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Chemical Name: | p,p'-Dichlorodiphenyl Sulfone |
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CASRN: | ="80-07-9" |
Study Number: | C88120 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | FEED |
TDMS Number: | 8812002.ss |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Hematology Individual Animal Data | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (ppm) | Control Code | Erythrcyt (million/uL) | Hgb (g/dL) | HCT (Automated) (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | Retics (million/uL) | Platelet (1000/mL) | Leukocytes (1000/mL) | Seg Neut (1000/mL) | Lymph (1000/mL) | Mono (1000/mL) | EOS (1000/mL) | NRBC (1000/uL) |
Day 92 | 0181 | 0 | U | 10.53 | 17.5 | 50.5 | 48 | 16.6 | 34.7 | 0.18954 | 990 | 7.9 | 1.896 | 5.925 | 0.079 | 0 | 0 |
Day 92 | 0182 | 0 | U | 9.85 | 16.4 | 47.1 | 47.8 | 16.6 | 34.8 | 0.06895 | 838 | 6.7 | 1.608 | 5.092 | 0 | 0 | 0 |
Day 92 | 0183 | 0 | U | 10.04 | 16.9 | 47.8 | 47.6 | 16.8 | 35.4 | 0.08032 | 1084 | 5.1 | 1.275 | 3.672 | 0.051 | 0.102 | 0 |
Day 92 | 0184 | 0 | U | 10.27 | 17 | 48.4 | 47.1 | 16.6 | 35.1 | 0.07189 | 1013 | 6.7 | 1.407 | 4.958 | 0.134 | 0.201 | 0 |
Day 92 | 0185 | 0 | U | 10.17 | 16.4 | 48.4 | 47.6 | 16.1 | 33.9 | 0.05085 | 946 | 6.8 | 0.952 | 5.78 | 0 | 0.068 | 0 |
Day 92 | 0186 | 0 | U | 10.09 | 16.8 | 47.9 | 47.5 | 16.7 | 35.1 | 0.08072 | 957 | 5.6 | 0.616 | 4.872 | 0.056 | 0.056 | 0 |
Day 92 | 0187 | 0 | U | 10.2 | 17 | 47.5 | 46.6 | 16.7 | 35.8 | 0.1734 | 954 | 6 | 0.84 | 4.98 | 0.06 | 0.12 | 0 |
Day 92 | 0188 | 0 | U | 9.64 | 16.6 | 47.1 | 48.9 | 17.2 | 35.2 | 0.08676 | 934 | 7.2 | 0.792 | 6.264 | 0.072 | 0.072 | 0 |
Day 92 | 0189 | 0 | U | 9.97 | 16.8 | 48.7 | 48.8 | 16.9 | 34.5 | 0.07976 | 895 | 7.9 | 1.343 | 6.478 | 0 | 0.079 | 0 |
Day 92 | 0190 | 0 | U | 9.76 | 16.6 | 45.8 | 46.9 | 17 | 36.2 | 0.08784 | 915 | 4.5 | 0.63 | 3.87 | 0 | 0 | 0 |
Day 92 | 0191 | 30 | 10.73 | 17 | 50.4 | 47 | 15.8 | 33.7 | 0.15022 | 1024 | 3.7 | 0.37 | 3.219 | 0.074 | 0.037 | 0 | |
