Alimentary System |
Gallbladder |
|
Vehicle Control |
50 |
1 |
1 |
732 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Gallbladder |
|
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Colon |
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Parasite Metazoan |
|
Dead |
Alimentary System |
Intestine Large |
Rectum |
50 MG/KG |
50 |
50 |
50 |
731 |
1 |
Parasite Metazoan |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
4 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
44 |
19 |
733 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
50 |
23 |
14 |
727 |
1 |
Cyst |
|
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
50 |
29 |
43 |
634 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Alimentary System |
Liver |
|
25 MG/KG |
50 |
25 |
23 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
4 |
17 |
729 |
1 |
Hemorrhage |
Marked |
Dead |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Hepatodiaphragmatic Nodule |
|
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
50 |
26 |
30 |
617 |
1 |
Inflammation |
Mild, Necrotizing |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Leukocytosis |
|
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
7 |
733 |
1 |
Leukocytosis |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Leukocytosis |
|
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
43 |
13 |
691 |
1 |
Leukocytosis |
|
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Leukocytosis |
|
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Mineralization |
Mild |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
8 |
40 |
638 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Necrosis |
Marked, Coagulative |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
7 |
34 |
589 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
5 |
21 |
732 |
1 |
Necrosis |
Minimal, Coagulative |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 MG/KG |
50 |
26 |
30 |
617 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
50 |
27 |
31 |
652 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
25 MG/KG |
50 |
29 |
42 |
455 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
42 |
9 |
478 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
44 |
17 |
582 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
45 |
25 |
486 |
1 |
Necrosis |
Moderate, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
48 |
40 |
476 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Necrosis |
Mild, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Necrosis |
Moderate, Coagulative |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
41 |
4 |
731 |
1 |
Necrosis |
Mild, Coagulative |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Pigmentation |
Mild, Hematoidin |
Moribund |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Vacuolization Cytoplasmic |
Mild |
Dead |
Alimentary System |
Liver |
|
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Vacuolization Cytoplasmic |
Mild |
Moribund |
Alimentary System |
Mesentery |
|
Vehicle Control |
43 |
6 |
28 |
297 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Alimentary System |
Mesentery |
|
50 MG/KG |
49 |
41 |
3 |
366 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Alimentary System |
Mesentery |
|
50 MG/KG |
49 |
46 |
26 |
181 |
1 |
Inflammation |
Moderate, Chronic Active |
Dead |
Alimentary System |
Mesentery |
|
50 MG/KG |
49 |
46 |
30 |
589 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Alimentary System |
Mesentery |
|
50 MG/KG |
49 |
48 |
37 |
731 |
1 |
Necrosis |
Marked |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
Vehicle Control |
50 |
1 |
4 |
732 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
25 MG/KG |
22 |
29 |
41 |
711 |
1 |
Cyst |
|
Moribund |
Alimentary System |
Pancreas |
|
50 MG/KG |
50 |
44 |
16 |
476 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Alimentary System |
Pancreas |
|
25 MG/KG |
22 |
29 |
42 |
455 |
1 |
Necrosis |
Mild, Coagulative |
Dead |
Alimentary System |
Pancreas |
|
50 MG/KG |
50 |
46 |
28 |
645 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Salivary Glands |
|
25 MG/KG |
20 |
22 |
8 |
50 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Alimentary System |
Salivary Glands |
|
50 MG/KG |
50 |
48 |
40 |
476 |
1 |
Necrosis |
Marked, Coagulative |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
4 |
19 |
617 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
4 |
20 |
467 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
23 |
683 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
25 |
732 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
7 |
31 |
464 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
7 |
33 |
182 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
10 |
47 |
683 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
3 |
12 |
684 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
4 |
18 |
220 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
1 |
2 |
732 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
3 |
11 |
731 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
3 |
14 |
731 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
22 |
733 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
24 |
732 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
6 |
30 |
731 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
9 |
45 |
733 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
21 |
4 |
117 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
22 |
6 |
126 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
25 |
21 |
460 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
26 |
30 |
617 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
29 |
42 |
455 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
21 |
1 |
708 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
21 |
3 |
687 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
21 |
5 |
112 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
22 |
8 |
50 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
23 |
12 |
165 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
26 |
26 |
683 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
26 |
28 |
690 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
28 |
40 |
691 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
29 |
41 |
711 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
30 |
49 |
634 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
22 |
7 |
731 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
23 |
11 |
732 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
25 |
23 |
733 |
1 |
Acanthosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
25 |
24 |
731 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
25 |
25 |
733 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
28 |
36 |
732 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
28 |
37 |
731 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
30 |
50 |
731 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
41 |
5 |
729 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
43 |
15 |
548 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
45 |
22 |
626 |
1 |
Acanthosis |
Marked |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
45 |
25 |
486 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
46 |
26 |
181 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
46 |
28 |
645 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
47 |
31 |
485 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
47 |
33 |
729 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
48 |
38 |
687 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
48 |
39 |
257 |
1 |
Acanthosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
48 |
40 |
476 |
1 |
Acanthosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
42 |
8 |
690 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
44 |
20 |
