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Current Search Critera
Short-Term Study
Individual Animal Clinical Observations
Study Information:
Chemical Name: | Dimethylaminopropyl chloride, hydrochloride |
CASRN: | ="5407-04-5" |
Study Number: | C96006 |
Exposure Route: | GAVAGE |
TDMS Number: | 9600603 |
Sex: | Female |
Strain and Species: | F 344/N Rats |
Animal Number |
Dose Group |
Clinical Observation |
Qualifier |
Incident Number |
Observation Date |
First Dose Date |
Days On Study |
Removal Observation |
81 |
200 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
81 |
200 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
81 |
200 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
82 |
200 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
82 |
200 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
82 |
200 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
82 |
200 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
88 |
200 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
88 |
200 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
88 |
200 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
89 |
200 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
89 |
200 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
89 |
200 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
90 |
200 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
90 |
200 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
91 |
400 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
91 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
91 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
91 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
92 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
92 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
93 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
93 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
93 |
400 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
93 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
94 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
94 |
400 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
94 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
94 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
95 |
400 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
95 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
95 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
95 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
96 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
96 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
96 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
97 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
97 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
97 |
400 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
97 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
98 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
98 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
99 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
99 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
100 |
400 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
100 |
400 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
100 |
400 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
100 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
101 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
101 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
102 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
102 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
102 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
102 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
103 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
103 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
103 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
103 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
104 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
104 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
104 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
104 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
105 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
105 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
105 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
105 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
106 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
106 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
106 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
107 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
107 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
107 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
108 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
108 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
108 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
108 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
109 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
109 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
109 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
110 |
800 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
110 |
800 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
110 |
800 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
110 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
111 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
111 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
111 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
112 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/01/2000 |
02/01/00 |
1.00 |
Yes |
113 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
113 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
113 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
114 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
114 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
114 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
115 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
115 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
115 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
115 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
116 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
116 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
116 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
116 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
117 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
117 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
117 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
117 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
118 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
118 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
118 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
118 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
119 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
119 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
119 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
120 |
1000 MG/KG |
Abnormal Breathing |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
120 |
1000 MG/KG |
Clonic Seizures |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
120 |
1000 MG/KG |
Lethargic |
|
|
02/01/2000 |
02/01/00 |
1.00 |
No |
120 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
202 |
200 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
211 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
212 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
213 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
214 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
216 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
217 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
218 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
220 |
400 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
223 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
224 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
225 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
226 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
228 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
229 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
230 |
800 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
231 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
232 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
233 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
234 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
235 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
237 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
239 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |
240 |
1000 MG/KG |
Nasal/Eye Discharge |
|
|
02/02/2000 |
02/01/00 |
2.00 |
Yes |