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Chemical Name: | alpha/beta Thujone Mixture |
---|---|
CASRN: | ="76231-76-0" |
Study Number: | C99037B |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | GAV |
TDMS Number: | 9903703.fixtime |
Sex: | Male |
Strain and Species: | Fischer 344 Rats |
Hematology Individual Animal Data | |||||||||||||||||||||||||||||||||||||||
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Measurement Time | Animal Number | Dose Group (mg/kg) | Control Code | Erythrcyt | Erythrcyt (million/uL) | Hgb | Hgb (g/dL) | HCT (Automated) | HCT (Automated) (%) | HCT (spun) | HCT (spun) (%) | MCV | MCV (fL) | MCH | MCH (pg) | MCHC | MCHC (g/dL) | Retics | Retics (million/uL) | Retics | Retics (%) | Platelet | Platelet (1000/mL) | Leukocytes | Leukocytes (1000/mL) | Neut | Neut (1000/mL) | Lymph | Lymph (1000/mL) | Mono | Mono (1000/mL) | EOS | EOS (1000/mL) | Basophils | Basophils (1000/mL) | NRBC | NRBC (per 100 WC) | LUC | LUC (1000/mL) |
Day 93 | 0001 | 0 | V | 8.91 | 15.5 | 46.0 | 46.0 | 51.7 | 17.4 | 33.6 | .199 | 2.2 | 687 | 9.64 | 1.23 | 8.03 | 0.20 | 0.07 | 0.04 | 0 | 0.07 | ||||||||||||||||||
Day 93 | 0002 | 0 | V | 8.81 | 15.0 | 44.9 | 45.5 | 51.0 | 17.0 | 33.4 | .242 | 2.7 | 671 | 10.10 | 1.45 | 8.31 | 0.17 | 0.09 | 0.03 | 0 | 0.05 | ||||||||||||||||||
Day 93 | 0003 | 0 | V | 9.22 | 16.3 | 48.9 | 47.0 | 53.0 | 17.7 | 33.3 | .207 | 2.2 | 661 | 10.57 | 1.22 | 8.91 | 0.17 | 0.08 | 0.09 | 0 | 0.10 | ||||||||||||||||||
Day 93 | 0004 | 0 | V | 8.76 | 15.1 | 45.8 | 45.0 | 52.2 | 17.2 | 33.0 | .205 | 2.3 | 687 | 11.42 | 1.61 | 9.43 | 0.18 | 0.10 | 0.04 | 0 | 0.07 | ||||||||||||||||||
Day 93 | 0005 | 0 | V | 8.84 | 15.3 | 46.2 | 45.0 | 52.3 | 17.3 | 33.1 | .206 | 2.3 | 648 | 8.24 | 1.35 | 6.64 | 0.16 | 0.05 | 0.02 | 1 | 0.03 | ||||||||||||||||||
Day 93 | 0006 | 0 | V | 8.52 | 14.5 | 44.0 | 43.0 | 51.6 | 17.1 | 33.1 | .226 | 2.7 | 665 | 9.99 | 1.36 | 8.25 | 0.23 | 0.05 | 0.03 | 0 | 0.06 | ||||||||||||||||||
Day 93 | 0007 | 0 | V | 9.23 | 15.9 | 48.2 | 46.0 | 52.2 | 17.2 | 33.0 | .212 | 2.3 | 706 | 10.19 | 1.30 | 8.49 | 0.22 | 0.06 | 0.04 | 0 | 0.07 | ||||||||||||||||||
Day 93 | 0008 | 0 | V | 8.64 | 14.6 | 44.3 | 43.5 | 51.3 | 16.9 | 33.0 | .215 | 2.5 | 641 | 9.33 | 1.38 | 7.46 | 0.28 | 0.09 | 0.05 | 0 | 0.07 | ||||||||||||||||||
Day 93 | 0009 | 0 | V | 8.36 | 14.5 | 43.4 | 43.0 | 51.9 | 17.3 | 33.4 | .231 | 2.8 | 702 | 11.42 | 1.57 | 9.44 | 0.23 | 0.08 | 0.04 | 0 | 0.06 | ||||||||||||||||||
Day 93 | 0010 | 0 | V | 8.87 | 15.1 | 45.0 | 44.5 | 50.7 | 17.1 | 33.6 | .221 | 2.5 | 602 | 10.24 | 1.44 | 8.41 | 0.15 | 0.15 | 0.03 | 0 | 0.06 | ||||||||||||||||||
Day 93 | 0011 | 12.5 | 8.67 | 14.7 | 44.9 | 43.3 | 51.8 | 17.0 | 32.8 | .267 | 3.1 | 730 | 12.90 | 1.52 | 10.91 | 0.25 | 0.08 | 0.06 | 0 | 0.08 | |||||||||||||||||||