667 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
46 |
27 |
647 |
1 |
Acanthosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
49 |
43 |
670 |
1 |
Acanthosis |
Minimal |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
50 |
46 |
528 |
Multiple |
Acanthosis |
Marked |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
44 |
18 |
733 |
1 |
Acanthosis |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
47 |
32 |
731 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
49 |
42 |
733 |
1 |
Acanthosis |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
50 |
50 |
731 |
1 |
Acanthosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
4 |
19 |
617 |
1 |
Hyperkeratosis |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
4 |
20 |
467 |
1 |
Hyperkeratosis |
Mild |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
5 |
23 |
683 |
1 |
Hyperkeratosis |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
10 |
47 |
683 |
1 |
Hyperkeratosis |
Mild |
Moribund |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
22 |
6 |
126 |
1 |
Hyperkeratosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
41 |
5 |
729 |
1 |
Hyperkeratosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Hyperkeratosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
46 |
28 |
645 |
1 |
Hyperkeratosis |
Moderate |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
47 |
33 |
729 |
1 |
Hyperkeratosis |
Minimal |
Dead |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Hyperkeratosis |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
46 |
27 |
647 |
1 |
Hyperkeratosis |
Moderate |
Moribund |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Hyperkeratosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Hyperkeratosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
8 |
40 |
638 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
2 |
9 |
732 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
25 MG/KG |
50 |
25 |
23 |
733 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
25 MG/KG |
50 |
30 |
47 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Alimentary System |
Tooth |
|
Vehicle Control |
50 |
1 |
2 |
732 |
1 |
Dysplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
50 |
6 |
30 |
731 |
1 |
Dysplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Dysplasia |
Marked |
Moribund |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Dysplasia |
Mild |
Moribund |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
44 |
18 |
733 |
1 |
Dysplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
45 |
21 |
733 |
1 |
Dysplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
45 |
24 |
733 |
1 |
Dysplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
47 |
35 |
731 |
1 |
Dysplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Dysplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Dysplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
44 |
19 |
733 |
1 |
Foreign Body |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
50 |
8 |
40 |
638 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Alimentary System |
Tooth |
|
Vehicle Control |
50 |
1 |
2 |
732 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
50 |
2 |
8 |
732 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
50 |
5 |
24 |
732 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Inflammation |
Moderate, Chronic Active |
Dead |
Alimentary System |
Tooth |
|
50 MG/KG |
50 |
44 |
19 |
733 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
Mesent Artery |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Cardiovascular System |
Blood Vessel |
Mesent Artery |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Necrosis |
Marked, Fibrinoid |
Moribund |
Cardiovascular System |
Blood Vessel |
Pulmn Artery |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Cardiovascular System |
Blood Vessel |
Pulmn Artery |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Necrosis |
Moderate, Fibrinoid |
Moribund |
Cardiovascular System |
Blood Vessel |
Renal Artery |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Cardiovascular System |
Blood Vessel |
Renal Artery |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Necrosis |
Marked, Fibrinoid |
Moribund |
Cardiovascular System |
Blood Vessel |
Renal Artery |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Thrombosis |
|
Moribund |
Cardiovascular System |
Blood Vessel |
Thoracic |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Cardiovascular System |
Blood Vessel |
Thoracic |
Vehicle Control |
47 |
6 |
28 |
297 |
1 |
Necrosis |
Marked, Fibrinoid |
Moribund |
Cardiovascular System |
Heart |
Atrium |
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Thrombosis |
|
Moribund |
Cardiovascular System |
Heart |
Coron Artery |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Cardiovascular System |
Heart |
Coron Artery |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Necrosis |
Moderate, Fibrinoid |
Moribund |
Cardiovascular System |
Heart |
Valve |
Vehicle Control |
50 |
4 |
20 |
467 |
1 |
Bacterium |
|
Dead |
Cardiovascular System |
Heart |
Valve |
25 MG/KG |
20 |
25 |
21 |
460 |
1 |
Bacterium |
|
Dead |
Cardiovascular System |
Heart |
Valve |
25 MG/KG |
20 |
26 |
29 |
485 |
1 |
Bacterium |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Bacterium |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
41 |
3 |
366 |
1 |
Bacterium |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
44 |
16 |
476 |
1 |
Bacterium |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
45 |
25 |
486 |
1 |
Bacterium |
|
Dead |
Cardiovascular System |
Heart |
Valve |
25 MG/KG |
20 |
25 |
21 |
460 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Cardiovascular System |
Heart |
Valve |
25 MG/KG |
20 |
26 |
29 |
485 |
1 |
Inflammation |
Marked, Suppurative |
Dead |
Cardiovascular System |
Heart |
Valve |
Vehicle Control |
50 |
4 |
20 |
467 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
Valve |
25 MG/KG |
20 |
25 |
21 |
460 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
Valve |
25 MG/KG |
20 |
26 |
29 |
485 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
41 |
3 |
366 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
44 |
16 |
476 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
45 |
25 |
486 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
Valve |
50 MG/KG |
50 |
48 |
40 |
476 |
1 |
Thrombosis |
|
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
50 |
49 |
45 |
668 |
1 |
Cardiomyopathy |
Mild, Chronic |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
50 |
43 |
13 |
691 |
1 |
Cardiomyopathy |
Mild, Chronic |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
50 |
44 |
20 |
667 |
1 |
Cardiomyopathy |
Mild, Chronic |
Moribund |
Cardiovascular System |
Heart |
|
50 MG/KG |
50 |
48 |
37 |
731 |
1 |
Cardiomyopathy |
Mild, Chronic |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
50 MG/KG |
50 |
44 |
16 |
476 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Cardiovascular System |
Heart |
|
50 MG/KG |
50 |
45 |
25 |
486 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Mineralization |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Cortex |
Vehicle Control |
49 |
3 |
12 |
684 |
1 |
Accessory Adrenal Cortical Nodule |
|
Moribund |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Accessory Adrenal Cortical Nodule |
|
Dead |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
45 |
21 |
733 |
1 |
Accessory Adrenal Cortical Nodule |
|
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
Vehicle Control |
49 |
10 |
48 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
Vehicle Control |
49 |
6 |
27 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
25 MG/KG |
21 |
26 |
29 |
485 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
42 |
8 |
690 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Adrenal Gland |
Cortex |
Vehicle Control |
49 |
4 |
19 |
617 |
