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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: 5-Azacytidine
CASRN: ="320-67-2"
Study Number: C01569
Exposure Route: Intraperitoneal Injection
TDMS Number:
Sex: Male
Strain and Species: Sprague Dawley Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Bile Duct 002.5 ML/KG 34 NA 2_064 85.00 1 Inflammation, Chronic Scheduled Sacrifice
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_064 49.00 1 Necrosis, Coagulative Moribund Sacrifice
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_013 49.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_014 49.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_021 49.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_053 49.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_061 49.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_072 49.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_073 49.00 1 Necrosis, Nos Natural Death
Alimentary System Liver Centrilobular 002.5 ML/KG 33 NA 1_075 49.00 1 Necrosis, Coagulative Natural Death
Alimentary System Liver 002.5 ML/KG 33 NA 1_025 49.00 1 Necrosis, Central Moribund Sacrifice
Alimentary System Liver 002.5 ML/KG 33 NA 1_043 49.00 1 Necrosis, Coagulative Moribund Sacrifice
Alimentary System Liver 002.5 ML/KG 33 NA 1_044 49.00 1 Necrosis, Coagulative Moribund Sacrifice
Alimentary System Liver 002.5 ML/KG 33 NA 1_074 49.00 1 Inflammation, Necrotizing Moribund Sacrifice
Alimentary System Liver 002.5 ML/KG 30 NA 2_015 85.00 1 Necrosis, Central Natural Death
Alimentary System Liver 002.5 ML/KG 30 NA 2_025 85.00 1 Necrosis, Central Natural Death
Alimentary System Liver 002.5 ML/KG 30 NA 2_053 85.00 1 Necrosis, Central Natural Death
Alimentary System Liver 002.5 ML/KG 30 NA 2_054 85.00 1 Necrosis, Central Natural Death
Alimentary System Liver 002.5 ML/KG 30 NA 2_062 85.00 1 Necrosis, Central Natural Death
Alimentary System Liver 002.5 ML/KG 33 NA 1_041 49.00 1 Congestion, Passive Natural Death
Alimentary System Liver 002.5 ML/KG 33 NA 1_052 49.00 1 Necrosis, Central Natural Death
Alimentary System Liver 002.5 ML/KG 33 NA 1_062 49.00 1 Congestion, Chronic Passive Natural Death
Alimentary System Liver 002.5 ML/KG 33 NA 1_062 49.00 1 Necrosis, Central Natural Death
Alimentary System Stomach Submucosa 002.5 ML/KG 33 NA 1_065 49.00 1 Abscess, Chronic Natural Death
Cardiovascular System Heart Atrium 002.5 ML/KG 32 NA 1_041 49.00 1 Thrombosis, Nos Natural Death
Cardiovascular System Heart Myocardium Nos 002.5 ML/KG 32 NA 1_074 49.00 1 Inflammation, Necrotizing Moribund Sacrifice
Cardiovascular System Heart Myocardium Nos 002.5 ML/KG 32 NA 1_041 49.00 1 Degeneration, Nos Natural Death
Genital System Prostate 002.5 ML/KG 30 NA 1_045 49.00 1 Inflammation, Suppurative Natural Death
Hematopoietic System Bone marrow Vehicle Control 15 NA 3_013 86.00 1 Atrophy, Nos Scheduled Sacrifice
Hematopoietic System Bone marrow Vehicle Control 15 NA 3_014 86.00 1 Atrophy, Nos Scheduled Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 2_072 85.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_011 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_015 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_022 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_023 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_024 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_025 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_031 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_044 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_055 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_064 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_074 49.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 2_012 85.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 2_015 85.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 2_025 85.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 29 NA 2_053 85.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_012 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_013 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_014 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_021 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_041 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_042 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_051 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_052 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_053 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_061 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_062 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_065 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_072 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_073 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 33 NA 1_075 49.00 1 Atrophy, Nos Natural Death