Day 93 | 0012 | 12.5 | 8.79 | 15.1 | 45.3 | 44.8 | 51.6 | 17.2 | 33.3 | .239 | 2.7 | 735 | 10.37 | 1.22 | 8.77 | 0.20 | 0.08 | 0.02 | 0 | 0.08 | |||||||||||||||||||
Day 93 | 0013 | 12.5 | 8.56 | 15.3 | 46.0 | 45.0 | 53.7 | 17.8 | 33.2 | .255 | 3.0 | 729 | 10.98 | 1.50 | 9.14 | 0.21 | 0.03 | 0.05 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0014 | 12.5 | 8.45 | 14.6 | 44.1 | 43.5 | 52.2 | 17.3 | 33.2 | .236 | 2.8 | 687 | 9.85 | 1.42 | 8.12 | 0.16 | 0.06 | 0.04 | 0 | 0.05 | |||||||||||||||||||
Day 93 | 0015 | 12.5 | 8.70 | 14.9 | 45.9 | 44.0 | 52.7 | 17.2 | 32.5 | .245 | 2.8 | 621 | 8.71 | 1.39 | 7.04 | 0.12 | 0.08 | 0.04 | 0 | 0.05 | |||||||||||||||||||
Day 93 | 0016 | 12.5 | 8.01 | 13.9 | 41.3 | 40.0 | 51.5 | 17.3 | 33.6 | .225 | 2.8 | 636 | 10.73 | 1.52 | 8.85 | 0.13 | 0.13 | 0.03 | 0 | 0.07 | |||||||||||||||||||
Day 93 | 0017 | 12.5 | 8.45 | 14.6 | 43.8 | 43.5 | 51.8 | 17.3 | 33.3 | .254 | 3.0 | 636 | 11.27 | 1.57 | 9.38 | 0.17 | 0.08 | 0.04 | 0 | 0.04 | |||||||||||||||||||
Day 93 | 0018 | 12.5 | 8.93 | 15.2 | 45.2 | 45.0 | 50.6 | 17.1 | 33.7 | .233 | 2.6 | 669 | 10.01 | 1.52 | 8.17 | 0.17 | 0.08 | 0.04 | 0 | 0.04 | |||||||||||||||||||
Day 93 | 0019 | 12.5 | 8.46 | 14.6 | 43.7 | 42.5 | 51.6 | 17.2 | 33.3 | .251 | 3.0 | 700 | 9.50 | 1.47 | 7.72 | 0.13 | 0.08 | 0.04 | 0 | 0.05 | |||||||||||||||||||
Day 93 | 0020 | 12.5 | 8.23 | 14.3 | 42.7 | 42.0 | 51.9 | 17.3 | 33.4 | .218 | 2.6 | 691 | 10.02 | 1.40 | 8.26 | 0.14 | 0.08 | 0.05 | 0 | 0.08 | |||||||||||||||||||
Day 93 | 0021 | 25 | 8.69 | 15.1 | 44.9 | 44.8 | 51.7 | 17.4 | 33.7 | .242 | 2.8 | 728 | 12.78 | 1.63 | 10.78 | 0.15 | 0.10 | 0.06 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0022 | 25 | 8.71 | 15.2 | 45.4 | 45.0 | 52.1 | 17.4 | 33.4 | .219 | 2.5 | 804 | 10.21 | 1.50 | 8.35 | 0.17 | 0.08 | 0.04 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0023 | 25 | 8.50 | 14.7 | 44.2 | 44.0 | 52.0 | 17.3 | 33.3 | .229 | 2.7 | 691 | 10.40 | 1.37 | 8.77 | 0.15 | 0.06 | 0.02 | 0 | 0.04 | |||||||||||||||||||
Day 93 | 0024 | 25 | 8.94 | 15.0 | 46.3 | 44.0 | 51.8 | 16.8 | 32.5 | .247 | 2.8 | 726 | 10.28 | 1.44 | 8.41 | 0.19 | 0.09 | 0.04 | 0 | 0.10 | |||||||||||||||||||
Day 93 | 0025 | 25 | 8.73 | 15.2 | 45.7 | 45.0 | 52.4 | 17.4 | 33.2 | .25 | 2.9 | 711 | 9.95 | 1.37 | 8.25 | 0.15 | 0.08 | 0.04 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0026 | 25 | 8.28 | 14.3 | 42.7 | 42.0 | 51.6 | 17.3 | 33.5 | .2 | 2.4 | 706 | 12.81 | 1.46 | 10.83 | 0.20 | 0.13 | 0.06 | 0 | 0.13 | |||||||||||||||||||
Day 93 | 0027 | 25 | 8.47 | 14.4 | 43.4 | 43.0 | 51.3 | 17.1 | 33.2 | .229 | 2.7 | 672 | 12.08 | 1.56 | 10.18 | 0.18 | 0.06 | 0.03 | 0 | 0.07 | |||||||||||||||||||