1 |
Hypertrophy |
Mild |
Dead |
Endocrine System |
Adrenal Gland |
Cortex |
Vehicle Control |
49 |
10 |
48 |
733 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
Vehicle Control |
49 |
5 |
21 |
732 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
47 |
33 |
729 |
1 |
Hypertrophy |
Mild |
Dead |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
44 |
18 |
733 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
44 |
19 |
733 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
45 |
21 |
733 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Cortex |
50 MG/KG |
50 |
47 |
35 |
731 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Medulla |
Vehicle Control |
49 |
3 |
11 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Medulla |
Vehicle Control |
49 |
6 |
30 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Medulla |
Vehicle Control |
49 |
9 |
45 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Medulla |
25 MG/KG |
21 |
24 |
16 |
502 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Adrenal Gland |
Medulla |
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Adrenal Gland |
Medulla |
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Hyperplasia |
Mild |
Dead |
Endocrine System |
Adrenal Gland |
Medulla |
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Medulla |
50 MG/KG |
50 |
46 |
29 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Gland |
Medulla |
50 MG/KG |
50 |
47 |
32 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Hyperplasia |
Moderate |
Moribund |
Endocrine System |
Islets |
Pancreatic |
50 MG/KG |
50 |
47 |
35 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
4 |
16 |
103 |
1 |
Cyst |
|
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
1 |
2 |
732 |
1 |
Cyst |
|
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Cyst |
|
Moribund |
Endocrine System |
Pituitary Gland |
Pars Distalis |
50 MG/KG |
50 |
46 |
29 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
50 |
8 |
39 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
Vehicle Control |
50 |
9 |
45 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
Follicular Cel |
50 MG/KG |
50 |
49 |
43 |
670 |
1 |
Hyperplasia |
Mild |
Moribund |
Endocrine System |
Thyroid Gland |
Follicular Cel |
50 MG/KG |
50 |
47 |
34 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
50 MG/KG |
50 |
48 |
37 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicular Cel |
50 MG/KG |
50 |
49 |
42 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Necrosis |
Moderate, Fibrinoid |
Moribund |
Endocrine System |
Thyroid Gland |
|
25 MG/KG |
20 |
24 |
16 |
502 |
1 |
Ultimobranchial Cyst |
|
Moribund |
Genital System |
Coagulating Gland |
|
50 MG/KG |
46 |
44 |
18 |
733 |
1 |
Dilatation |
Mild |
Terminal Sacrifice |
Genital System |
Coagulating Gland |
|
50 MG/KG |
46 |
50 |
49 |
733 |
1 |
Dilatation |
Marked |
Terminal Sacrifice |
Genital System |
Coagulating Gland |
|
50 MG/KG |
46 |
46 |
26 |
181 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Genital System |
Epididymis |
|
25 MG/KG |
20 |
29 |
43 |
634 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Genital System |
Penis |
|
25 MG/KG |
2 |
22 |
9 |
201 |
1 |
Inflammation |
Moderate, Chronic Active |
Dead |
Genital System |
Penis |
|
50 MG/KG |
4 |
46 |
26 |
181 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Genital System |
Penis |
|
Vehicle Control |
4 |
1 |
5 |
731 |
1 |
Mineralization |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
Duct |
25 MG/KG |
9 |
21 |
2 |
135 |
1 |
Ectasia |
Moderate |
Dead |
Genital System |
Preputial Gland |
Lymphatic |
25 MG/KG |
9 |
21 |
2 |
135 |
1 |
Ectasia |
Moderate |
Dead |
Genital System |
Preputial Gland |
Lymphatic |
50 MG/KG |
6 |
42 |
9 |
478 |
1 |
Ectasia |
Marked |
Dead |
Genital System |
Preputial Gland |
|
Vehicle Control |
3 |
6 |
28 |
297 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Genital System |
Preputial Gland |
|
Vehicle Control |
3 |
5 |
24 |
732 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
3 |
8 |
38 |
732 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
25 MG/KG |
9 |
26 |
26 |
683 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Genital System |
Preputial Gland |
|
50 MG/KG |
6 |
49 |
45 |
668 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Genital System |
Preputial Gland |
|
50 MG/KG |
6 |
42 |
10 |
502 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Genital System |
Preputial Gland |
|
50 MG/KG |
6 |
47 |
35 |
731 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
50 MG/KG |
6 |
49 |
42 |
733 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Genital System |
Prostate |
Artery |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Necrosis |
Moderate, Fibrinoid |
Moribund |
Genital System |
Prostate |
|
Vehicle Control |
50 |
7 |
33 |
182 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Genital System |
Prostate |
|
Vehicle Control |
50 |
10 |
50 |
432 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Genital System |
Prostate |
|
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Genital System |
Prostate |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Genital System |
Prostate |
|
25 MG/KG |
20 |
22 |
9 |
201 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Genital System |
Prostate |
|
25 MG/KG |
20 |
22 |
8 |
50 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Genital System |
Prostate |
|
25 MG/KG |
20 |
23 |
12 |
165 |
1 |
Inflammation |
Minimal, Chronic Active |
Moribund |
Genital System |
Prostate |
|
50 MG/KG |
50 |
46 |
26 |
181 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
4 |
17 |
729 |
1 |
Dilatation |
Marked |
Dead |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
9 |
43 |
199 |
1 |
Dilatation |
Moderate |
Moribund |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
5 |
21 |
732 |
1 |
Dilatation |
Marked |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
8 |
37 |
731 |
1 |
Dilatation |
Marked |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
8 |
38 |
732 |
1 |
Dilatation |
Moderate |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
25 MG/KG |
21 |
30 |
50 |
731 |
1 |
Dilatation |
Marked |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
50 MG/KG |
36 |
41 |
5 |
729 |
1 |
Dilatation |
Marked |
Dead |
Genital System |
Seminal Vesicle |
|
50 MG/KG |
36 |
44 |
18 |
733 |
1 |
Dilatation |
Marked |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
50 MG/KG |
36 |
47 |
32 |
731 |
1 |
Dilatation |
Mild |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
50 MG/KG |
36 |
50 |
49 |
733 |
1 |
Dilatation |
Mild |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
6 |
28 |
297 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
10 |
49 |
733 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
Vehicle Control |
29 |
8 |
37 |
731 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Seminal Vesicle |
|
25 MG/KG |
21 |
22 |
9 |
201 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Genital System |
Seminal Vesicle |
|
50 MG/KG |
36 |
49 |
44 |
732 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
25 MG/KG |
20 |
21 |
2 |
135 |
1 |
Hyperplasia |
Mild |
Dead |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
|
25 MG/KG |
20 |
21 |
2 |
135 |
1 |
Mineralization |
Minimal |
Dead |
Hematopoietic System |
Blood |
|
Vehicle Control |
3 |
4 |
18 |
220 |
1 |
Neutrophilia |
|
Moribund |
Hematopoietic System |
Blood |
|
25 MG/KG |
2 |
27 |
35 |
432 |
1 |
Neutrophilia |
|
Moribund |
Hematopoietic System |
Blood |
|
25 MG/KG |
2 |
29 |
43 |
634 |
1 |
Neutrophilia |
|
Moribund |
Hematopoietic System |
Bone Marrow |
Femoral |
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Hyperplasia |
Marked |
Moribund |
Hematopoietic System |
Bone Marrow |
Femoral |
Vehicle Control |
50 |
2 |
8 |
732 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
Femoral |
25 MG/KG |
20 |
27 |
32 |
221 |
1 |
Hyperplasia |
Marked |
Dead |
Hematopoietic System |
Bone Marrow |
Femoral |
25 MG/KG |
20 |
22 |
8 |
50 |
1 |
Hyperplasia |
Marked |
Moribund |
Hematopoietic System |
Bone Marrow |
Femoral |
25 MG/KG |
20 |
29 |
43 |
634 |
1 |
Hyperplasia |
Marked |
Moribund |
Hematopoietic System |
Bone Marrow |
Femoral |
50 MG/KG |
50 |
41 |
3 |
366 |
1 |
Hyperplasia |
Marked |
Dead |
Hematopoietic System |
Bone Marrow |
Femoral |
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Hyperplasia |
Marked |
Dead |
Hematopoietic System |
Bone Marrow |
Femoral |
50 MG/KG |
50 |
46 |
26 |
181 |
1 |
Hyperplasia |
Marked |
Dead |
Hematopoietic System |
Bone Marrow |
Femoral |
50 MG/KG |
50 |
47 |
33 |
729 |
1 |
Hyperplasia |
Marked |
Dead |
Hematopoietic System |
Bone Marrow |
Femoral |
50 MG/KG |
50 |
43 |
13 |
691 |
1 |
Hyperplasia |
Marked |
Moribund |
Hematopoietic System |
Bone Marrow |
Femoral |
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Hyperplasia |
Marked |
Moribund |
Hematopoietic System |
Lymph Node |
Axillary |
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Hemorrhage |
Moderate, Acute |
Dead |
Hematopoietic System |
Lymph Node |
Axillary |
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Dead |
Hematopoietic System |
Lymph Node |
Lumbar |
25 MG/KG |
32 |
21 |
5 |
112 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
25 MG/KG |
32 |
25 |
23 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
50 |
4 |
18 |
220 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
50 |
4 |
18 |
220 |
1 |
Hyperplasia |
Marked, Plasma Cell |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
25 MG/KG |
32 |
28 |
37 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
50 MG/KG |
50 |
42 |
8 |
690 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
50 MG/KG |
50 |
46 |
29 |
731 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
50 MG/KG |
50 |
47 |
34 |
732 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
50 MG/KG |
50 |
50 |
47 |
733 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
50 |
4 |
18 |
220 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Necrosis |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
50 |
5 |
23 |
683 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Hematopoietic System |
Lymph Node |
Mediastinal |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Angiectasis |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
1 |
5 |
731 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
10 |
48 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
10 |
49 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
2 |
7 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
3 |
11 |
731 |
1 |
Angiectasis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
8 |
39 |
732 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
9 |
41 |
733 |
1 |
Angiectasis |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
23 |
14 |
727 |
1 |
Angiectasis |
Mild |
Dead |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
30 |
48 |
501 |
1 |
Angiectasis |
Moderate |
Dead |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
27 |
35 |
432 |
1 |
Angiectasis |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
29 |
43 |
634 |
1 |
Angiectasis |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
30 |
49 |
634 |
1 |
Angiectasis |
Marked |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
24 |
19 |
731 |
1 |
Angiectasis |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
24 |
20 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
25 |
25 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
27 |
34 |
731 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
28 |
37 |
731 |
1 |
Angiectasis |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
48 |
38 |
687 |
1 |
Angiectasis |
Moderate |
Dead |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Angiectasis |
Marked |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Angiectasis |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
42 |
8 |
690 |
1 |
Angiectasis |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
46 |
27 |
647 |
1 |
Angiectasis |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
46 |
30 |
589 |
1 |
Angiectasis |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Angiectasis |
Marked |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
41 |
4 |
731 |
1 |
Angiectasis |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
44 |
19 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
48 |
36 |
732 |
1 |
Angiectasis |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
49 |
41 |
732 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
49 |
42 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
1 |
5 |
731 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
10 |
48 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
10 |
49 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
2 |
7 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
3 |
11 |
731 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
6 |
30 |
731 |
1 |
Hematopoietic Cell Proliferation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
9 |
41 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
9 |
42 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
23 |
14 |
727 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
27 |
35 |
432 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
29 |
43 |
634 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
30 |
49 |
634 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
24 |
19 |
731 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
24 |
20 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
25 |
23 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
25 |
25 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
27 |
34 |
731 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
28 |
37 |
731 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 MG/KG |
32 |
28 |
39 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
48 |
38 |
687 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Dead |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
49 |
45 |
668 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Dead |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
48 |
36 |
732 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
49 |
41 |
732 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
49 |
42 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
6 |
30 |
731 |
1 |
Hyperplasia, Reticulum Cell |
Mild, Reticulum Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
8 |
39 |
732 |
1 |
Hyperplasia |
Marked, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
50 MG/KG |
50 |
50 |
47 |
733 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Renal |
25 MG/KG |
32 |
29 |
43 |
634 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Lymph Node |
|
25 MG/KG |
32 |
26 |
28 |
690 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
7 |
33 |
182 |
1 |
Depletion Lymphoid |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Depletion Lymphoid |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
49 |
45 |
668 |
1 |
Fibrosis |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
5 |
25 |
732 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
10 |
50 |
432 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
3 |
12 |
684 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
4 |
18 |
220 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
10 |
46 |
732 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
2 |
7 |
733 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
9 |
41 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
9 |
44 |
732 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
21 |
4 |
117 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
23 |
13 |
600 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
23 |
14 |
727 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
26 |
29 |
485 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
29 |
42 |
455 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
30 |
48 |
501 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
22 |
8 |
50 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
26 |
28 |
690 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
27 |
35 |
432 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
29 |
43 |
634 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
25 |
23 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
28 |
38 |
731 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
28 |
39 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
41 |
2 |
444 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
41 |
3 |
366 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
41 |
5 |
729 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
44 |
16 |
476 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
45 |
22 |
626 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
45 |
25 |
486 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
46 |
26 |
181 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
47 |
31 |
485 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
48 |
38 |
687 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
48 |
40 |
476 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
49 |
45 |
668 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
42 |
8 |
690 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
43 |
13 |
691 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
44 |
20 |
667 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
46 |
27 |
647 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
46 |
30 |
589 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
49 |
43 |
670 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
50 |
46 |
528 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Hematopoietic Cell Proliferation |
Marked |
Moribund |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
42 |
7 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
45 |
21 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
45 |
24 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
47 |
34 |
732 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
47 |
35 |
731 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
48 |
36 |
732 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
48 |
37 |
731 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
49 |
41 |
732 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
49 |
42 |
733 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
50 |
47 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
50 |
50 |
731 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
42 |
9 |
478 |
1 |
Infarct |
Moderate |
Dead |
Hematopoietic System |
Spleen |
|
50 MG/KG |
50 |
46 |
28 |
645 |
1 |
Infarct |
Marked |
Dead |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Necrosis |
Mild |
Moribund |
Hematopoietic System |
Spleen |
|
25 MG/KG |
26 |
22 |
9 |
201 |
1 |
Necrosis |
Mild |
Dead |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
4 |
19 |
617 |
1 |
Cyst |
|
Dead |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Cyst |
|
Moribund |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
7 |
32 |
733 |
1 |
Cyst |
|
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Necrosis |
Marked |
Moribund |
Hematopoietic System |
Thymus |
|
25 MG/KG |
20 |
21 |
4 |
117 |
1 |
Necrosis |
Moderate |
Dead |
Hematopoietic System |
Thymus |
|
25 MG/KG |
20 |
22 |
6 |
126 |
1 |
Necrosis |
Moderate |
Dead |
Hematopoietic System |
Thymus |
|
25 MG/KG |
20 |
22 |
9 |
201 |
1 |
Necrosis |
Marked |
Dead |
Hematopoietic System |
Thymus |
|
25 MG/KG |
20 |
27 |
32 |
221 |
1 |
Necrosis |
Marked |
Dead |
Hematopoietic System |
Thymus |
|
25 MG/KG |
20 |
21 |
5 |
112 |
1 |
Necrosis |
Marked |
Moribund |
Hematopoietic System |
Thymus |
|
25 MG/KG |
20 |
23 |
12 |
165 |
1 |
Necrosis |
Moderate |
Moribund |
Integumentary System |
Skin |
Lymphatic |
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Ectasia |
Mild |
Terminal Sacrifice |
Integumentary System |
Skin |
Prepuce |
25 MG/KG |
33 |
23 |
12 |
165 |
1 |
Concretion |
Marked |
Moribund |
Integumentary System |
Skin |
Prepuce |
25 MG/KG |
33 |
23 |
12 |
165 |
1 |
Dilatation |
Marked |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
21 |
4 |
117 |
1 |
Abscess |
Moderate |
Dead |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
21 |
5 |
112 |
1 |
Abscess |
Moderate |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Acanthosis |
Mild |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
2 |
9 |
732 |
1 |
Acanthosis |
Moderate |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
9 |
41 |
733 |
1 |
Acanthosis |
Mild |
Terminal Sacrifice |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Acanthosis |
Mild |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Alopecia |
|
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
42 |
9 |
478 |
1 |
Edema |
Moderate |
Dead |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
2 |
9 |
732 |
1 |
Fibrosis |
Moderate |
Terminal Sacrifice |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Fibrosis |
Moderate |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Fibrosis |
Mild |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Hyperkeratosis |
Mild |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
2 |
9 |
732 |
1 |
Hyperkeratosis |
Mild |
Terminal Sacrifice |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Hyperkeratosis |
Mild |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
7 |
31 |
464 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
10 |
47 |
683 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
4 |
18 |
220 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
10 |
46 |
732 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
9 |
41 |
733 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
21 |
2 |
135 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
21 |
4 |
117 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
22 |
9 |
201 |
1 |
Inflammation |
Moderate, Chronic Active |
Dead |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
27 |
32 |
221 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
21 |
5 |
112 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
22 |
8 |
50 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
23 |
12 |
165 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
26 |
27 |
684 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
25 |
23 |
733 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
28 |
36 |
732 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Inflammation |
Moderate, Chronic Active |
Dead |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
46 |
26 |
181 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
47 |
33 |
729 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
42 |
8 |
690 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
46 |
27 |
647 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
43 |
14 |
731 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
50 MG/KG |
50 |
50 |
50 |
731 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Integumentary System |
Skin |
|
25 MG/KG |
33 |
29 |
42 |
455 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Dead |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Necrosis |
Marked, Coagulative |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Femur, Joint, Tibia |
Vehicle Control |
50 |
1 |
5 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Femur, Joint, Tibia |
25 MG/KG |
34 |
28 |
37 |
731 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
3 |
13 |
624 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
4 |
19 |
617 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
7 |
31 |
464 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
8 |
40 |
