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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Milk thistle extract |
CASRN: | ="84604-20-6" |
Study Number: | C20008 |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | DOSED FEED |
TDMS Number: | 2000803 |
Sex: | Female |
Strain and Species: | F 344/N Rats |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (PPM) |
Control Code |
Final Body Weight (g) |
Day 80 |
325 |
25000 |
|
0 |
Day 200 |
250 |
0 |
|
0 |
Day 302 |
211 |
0 |
|
194.9 |
Day 434 |
220 |
0 |
|
0 |
Day 451 |
333 |
25000 |
|
260.8 |
Day 459 |
283 |
12500 |
|
0 |
Day 477 |
279 |
12500 |
|
242.1 |
Day 477 |
329 |
25000 |
|
293.3 |
Day 484 |
335 |
25000 |
|
202 |
Day 507 |
309 |
25000 |
|
252.7 |
Day 546 |
388 |
50000 |
|
289.2 |
Day 567 |
312 |
25000 |
|
186.6 |
Day 575 |
241 |
0 |
|
0 |
Day 592 |
251 |
12500 |
|
272.5 |
Day 599 |
257 |
12500 |
|
319.5 |
Day 609 |
297 |
12500 |
|
0 |
Day 613 |
379 |
50000 |
|
0 |
Day 618 |
244 |
0 |
|
193.3 |
Day 618 |
281 |
12500 |
|
0 |
Day 619 |
262 |
12500 |
|
281 |
Day 619 |
299 |
12500 |
|
201.7 |
Day 619 |
366 |
50000 |
|
225.4 |
Day 619 |
372 |
50000 |
|
230 |
Day 623 |
232 |
0 |
|
0 |
Day 637 |
206 |
0 |
|
0 |
Day 637 |
259 |
12500 |
|
0 |
Day 638 |
371 |
50000 |
|
0 |
Day 647 |
326 |
25000 |
|
268.8 |
Day 647 |
394 |
50000 |
|
171.9 |
Day 660 |
231 |
0 |
|
0 |
Day 660 |
271 |
12500 |
|
315.6 |
Day 660 |
288 |
12500 |
|
212.4 |
Day 660 |
314 |
25000 |
|
226 |
Day 664 |
359 |
50000 |
|
0 |
Day 667 |
323 |
25000 |
|
177.5 |
Day 667 |
389 |
50000 |
|
230.9 |
Day 672 |
258 |
12500 |
|
188 |
Day 674 |
385 |
50000 |
|
0 |
Day 676 |
302 |
25000 |
|
195.2 |
Day 687 |
202 |
0 |
|
204 |
Day 687 |
223 |
0 |
|
239 |
Day 687 |
347 |
25000 |
|
268.8 |
Day 693 |
353 |
50000 |
|
0 |
Day 703 |
310 |
25000 |
|
289.2 |
Day 703 |
311 |
25000 |
|
220.8 |
Day 703 |
320 |
25000 |
|
192.6 |
Day 703 |
393 |
50000 |
|
212.9 |
Day 710 |
217 |
0 |
|
200.3 |
Day 711 |
346 |
25000 |
|
215.5 |
Day 721 |
397 |
50000 |
|
202.8 |
Day 722 |
261 |
12500 |
|
238.6 |
Day 722 |
364 |
50000 |
|
189.3 |
Day 725 |
247 |
0 |
|
309.2 |
Day 725 |
256 |
12500 |
|
0 |
Day 725 |
337 |
25000 |
|
0 |
Day 729 |
351 |
50000 |
|
307.6 |
Day 729 |
352 |
50000 |
|
313 |
Day 729 |
354 |
50000 |
|
273.8 |
Day 729 |
355 |
50000 |
|
290.9 |
Day 729 |
361 |
50000 |
|
307 |
Day 729 |
362 |
50000 |
|
277.8 |
Day 729 |
363 |
50000 |
|
319.7 |
Day 729 |
365 |
50000 |
|
340.8 |
Day 732 |
207 |
0 |
|
282.7 |
Day 732 |
208 |
0 |
|
326.4 |
Day 732 |
209 |
0 |
|
349.2 |
Day 732 |
210 |
0 |
|
338.4 |
Day 732 |
221 |
0 |
|
314.8 |
Day 732 |
222 |
0 |
|
290.2 |
Day 732 |
224 |
0 |
|
318.6 |
Day 732 |
225 |
0 |
|
294.2 |
Day 732 |
233 |
0 |
|
325.8 |
Day 732 |
234 |
0 |
|
357.1 |
Day 732 |
235 |
0 |
|
338.9 |
Day 732 |
260 |
12500 |
|
283.1 |
Day 732 |
272 |
12500 |
|
333.6 |
Day 732 |
273 |
12500 |
|
337 |
Day 732 |
274 |
12500 |
|
333.5 |
Day 732 |
275 |
12500 |
|
317.5 |
Day 732 |
282 |
12500 |
|
349.9 |
Day 732 |
284 |
12500 |
|
314.1 |
Day 732 |
285 |
12500 |
|
349.3 |
Day 732 |
286 |
12500 |
|
315.1 |
Day 732 |
287 |
12500 |
|
316.3 |
Day 732 |
289 |
12500 |
|
349.3 |
Day 732 |
290 |
12500 |
|
321.5 |
Day 732 |
291 |
12500 |
|
319.1 |
Day 732 |
292 |
12500 |
|
343.3 |
Day 732 |
293 |
12500 |
|
375.4 |
Day 732 |
294 |
12500 |
|
341.8 |
Day 732 |
295 |
12500 |
|
317.4 |
Day 732 |
296 |
12500 |
|
0 |
Day 732 |
301 |
25000 |
|
276.3 |
Day 732 |
303 |
25000 |
|
307.4 |
Day 732 |
304 |
25000 |
|
286.7 |
Day 732 |
305 |
25000 |
|
283.7 |
Day 732 |
306 |
25000 |
|
319.7 |
Day 732 |
307 |
25000 |
|
326.3 |
Day 732 |
308 |
25000 |
|
251.4 |
Day 732 |
386 |
50000 |
|
309.2 |
Day 732 |
387 |
50000 |
|
292.4 |
Day 732 |
390 |
50000 |
|
317.3 |
Day 735 |
201 |
0 |
|
330.7 |
Day 735 |
203 |
0 |
|
337.7 |
Day 735 |
204 |
0 |
|
360.2 |
Day 735 |
205 |
0 |
|
311.1 |
Day 735 |
216 |
0 |
|
337.9 |
Day 735 |
218 |
0 |
|
344.3 |
Day 735 |
219 |
0 |
|
322.2 |
Day 735 |
226 |
0 |
|
335.9 |
Day 735 |
227 |
0 |
|
343 |
Day 735 |
228 |
0 |
|
343 |
Day 735 |
229 |
0 |
|
332.5 |
Day 735 |
230 |
0 |
|
303.3 |
Day 735 |
236 |
0 |
|
324.9 |
Day 735 |
237 |
0 |
|
342.6 |
Day 735 |
238 |
0 |
|
343.5 |
Day 735 |
239 |
0 |
|
329.5 |
Day 735 |
240 |
0 |
|
279.8 |
Day 735 |
242 |
0 |
|
326.4 |
Day 735 |
243 |
0 |
|
324.2 |
Day 735 |
245 |
0 |
|
340.9 |
Day 735 |
246 |
0 |
|
320.6 |
Day 735 |
248 |
0 |
|
332.6 |
Day 735 |
249 |
0 |
|
347.5 |
Day 735 |
266 |
12500 |
|
327.1 |
Day 735 |
267 |
12500 |
|
271.1 |
Day 735 |
268 |
12500 |
|
310.7 |
Day 735 |
269 |
12500 |
|
310.9 |
Day 735 |
270 |
12500 |
|
303.5 |
Day 735 |
298 |
12500 |
|
341 |
Day 735 |
300 |
12500 |
|
292.9 |
