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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Oxymetholone |
CASRN: | ="434-07-1" |
Study Number: | C88032B |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | GAVAGE |
TDMS Number: | 8803205 |
Sex: | Male |
Strain and Species: | F 344/N Rats |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (MG/KG) |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 34 |
310 |
150 |
|
166.4 |
|
Day 80 |
333 |
150 |
|
288.7 |
|
Day 92 |
18 |
0 |
|
371.3 |
|
Day 92 |
24 |
0 |
|
390.8 |
|
Day 92 |
25 |
0 |
|
411.3 |
|
Day 92 |
3 |
0 |
|
380 |
|
Day 92 |
31 |
0 |
|
341.9 |
|
Day 92 |
33 |
0 |
|
365.4 |
|
Day 92 |
45 |
0 |
|
360.9 |
|
Day 92 |
71 |
0 |
|
407.4 |
|
Day 92 |
76 |
0 |
|
386.2 |
|
Day 92 |
8 |
0 |
|
369.5 |
|
Day 92 |
100 |
3 |
|
363.1 |
|
Day 92 |
104 |
3 |
|
365.3 |
|
Day 92 |
105 |
3 |
|
383 |
|
Day 92 |
140 |
3 |
|
353 |
|
Day 92 |
146 |
3 |
|
384.5 |
|
Day 92 |
157 |
3 |
|
348.7 |
|
Day 92 |
158 |
3 |
|
354.2 |
|
Day 92 |
160 |
3 |
|
345.2 |
|
Day 92 |
163 |
3 |
|
337.4 |
|
Day 92 |
170 |
3 |
|
375.6 |
|
Day 92 |
195 |
30 |
|
345.6 |
|
Day 92 |
199 |
30 |
|
363.2 |
|
Day 92 |
202 |
30 |
|
366.7 |
|
Day 92 |
207 |
30 |
|
343.4 |
|
Day 92 |
226 |
30 |
|
323.7 |
|
Day 92 |
228 |
30 |
|
323.1 |
|
Day 92 |
236 |
30 |
|
355.7 |
|
Day 92 |
248 |
30 |
|
373.5 |
|
Day 92 |
260 |
30 |
|
382.9 |
|
Day 92 |
263 |
30 |
|
349.1 |
|
Day 92 |
271 |
150 |
|
315.7 |
|
Day 92 |
273 |
150 |
|
275.7 |
|
Day 92 |
297 |
150 |
|
307.1 |
|
Day 92 |
318 |
150 |
|
289.1 |
|
Day 92 |
330 |
150 |
|
|
|
Day 92 |
337 |
150 |
|
324.1 |
|
Day 92 |
339 |
150 |
|
272.7 |
|
Day 92 |
346 |
150 |
|
298.5 |
|
Day 92 |
351 |
150 |
|
300.4 |
|
Day 92 |
357 |
150 |
|
277.2 |
|
Day 114 |
292 |
150 |
|
304.1 |
|
Day 115 |
328 |
150 |
|
267.1 |
|
Day 116 |
335 |
150 |
|
279.1 |
|
Day 145 |
317 |
150 |
|
310.3 |
|
Day 146 |
155 |
3 |
|
346 |
|
Day 184 |
11 |
0 |
|
408.8 |
|
Day 184 |
17 |
0 |
|
461.3 |
|
Day 184 |
27 |
0 |
|
437.9 |
|
Day 184 |
46 |
0 |
|
418.4 |
|
Day 184 |
68 |
0 |
|
428 |
|
Day 184 |
7 |
0 |
|
415.5 |
|
Day 184 |
75 |
0 |
|
409.2 |
|
Day 184 |
78 |
0 |
|
436 |
|
Day 184 |
85 |
0 |
|
484.6 |
|
Day 184 |
9 |
0 |
|
429.6 |
|
Day 184 |
101 |
3 |
|
455.6 |
|
Day 184 |
110 |
3 |
|
471 |
|
Day 184 |
114 |
3 |
|
377.7 |
|
Day 184 |
120 |
3 |
|
406.9 |
|
Day 184 |
122 |
3 |
|
439.3 |
|
Day 184 |
142 |
3 |
|
375.3 |
|
Day 184 |
171 |