638 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
2 |
6 |
661 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Moribund |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
7 |
34 |
589 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Moribund |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Moribund |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
1 |
1 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
1 |
5 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
10 |
46 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
2 |
10 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
2 |
7 |
733 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
2 |
8 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
3 |
11 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
3 |
14 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
5 |
24 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
6 |
27 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
6 |
30 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
7 |
32 |
733 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
8 |
39 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
9 |
41 |
733 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
9 |
42 |
733 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
Vehicle Control |
50 |
9 |
45 |
733 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
23 |
14 |
727 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
23 |
15 |
686 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
25 |
22 |
611 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
26 |
30 |
617 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
22 |
10 |
732 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
23 |
11 |
732 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
24 |
19 |
731 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
24 |
20 |
733 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
25 |
24 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
27 |
33 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
27 |
34 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
28 |
36 |
732 |
1 |
Metaplasia, Osseous |
Mild, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
28 |
37 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
28 |
38 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
29 |
44 |
733 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
25 MG/KG |
34 |
29 |
45 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
43 |
15 |
548 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
48 |
38 |
687 |
1 |
Metaplasia, Osseous |
Moderate, Osseous |
Dead |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
44 |
20 |
667 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Moribund |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
41 |
4 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
43 |
14 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
47 |
34 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
48 |
36 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Joint, Tarsal |
50 MG/KG |
50 |
50 |
50 |
731 |
1 |
Metaplasia, Osseous |
Marked, Osseous |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
Sternum |
25 MG/KG |
34 |
28 |
38 |
731 |
1 |
Developmental Malformation |
|
Terminal Sacrifice |
Nervous System |
Brain |
Artery, Cerebrum |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Necrosis |
Moderate, Fibrinoid |
Moribund |
Nervous System |
Brain |
|
Vehicle Control |
50 |
7 |
34 |
589 |
1 |
Hemorrhage |
Mild, Acute |
Moribund |
Nervous System |
Brain |
|
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Nervous System |
Peripheral Nerve |
Sciatic |
25 MG/KG |
50 |
23 |
14 |
727 |
1 |
Degeneration |
Mild |
Dead |
Nervous System |
Peripheral Nerve |
Sciatic |
50 MG/KG |
50 |
41 |
1 |
645 |
1 |
Degeneration |
Mild |
Moribund |
Nervous System |
Peripheral Nerve |
Sciatic |
50 MG/KG |
50 |
42 |
8 |
690 |
1 |
Degeneration |
Minimal |
Moribund |
Nervous System |
Peripheral Nerve |
Sciatic |
50 MG/KG |
50 |
43 |
13 |
691 |
1 |
Degeneration |
Minimal |
Moribund |
Nervous System |
Spinal Cord |
White Matter |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Degeneration |
Mild |
Moribund |
Nervous System |
Spinal Cord |
White Matter |
Vehicle Control |
50 |
10 |
49 |
733 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Nervous System |
Spinal Cord |
White Matter |
50 MG/KG |
50 |
41 |
4 |
731 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Nervous System |
Spinal Cord |
White Matter |
50 MG/KG |
50 |
49 |
41 |
732 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Nervous System |
Spinal Cord |
White Matter |
50 MG/KG |
50 |
50 |
49 |
733 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
4 |
20 |
467 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
7 |
35 |
673 |
1 |
Hyperplasia |
Minimal |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
10 |
49 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
2 |
9 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
3 |
11 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
5 |
21 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
5 |
24 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
6 |
26 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
8 |
37 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
49 |
9 |
42 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
23 |
13 |
600 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
23 |
15 |
686 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
24 |
18 |
415 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
27 |
31 |
652 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
29 |
42 |
455 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
24 |
16 |
502 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
27 |
35 |
432 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
29 |
43 |
634 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
24 |
17 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
24 |
19 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
24 |
20 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
27 |
33 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
28 |
36 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
28 |
37 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
28 |
39 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
29 |
44 |
733 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
25 MG/KG |
50 |
29 |
45 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
44 |
17 |
582 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
47 |
31 |
485 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
47 |
33 |
729 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
48 |
40 |
476 |
1 |
Hyperplasia |
Mild |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
49 |
45 |
668 |
1 |
Hyperplasia |
Moderate |
Dead |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
44 |
20 |
667 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
50 |
46 |
528 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Hyperplasia |
Mild |
Moribund |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
43 |
14 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
44 |
18 |
733 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
45 |
24 |
733 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
46 |
29 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
48 |
37 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
10 |
47 |
683 |
1 |
Hemorrhage |
Mild, Acute |
Moribund |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
2 |
8 |
732 |
1 |
Hemorrhage |
Mild, Acute |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Hemorrhage |
Moderate, Acute |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
46 |
29 |
731 |
1 |
Hemorrhage |
Mild, Acute |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