Day 735 |
313 |
25000 |
|
277.3 |
Day 735 |
315 |
25000 |
|
300.9 |
Day 735 |
316 |
25000 |
|
314.5 |
Day 735 |
317 |
25000 |
|
325.4 |
Day 735 |
318 |
25000 |
|
288.3 |
Day 735 |
319 |
25000 |
|
324.5 |
Day 735 |
321 |
25000 |
|
297.7 |
Day 735 |
322 |
25000 |
|
335 |
Day 735 |
324 |
25000 |
|
336.4 |
Day 735 |
331 |
25000 |
|
311.3 |
Day 735 |
332 |
25000 |
|
306.7 |
Day 735 |
334 |
25000 |
|
345.1 |
Day 735 |
381 |
50000 |
|
299 |
Day 735 |
382 |
50000 |
|
317.4 |
Day 735 |
383 |
50000 |
|
291 |
Day 735 |
384 |
50000 |
|
246.2 |
Day 735 |
391 |
50000 |
|
275.3 |
Day 735 |
392 |
50000 |
|
331.6 |
Day 735 |
395 |
50000 |
|
293.7 |
Day 736 |
212 |
0 |
|
325.9 |
Day 736 |
213 |
0 |
|
343.6 |
Day 736 |
214 |
0 |
|
299.2 |
Day 736 |
215 |
0 |
|
322.8 |
Day 736 |
252 |
12500 |
|
299.7 |
Day 736 |
253 |
12500 |
|
340.3 |
Day 736 |
254 |
12500 |
|
305.1 |
Day 736 |
255 |
12500 |
|
320.5 |
Day 736 |
263 |
12500 |
|
325.7 |
Day 736 |
264 |
12500 |
|
231.7 |
Day 736 |
265 |
12500 |
|
347.9 |
Day 736 |
276 |
12500 |
|
326.6 |
Day 736 |
277 |
12500 |
|
308.4 |
Day 736 |
278 |
12500 |
|
342.2 |
Day 736 |
280 |
12500 |
|
336.7 |
Day 736 |
327 |
25000 |
|
317.9 |
Day 736 |
328 |
25000 |
|
303.6 |
Day 736 |
330 |
25000 |
|
324.5 |
Day 736 |
336 |
25000 |
|
319.7 |
Day 736 |
338 |
25000 |
|
318.9 |
Day 736 |
339 |
25000 |
|
312.1 |
Day 736 |
340 |
25000 |
|
349.2 |
Day 736 |
341 |
25000 |
|
322 |
Day 736 |
342 |
25000 |
|
308.3 |
Day 736 |
343 |
25000 |
|
309 |
Day 736 |
344 |
25000 |
|
345.8 |
Day 736 |
345 |
25000 |
|
352.3 |
Day 736 |
348 |
25000 |
|
325 |
Day 736 |
349 |
25000 |
|
300.7 |
Day 736 |
350 |
25000 |
|
321 |
Day 736 |
356 |
50000 |
|
303.3 |
Day 736 |
357 |
50000 |
|
300.6 |
Day 736 |
358 |
50000 |
|
237 |
Day 736 |
360 |
50000 |
|
296.2 |
Day 736 |
367 |
50000 |
|
323 |
Day 736 |
368 |
50000 |
|
290.9 |
Day 736 |
369 |
50000 |
|
317.3 |
Day 736 |
370 |
50000 |
|
280.2 |
Day 736 |
373 |
50000 |
|
300.6 |
Day 736 |
374 |
50000 |
|
312 |
Day 736 |
375 |
50000 |
|
323.3 |
Day 736 |
376 |
50000 |
|
315.9 |
Day 736 |
377 |
50000 |
|
301.3 |
Day 736 |
378 |
50000 |
|
213.1 |
Day 736 |
380 |
50000 |
|
252.6 |
Day 736 |
396 |
50000 |
|
286.9 |
Day 736 |
398 |
50000 |
|
310.1 |
Day 736 |
399 |
50000 |
|
317.5 |
Day 736 |
400 |
50000 |
|
299.1 |
Abbreviations: |
NA: Not Available
|