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Chemical Name: | p,p'-Dichlorodiphenyl Sulfone |
---|---|
CASRN: | ="80-07-9" |
Study Number: | C88120 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | FEED |
TDMS Number: | 8812001.ss |
Sex: | Male |
Strain and Species: | Fischer 344 Rats |
Clinical Chemistry Individual Animal Data | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (ppm) | Control Code | BUN (mg_dL) | Creat (U per L) | Creatine (mg per dL) | TP (g_dL) | ALB (g_dL) | Creat Kinase (IU_L) | ALT (IU_L) | SDH (IU_L) | ALP (IU_L) | TBA (umol per g) |
Day 92 | 0001 | 0 | U | 22 | 0.6 | 1.1 | 6.9 | 4.7 | 133 | 58 | 18.4 | 549 | 17.1 |
Day 92 | 0002 | 0 | U | 19 | 0.7 | 1.4 | 7.5 | 5 | 231 | 54 | 19 | 573 | 22.3 |
Day 92 | 0003 | 0 | U | 19 | 0.7 | 1.1 | 7.1 | 4.8 | 224 | 86 | 31.3 | 593 | 19.6 |
Day 92 | 0004 | 0 | U | 20 | 0.7 | 1.3 | 7.5 | 5 | 94 | 68 | 20.2 | 600 | 27.7 |
Day 92 | 0005 | 0 | U | 20 | 0.7 | 1.2 | 7.4 | 5 | 211 | 59 | 17.8 | 588 | 37.9 |
Day 92 | 0006 | 0 | U | 21 | 0.6 | 1.6 | 7 | 4.6 | 166 | 61 | 15.3 | 587 | 15 |
Day 92 | 0007 | 0 | U | 20 | 0.7 | 1.7 | 7.9 | 5.2 | 181 | 70 | 22.7 | 607 | 32.1 |
Day 92 | 0008 | 0 | U | 21 | 0.7 | 2 | 7.8 | 5.1 | 102 | 113 | 31.9 | 675 | 19.8 |
Day 92 | 0009 | 0 | U | 21 | 0.7 | 1.4 | 7.3 | 4.9 | 196 | 92 | 35.6 | 600 | 31.9 |
Day 92 | 0010 | 0 | U | 22 | 0.7 | 2 | 7.5 | 5.1 | 122 | 67 | 17.2 | 649 | 28.1 |
Day 92 | 0011 | 30 | 14 | 0.6 | 1.9 | 5.8 | 3.8 | 141 | 29 | 14.1 | 297 | 19.2 | |
Day 92 | 0012 | 30 | 19 | 0.7 | 1.7 | 7.6 | 5.1 | 351 | 62 | 31.3 | 536 | 21.5 | |
Day 92 | 0013 | 30 | 19 | 0.7 | 1.2 | 7.6 | 5.1 | 258 | 81 | 37.4 | 545 | 23.5 | |
Day 92 | 0014 | 30 | 18 | 0.7 | 1.2 | 7.8 | 5.2 | 193 | 58 | 24.5 | 457 | 32.3 | |
Day 92 | 0015 | 30 | 20 | 0.7 | 1.3 | 7.5 | 5 | 113 | 51 | 22.1 | 484 | 30.4 | |
Day 92 | 0016 | 30 | 19 | 0.7 | 0.9 | 7.6 | 5.1 | 185 | 54 | 23.9 | 553 | 21.9 | |
Day 92 | 0017 | 30 | 18 | 0.7 | 0.9 | 7.6 | 5.1 | 180 | 43 | 12.9 | 546 | 19.4 | |
Day 92 | 0018 | 30 | 18 | 0.7 | 0.6 | 7.3 | 4.8 | 793 | 59 | 25.1 | 515 | 21.7 | |
Day 92 | 0019 | 30 | 19 | 0.7 | 0.9 | 7.6 | 5.1 | 252 | 47 | 26.4 | 592 | 20.4 | |
Day 92 | 0020 | 30 | 18 | 0.8 | 1.1 | 7.7 | 5.1 | 283 | 49 | 22.7 | 566 | 25.2 | |
Day 92 | 0021 | 100 | 21 | 0.7 | 1 | 7.3 | 4.8 | 225 | 43 | 19 | 456 | 28.7 | |
Day 92 | 0022 | 100 | 21 | 0.7 | 1.4 | 8.3 | 5.5 | 145 | 50 | 17.2 | 493 | 23.7 | |
Day 92 | 0023 | 100 | 18 | 0.7 | 1.2 | 7.6 | 5 | 448 | 48 | 22.1 | 465 | 22.1 | |
Day 92 | 0024 | 100 | 18 | 0.7 | 1 | 7.6 | 4.9 | 162 | 40 | 16.6 | 428 | 19 | |
Day 92 | 0025 | 100 | 21 | 0.7 | 1 | 7.1 | 4.7 | 174 | 57 | 27.6 | 459 | 22.3 | |
Day 92 | 0026 | 100 | 19 | 0.7 | 1 | 7.8 | 5.1 | 403 | 56 | 22.7 | 417 | 50.6 | |
Day 92 | 0027 | 100 | 21 | 0.7 | 1.3 | 7.9 | 5.3 | 435 | 50 | 20.2 | 476 | 32.9 | |