Hematopoietic System Lymph node 002.5 ML/KG 28 NA 1_055 49.00 1 Inflammation, Necrotizing Moribund Sacrifice
Hematopoietic System Spleen 002.5 ML/KG 32 NA 1_055 49.00 1 Inflammation, Necrotizing Moribund Sacrifice
Hematopoietic System Spleen 002.5 ML/KG 32 NA 1_013 49.00 1 Necrosis, Nos Natural Death
Hematopoietic System Spleen 002.5 ML/KG 32 NA 1_021 49.00 1 Necrosis, Nos Natural Death
Hematopoietic System Spleen 002.5 ML/KG 32 NA 1_072 49.00 1 Necrosis, Nos Natural Death
Respiratory System Lung Bronchiole 002.5 ML/KG 31 NA 2_042 85.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice
Respiratory System Lung Untreated Control 14 NA 4_034 86.00 1 Bronchopneumonia Suppurative Natural Death
Respiratory System Lung Untreated Control 14 NA 4_014 86.00 1 Bronchopneumonia Suppurative Scheduled Sacrifice
Respiratory System Lung Untreated Control 14 NA 4_022 86.00 1 Bronchopneumonia Suppurative Scheduled Sacrifice
Respiratory System Lung Vehicle Control 13 NA 3_013 86.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice
Respiratory System Lung Vehicle Control 13 NA 3_021 86.00 1 Inflammation, Interstitial Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_072 85.00 1 Bronchopneumonia Chronic Suppurative Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 32 NA 1_022 49.00 1 Inflammation, Interstitial Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 32 NA 1_043 49.00 1 Bronchopneumonia Chronic Suppurative Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_033 85.00 1 Inflammation, Interstitial Natural Death
Respiratory System Lung 002.5 ML/KG 31 NA 2_035 85.00 1 Bronchopneumonia Suppurative Natural Death
Respiratory System Lung 002.5 ML/KG 31 NA 2_053 85.00 1 Bronchopneumonia Suppurative Natural Death
Respiratory System Lung 002.5 ML/KG 31 NA 2_062 85.00 1 Bronchopneumonia Suppurative Natural Death
Respiratory System Lung 002.5 ML/KG 31 NA 2_011 85.00 1 Bronchopneumonia Suppurative Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_013 85.00 1 Bronchopneumonia Chronic Suppurative Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_014 85.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_034 85.00 1 Bronchopneumonia, Chronic Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_041 85.00 1 Hyperplasia, Lymphoid Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_045 85.00 1 Inflammation, Interstitial Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_055 85.00 1 Bronchopneumonia Chronic Suppurative Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_061 85.00 1 Bronchopneumonia Chronic Suppurative Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_064 85.00 1 Inflammation, Interstitial Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_073 85.00 1 Bronchopneumonia Suppurative Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 31 NA 2_075 85.00 1 Inflammation, Interstitial Scheduled Sacrifice
Respiratory System Trachea Vehicle Control 15 NA 3_021 86.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 27 NA 2_041 85.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 27 NA 2_045 85.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 27 NA 2_061 85.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 27 NA 2_064 85.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Urinary System Kidney Untreated Control 14 NA 4_033 86.00 1 Nephrosis, Hydro Moribund Sacrifice
Urinary System Kidney Untreated Control 14 NA 4_013 86.00 1 Glomerulonephritis, Membranous Scheduled Sacrifice
Urinary System Kidney Untreated Control 14 NA 4_014 86.00 1 Glomerulonephritis, Membranous Scheduled Sacrifice
Urinary System Kidney Untreated Control 14 NA 4_031 86.00 1 Glomerulonephritis, Membranous Scheduled Sacrifice
Urinary System Kidney Vehicle Control 15 NA 3_021 86.00 1 Glomerulonephritis, Membranous Scheduled Sacrifice
Urinary System Kidney 002.5 ML/KG 32 NA 1_074 49.00 1 Inflammation, Suppurative Moribund Sacrifice
Urinary System Kidney 002.5 ML/KG 32 NA 1_045 49.00 1 Pyelonephritis, Acute/Chronic Natural Death
Urinary System Kidney 002.5 ML/KG 30 NA 2_013 85.00 1 Glomerulonephritis, Membranous Scheduled Sacrifice
Urinary System Kidney 002.5 ML/KG 30 NA 2_014 85.00 1 Inflammation, Interstitial Scheduled Sacrifice
Urinary System Kidney 002.5 ML/KG 30 NA 2_055 85.00 1 Inflammation, Interstitial Scheduled Sacrifice
Urinary System Kidney 002.5 ML/KG 30 NA 2_071 85.00 1 Inflammation, Chronic Scheduled Sacrifice