3 |
|
433.8 |
|
Day 184 |
174 |
3 |
|
431.6 |
|
Day 184 |
95 |
3 |
|
379.8 |
|
Day 184 |
99 |
3 |
|
441.9 |
|
Day 184 |
189 |
30 |
|
430.1 |
|
Day 184 |
201 |
30 |
|
418.6 |
|
Day 184 |
216 |
30 |
|
407.4 |
|
Day 184 |
219 |
30 |
|
394.8 |
|
Day 184 |
224 |
30 |
|
406.5 |
|
Day 184 |
241 |
30 |
|
427.4 |
|
Day 184 |
249 |
30 |
|
375.3 |
|
Day 184 |
256 |
30 |
|
373.2 |
|
Day 184 |
259 |
30 |
|
372.6 |
|
Day 184 |
270 |
30 |
|
402.8 |
|
Day 184 |
275 |
150 |
|
312.8 |
|
Day 184 |
285 |
150 |
|
325.7 |
|
Day 184 |
311 |
150 |
|
340.4 |
|
Day 184 |
314 |
150 |
|
349.1 |
|
Day 184 |
322 |
150 |
|
353.8 |
|
Day 184 |
323 |
150 |
|
357.2 |
|
Day 184 |
341 |
150 |
|
312.1 |
|
Day 184 |
342 |
150 |
|
286.5 |
|
Day 184 |
347 |
150 |
|
326.6 |
|
Day 184 |
349 |
150 |
|
319.1 |
|
Day 202 |
136 |
3 |
|
313.6 |
|
Day 281 |
267 |
30 |
|
355.3 |
|
Day 316 |
62 |
0 |
|
479.9 |
|
Day 321 |
109 |
3 |
|
458.4 |
|
Day 353 |
268 |
30 |
|
451.4 |
|
Day 366 |
12 |
0 |
|
473.8 |
|
Day 366 |
15 |
0 |
|
503.4 |
|
Day 366 |
26 |
0 |
|
475.6 |
|
Day 366 |
40 |
0 |
|
509.6 |
|
Day 366 |
43 |
0 |
|
484.8 |
|
Day 366 |
49 |
0 |
|
530.4 |
|
Day 366 |
61 |
0 |
|
440.1 |
|
Day 366 |
70 |
0 |
|
470.6 |
|
Day 366 |
81 |
0 |
|
392.1 |
|
Day 366 |
90 |
0 |
|
508.8 |
|
Day 366 |
103 |
3 |
|
479.3 |
|
Day 366 |
106 |
3 |
|
477.7 |
|
Day 366 |
107 |
3 |
|
477.1 |
|
Day 366 |
108 |
3 |
|
493.6 |
|
Day 366 |
116 |
3 |
|
474.1 |
|
Day 366 |
137 |
3 |
|
509.6 |
|
Day 366 |
141 |
3 |
|
453.2 |
|
Day 366 |
156 |
3 |
|
486.4 |
|
Day 366 |
161 |
3 |
|
494.5 |
|
Day 366 |
172 |
3 |
|
494.8 |
|
Day 366 |
187 |
30 |
|
435.8 |
|
Day 366 |
191 |
30 |
|
457.1 |
|
Day 366 |
200 |
30 |
|
429.7 |
|
Day 366 |
214 |
30 |
|
434.8 |
|
Day 366 |
218 |
30 |
|
424.8 |
|
Day 366 |
223 |
30 |
|
452 |
|
Day 366 |
239 |
30 |
|
423.2 |
|
Day 366 |
255 |
30 |
|
465.8 |
|
Day 366 |
265 |
30 |
|
430.3 |
|
Day 366 |
269 |
30 |
|
424.9 |
|
Day 366 |
280 |
150 |
|
349.9 |
|
Day 366 |
283 |
150 |
|
312.4 |
|
Day 366 |
293 |
150 |
|
363.6 |
|
Day 366 |
306 |
150 |
|
365.7 |
|
Day 366 |
312 |
150 |
|
316.2 |
|
Day 366 |
324 |
150 |
|
292.6 |
|
Day 366 |
334 |
150 |
|
339 |
|
Day 366 |
338 |
150 |
|
321.2 |
|
Day 366 |
344 |
150 |
|
305.9 |
|
Day 366 |
353 |
150 |
|
370.1 |
|
Day 384 |
66 |
0 |
|
372.4 |
|
Day 408 |
164 |
3 |
|
393.8 |
|
Day 424 |
96 |
3 |
|
483.5 |
|
Day 429 |
87 |
0 |
|
425.2 |
|
Day 434 |
327 |
150 |
|
408.7 |
|
Day 437 |