Day 92 | 0192 | 30 | 10.6 | 17.2 | 50.4 | 47.5 | 16.2 | 34.1 | 0.1802 | 1081 | 6.7 | 1.005 | 5.561 | 0.067 | 0.067 | 0 | |
Day 92 | 0193 | 30 | 10.32 | 16.5 | 48.8 | 47.3 | 16 | 33.8 | 0.17544 | 928 | 5.9 | 0.531 | 5.074 | 0 | 0.295 | 0 | |
Day 92 | 0194 | 30 | 10.3 | 17.2 | 49 | 47.6 | 16.7 | 35.1 | 0.0824 | 1059 | 4.8 | 0.384 | 4.368 | 0 | 0.048 | 0 | |
Day 92 | 0195 | 30 | 9.77 | 16.2 | 46 | 47.1 | 16.6 | 35.2 | 0.05862 | 981 | 3.9 | 0.546 | 3.354 | 0 | 0 | 0 | |
Day 92 | 0196 | 30 | 10.25 | 17.3 | 48.4 | 47.2 | 16.9 | 35.7 | 0.15375 | 986 | 7.5 | 1.2 | 6 | 0.075 | 0.225 | 0 | |
Day 92 | 0197 | 30 | 10.44 | 16.9 | 49.1 | 47 | 16.2 | 34.4 | 0.09396 | 983 | 4.5 | 0.63 | 3.78 | 0 | 0.09 | 0 | |
Day 92 | 0198 | 30 | 10.29 | 16.7 | 48.3 | 46.9 | 16.2 | 34.6 | 0.12348 | 964 | 4 | 0.44 | 3.44 | 0 | 0.12 | 0 | |
Day 92 | 0199 | 30 | 10.17 | 16.9 | 48.6 | 47.8 | 16.6 | 34.8 | 0.1017 | 964 | 7.9 | 1.659 | 6.162 | 0 | 0.079 | 0 | |
Day 92 | 0200 | 30 | 9.99 | 16.4 | 47.8 | 47.8 | 16.4 | 34.3 | 0.08991 | 1038 | 6.5 | 0.91 | 5.525 | 0.065 | 0 | 0 | |
Day 92 | 0201 | 100 | 10.09 | 16.3 | 47.2 | 46.8 | 16.2 | 34.5 | 0.08072 | 1021 | 4.4 | 0.44 | 3.872 | 0.044 | 0.044 | 0 | |
Day 92 | 0202 | 100 | 9.61 | 16.7 | 46.2 | 48.1 | 17.4 | 36.1 | 0.06727 | 940 | 10.2 | 1.53 | 8.568 | 0 | 0.102 | 0 | |
Day 92 | 0203 | 100 | 9.85 | 16.8 | 46.9 | 47.6 | 17.1 | 35.8 | 0.1379 | 971 | 5.5 | 1.815 | 3.465 | 0.11 | 0.11 | 0 | |
Day 92 | 0204 | 100 | 10.15 | 17.5 | 48.5 | 47.8 | 17.2 | 36.1 | 0.13195 | 1021 | 5.3 | 0.689 | 4.558 | 0.053 | 0 | 0 | |
Day 92 | 0205 | 100 | 9.74 | 16.5 | 46 | 47.2 | 16.9 | 35.9 | 0.10714 | 891 | 8.4 | 1.176 | 7.224 | 0 | 0 | 0 | |
Day 92 | 0206 | 100 | 9.9 | 16.4 | 47.2 | 47.7 | 16.6 | 34.7 | 0.0891 | 924 | 8.3 | 2.158 | 6.059 | 0 | 0.083 | 0 | |
Day 92 | 0207 | 100 | 9.9 | 16.7 | 46.7 | 47.2 | 16.9 | 35.8 | 0.099 | 937 | 6.8 | 2.04 | 4.692 | 0.068 | 0 | 0 | |
Day 92 | 0208 | 100 | 10.1 | 16.6 | 47.8 | 47.3 | 16.4 | 34.7 | 0.1818 | 1027 | 4 | 0.68 | 3.24 | 0.08 | 0 | 0 | |
Day 92 | 0209 | 100 | 10.22 | 16.8 | 47.6 | 46.6 | 16.4 | 35.3 | 0.13286 | 928 | 4.3 | 0.774 | 3.44 | 0.043 | 0.043 | 0 | |
