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Long-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Isophosphamide
CASRN: ="3778-73-2"
Study Number: C01638
Exposure Route: Intraperitoneal Injection
TDMS Number:
Sex: Female
Strain and Species: Sprague Dawley Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Weeks on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Cecum, Colon 002.5 ML/KG 34 NA 1_011 85.00 1 Cyst, Hemorrhagic Moribund Sacrifice
Alimentary System Liver 002.5 ML/KG 33 NA 1_031 85.00 1 Hemorrhage Natural Death
Alimentary System Liver 002.5 ML/KG 33 NA 1_031 85.00 1 Necrosis, Coagulative Natural Death
Alimentary System Pancreas 002.5 ML/KG 33 NA 1_021 85.00 1 Hemorrhage Moribund Sacrifice
Alimentary System Pancreas 002.5 ML/KG 33 NA 1_022 85.00 1 Atrophy, Nos Moribund Sacrifice
Alimentary System Pancreas 002.5 ML/KG 33 NA 1_022 85.00 1 Inflammation, Interstitial Moribund Sacrifice
Alimentary System Stomach Submucosa 002.5 ML/KG 34 NA 1_021 85.00 1 Hemorrhage Moribund Sacrifice
Alimentary System Stomach 002.5 ML/KG 33 NA 2_051 89.00 1 Ulcer, Nos Natural Death
Alimentary System Stomach 002.5 ML/KG 33 NA 2_064 89.00 1 Ulcer, Nos Natural Death
All Others Unspecified Multiple Organs Nos 002.5 ML/KG NA NA 1_035 85.00 1 Plasmacytosis Moribund Sacrifice
All Others Unspecified Multiple Organs Nos 002.5 ML/KG NA NA 1_062 85.00 1 Hyperplasia, Lymphoid Natural Death
Cardiovascular System Heart Endocardium Nos 002.5 ML/KG 33 NA 2_061 89.00 1 Fibrosis Moribund Sacrifice
Cardiovascular System Heart Pericardium Nos 002.5 ML/KG NA NA 1_023 85.00 1 Inflammation, Chronic Moribund Sacrifice
Cardiovascular System Heart Vehicle Control 9 NA 3_015 89.00 1 Periarteritis Scheduled Sacrifice
Cardiovascular System Heart 002.5 ML/KG 33 NA 1_042 85.00 1 Plasmacytosis Natural Death
Cardiovascular System Heart 002.5 ML/KG 33 NA 1_051 85.00 1 Periarteritis Natural Death
General Body System Peritoneum 002.5 ML/KG NA NA 1_021 85.00 1 Hemorrhage Moribund Sacrifice
General Body System Peritoneum 002.5 ML/KG NA NA 1_022 85.00 1 Inflammation, Fibrinous Moribund Sacrifice
General Body System Peritoneum 002.5 ML/KG NA NA 1_023 85.00 1 Inflammation, Chronic Moribund Sacrifice
General Body System Peritoneum 002.5 ML/KG NA NA 1_052 85.00 1 Hemorrhage Moribund Sacrifice
General Body System Peritoneum 002.5 ML/KG NA NA 1_063 85.00 1 Inflammation, Chronic Moribund Sacrifice
General Body System Peritoneum 002.5 ML/KG NA NA 1_013 85.00 1 Inflammation, Fibrinous Natural Death
Genital System Ovary 002.5 ML/KG 21 NA 2_073 89.00 1 Cyst, Nos Moribund Sacrifice
Genital System Ovary 002.5 ML/KG 26 NA 1_021 85.00 1 Hemorrhage Moribund Sacrifice
Genital System Ovary 002.5 ML/KG 26 NA 1_074 85.00 1 Inflammation, Suppurative Moribund Sacrifice
Genital System Uterus Endometrium 002.5 ML/KG 32 NA 2_011 89.00 1 Inflammation, Nos Moribund Sacrifice
Genital System Uterus Fallopian Tube 002.5 ML/KG 26 NA 1_074 85.00 1 Inflammation, Nos Moribund Sacrifice
Genital System Uterus Untreated Control 9 NA 4_015 90.00 1 Pyometra Scheduled Sacrifice
Genital System Uterus Untreated Control 9 NA 4_022 90.00 1 Pyometra Scheduled Sacrifice
Genital System Uterus Untreated Control 9 NA 4_024 90.00 1 Pyometra Scheduled Sacrifice
Genital System Uterus 002.5 ML/KG 34 NA 1_062 85.00 1 Hemorrhage, Chronic Natural Death
Genital System Uterus 002.5 ML/KG 32 NA 2_015 89.00 1 Pyometra Scheduled Sacrifice
Genital System Uterus 002.5 ML/KG 32 NA 2_021 89.00 1 Pyometra Scheduled Sacrifice
Genital System Uterus 002.5 ML/KG 32 NA 2_031 89.00 1 Pyometra Scheduled Sacrifice
Genital System Uterus 002.5 ML/KG 32 NA 2_055 89.00 1 Angiectasis Scheduled Sacrifice
Genital System Uterus 002.5 ML/KG 32 NA 2_055 89.00 1 Hemorrhage Scheduled Sacrifice
Hematopoietic System Bone marrow Vehicle Control 9 NA 3_012 89.00 1 Atrophy, Nos Scheduled Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 32 NA 1_022 85.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 32 NA 1_033 85.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 32 NA 1_041 85.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 32 NA 1_052 85.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 32 NA 1_065 85.00 1 Atrophy, Nos Moribund Sacrifice
Hematopoietic System Bone marrow 002.5 ML/KG 32 NA 1_031 85.00 1 Atrophy, Nos Natural Death
Hematopoietic System Bone marrow 002.5 ML/KG 32 NA 2_051 89.00 1 Fibrosis Natural Death
Hematopoietic System Lymph node 002.5 ML/KG 30 NA 1_014 85.00 1 Inflammation, Necrotizing Natural Death
Hematopoietic System Lymph node 002.5 ML/KG 30 NA 1_042 85.00 1 Plasmacytosis Natural Death
Hematopoietic System Spleen 002.5 ML/KG 33 NA 2_064 89.00 1 Necrosis, Nos Natural Death
Hematopoietic System Thymus 002.5 ML/KG 28 NA 1_042 85.00 1 Plasmacytosis Natural Death
Integumentary System Mammary gland Untreated Control 9 NA 4_021 90.00 1 Hyperplasia, Cystic Scheduled Sacrifice
Integumentary System Mammary gland 002.5 ML/KG 26 NA 1_074 85.00 1 Hyperplasia, Cystic Moribund Sacrifice
Integumentary System Mammary gland 002.5 ML/KG 26 NA 1_075 85.00 1 Hyperplasia, Cystic Natural Death
Integumentary System Skin Vehicle Control 10 NA 3_025 89.00 1 Inflammation, Granulomatous Scheduled Sacrifice
Musculoskeletal System Bone Joint Nos 002.5 ML/KG NA NA 1_053 85.00 1 Inflammation, Chronic Suppurative Moribund Sacrifice
Musculoskeletal System Bone Joint Nos 002.5 ML/KG NA NA 1_051 85.00 1 Inflammation, Chronic Suppurative Natural Death
Nervous System Brain Cerebellum Nos 002.5 ML/KG 31 NA 2_033 89.00 1 Hamartoma Moribund Sacrifice
Respiratory System Larynx Untreated Control 1 NA 4_021 90.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Larynx 002.5 ML/KG 4 NA 1_032 85.00 1 Inflammation, Suppurative Natural Death
Respiratory System Lung Bronchus Untreated Control 9 NA 4_021 90.00 1 Bronchiectasis Scheduled Sacrifice
Respiratory System Lung Bronchus Vehicle Control 10 NA 3_012 89.00 1 Bronchiectasis Scheduled Sacrifice
Respiratory System Lung Bronchus Vehicle Control 10 NA 3_014 89.00 1 Bronchiectasis Scheduled Sacrifice
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_023 85.00 1 Bronchiectasis Moribund Sacrifice
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_063 85.00 1 Bronchiectasis Moribund Sacrifice
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 2_063 89.00 1 Bronchiectasis Moribund Sacrifice
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_013 85.00 1 Bronchiectasis Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_013 85.00 1 Inflammation, Nos Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_014 85.00 1 Bronchiectasis Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_014 85.00 1 Inflammation, Nos Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_024 85.00 1 Bronchiectasis Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_024 85.00 1 Inflammation, Nos Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_032 85.00 1 Inflammation, Nos Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 1_034 85.00 1 Bronchiectasis Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 2_064 89.00 1 Bronchiectasis Natural Death
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 2_015 89.00 1 Bronchiectasis Scheduled Sacrifice
Respiratory System Lung Bronchus 002.5 ML/KG 33 NA 2_044 89.00 1 Bronchiectasis Scheduled Sacrifice
Respiratory System Lung Pleura Nos 002.5 ML/KG NA NA 1_041 85.00 1 Inflammation, Chronic Moribund Sacrifice
Respiratory System Lung Pleura Nos 002.5 ML/KG NA NA 1_053 85.00 1 Inflammation, Chronic Moribund Sacrifice
Respiratory System Lung Pleura Nos 002.5 ML/KG NA NA 1_071 85.00 1 Inflammation, Nos Natural Death
Respiratory System Lung Pleura Nos 002.5 ML/KG NA NA 1_073 85.00 1 Inflammation, Nos Natural Death
Respiratory System Lung Untreated Control 9 NA 4_021 90.00 1 Inflammation, Chronic Scheduled Sacrifice
Respiratory System Lung Vehicle Control 10 NA 3_012 89.00 1 Bronchopneumonia, Nos Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_011 85.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_012 85.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_023 85.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_041 85.00 1 Inflammation, Interstitial Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_044 85.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_053 85.00 1 Inflammation, Chronic Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_054 85.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_055 85.00 1 Inflammation, Interstitial Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_063 85.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_065 85.00 1 Inflammation, Interstitial Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 2_013 89.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 2_041 89.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 2_063 89.00 1 Bronchopneumonia, Nos Moribund Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 1_014 85.00 1 Inflammation, Necrotizing Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_032 85.