Alimentary System |
Liver |
Centrilobular, Hepatocyte |
Vehicle Control |
10 |
51 |
52 |
92 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
Vehicle Control |
10 |
51 |
54 |
92 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
Vehicle Control |
10 |
52 |
58 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
100.0 MG/KG |
10 |
59 |
95 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
100.0 MG/KG |
10 |
60 |
97 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
100.0 MG/KG |
10 |
60 |
98 |
92 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
52 |
60 |
92 |
1 |
Inflammation |
Minimal, Focal, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
52 |
56 |
92 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
52 |
58 |
92 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100.0 MG/KG |
10 |
60 |
96 |
42 |
1 |
Necrosis |
Minimal, Focal |
Natural Death |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
Vehicle Control |
10 |
51 |
52 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
Vehicle Control |
10 |
51 |
53 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
Vehicle Control |
10 |
51 |
54 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
Vehicle Control |
10 |
51 |
55 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
Vehicle Control |
10 |
52 |
56 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
100.0 MG/KG |
10 |
59 |
92 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
100.0 MG/KG |
10 |
59 |
93 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
100.0 MG/KG |
10 |
59 |
94 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
100.0 MG/KG |
10 |
60 |
97 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Bilateral, Capsule |
100.0 MG/KG |
10 |
60 |
99 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Capsule |
Vehicle Control |
10 |
52 |
57 |
92 |
1 |
Hyperplasia |
Minimal, Focal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
100.0 MG/KG |
10 |
59 |
93 |
92 |
1 |
Ultimobranchial Cyst |
Mild |
Terminal Sacrifice |
Genital System |
Ovary |
|
100.0 MG/KG |
10 |
60 |
96 |
42 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Genital System |
Uterus |
Endometrium |
Vehicle Control |
10 |
51 |
55 |
92 |
1 |
Hyperplasia |
Minimal, Cystic |
Terminal Sacrifice |
Genital System |
Uterus |
Endometrium |
Vehicle Control |
10 |
52 |
58 |
92 |
1 |
Hyperplasia |
Minimal, Cystic |
Terminal Sacrifice |
Genital System |
Uterus |
Endometrium |
Vehicle Control |
10 |
52 |
59 |
92 |
1 |
Hyperplasia |
Minimal, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
100.0 MG/KG |
10 |
60 |
98 |
92 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
52 |
56 |
92 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
52 |
56 |
92 |
1 |
Hyperplasia |
Minimal, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
10 |
51 |
54 |
92 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
100.0 MG/KG |
10 |
59 |
91 |
92 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
100.0 MG/KG |
10 |
59 |
93 |
92 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
100.0 MG/KG |
10 |
59 |
95 |
92 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
Vehicle Control |
10 |
51 |
53 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
100.0 MG/KG |
10 |
59 |
91 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
100.0 MG/KG |
10 |
59 |
94 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
100.0 MG/KG |
10 |
59 |
93 |
92 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
|
100.0 MG/KG |
10 |
60 |
100 |
92 |
1 |
Infiltration Cellular |
Minimal, Lymphocyte |
Terminal Sacrifice |