238 |
30 |
|
231.6 |
|
Day 464 |
74 |
0 |
|
444.8 |
|
Day 471 |
86 |
0 |
|
390.8 |
|
Day 479 |
30 |
0 |
|
410.1 |
|
Day 479 |
124 |
3 |
|
610.8 |
|
Day 485 |
102 |
3 |
|
519.5 |
|
Day 485 |
98 |
3 |
|
352.7 |
|
Day 486 |
56 |
0 |
|
362.8 |
|
Day 486 |
57 |
0 |
|
359.1 |
|
Day 499 |
139 |
3 |
|
490.8 |
|
Day 517 |
188 |
30 |
|
386.6 |
|
Day 519 |
47 |
0 |
|
336.2 |
|
Day 524 |
59 |
0 |
|
441.5 |
|
Day 527 |
245 |
30 |
|
347.8 |
|
Day 538 |
231 |
30 |
|
337 |
|
Day 548 |
13 |
0 |
|
521.2 |
|
Day 548 |
35 |
0 |
|
513 |
|
Day 548 |
38 |
0 |
|
521.9 |
|
Day 548 |
41 |
0 |
|
535.2 |
|
Day 548 |
55 |
0 |
|
481.2 |
|
Day 548 |
58 |
0 |
|
525.6 |
|
Day 548 |
6 |
0 |
|
511.6 |
|
Day 548 |
65 |
0 |
|
524.6 |
|
Day 548 |
79 |
0 |
|
493.2 |
|
Day 548 |
89 |
0 |
|
480.1 |
|
Day 548 |
127 |
3 |
|
509.1 |
|
Day 548 |
132 |
3 |
|
534.4 |
|
Day 548 |
134 |
3 |
|
537.7 |
|
Day 548 |
138 |
3 |
|
538.4 |
|
Day 548 |
149 |
3 |
|
526.6 |
|
Day 548 |
162 |
3 |
|
410.6 |
|
Day 548 |
166 |
3 |
|
546.2 |
|
Day 548 |
167 |
3 |
|
481.1 |
|
Day 548 |
175 |
3 |
|
562.9 |
|
Day 548 |
97 |
3 |
|
422.7 |
|
Day 548 |
203 |
30 |
|
471.8 |
|
Day 548 |
217 |
30 |
|
451.1 |
|
Day 548 |
221 |
30 |
|
442.7 |
|
Day 548 |
233 |
30 |
|
464.6 |
|
Day 548 |
235 |
30 |
|
386.7 |
|
Day 548 |
242 |
30 |
|
470.1 |
|
Day 548 |
251 |
30 |
|
470.1 |
|
Day 548 |
252 |
30 |
|
466.9 |
|
Day 548 |
254 |
30 |
|
477.9 |
|
Day 548 |
266 |
30 |
|
417.8 |
|
Day 548 |
278 |
150 |
|
314.7 |
|
Day 548 |
296 |
150 |
|
353.9 |
|
Day 548 |
301 |
150 |
|
328.5 |
|
Day 548 |
303 |
150 |
|
318.5 |
|
Day 548 |
307 |
150 |
|
345 |
|
Day 548 |
320 |
150 |
|
394.5 |
|
Day 548 |
331 |
150 |
|
356.8 |
|
Day 548 |
332 |
150 |
|
349.1 |
|
Day 548 |
345 |
150 |
|
344.7 |
|
Day 548 |
354 |
150 |
|
327.7 |
|
Day 549 |
19 |
0 |
|
318.8 |
|
Day 549 |
22 |
0 |
|
275.2 |
|
Day 551 |
276 |
150 |
|
239.1 |
|
Day 553 |
69 |
0 |
|
296 |
|
Day 561 |
165 |
3 |
|
348.7 |
|
Day 561 |
295 |
150 |
|
421.8 |
|
Day 563 |
143 |
3 |
|
432.2 |
|
Day 563 |
277 |
150 |
|
278.8 |
|
Day 563 |
326 |
150 |
|
319.5 |
|
Day 564 |
192 |
30 |
|
424.3 |
|
Day 577 |
237 |
30 |
|
288.2 |
|
Day 577 |
315 |
150 |
|
357 |
|
Day 588 |
153 |
3 |
|
336 |
|
Day 589 |
73 |
0 |
|
441.6 |
|
Day 591 |
16 |
0 |
|
371 |
|
Day 596 |
4 |
0 |
|
472.8 |
|
Day 597 |
131 |
3 |
|
474 |
|
Day 597 |
185 |
30 |
|
294.5 |
|
Day 598 |
152 |
3 |
|
330.6 |
|
Day 600 |
34 |
0 |
|
430.5 |
|
Day 600 |
