | 36 | 11.3 | 268 | 24.9 | |
Day 25 | 0217 | 50 | 16.8 | 0.6 | 6.3 | 4.5 | 156 | 43 | 11.1 | 335 | 21.9 | |
Day 25 | 0218 | 50 | 17.3 | 0.6 | 6.4 | 4.6 | 344 | 43 | 8.0 | 294 | 12.5 | |
Day 25 | 0219 | 50 | 17.9 | 0.6 | 6.5 | 4.6 | 414 | 45 | 7.6 | 290 | 20.6 | |
Day 25 | 0220 | 50 | 15.7 | 0.5 | 6.2 | 4.4 | 303 | 45 | 4.6 | 291 | 25.0 | |
Day 25 | 0221 | 75 | 16.0 | 0.5 | 5.8 | 4.3 | 326 | 46 | 15.6 | 298 | 23.5 | |
Day 25 | 0222 | 75 | 16.6 | 0.6 | 5.9 | 4.4 | 561 | 50 | 8.4 | 348 | 26.3 | |
Day 25 | 0223 | 75 | 17.0 | 0.5 | 5.9 | 4.3 | 308 | 48 | 15.8 | 298 | 23.3 | |
Day 25 | 0224 | 75 | 18.7 | 0.6 | 6.3 | 4.6 | 258 | 48 | 12.7 | 309 | 15.2 | |
Day 25 | 0225 | 75 | 20.7 | 0.6 | 6.0 | 4.4 | 568 | 41 | 7.2 | 316 | 27.2 | |
Day 25 | 0226 | 75 | 17.5 | 0.6 | 6.6 | 4.6 | 189 | 42 | 12.0 | 310 | 21.6 | |
Day 25 | 0227 | 75 | 17.9 | 0.6 | 6.7 | 4.6 | 251 | 44 | 11.7 | 323 | 24.9 | |
Day 25 | 0228 | 75 | 16.8 | 0.6 | 6.4 | 4.6 | 202 | 44 | 12.7 | 317 | 15.1 | |
Day 25 | 0229 | 75 | 18.9 | 0.6 | 5.8 | 4.3 | 222 | 43 | 11.3 | 282 | 17.9 | |
Day 25 | 0230 | 75 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |
Day 25 | 0231 | 100 | 17.1 | 0.5 | 5.7 | 4.2 | 271 | 41 | 14.4 | 300 | 26.2 | |
Day 25 | 0232 | 100 | 19.5 | 0.5 | 6.0 | 4.4 | 465 | 49 | 6.8 | 307 | 25.1 | |
Day 25 | 0233 | 100 | 20.1 | 0.5 | 5.9 | 4.3 | 317 | 53 | 9.6 | 336 | 25.2 | |
Day 25 | 0234 | 100 | 19.5 | 0.6 | 5.9 | 4.4 | 347 | 41 | 10.5 | 305 | 26.4 | |
Day 25 | 0235 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |
Day 25 | 0236 | 100 | 17.0 | 0.5 | 6.6 | 4.7 | 220 | 43 | 13.0 | 300 | 22.8 | |
Day 25 | 0237 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |
Day 25 | 0238 | 100 | 15.7 | 0.5 | 6.3 | 4.4 | 168 | 42 | 9.9 | 302 | 28.8 | |
Day 25 | 0239 | 100 | 16.2 | 0.6 | 6.0 | 4.3 | 240 | 50 | 9.6 | 324 | 21.3 | |
Day 25 | 0240 | 100 | 18.7 | 0.6 | 6.5 | 4.5 | 260 | 47 | 12.9 | 282 | 18.6 | |
Abbreviations: | ||||||||||||
NA: Not Available, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue |