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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Melatonin
CASRN: ="73-31-4"
Study Number: C96013
Exposure Route: GAVAGE
TDMS Number: 9601303
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Vehicle Control 10 25 153 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 5 UG/KG 1 27 255 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 50 UG/KG 2 29 351 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 50 UG/KG 2 29 354 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 5000 UG/KG 2 31 455 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 5000 UG/KG 2 32 458 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 50,000 UG/KG 1 33 555 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 36 659 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 25 151 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 25 152 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 25 154 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 25 155 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 26 156 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 26 157 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 26 159 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 26 160 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 50 UG/KG 2 29 354 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 35 651 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 35 652 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 35 653 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 35 654 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 35 655 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 36 656 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 36 658 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 36 659 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 36 660 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Pancreas Acinus Vehicle Control 10 25 154 94 1 Atrophy Mild Terminal Sacrifice
Cardiovascular System Heart Myocardium Vehicle Control 10 25 155 94 1 Mineralization Mild Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 25 153 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 25 155 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 26 156 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 26 157 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 26 158 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 26 159 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 26 160 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 35 651 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 35 653 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 35 654 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 36 656 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 36 657 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 36 658 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 36 659 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 36 660 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 200,000 UG/KG 10 35 654 94 1 Cyst Terminal Sacrifice
Genital System Clitoral Gland 200,000 UG/KG 10 36 657 94 1 Cyst Minimal Terminal Sacrifice
Genital System Ovary Vehicle Control 10 26 157 94 1 Cyst Terminal Sacrifice
Genital System Ovary 5 UG/KG 10 27 251 94 1 Mineralization Minimal Terminal Sacrifice
Genital System Uterus Vehicle Control 10 25 153 94 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus Vehicle Control 10 25 154 94 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus Vehicle Control 10 26 160 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 5 UG/KG 10 27 255 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 5 UG/KG 10 28 259 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 50 UG/KG 10 29 351 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 50 UG/KG 10 29 352 94 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus 50 UG/KG 10 30 357 94 1 Dilatation Mild Terminal Sacrifice
Genital System Uterus 5000 UG/KG 10 31 453 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 5000 UG/KG 10 32 458 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 5000 UG/KG 10 32 460 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 50,000 UG/KG 10 33 555 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus 50,000 UG/KG 10 34 557 94 1 Dilatation Minimal Terminal Sacrifice
Genital System Uterus Vehicle Control 10 25 155 94 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Genital System Uterus Vehicle Control 10 26 159 94 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Hematopoietic System Bone Marrow Vehicle Control 10 26 156 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Integumentary System Skin Lip Vehicle Control 10 26 157 94 1 Inflammation Moderate, Chronic Active Terminal Sacrifice
Integumentary System Skin Lip Vehicle Control 10 26 157 94 1 Ulcer Moderate Terminal Sacrifice
Nervous System Brain Cranial Nerve Vehicle Control 10 26 160 94 1 Degeneration Mild Terminal Sacrifice
Nervous System Brain Pineal Gland Vehicle Control 10 25 154 94 1 Infiltration Cellular Minimal, Lymphocyte Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 36 656 94 1 Hemorrhage Mild, Acute Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 26 158 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 35 651 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 35 652 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 35 653 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 36 657 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 36 660 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Nose 200,000 UG/KG 10 35 653 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Eye Retina 200,000 UG/KG 10 35 651 94 1 Dysplasia Mild Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 26 157 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 26 158 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 26 160 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 26 159 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5 UG/KG 10 27 254 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5 UG/KG 10 28 256 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5 UG/KG 10 28 260 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50 UG/KG 10 29 351 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50 UG/KG 10 29 353 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50 UG/KG 10 29 355 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50 UG/KG 10 30 357 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 31 451 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 32 456 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 32 457 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 32 459 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 32 460 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 33 551 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 33 552 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 33 555 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 34 557 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 34 558 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 35 651 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 35 652 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 35 653 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 35 654 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 35 655 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 36 656 94 1 Pigmentation Moderate Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 36 657 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 36 658 94 1 Pigmentation Mild Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 154 94 1 Infarct Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 152 94 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 36 657 94 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 152 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 153 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 25 155 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 26 156 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 26 158 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 35 653 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 35 654 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 36 656 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 36 657 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 35 653 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 36 658 94 1 Nephropathy Minimal Terminal Sacrifice