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_034 85.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_042 85.00 1 Edema, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_042 85.00 1 Inflammation, Interstitial Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_042 85.00 1 Plasmacytosis Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_043 85.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_071 85.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_072 85.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_073 85.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 1_075 85.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 2_025 89.00 1 Bronchopneumonia, Nos Natural Death
Respiratory System Lung 002.5 ML/KG 33 NA 2_015 89.00 1 Bronchopneumonia, Nos Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 2_021 89.00 1 Bronchopneumonia, Nos Scheduled Sacrifice
Respiratory System Lung 002.5 ML/KG 33 NA 2_024 89.00 1 Abscess, Nos Scheduled Sacrifice
Respiratory System Trachea Vehicle Control 10 NA 3_021 89.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea Untreated Control 9 NA 4_011 90.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Untreated Control 9 NA 4_012 90.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Untreated Control 9 NA 4_013 90.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Untreated Control 9 NA 4_014 90.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Untreated Control 9 NA 4_015 90.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Untreated Control 9 NA 4_023 90.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Vehicle Control 10 NA 3_011 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Vehicle Control 10 NA 3_013 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea Vehicle Control 10 NA 3_025 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_012 85.00 1 Inflammation, Nos Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_015 85.00 1 Inflammation, Nos Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_023 85.00 1 Inflammation, Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_044 85.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_045 85.00 1 Inflammation, Nos Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_053 85.00 1 Inflammation, Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_054 85.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_055 85.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_063 85.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_013 89.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_014 89.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_063 89.00 1 Inflammation, Acute/Chronic Moribund Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 1_013 85.00 1 Inflammation, Acute Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_014 85.00 1 Inflammation, Acute Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_024 85.00 1 Inflammation, Nos Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_051 85.00 1 Inflammation, Suppurative Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_062 85.00 1 Inflammation, Acute/Chronic Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_071 85.00 1 Inflammation, Nos Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_072 85.00 1 Inflammation, Acute/Chronic Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_073 85.00 1 Inflammation, Acute/Chronic Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_075 85.00 1 Inflammation, Nos Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 2_025 89.00 1 Inflammation, Acute/Chronic Natural Death
Respiratory System Trachea 002.5 ML/KG 29 NA 1_064 85.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_021 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_024 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_042 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_044 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_045 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_053 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_055 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Respiratory System Trachea 002.5 ML/KG 29 NA 2_072 89.00 1 Inflammation, Acute/Chronic Scheduled Sacrifice
Urinary System Kidney Pelvis 002.5 ML/KG 34 NA 1_074 85.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 002.5 ML/KG 33 NA 2_061 89.00 1 Inflammation, Chronic Moribund Sacrifice
Urinary System Kidney 002.5 ML/KG 34 NA 1_074 85.00 1 Inflammation, Chronic Moribund Sacrifice