Day 92 | 0210 | 100 | 10.36 | 17.2 | 48.9 | 47.2 | 16.6 | 35.2 | 0.17612 | 1010 | 4.4 | 0.836 | 3.564 | 0 | 0 | 0 | |
Day 92 | 0211 | 300 | 9.88 | 16.8 | 48 | 48.6 | 17 | 35 | 0.13832 | 1025 | 5.9 | 0.59 | 5.251 | 0 | 0.059 | 0 | |
Day 92 | 0212 | 300 | 9.87 | 16.8 | 47.2 | 47.8 | 17 | 35.6 | 0.18753 | 998 | 6.7 | 0.871 | 5.628 | 0.067 | 0.134 | 0 | |
Day 92 | 0213 | 300 | 10.27 | 17.2 | 49.4 | 48.1 | 16.7 | 34.8 | 0.09243 | 997 | 5.2 | 1.352 | 3.64 | 0.104 | 0.104 | 0 | |
Day 92 | 0214 | 300 | 9.14 | 16.1 | 43.7 | 47.8 | 17.6 | 36.8 | 0.10054 | 998 | 3.4 | 0.612 | 2.686 | 0 | 0.102 | 0 | |
Day 92 | 0215 | 300 | 9.69 | 16.2 | 45.9 | 47.4 | 16.7 | 35.3 | 0.06783 | 1046 | 5.5 | 1.485 | 3.905 | 0.055 | 0.055 | 0 | |
Day 92 | 0216 | 300 | 9.3 | 16.3 | 45.5 | 48.9 | 17.5 | 35.8 | 0.0744 | 1028 | 5.2 | 0.988 | 4.212 | 0 | 0 | 0 | |
Day 92 | 0217 | 300 | 10.18 | 17 | 48.4 | 47.5 | 16.7 | 35.1 | 0.1018 | 956 | 5.3 | 1.272 | 4.028 | 0 | 0 | 0 | |
Day 92 | 0218 | 300 | 9.8 | 16.8 | 47 | 48 | 17.1 | 35.7 | 0.0686 | 1017 | 5 | 0.9 | 4.1 | 0 | 0 | 0 | |
Day 92 | 0219 | 300 | 9.87 | 16.7 | 47.2 | 47.8 | 16.9 | 35.4 | 0.18753 | 957 | 5.3 | 1.537 | 3.71 | 0 | 0.053 | 0 | |
Day 92 | 0220 | 300 | 9.83 | 17 | 47 | 47.8 | 17.3 | 36.2 | 0.06881 | 934 | 5.5 | 1.155 | 4.18 | 0.165 | 0 | 0 | |
Day 92 | 0221 | 1000 | 9.42 | 17 | 45.9 | 48.7 | 18 | 37 | 0.08478 | 974 | 5.8 | 1.102 | 4.466 | 0.232 | 0 | 0 | |
Day 92 | 0222 | 1000 | 9.55 | 16.8 | 46.8 | 49 | 17.6 | 35.9 | 0.0764 | 1009 | 3.6 | 0.648 | 2.772 | 0.072 | 0.108 | 0 | |
Day 92 | 0223 | 1000 | 9.74 | 17.2 | 47.8 | 49.1 | 17.7 | 36 | 0.07792 | 966 | 12.5 | 1.75 | 10.75 | 0 | 0 | 0 | |
Day 92 | 0224 | 1000 | 9.29 | 16.4 | 46.5 | 50 | 17.7 | 35.3 | 0.0929 | 937 | 5.4 | 0.756 | 4.482 | 0.054 | 0.108 | 0 | |
Day 92 | 0225 | 1000 | 9.74 | 16.9 | 47.6 | 48.9 | 17.4 | 35.5 | 0.0974 | 1005 | 10.4 | 1.768 | 8.632 | 0 | 0 | 0 | |
Day 92 | 0226 | 1000 | 10.18 | 17.2 | 49 | 48.1 | 16.9 | 35.1 | 0.07126 | 1058 | 4.3 | 0.989 | 3.311 | 0 | 0 | 0 | |