4 |
20 |
467 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
8 |
36 |
675 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
10 |
49 |
733 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
2 |
9 |
732 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
5 |
21 |
732 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
5 |
24 |
732 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
8 |
37 |
731 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
9 |
42 |
733 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
26 |
29 |
485 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
27 |
32 |
221 |
1 |
Inflammation |
Moderate, Chronic |
Dead |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
29 |
42 |
455 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
24 |
16 |
502 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
27 |
35 |
432 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
28 |
40 |
691 |
1 |
Inflammation |
Minimal, Chronic |
Moribund |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
29 |
43 |
634 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
24 |
20 |
733 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
28 |
36 |
732 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
28 |
39 |
733 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
29 |
44 |
733 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
29 |
45 |
731 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
43 |
11 |
654 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
44 |
17 |
582 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
47 |
31 |
485 |
1 |
Inflammation |
Mild, Chronic |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
48 |
40 |
476 |
1 |
Inflammation |
Minimal, Chronic |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
49 |
45 |
668 |
1 |
Inflammation |
Moderate, Chronic |
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
42 |
6 |
501 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
44 |
20 |
667 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
46 |
30 |
589 |
1 |
Inflammation |
Moderate, Chronic |
Moribund |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
50 |
46 |
528 |
1 |
Inflammation |
Mild, Chronic |
Moribund |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
50 |
48 |
732 |
1 |
Inflammation |
Minimal, Chronic |
Moribund |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
43 |
12 |
733 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
43 |
14 |
731 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
44 |
18 |
733 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
45 |
24 |
733 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
46 |
29 |
731 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
48 |
37 |
731 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
49 |
44 |
732 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
50 |
50 |
731 |
1 |
Inflammation |
Marked, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
49 |
2 |
6 |
661 |
1 |
Leukocytosis |
|
Moribund |
Respiratory System |
Lung |
|
25 MG/KG |
50 |
25 |
22 |
611 |
1 |
Leukocytosis |
|
Dead |
Respiratory System |
Lung |
|
50 MG/KG |
50 |
45 |
23 |
569 |
1 |
Leukocytosis |
|
Dead |
Respiratory System |
Nose |
Nasolacrim Dct |
Vehicle Control |
50 |
4 |
19 |
617 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
Nasolacrim Dct |
Vehicle Control |
50 |
8 |
40 |
638 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
Nasolacrim Dct |
Vehicle Control |
50 |
7 |
35 |
673 |
1 |
Inflammation |
Minimal, Suppurative |
Moribund |
Respiratory System |
Nose |
Nasolacrim Dct |
25 MG/KG |
20 |
23 |
13 |
600 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Respiratory System |
Nose |
Nasolacrim Dct |
50 MG/KG |
50 |
46 |
28 |
645 |
1 |
Inflammation |
Moderate, Suppurative |
Dead |
Respiratory System |
Nose |
Nasolacrim Dct |
50 MG/KG |
50 |
43 |
13 |
691 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Respiratory System |
Nose |
Nasolacrim Dct |
50 MG/KG |
50 |
49 |
43 |
670 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Respiratory System |
Nose |
|
25 MG/KG |
20 |
21 |
4 |
117 |
1 |
Foreign Body |
Mild |
Dead |
Respiratory System |
Nose |
|
25 MG/KG |
20 |
21 |
4 |
117 |
1 |
Granuloma |
Mild |
Dead |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
2 |
8 |
732 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
|
50 MG/KG |
50 |
47 |
34 |
732 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
50 MG/KG |
4 |
47 |
34 |
732 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Special Senses System |
Eye |
Lens |
25 MG/KG |
2 |
28 |
40 |
691 |
1 |
Cataract |
Moderate |
Moribund |
Special Senses System |
Eye |
Lens |
25 MG/KG |
2 |
28 |
37 |
731 |
1 |
Cataract |
Moderate |
Terminal Sacrifice |
Special Senses System |
Eye |
Lens |
50 MG/KG |
4 |
46 |
29 |
731 |
1 |
Cataract |
Moderate |
Terminal Sacrifice |
Special Senses System |
Eye |
Retina |
25 MG/KG |
2 |
28 |
40 |
691 |
1 |
Atrophy |
Moderate |
Moribund |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
50 |
2 |
9 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
50 MG/KG |
50 |
44 |
19 |
733 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
50 MG/KG |
50 |
48 |
37 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Artery |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Urinary System |
Kidney |
Artery |
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Urinary System |
Kidney |
Artery |
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Necrosis |
Marked, Fibrinoid |
Moribund |
Urinary System |
Kidney |
Artery |
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Necrosis |
Mild, Fibrinoid |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
49 |
44 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
22 |
8 |
50 |
1 |
Bacterium |
|
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
46 |
29 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Hemorrhage |
Moderate |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Hydronephrosis |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
22 |
9 |
201 |
1 |
Hydronephrosis |
Moderate |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
4 |
20 |
467 |
1 |
Infarct |
Moderate |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Infarct |
Moderate |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
23 |
13 |
600 |
1 |
Infarct |
Mild |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
25 |
21 |
460 |
1 |
Infarct |
Moderate |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
26 |
29 |
485 |
1 |
Infarct |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
41 |
2 |
444 |
1 |
Infarct |
Moderate |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
41 |
3 |
366 |
1 |
Infarct |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
44 |
16 |
476 |
1 |
Infarct |
Moderate |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
48 |
40 |
476 |
1 |
Infarct |
Marked |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
43 |
13 |
691 |
1 |
Infarct |
Marked |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
45 |
21 |
733 |
1 |
Infarct |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
46 |
29 |
731 |
1 |
Infarct |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
48 |
36 |
732 |
1 |
Infarct |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
7 |
33 |
182 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
2 |
8 |
732 |
1 |
Inflammation |
Moderate, Suppurative |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
22 |
9 |
201 |
1 |
Inflammation |
Minimal, Suppurative |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
22 |
8 |
50 |
1 |
Inflammation |
Marked, Suppurative |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
23 |
12 |
165 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
43 |
13 |
691 |
1 |
Inflammation |
Moderate, Suppurative |
Moribund |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