93 |
3 |
|
397.8 |
|
Day 601 |
262 |
30 |
|
372.6 |
|
Day 605 |
53 |
0 |
|
310.6 |
|
Day 605 |
222 |
30 |
|
267.2 |
|
Day 609 |
253 |
30 |
|
381 |
|
Day 611 |
44 |
0 |
|
290.4 |
|
Day 611 |
5 |
0 |
|
412 |
|
Day 611 |
302 |
150 |
|
253.8 |
|
Day 618 |
154 |
3 |
|
436.9 |
|
Day 622 |
147 |
3 |
|
430.4 |
|
Day 622 |
247 |
30 |
|
246.2 |
|
Day 629 |
115 |
3 |
|
369 |
|
Day 629 |
196 |
30 |
|
374.5 |
|
Day 629 |
343 |
150 |
|
268.7 |
|
Day 633 |
37 |
0 |
|
324.5 |
|
Day 636 |
300 |
150 |
|
169.5 |
|
Day 639 |
294 |
150 |
|
265.2 |
|
Day 640 |
194 |
30 |
|
446.8 |
|
Day 641 |
274 |
150 |
|
309.1 |
|
Day 644 |
208 |
30 |
|
299 |
|
Day 644 |
211 |
30 |
|
300.4 |
|
Day 644 |
316 |
150 |
|
259.3 |
|
Day 646 |
1 |
0 |
|
326.6 |
|
Day 646 |
54 |
0 |
|
293.6 |
|
Day 646 |
352 |
150 |
|
245 |
|
Day 653 |
190 |
30 |
|
279.3 |
|
Day 654 |
32 |
0 |
|
441.6 |
|
Day 654 |
72 |
0 |
|
294.9 |
|
Day 657 |
52 |
0 |
|
431.3 |
|
Day 659 |
112 |
3 |
|
515.5 |
|
Day 659 |
304 |
150 |
|
206.4 |
|
Day 660 |
28 |
0 |
|
331.3 |
|
Day 660 |
284 |
150 |
|
217.7 |
|
Day 666 |
2 |
0 |
|
319.1 |
|
Day 666 |
210 |
30 |
|
265 |
|
Day 666 |
225 |
30 |
|
293.8 |
|
Day 666 |
287 |
150 |
|
249.2 |
|
Day 669 |
227 |
30 |
|
353.6 |
|
Day 675 |
144 |
3 |
|
310.2 |
|
Day 675 |
173 |
3 |
|
464.9 |
|
Day 675 |
281 |
150 |
|
218.8 |
|
Day 675 |
290 |
150 |
|
295.5 |
|
Day 679 |
128 |
3 |
|
287.3 |
|
Day 680 |
206 |
30 |
|
264.9 |
|
Day 681 |
181 |
30 |
|
273.7 |
|
Day 688 |
329 |
150 |
|
215.2 |
|
Day 692 |
39 |
0 |
|
403.9 |
|
Day 692 |
130 |
3 |
|
394 |
|
Day 692 |
94 |
3 |
|
267.2 |
|
Day 692 |
184 |
30 |
|
247.4 |
|
Day 693 |
125 |
3 |
|
311.5 |
|
Day 693 |
198 |
30 |
|
294.2 |
|
Day 696 |
220 |
30 |
|
222.5 |
|
Day 700 |
186 |
30 |
|
229.4 |
|
Day 702 |
23 |
0 |
|
298.4 |
|
Day 703 |
159 |
3 |
|
267.1 |
|
Day 703 |
176 |
3 |
|
629.6 |
|
Day 703 |
240 |
30 |
|
261.9 |
|
Day 703 |
258 |
30 |
|
328.9 |
|
Day 703 |
272 |
150 |
|
233.7 |
|
Day 705 |
193 |
30 |
|
243.8 |
|
Day 706 |
51 |
0 |
|
388.4 |
|
Day 706 |
123 |
3 |
|
282.4 |
|
Day 706 |
148 |
3 |
|
301.3 |
|
Day 706 |
182 |
30 |
|
529.5 |
|
Day 707 |
10 |
0 |
|
512.3 |
|
Day 707 |
92 |
3 |
|
287.1 |
|
Day 707 |
234 |
30 |
|
462.8 |
|
Day 708 |
313 |
150 |
|
267.5 |
|
Day 709 |
121 |
3 |
|
459.6 |
|
Day 709 |
151 |
3 |
|
315.7 |
|
Day 712 |
356 |
150 |
|
208.2 |
|
Day 714 |
82 |
0 |
|
386.9 |
|
Day 714 |
119 |
3 |
|
283.3 |
|
Day 715 |
350 |
150 |
|
330.6 |