Day 93 | 0028 | 25 | 8.57 | 14.4 | 44.0 | 42.5 | 51.3 | 16.8 | 32.7 | .217 | 2.5 | 759 | 12.61 | 1.24 | 10.87 | 0.19 | 0.09 | 0.10 | 0 | 0.12 | |||||||||||||||||||
Day 93 | 0029 | 25 | 8.67 | 14.8 | 44.7 | 44.0 | 51.5 | 17.1 | 33.1 | .252 | 2.9 | 730 | 12.01 | 1.42 | 10.15 | 0.18 | 0.09 | 0.09 | 0 | 0.09 | |||||||||||||||||||
Day 93 | 0030 | 25 | 8.27 | 14.1 | 42.3 | 41.0 | 51.1 | 17.0 | 33.3 | .256 | 3.1 | 763 | 10.00 | 1.43 | 8.22 | 0.15 | 0.09 | 0.05 | 0 | 0.05 | |||||||||||||||||||
Day 93 | 0031 | 50 | 8.25 | 14.1 | 42.7 | 42.3 | 51.8 | 17.1 | 32.9 | .217 | 2.6 | 765 | 12.01 | 1.39 | 10.08 | 0.29 | 0.09 | 0.05 | 1 | 0.10 | |||||||||||||||||||
Day 93 | 0032 | 50 | 8.36 | 14.6 | 43.3 | 43.5 | 51.8 | 17.4 | 33.7 | .232 | 2.8 | 737 | 12.47 | 1.45 | 10.59 | 0.23 | 0.10 | 0.05 | 0 | 0.05 | |||||||||||||||||||
Day 93 | 0033 | 50 | 8.60 | 14.8 | 44.2 | 43.5 | 51.4 | 17.3 | 33.6 | .212 | 2.5 | 725 | 11.62 | 1.42 | 9.79 | 0.24 | 0.06 | 0.04 | 0 | 0.07 | |||||||||||||||||||
Day 93 | 0034 | 50 | 9.03 | 15.4 | 47.4 | 45.5 | 52.6 | 17.1 | 32.4 | .249 | 2.8 | 759 | 11.71 | 1.57 | 9.73 | 0.18 | 0.09 | 0.07 | 0 | 0.07 | |||||||||||||||||||
Day 93 | 0035 | 50 | 8.40 | 14.4 | 43.5 | 42.0 | 51.8 | 17.2 | 33.2 | .214 | 2.6 | 670 | 10.09 | 1.23 | 8.56 | 0.16 | 0.05 | 0.03 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0036 | 50 | 7.93 | 13.5 | 40.9 | 40.0 | 51.6 | 17.0 | 33.0 | .142 | 1.8 | 611 | 12.59 | 1.29 | 10.83 | 0.15 | 0.12 | 0.08 | 0 | 0.12 | |||||||||||||||||||
Day 93 | 0037 | 50 | 8.44 | 14.5 | 43.4 | 43.5 | 51.4 | 17.1 | 33.4 | .197 | 2.3 | 603 | 11.27 | 1.68 | 9.08 | 0.27 | 0.12 | 0.04 | 0 | 0.09 | |||||||||||||||||||
Day 93 | 0038 | 50 | 8.47 | 14.3 | 43.4 | 42.0 | 51.2 | 16.9 | 33.0 | .186 | 2.2 | 665 | 14.63 | 3.44 | 10.38 | 0.30 | 0.24 | 0.12 | 1 | 0.16 | |||||||||||||||||||
Day 93 | 0039 | 50 | 8.67 | 14.9 | 44.4 | 43.5 | 51.3 | 17.2 | 33.5 | .183 | 2.1 | 689 | 13.06 | 1.74 | 10.77 | 0.25 | 0.09 | 0.11 | 0 | 0.11 | |||||||||||||||||||
Day 93 | 0040 | 50 | 7.46 | 12.7 | 38.8 | 38.0 | 51.9 | 17.0 | 32.7 | .222 | 3.0 | 914 | 12.22 | 2.95 | 8.86 | 0.23 | 0.07 | 0.05 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0041 | 75 | 8.15 | 13.8 | 42.3 | 42.0 | 51.9 | 17.0 | 32.7 | .227 | 2.8 | 674 | 12.12 | 1.51 | 10.18 | 0.24 | 0.06 | 0.04 | 0 | 0.08 | |||||||||||||||||||
Day 93 | 0042 | 75 | 8.37 | 14.6 | 43.7 | 43.8 | 52.2 | 17.4 | 33.4 | .235 | 2.8 | 648 | 11.51 | 1.52 | 9.66 | 0.15 | 0.07 | 0.05 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0043 | 75 | 8.36 | 14.3 | 43.4 | 43.0 | 51.9 | 17.1 | 32.9 | .249 | 3.0 | 630 | 9.38 | 1.62 | 7.48 | 0.12 | 0.08 | 0.04 | 0 | 0.04 | |||||||||||||||||||
Day 93 | 0044 | 75 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0045 | 75 | 8.66 | 14.8 | 45.5 | 44.0 | 52.6 | 17.1 | 32.6 | .207 | 2.4 | 646 | 10.79 | 1.47 | 9.02 | 0.16 | 0.07 | 0.03 | 1 | 0.04 | |||||||||||||||||||
