If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: 4-Chloro-o-phenylenediamine
CASRN: ="95-83-0"
Study Number: C03292
Exposure Route: Dosed-Feed
TDMS Number:
Sex: Female
Strain and Species: B6C3F1 Mice

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Small Peyers Patch 10000 PPM NA NA 1_023 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Alimentary System Intestine Small Peyers Patch 10000 PPM NA NA 1_045 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Alimentary System Intestine Small Peyers Patch 20000 PPM NA NA 2_029 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_003 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_005 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_009 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_010 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_017 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_018 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_020 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_030 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_043 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_044 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 10000 PPM 48 NA 1_049 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_006 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_007 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_015 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_018 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_019 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_030 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_041 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_043 102.00 1 Hepatocellular Carcinoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_045 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Liver 20000 PPM 47 NA 2_049 102.00 1 Hepatocellular Adenoma Scheduled Sacrifice
Alimentary System Pancreas Islets 20000 PPM 42 NA 2_042 102.00 1 Islet-Cell Adenoma Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_008 103.00 1 Lymphoma, Histiocytic-Malignant Type Moribund Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_039 103.00 1 Lymphoma, Nos-Malignant Natural Death
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_013 103.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos Untreated Control NA NA 3_046 103.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_022 102.00 1 Leukemia, Undifferentiated Natural Death
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_001 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_003 102.00 1 Lymphoma, Undifferentiated-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_014 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_017 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_026 102.00 1 Lymphoma, Undifferentiated-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_028 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 10000 PPM NA NA 1_034 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
All Others Unspecified Multiple Organs Nos 20000 PPM NA NA 2_001 102.00 1 Leukemia, Undifferentiated Natural Death
All Others Unspecified 10000 PPM NA NA 1_025 102.00 1 Hemangiosarcoma Scheduled Sacrifice
Endocrine System Adrenal gland Capsule Untreated Control 40 NA 3_033 103.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Adrenal gland Medulla 10000 PPM 45 NA 1_023 102.00 1 Neuroblastoma Scheduled Sacrifice
Endocrine System Pituitary gland Untreated Control 33 NA 3_020 103.00 1 Adenoma, Nos Moribund Sacrifice
Endocrine System Pituitary gland 10000 PPM 34 NA 1_030 102.00 1 Adenoma, Nos Scheduled Sacrifice
Endocrine System Thyroid Untreated Control 29 NA 3_018 103.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Endocrine System Thyroid 10000 PPM 46 NA 1_029 102.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Endocrine System Thyroid 20000 PPM 39 NA 2_025 102.00 1 Follicular-Cell Adenoma Scheduled Sacrifice
Genital System Ovary Untreated Control 40 NA 3_025 103.00 1 Papillary Adenoma Scheduled Sacrifice
Genital System Ovary 20000 PPM 38 NA 2_021 102.00 1 Granulosa-Cell Tumor Scheduled Sacrifice
Genital System Ovary 20000 PPM 38 NA 2_040 102.00 1 Papillary Adenoma Scheduled Sacrifice
Genital System Uterus 20000 PPM 44 NA 2_016 102.00 1 Leiomyosarcoma Moribund Sacrifice
Genital System Uterus 20000 PPM 44 NA 2_022 102.00 1 Hemangioma Scheduled Sacrifice
Hematopoietic System Lymph node Mesenteric Lymph Node 20000 PPM 46 NA 2_015 102.00 1 Lymphoma, Nos-Malignant Scheduled Sacrifice
Hematopoietic System Lymph node 10000 PPM 46 NA 1_039 102.00 1 Alveolar/Bronchiolar Carcinoma, Metastatic Natural Death
Hematopoietic System Lymph node 10000 PPM 46 NA 1_032 102.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen Untreated Control 45 NA 3_027 103.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen Untreated Control 45 NA 3_042 103.00 1 Lymphoma, Histiocytic-Malignant Type Scheduled Sacrifice
Hematopoietic System Spleen 10000 PPM 48 NA 1_025 102.00 1 Hemangiosarcoma Scheduled Sacrifice
Hematopoietic System Spleen 10000 PPM 48 NA 1_035 102.00 1 Hemangioma Scheduled Sacrifice
Hematopoietic System Spleen 20000 PPM 48 NA 2_022 102.00 1 Hemangioma Scheduled Sacrifice
Integumentary System Skin Untreated Control 44 NA 3_033 103.00 1 Keratoacanthoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 46 NA 3_001 103.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 46 NA 3_005 103.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 46 NA 3_032 103.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung Untreated Control 46 NA 3_048 103.00 1 Alveolar/Bronchiolar Carcinoma Scheduled Sacrifice
Respiratory System Lung 10000 PPM 48 NA 1_039 102.00 1 Alveolar/Bronchiolar Carcinoma Natural Death
Respiratory System Lung 10000 PPM 48 NA 1_028 102.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 20000 PPM 45 NA 2_019 102.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 20000 PPM 45 NA 2_020 102.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Respiratory System Lung 20000 PPM 45 NA 2_042 102.00 1 Alveolar/Bronchiolar Adenoma Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland 10000 PPM NA NA 1_049 102.00 1 Papillary Adenoma Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland 20000 PPM NA NA 2_015 102.00 1 Papillary Cystadenoma, Nos Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland 20000 PPM NA NA 2_034 102.00 1 Cystadenoma, Nos Scheduled Sacrifice
Special Senses System Harderian gland Hardarian Gland 20000 PPM NA NA 2_037 102.00 1 Cystadenoma, Nos Scheduled Sacrifice