|
Day 716 |
50 |
0 |
|
358.6 |
|
Day 716 |
230 |
30 |
|
256.6 |
|
Day 718 |
150 |
3 |
|
483 |
|
Day 719 |
243 |
30 |
|
233.8 |
|
Day 720 |
42 |
0 |
|
319.5 |
|
Day 720 |
91 |
3 |
|
304.8 |
|
Day 720 |
215 |
30 |
|
271.2 |
|
Day 724 |
348 |
150 |
|
253.8 |
|
Day 727 |
213 |
30 |
|
261.5 |
|
Day 728 |
14 |
0 |
|
437.7 |
|
Day 728 |
20 |
0 |
|
501.3 |
|
Day 728 |
21 |
0 |
|
495.4 |
|
Day 728 |
29 |
0 |
|
350.7 |
|
Day 728 |
36 |
0 |
|
437.4 |
|
Day 728 |
48 |
0 |
|
369 |
|
Day 728 |
60 |
0 |
|
334.8 |
|
Day 728 |
63 |
0 |
|
406.6 |
|
Day 728 |
64 |
0 |
|
407.4 |
|
Day 728 |
67 |
0 |
|
471.4 |
|
Day 728 |
77 |
0 |
|
439.9 |
|
Day 728 |
80 |
0 |
|
363.8 |
|
Day 728 |
83 |
0 |
|
472.8 |
|
Day 728 |
84 |
0 |
|
447.5 |
|
Day 728 |
88 |
0 |
|
334.1 |
|
Day 728 |
111 |
3 |
|
445.5 |
|
Day 728 |
113 |
3 |
|
387.3 |
|
Day 728 |
117 |
3 |
|
463.7 |
|
Day 728 |
118 |
3 |
|
347.2 |
|
Day 728 |
126 |
3 |
|
401.3 |
|
Day 728 |
129 |
3 |
|
385.1 |
|
Day 728 |
133 |
3 |
|
432.7 |
|
Day 728 |
135 |
3 |
|
337.6 |
|
Day 728 |
145 |
3 |
|
391.4 |
|
Day 728 |
168 |
3 |
|
439.7 |
|
Day 728 |
169 |
3 |
|
394.4 |
|
Day 728 |
177 |
3 |
|
483.2 |
|
Day 728 |
178 |
3 |
|
460.5 |
|
Day 728 |
179 |
3 |
|
406.2 |
|
Day 728 |
180 |
3 |
|
427.2 |
|
Day 728 |
183 |
30 |
|
346.1 |
|
Day 728 |
197 |
30 |
|
320.6 |
|
Day 728 |
204 |
30 |
|
297.4 |
|
Day 728 |
205 |
30 |
|
366.5 |
|
Day 728 |
209 |
30 |
|
431.2 |
|
Day 728 |
212 |
30 |
|
251.6 |
|
Day 728 |
229 |
30 |
|
425 |
|
Day 728 |
232 |
30 |
|
290.5 |
|
Day 728 |
244 |
30 |
|
430.8 |
|
Day 728 |
246 |
30 |
|
382.9 |
|
Day 728 |
250 |
30 |
|
430.4 |
|
Day 728 |
257 |
30 |
|
439 |
|
Day 728 |
261 |
30 |
|
407.3 |
|
Day 728 |
264 |
30 |
|
401.8 |
|
Day 728 |
279 |
150 |
|
339.4 |
|
Day 728 |
282 |
150 |
|
300.4 |
|
Day 728 |
286 |
150 |
|
346.8 |
|
Day 728 |
288 |
150 |
|
365.4 |
|
Day 728 |
289 |
150 |
|
214.2 |
|
Day 728 |
291 |
150 |
|
362.2 |
|
Day 728 |
298 |
150 |
|
291.1 |
|
Day 728 |
299 |
150 |
|
326.1 |
|
Day 728 |
305 |
150 |
|
315.3 |
|
Day 728 |
308 |
150 |
|
318.3 |
|
Day 728 |
309 |
150 |
|
344.4 |
|
Day 728 |
319 |
150 |
|
328.1 |
|
Day 728 |
321 |
150 |
|
329.1 |
|
Day 728 |
325 |
150 |
|
336.2 |
|
Day 728 |
336 |
150 |
|
265 |
|
Day 728 |
340 |
150 |
|
302.6 |
|
Day 728 |
355 |
150 |
|
318.1 |
|
Day 728 |
358 |
150 |
|
311.6 |
|
Day 728 |
359 |
150 |
|
318.3 |
|
Day 728 |
360 |
150 |
|
339.6 |
|
Abbreviations: |
NA: Not Available
|