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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Melatonin
CASRN: ="73-31-4"
Study Number: C96013
Exposure Route: GAVAGE
TDMS Number: 9601303
Sex: Male
Strain and Species: F 344/N Rats

Male Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Vehicle Control 10 3 107 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 5 UG/KG 2 5 202 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 5 UG/KG 2 8 210 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 5000 UG/KG 1 13 403 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver 50,000 UG/KG 1 18 504 94 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 1 102 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 3 106 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 4 109 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 50,000 UG/KG 1 18 504 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 21 601 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 22 604 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 23 606 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Alimentary System Liver 200,000 UG/KG 10 24 609 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 102 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 1 103 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 104 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 2 105 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 3 106 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 3 107 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 3 108 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 4 109 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 4 110 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 21 601 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 21 602 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 21 603 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 22 604 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 23 606 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 23 607 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 23 608 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 24 609 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Cardiovascular System Heart 200,000 UG/KG 10 24 610 94 1 Cardiomyopathy Minimal Terminal Sacrifice
Respiratory System Lung Alveolar Epith Vehicle Control 10 1 103 94 1 Hyperplasia Minimal, Focal Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 101 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 102 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 1 103 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 104 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 2 105 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 3 106 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 3 107 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung Vehicle Control 10 4 109 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 21 603 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 23 607 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 200,000 UG/KG 10 22 605 94 1 Metaplasia, Osseous Minimal, Osseous Terminal Sacrifice
Special Senses System Eye Cornea 50,000 UG/KG 10 20 509 94 1 Inflammation Mild Terminal Sacrifice
Special Senses System Eye Retina 50 UG/KG 10 9 303 94 1 Dysplasia Minimal Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 3 106 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 13 401 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 15 406 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 15 407 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 23 608 94 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 3 107 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland Vehicle Control 10 3 108 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50 UG/KG 10 9 301 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 13 401 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 13 403 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 14 404 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 15 406 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 5000 UG/KG 10 16 410 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 17 503 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 18 504 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 18 505 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 19 506 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 19 507 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 19 508 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 20 509 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 50,000 UG/KG 10 20 510 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 21 601 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 21 602 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 21 603 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 22 604 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 22 605 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 23 606 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 23 607 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 23 608 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 24 609 94 1 Pigmentation Mild Terminal Sacrifice
Special Senses System Harderian Gland 200,000 UG/KG 10 24 610 94 1 Pigmentation Mild Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 3 106 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 4 110 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 21 601 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 21 602 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 23 607 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 24 609 94 1 Mineralization Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 101 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 1 102 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 104 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 2 105 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 3 106 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 3 107 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 3 108 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 4 109 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 4 110 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 21 601 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 21 602 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 23 606 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 23 608 94 1 Nephropathy Minimal Terminal Sacrifice
Urinary System Kidney 200,000 UG/KG 10 24 610 94 1 Nephropathy Minimal Terminal Sacrifice