Day 92 | 0028 | 100 | 20 | 0.7 | 1.6 | 7.5 | 5.1 | 123 | 39 | 12.3 | 458 | 24.2 | |
Day 92 | 0029 | 100 | 20 | 0.7 | 1.7 | 7.6 | 5 | 473 | 52 | 23.3 | 463 | 33.1 | |
Day 92 | 0030 | 100 | 19 | 0.6 | 1.3 | 7.8 | 5.3 | 364 | 69 | 22.7 | 487 | 21.7 | |
Day 92 | 0031 | 300 | 21 | 0.7 | 1.1 | 8.3 | 5.5 | 110 | 46 | 15.9 | 443 | 21.9 | |
Day 92 | 0032 | 300 | 20 | 0.7 | 1 | 9.1 | 5.9 | 139 | 71 | 29.4 | 515 | 27.5 | |
Day 92 | 0033 | 300 | 20 | 0.7 | 0.7 | 7.9 | 5.2 | 858 | 48 | 23.9 | 422 | 29 | |
Day 92 | 0034 | 300 | 22 | 0.7 | 1 | 8 | 5.3 | 263 | 49 | 23.9 | 472 | 25.4 | |
Day 92 | 0035 | 300 | 22 | 0.7 | 1.1 | 7.9 | 5.2 | 108 | 60 | 19.6 | 460 | 24.6 | |
Day 92 | 0036 | 300 | 19 | 0.6 | 1.7 | 8 | 5.3 | 112 | 53 | 16.6 | 512 | 22.7 | |
Day 92 | 0037 | 300 | 21 | 0.7 | 1.3 | 8.4 | 5.4 | 181 | 56 | 22.1 | 469 | 27.9 | |
Day 92 | 0038 | 300 | 21 | 0.7 | 1.4 | 8.1 | 5.3 | 156 | 58 | 17.2 | 495 | 21.3 | |
Day 92 | 0039 | 300 | 22 | 0.7 | 1 | 8 | 5.5 | 125 | 53 | 17.8 | 472 | 23.7 | |
Day 92 | 0040 | 300 | 22 | 0.7 | 1.3 | 8.2 | 5.5 | 191 | 113 | 48.4 | 476 | 26.2 | |
Day 92 | 0041 | 1000 | 21 | 0.7 | 1.4 | 8.1 | 5.1 | 104 | 52 | 17.2 | 441 | 23.1 | |
Day 92 | 0042 | 1000 | 21 | 0.8 | 1.1 | 8.3 | 5.3 | 143 | 53 | 23.9 | 439 | 26 | |
Day 92 | 0043 | 1000 | 20 | 0.7 | 1.3 | 8.3 | 5.2 | 97 | 62 | 24.5 | 394 | 26 | |
Day 92 | 0044 | 1000 | 22 | 0.7 | 0.9 | 8 | 5.1 | 146 | 72 | 38 | 394 | 28.7 | |
Day 92 | 0045 | 1000 | 22 | 0.7 | 1.5 | 8.1 | 4.9 | 120 | 94 | 33.1 | 425 | 27.5 | |
Day 92 | 0046 | 1000 | 21 | 0.7 | 0.7 | 7.9 | 5.2 | 328 | 52 | 19 | 377 | 25.6 | |
Day 92 | 0047 | 1000 | 22 | 0.8 | 1.2 | 8.7 | 5.2 | 151 | 47 | 22.1 | 399 | 26.2 | |
Day 92 | 0048 | 1000 | 20 | 0.6 | 0.8 | 7.8 | 5 | 176 | 81 | 38.6 | 364 | 26.5 | |
Day 92 | 0049 | 1000 | 22 | 0.7 | 1.1 | 7.9 | 5 | 251 | 63 | 28.2 | 406 | 26.7 | |
Day 92 | 0050 | 1000 | 19 | 0.7 | 1.1 | 8.5 | 5.1 | 118 | 58 | 23.9 | 383 | 25.8 | |
Day 92 | 0051 | 3000 | 24 | 0.8 | 1.7 | 9.2 | 5.7 | 118 | 66 | 31.9 | 451 | 28.7 | |
Day 92 | 0052 | 3000 | 24 | 0.8 | 1 | 8.6 | 5.3 | 330 | 76 | 49.1 | 414 | 33.1 | |
Day 92 | 0053 | 3000 | 25 | 0.8 | 1.8 | 8.8 | 5.6 | 175 | 66 | 38 | 406 | 37.3 | |
Day 92 | 0054 | 3000 | 24 | 0.7 | 1.1 | 8.6 | 5.2 | 196 | 73 | 39.9 | 385 | 32.7 | |
Day 92 | 0055 | 3000 | 25 | 0.8 | 1.5 | 8.5 | 5.3 | 124 | 71 | 42.3 | 395 | 39.6 | |
Day 92 | 0056 | 3000 | 23 | 0.7 | 1.4 | 8.1 | 4.9 | 136 | 70 | 38.6 | 429 | 27.9 | |
Day 92 | 0057 | 3000 | 24 | 0.7 | 1.4 | 8.7 | 5.4 | 129 | 93 | 54.6 | 419 | 32.1 | |
Day 92 | 0058 | 3000 | 23 | 0.7 | 1.5 | 8.3 | 5.1 | 194 | 50 | 27 | 408 | 26.2 | |
Day 92 | 0059 | 3000 | 25 | 0.8 | 1.5 | 8.1 | 4.9 | 210 | 54 | 29.4 | 440 | 28.8 | |
Day 92 | 0060 | 3000 | 23 | 0.8 | 1.6 | 8.9 | 5.5 | 130 | 113 | 70.5 | 462 | 33.3 | |
Abbreviations: | |||||||||||||
NA: Not Available, U: Untreated Control, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue |