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Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: 2,3,7,8-Tetrachlorodibenzo-p-dioxin
CASRN: ="1746-01-6"
Study Number: C03714B
Exposure Route: Topical Application
TDMS Number:
Sex: Male
Strain and Species: Swiss Webster Mice

Male Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Mesentery Nos 050.0 UG NA NA 3_004 111.00 1 Lipoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 28 NA 2_014 111.00 1 Hemangioma Natural Death
Alimentary System Liver Vehicle Control 84 NA 5_051 111.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver Untreated Control 28 NA 4_005 111.00 1 Hemangiosarcoma Scheduled Sacrifice
Alimentary System Liver Untreated Control 28 NA 4_007 111.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver Vehicle Control 84 NA 5_004 111.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 001.0 NG 27 NA 1_002 106.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver 001.0 NG 27 NA 1_010 106.00 1 Hemangiosarcoma Natural Death
Alimentary System Liver 001.0 NG 27 NA 1_006 106.00 1 Hemangiosarcoma Scheduled Sacrifice
Alimentary System Liver 001.0 NG 27 NA 1_020 106.00 1 Hemangiosarcoma Scheduled Sacrifice
Alimentary System Salivary gland Parotid Gland Nos 001.0 NG NA NA 1_027 106.00 1 Adenoma, Nos Scheduled Sacrifice
All Others Unspecified Back Vehicle Control NA NA 5_039 111.00 1 Fibrosarcoma Scheduled Sacrifice
All Others Unspecified Back 001.0 NG NA NA 1_007 106.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Back 001.0 NG NA NA 1_010 106.00 1 Fibrosarcoma Natural Death
All Others Unspecified Back 001.0 NG NA NA 1_019 106.00 1 Fibrosarcoma Natural Death
All Others Unspecified Back 001.0 NG NA NA 1_029 106.00 1 Fibrosarcoma Natural Death
All Others Unspecified Back 050.0 UG NA NA 3_011 111.00 1 Fibrosarcoma Natural Death
All Others Unspecified Back 050.0 UG NA NA 3_030 111.00 1 Fibrosarcoma Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 5_033 111.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 5_035 111.00 1 Lymphoma, Nos-Malignant Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 5_040 111.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 2_003 111.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 4_006 111.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 5_029 111.00 1 Leukemia, Granulocytic Natural Death
All Others Unspecified Multiple Organs Nos Vehicle Control NA NA 5_039 111.00 1 Fibrosarcoma Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 001.0 NG NA NA 1_016 106.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 001.0 NG NA NA 1_024 106.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 050.0 UG NA NA 3_017 111.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 050.0 UG NA NA 3_020 111.00 1 Lymphoma, Lymphocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 050.0 UG NA NA 3_013 111.00 1 Lymphoma, Histiocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 050.0 UG NA NA 3_025 111.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Multiple Organs Nos 050.0 UG NA NA 3_031 111.00 1 Lymphoma, Lymphocytic-Malignant Type Natural Death
All Others Unspecified Neck 001.0 NG NA NA 1_026 106.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Neck 050.0 UG NA NA 3_028 111.00 1 Fibrosarcoma Natural Death
All Others Unspecified Vehicle Control NA NA 5_033 111.00 1 Fibroma Moribund Sacrifice
All Others Unspecified Vehicle Control NA NA 5_040 111.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified Vehicle Control NA NA 5_046 111.00 1 Sebaceous Adenoma Natural Death
All Others Unspecified 001.0 NG NA NA 1_025 106.00 1 Fibrosarcoma Moribund Sacrifice
All Others Unspecified 050.0 UG NA NA 3_003 111.00 1 Fibrosarcoma Natural Death
All Others Unspecified 050.0 UG NA NA 3_031 111.00 1 Fibrosarcoma Natural Death
Cardiovascular System Heart Untreated Control 26 NA 4_017 111.00 1 Hemangiosarcoma Scheduled Sacrifice
Endocrine System Adrenal gland Untreated Control 22 NA 4_003 111.00 1 Cortical Carcinoma Scheduled Sacrifice
Endocrine System Thyroid Untreated Control 26 NA 4_001 111.00 1 Adenoma, Nos Natural Death
Hematopoietic System Bone marrow 001.0 NG 25 NA 1_007 106.00 1 Fibrosarcoma, Invasive Moribund Sacrifice
Hematopoietic System Lymph node Brachial Lymph Node 050.0 UG 19 NA 3_003 111.00 1 Fibrosarcoma, Metastatic Natural Death
Hematopoietic System Lymph node Mesenteric Lymph Node 050.0 UG 27 NA 3_010 111.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Lymph node Pulmonary Lymph Node 050.0 UG 19 NA 3_008 111.00 1 Alveolar/Bronchiolar Carcinoma, Metastatic Natural Death
Hematopoietic System Thymus 050.0 UG 24 NA 3_017 111.00 1 Fibrosarcoma, Metastatic Moribund Sacrifice
Integumentary System Skin Untreated Control 28 NA 2_008 111.00 1 Fibroma Natural Death
Integumentary System Skin Vehicle Control 78 NA 5_007 111.00 1 Fibrosarcoma Natural Death
Integumentary System Skin 050.0 UG 25 NA 3_027 111.00 1 Fibroma Natural Death
Musculoskeletal System Skeletal muscle 001.0 NG NA NA 1_007 106.00 1 Fibrosarcoma, Invasive Moribund Sacrifice
Respiratory System Lung Untreated Control 26 NA 4_015 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung Untreated Control 26 NA 4_020 111.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung Untreated Control 28 NA 2_007 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung Vehicle Control 82 NA 5_007 111.00 1 Fibrosarcoma, Metastatic Natural Death
Respiratory System Lung Vehicle Control 82 NA 5_008 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung Vehicle Control 82 NA 5_016 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung Vehicle Control 82 NA 5_024 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung Vehicle Control 82 NA 5_038 111.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung Vehicle Control 82 NA 5_044 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung Vehicle Control 82 NA 5_044 111.00 1 Squamous Cell Carcinoma, Metastatic Natural Death
Respiratory System Lung Untreated Control 26 NA 4_003 111.00 1 Cortical Carcinoma, Metastatic Scheduled Sacrifice
Respiratory System Lung Untreated Control 26 NA 4_008 111.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 28 NA 2_020 111.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Vehicle Control 82 NA 5_004 111.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Vehicle Control 82 NA 5_037 111.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 001.0 NG 28 NA 1_031 106.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 001.0 NG 28 NA 1_006 106.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 050.0 UG 29 NA 3_003 111.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 050.0 UG 29 NA 3_008 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 050.0 UG 29 NA 3_008 111.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 050.0 UG 29 NA 3_009 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 050.0 UG 29 NA 3_018 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 050.0 UG 29 NA 3_031 111.00 1 Alveolar/Bronchiolar Adenoma Natural Death
Respiratory System Lung 050.0 UG 29 NA 3_001 111.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland Untreated Control NA NA 2_002 111.00 1 Papillary Adenoma Scheduled Sacrifice