22 |
9 |
201 |
1 |
Mineralization |
Mild |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
25 |
22 |
611 |
1 |
Mineralization |
Minimal |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
27 |
32 |
221 |
1 |
Mineralization |
Minimal |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
46 |
26 |
181 |
1 |
Mineralization |
Mild |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
47 |
33 |
729 |
1 |
Mineralization |
Minimal |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
49 |
45 |
668 |
1 |
Mineralization |
Minimal |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
41 |
1 |
645 |
1 |
Mineralization |
Mild |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
46 |
27 |
647 |
1 |
Mineralization |
Minimal |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
44 |
18 |
733 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
45 |
21 |
733 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
48 |
37 |
731 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
4 |
17 |
729 |
1 |
Nephropathy |
Mild, Chronic |
Dead |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
10 |
47 |
683 |
1 |
Nephropathy |
Marked, Chronic |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
3 |
15 |
528 |
1 |
Nephropathy |
Moderate, Chronic |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
7 |
34 |
589 |
1 |
Nephropathy |
Minimal, Chronic |
Moribund |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
1 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
3 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
4 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
5 |
731 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
10 |
46 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
10 |
48 |
733 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
10 |
49 |
733 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
2 |
9 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
3 |
11 |
731 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
5 |
21 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
5 |
24 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
6 |
30 |
731 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
8 |
37 |
731 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
8 |
38 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
42 |
733 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
44 |
732 |
1 |
Nephropathy |
Moderate, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
23 |
13 |
600 |
1 |
Nephropathy |
Minimal, Chronic |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
25 |
21 |
460 |
1 |
Nephropathy |
Mild, Chronic |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
26 |
29 |
485 |
1 |
Nephropathy |
Mild, Chronic |
Dead |
Urinary System |
Kidney |
|
25 MG/KG |
22 |
24 |
16 |
502 |
1 |
Nephropathy |
Minimal, Chronic |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
41 |
2 |
444 |
1 |
Nephropathy |
Minimal, Chronic |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
41 |
3 |
366 |
1 |
Nephropathy |
Moderate, Chronic |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
48 |
38 |
687 |
1 |
Nephropathy |
Mild, Chronic |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
48 |
40 |
476 |
1 |
Nephropathy |
Mild, Chronic |
Dead |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
42 |
10 |
502 |
1 |
Nephropathy |
Mild, Chronic |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
42 |
8 |
690 |
1 |
Nephropathy |
Minimal, Chronic |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
46 |
30 |
589 |
1 |
Nephropathy |
Mild, Chronic |
Moribund |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
41 |
4 |
731 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
42 |
7 |
733 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
43 |
12 |
733 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
44 |
18 |
733 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
44 |
19 |
733 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
47 |
32 |
731 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
47 |
34 |
732 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
47 |
35 |
731 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
48 |
37 |
731 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
49 |
41 |
732 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
49 |
42 |
733 |
1 |
Nephropathy |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
49 |
44 |
732 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
50 |
47 |
733 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
50 |
49 |
733 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
50 |
50 |
731 |
1 |
Nephropathy |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
50 MG/KG |
47 |
48 |
40 |
476 |
1 |
Thrombosis |
|
Dead |
Urinary System |
Ureter |
|
Vehicle Control |
39 |
7 |
33 |
182 |
1 |
Inflammation |
Mild, Suppurative |
Dead |
Urinary System |
Ureter |
|
Vehicle Control |
39 |
6 |
28 |
297 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund |
Urinary System |
Urethra |
|
Vehicle Control |
30 |
7 |
31 |
464 |
1 |
Concretion |
Mild |
Dead |
Urinary System |
Urethra |
|
Vehicle Control |
30 |
9 |
43 |
199 |
1 |
Concretion |
Marked |
Moribund |
Urinary System |
Urethra |
|
25 MG/KG |
8 |
21 |
4 |
117 |
1 |
Concretion |
Marked |
Dead |
Urinary System |
Urethra |
|
25 MG/KG |
8 |
22 |
9 |
201 |
1 |
Concretion |
Marked |
Dead |
Urinary System |
Urethra |
|
25 MG/KG |
8 |
27 |
32 |
221 |
1 |
Concretion |
Moderate |
Dead |
Urinary System |
Urethra |
|
25 MG/KG |
8 |
21 |
5 |
112 |
1 |
Concretion |
Marked |
Moribund |
Urinary System |
Urethra |
|
Vehicle Control |
30 |
7 |
33 |
182 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Urinary System |
Urethra |
|
25 MG/KG |
8 |
21 |
4 |
117 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Urinary System |
Urethra |
|
25 MG/KG |
8 |
21 |
5 |
112 |
1 |
Inflammation |
Marked, Chronic Active |
Moribund |
Urinary System |
Urethra |
|
50 MG/KG |
35 |
46 |
26 |
181 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |
Urinary System |
Urethra |
|
50 MG/KG |
35 |
43 |
13 |
691 |
1 |
Inflammation |
Mild, Suppurative |
Moribund |
Urinary System |
Urinary Bladder |
|
Vehicle Control |
50 |
10 |
50 |
432 |
1 |
Dilatation |
Mild |
Moribund |
Urinary System |
Urinary Bladder |
|
Vehicle Control |
50 |
9 |
43 |
199 |
1 |
Dilatation |
Moderate |
Moribund |
Urinary System |
Urinary Bladder |
|
Vehicle Control |
50 |
6 |
29 |
733 |
1 |
Dilatation |
Mild |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
22 |
9 |
201 |
1 |
Dilatation |
Moderate |
Dead |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
25 |
22 |
611 |
1 |
Dilatation |
Moderate |
Dead |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
26 |
30 |
617 |
1 |
Dilatation |
Marked |
Dead |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
27 |
32 |
221 |
1 |
Dilatation |
Moderate |
Dead |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
21 |
5 |
112 |
1 |
Dilatation |
Moderate |
Moribund |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
23 |
12 |
165 |
1 |
Dilatation |
Moderate |
Moribund |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
26 |
27 |
684 |
1 |
Dilatation |
Marked |
Moribund |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
25 |
25 |
733 |
1 |
Dilatation |
Mild |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
|
50 MG/KG |
50 |
45 |
22 |
626 |
1 |
Dilatation |
Marked |
Dead |
Urinary System |
Urinary Bladder |
|
50 MG/KG |
50 |
42 |
10 |
502 |
1 |
Dilatation |
Moderate |
Moribund |
Urinary System |
Urinary Bladder |
|
Vehicle Control |
50 |
7 |
33 |
182 |
1 |
Inflammation |
Marked, Chronic Active |
Dead |
Urinary System |
Urinary Bladder |
|
Vehicle Control |
50 |
6 |
28 |
297 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund |
Urinary System |
Urinary Bladder |
|
25 MG/KG |
22 |
21 |
2 |
135 |
1 |
Inflammation |
Mild, Chronic Active |
Dead |