Day 92 | 0227 | 1000 | 9.29 | 16.8 | 46.5 | 50 | 18.1 | 36.1 | 0.13935 | 1061 | 5.2 | 1.248 | 3.9 | 0.052 | 0 | 0 | |
Day 92 | 0228 | 1000 | 9.58 | 16.5 | 46.7 | 48.7 | 17.2 | 35.3 | 0.07664 | 1055 | 5.4 | 0.594 | 4.698 | 0.054 | 0.054 | 0 | |
Day 92 | 0229 | 1000 | 9.39 | 16.5 | 45.5 | 48.5 | 17.6 | 36.3 | 0.10329 | 962 | 9.4 | 2.82 | 6.392 | 0.188 | 0 | 0 | |
Day 92 | 0230 | 1000 | 9.36 | 16.6 | 46.1 | 49.2 | 17.7 | 36 | 0.08424 | 1105 | 4.3 | 0.817 | 3.483 | 0 | 0 | 0 | |
Day 92 | 0231 | 3000 | 9.51 | 16.6 | 45.8 | 48.2 | 17.5 | 36.2 | 0.11412 | 991 | 6.3 | 1.386 | 4.914 | 0 | 0 | 0 | |
Day 92 | 0232 | 3000 | 9.42 | 16.7 | 46.5 | 49.4 | 17.7 | 35.9 | 0.06594 | 991 | 3.1 | 0.527 | 2.573 | 0 | 0 | 0 | |
Day 92 | 0233 | 3000 | 9.36 | 17 | 45.7 | 48.8 | 18.2 | 37.2 | 0.07488 | 952 | 3.4 | 0.68 | 2.652 | 0.034 | 0.034 | 0 | |
Day 92 | 0234 | 3000 | 8.95 | 16.2 | 44.5 | 49.7 | 18.1 | 36.4 | 0.0895 | 1015 | 4.8 | 0.96 | 3.792 | 0 | 0.048 | 0 | |
Day 92 | 0235 | 3000 | 9.99 | 16.9 | 48.3 | 48.3 | 16.9 | 35 | 0.03996 | 994 | 4.5 | 0.9 | 3.6 | 0 | 0 | 0 | |
Day 92 | 0236 | 3000 | 9.41 | 16.5 | 46.3 | 49.2 | 17.5 | 35.6 | 0.05646 | 1040 | 5.2 | 0.624 | 4.42 | 0.156 | 0 | 0 | |
Day 92 | 0237 | 3000 | 9.69 | 17 | 47.9 | 49.4 | 17.5 | 35.5 | 0.11628 | 1043 | 6.7 | 0.938 | 5.695 | 0 | 0.067 | 0 | |
Day 92 | 0238 | 3000 | 9.52 | 16.6 | 47.7 | 50.1 | 17.4 | 34.8 | 0.16184 | 983 | 7.5 | 0.75 | 6.75 | 0 | 0 | 0 | |
Day 92 | 0239 | 3000 | 9.48 | 16.4 | 46.4 | 48.9 | 17.3 | 35.3 | 0.07584 | 1107 | 4.3 | 0.731 | 3.569 | 0 | 0 | 0 | |
Day 92 | 0240 | 3000 | 9.7 | 16.5 | 46.6 | 48 | 17 | 35.4 | 0.0873 | 1071 | 6.1 | 0.549 | 5.49 | 0.061 | 0 | 0 | |
Abbreviations: | |||||||||||||||||
NA: Not Available, U: Untreated Control, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, HCT (Automated): Hematocrit, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, Retics: Reticulocyte Count, Platelet: Platelet Count, Leukocytes: White Blood Cell Count, Seg Neut: Segmented Neutrophil Count, Lymph: Lymphocyte Count, Mono: Monocyte Count, EOS: Eosinophil Count, NRBC: Nucleated Rbc Count |