Day 93 | 0046 | 75 | 8.13 | 13.9 | 41.9 | 42.0 | 51.6 | 17.1 | 33.2 | .105 | 1.3 | 564 | 11.44 | 2.68 | 8.40 | 0.21 | 0.04 | 0.02 | 0 | 0.08 | |||||||||||||||||||
Day 93 | 0047 | 75 | 8.52 | 14.7 | 44.6 | 44.0 | 52.3 | 17.2 | 32.9 | .206 | 2.4 | 678 | 10.63 | 1.77 | 8.61 | 0.15 | 0.05 | 0.02 | 0 | 0.03 | |||||||||||||||||||
Day 93 | 0048 | 75 | 8.63 | 14.4 | 45.0 | 44.0 | 52.1 | 16.6 | 32.0 | .226 | 2.6 | 699 | 11.74 | 2.23 | 9.12 | 0.19 | 0.10 | 0.05 | 0 | 0.06 | |||||||||||||||||||
Day 93 | 0049 | 75 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0050 | 75 | 8.32 | 14.1 | 43.1 | 42.0 | 51.9 | 17.0 | 32.7 | .243 | 2.9 | 715 | 12.87 | 1.68 | 10.71 | 0.13 | 0.08 | 0.12 | 0 | 0.15 | |||||||||||||||||||
Day 93 | 0051 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0052 | 100 | 9.07 | 15.7 | 47.6 | 47.3 | 52.4 | 17.3 | 33.1 | .213 | 2.3 | 731 | 10.06 | 1.30 | 8.46 | 0.16 | 0.07 | 0.03 | 0 | 0.04 | |||||||||||||||||||
Day 93 | 0053 | 100 | 7.75 | 13.5 | 40.4 | 40.0 | 52.1 | 17.4 | 33.4 | .336 | 4.3 | 1033 | 10.55 | 1.94 | 8.21 | 0.23 | 0.06 | 0.04 | 2 | 0.06 | |||||||||||||||||||
Day 93 | 0054 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0055 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0056 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0057 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0058 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0059 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Day 93 | 0060 | 100 | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | DEAD | |||||||||||||||||||
Abbreviations: | |||||||||||||||||||||||||||||||||||||||
NA: Not Available, V: Vehicle Control, Erythrcyt: Red Blood Cell Count, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, Hgb: Hemoglobin, HCT (Automated): Hematocrit, HCT (Automated): Hematocrit, HCT (spun): Hematocrit Manual, HCT (spun): Hematocrit Manual, MCV: Mean Corpuscular Volume, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, MCHC: Mean Cell Hemoglobin Concentration, Retics: Reticulocyte Count, Retics: Reticulocyte Count, Retics: Reticulocyte Percentage, Retics: Reticulocyte Percentage, Platelet: Platelet Count, Platelet: Platelet Count, Leukocytes: White Blood Cell Count, Leukocytes: White Blood Cell Count, Neut: Neutrophil Count, Neut: Neutrophil Count, Lymph: Lymphocyte Count, Lymph: Lymphocyte Count, Mono: Monocyte Count, Mono: Monocyte Count, EOS: Eosinophil Count, EOS: Eosinophil Count, Basophils: Basophil Count, Basophils: Basophil Count, NRBC: Nucleated Rbc Per 100 Wbc, NRBC: Nucleated Rbc Per 100 Wbc, LUC: Large Unstained Cells Count, LUC: Large Unstained Cells Count |