If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 5-Azacytidine
CASRN: ="320-67-2"
Study Number: C01569
Exposure Route: Intraperitoneal Injection
TDMS Number:
Sex: Female
Strain and Species: Sprague Dawley Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Centrilobular 002.5 ML/KG 31 NA 1_013 51.00 1 Necrosis, Coagulative Moribund Sacrifice
Alimentary System Liver Centrilobular 002.5 ML/KG 31 NA 1_014 51.00 1 Necrosis, Coagulative Moribund Sacrifice
Alimentary System Liver Centrilobular 002.5 ML/KG 31 NA 1_032 51.00 1 Degeneration, Cytologic Moribund Sacrifice
Alimentary System Liver Centrilobular 002.5 ML/KG 31 NA 1_022 51.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 31 NA 1_031 51.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 31 NA 2_033 86.00 1 Necrosis, Nos Natural Death
Genital System Ovary 002.5 ML/KG 23 NA 2_055 86.00 1 Inflammation, Chronic Suppurative Moribund Sacrifice
Genital System Ovary 002.5 ML/KG 27 NA 1_065 51.00 1 Inflammation, Chronic Suppurative Natural Death
Genital System Ovary 002.5 ML/KG 23 NA 2_034 86.00 1 Inflammation, Suppurative Scheduled Sacrifice
Genital System Ovary 002.5 ML/KG 23 NA 2_053 86.00 1 Inflammation, Chronic Suppurative Scheduled Sacrifice
Genital System Ovary 002.5 ML/KG 23 NA 2_075 86.00 1 Inflammation, Chronic Suppurative Scheduled Sacrifice
Genital System Uterus Endometrium Untreated Control 15 NA 4_032 87.00 1 Inflammation, Suppurative Moribund Sacrifice
Genital System Uterus Endometrium Vehicle Control 15 NA 3_015 87.00 1 Inflammation, Suppurative Moribund Sacrifice
Genital System Uterus Endometrium Vehicle Control 15 NA 3_032 87.00 1 Inflammation, Suppurative Scheduled Sacrifice
Genital System Uterus Endometrium 002.5 ML/KG 30 NA 2_055 86.00 1 Inflammation, Chronic Suppurative Moribund Sacrifice
Genital System Uterus Endometrium 002.5 ML/KG 30 NA 2_024 86.00 1 Inflammation, Suppurative Natural Death
Genital System Uterus Endometrium 002.5 ML/KG 30 NA 2_034 86.00 1 Inflammation, Suppurative Scheduled Sacrifice
Genital System Uterus Endometrium 002.5 ML/KG 30 NA 2_045 86.00 1 Inflammation, Suppurative Scheduled Sacrifice
Genital System Uterus Endometrium 002.5 ML/KG 30 NA 2_053 86.00 1 Inflammation, Chronic Suppurative Scheduled Sacrifice
Genital System Uterus Endometrium 002.5 ML/KG 30 NA 2_075 86.00 1 Inflammation, Chronic Suppurative Scheduled Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_013 51.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_014 51.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_023 51.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_025 51.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_032 51.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_055 51.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_063 51.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_011 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_021 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_022 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_031 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_035 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_043 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_072 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 1_074 51.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 30 NA 2_033 86.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 30 NA 2_063 86.00 1 Atrophy, Nos Scheduled Sacrifice
Integumentary System Mammary gland Untreated Control 10 NA 4_011 87.00 1 Hyperplasia, Cystic Scheduled Sacrifice
Respiratory System Lung Untreated Control 15 NA 4_024 87.00 1 Bronchopneumonia Chronic Suppurative Scheduled Sacrifice
Respiratory System Lung Untreated Control 15 NA 4_035 87.00 1 Bronchopneumonia Suppurative Scheduled Sacrifice
Respiratory System Lung Vehicle Control 14 NA 3_014 87.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice
Respiratory System Lung Vehicle Control 14 NA 3_032 87.00 1 Inflammation, Interstitial Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 1_023 51.00 1 Hyperplasia, Lymphoid Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 1_052 51.00 1 Inflammation, Interstitial Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 1_063 51.00 1 Inflammation, Interstitial Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 2_011 86.00 1 Bronchopneumonia Suppurative Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 2_035 86.00 1 Bronchopneumonia Suppurative Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 2_074 86.00 1 Bronchopneumonia Suppurative Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 1_051 51.00 1 Bronchopneumonia Necrotizing Natural Death
Respiratory System Lung 002.5 ML/KG 30 NA 2_032 86.00 1 Inflammation, Interstitial Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 30 NA 2_034 86.00 1 Bronchopneumonia Suppurative Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_032 86.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice