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Current Search Critera

Long-Term Study Individual Animal Clinical Observations

Study Information:

Chemical Name: Milk thistle extract
CASRN: ="84604-20-6"
Study Number: C20008
Exposure Route:
TDMS Number: 2000804
Sex: Male
Strain and Species: B6C3F1 Mice

Animal Number Dose Group Clinical Observation Qualifier Incident Number Observation Date First Dose Date Days On Study Removal Observation
5 Untreated Control Eye Abnormality 12/01/2004 03/25/03 618.00 No
5 Untreated Control Mass Head, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
5 Untreated Control Mass Head, Small (1mm-5mm) 1 12/29/2004 03/25/03 646.00 No
5 Untreated Control Mass Head, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
5 Untreated Control Mass Head, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
5 Untreated Control Mass Head, Small (1mm-5mm) 1 03/23/2005 03/25/03 730.00 Yes
15 Untreated Control Mass Head, Small (1mm-5mm) 1 09/08/2004 03/25/03 534.00 No
15 Untreated Control Nasal/Eye Discharge 09/08/2004 03/25/03 534.00 No
15 Untreated Control Nasal/Eye Discharge 10/06/2004 03/25/03 562.00 No
15 Untreated Control Eye Abnormality 10/06/2004 03/25/03 562.00 No
15 Untreated Control Nasal/Eye Discharge 11/03/2004 03/25/03 590.00 No
15 Untreated Control Mass Head, Small (1mm-5mm) 1 11/03/2004 03/25/03 590.00 No
15 Untreated Control Eye Abnormality 11/03/2004 03/25/03 590.00 No
15 Untreated Control Nasal/Eye Discharge 12/01/2004 03/25/03 618.00 No
15 Untreated Control Eye Abnormality 12/01/2004 03/25/03 618.00 No
15 Untreated Control Mass Head, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
15 Untreated Control Nasal/Eye Discharge 12/29/2004 03/25/03 646.00 No
15 Untreated Control Mass Head, Small (1mm-5mm) 1 12/29/2004 03/25/03 646.00 No
15 Untreated Control Eye Abnormality 12/29/2004 03/25/03 646.00 No
15 Untreated Control Nasal/Eye Discharge 01/26/2005 03/25/03 674.00 No
15 Untreated Control Mass Head, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
15 Untreated Control Eye Abnormality 01/26/2005 03/25/03 674.00 No
15 Untreated Control Mass Head, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
15 Untreated Control Nasal/Eye Discharge 02/23/2005 03/25/03 702.00 No
15 Untreated Control Eye Abnormality 02/23/2005 03/25/03 702.00 No
15 Untreated Control Mass Head, Small (1mm-5mm) 1 03/24/2005 03/25/03 731.00 Yes
15 Untreated Control Eye Abnormality 03/24/2005 03/25/03 731.00 Yes
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 03/24/2004 03/25/03 366.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 04/21/2004 03/25/03 394.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 05/19/2004 03/25/03 422.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 06/16/2004 03/25/03 450.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 07/14/2004 03/25/03 478.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 08/11/2004 03/25/03 506.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 09/08/2004 03/25/03 534.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 10/06/2004 03/25/03 562.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 11/03/2004 03/25/03 590.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 12/29/2004 03/25/03 646.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
16 Untreated Control Mass Appendage, Small (1mm-5mm) 1 03/24/2005 03/25/03 731.00 Yes
20 Untreated Control Mass Torso/Ventral, Small (1mm-5mm) 1 03/23/2005 03/25/03 730.00 Yes
26 Untreated Control Mass Torso/Ventral, Medium (6mm-15mm) 1 03/23/2005 03/25/03 730.00 Yes
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 07/14/2004 03/25/03 478.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 08/11/2004 03/25/03 506.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 09/08/2004 03/25/03 534.00 No
31 Untreated Control Mass Appendage, Medium (6mm-15mm) 1 10/06/2004 03/25/03 562.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 11/03/2004 03/25/03 590.00 No
31 Untreated Control Ulcer/Abscess Appendage 1 11/03/2004 03/25/03 590.00 No
31 Untreated Control Ulcer/Abscess Appendage 1 12/01/2004 03/25/03 618.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 12/29/2004 03/25/03 646.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
31 Untreated Control Mass Appendage, Small (1mm-5mm) 1 03/23/2005 03/25/03 730.00 Yes
31 Untreated Control Head Tilt 03/23/2005 03/25/03 730.00 Yes
33 Untreated Control Nasal/Eye Discharge 11/03/2004 03/25/03 590.00 No
33 Untreated Control Eye Abnormality 11/03/2004 03/25/03 590.00 No
33 Untreated Control Nasal/Eye Discharge 12/01/2004 03/25/03 618.00 No
33 Untreated Control Eye Abnormality 12/01/2004 03/25/03 618.00 No
33 Untreated Control Eye Abnormality 12/29/2004 03/25/03 646.00 No
33 Untreated Control Nasal/Eye Discharge 12/29/2004 03/25/03 646.00 No
33 Untreated Control Eye Abnormality 01/26/2005 03/25/03 674.00 No
33 Untreated Control Mass Head, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
33 Untreated Control Eye Abnormality 02/23/2005 03/25/03 702.00 No
33 Untreated Control Mass Head, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
33 Untreated Control Mass Head, Small (1mm-5mm) 1 03/24/2005 03/25/03 731.00 Yes
33 Untreated Control Eye Abnormality 03/24/2005 03/25/03 731.00 Yes
40 Untreated Control Mass Appendage, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
40 Untreated Control Mass Appendage, Small (1mm-5mm) 1 03/24/2005 03/25/03 731.00 Yes
49 Untreated Control Mass Appendage, Medium (6mm-15mm) 1 02/23/2005 03/25/03 702.00 No
49 Untreated Control Ulcer/Abscess Appendage 1 02/23/2005 03/25/03 702.00 No
49 Untreated Control Ulcer/Abscess Appendage 1 03/23/2005 03/25/03 730.00 Yes
49 Untreated Control Mass Appendage, Large (16mm And Larger) 1 03/23/2005 03/25/03 730.00 Yes
49 Untreated Control Ulcer/Abscess Torso/Dorsal 2 03/23/2005 03/25/03 730.00 Yes
53 12500 PPM Nasal/Eye Discharge 09/08/2004 03/25/03 534.00 No
53 12500 PPM Mass Head, Small (1mm-5mm) 1 11/03/2004 03/25/03 590.00 No
53 12500 PPM Eye Abnormality 11/03/2004 03/25/03 590.00 No
53 12500 PPM Nasal/Eye Discharge 11/03/2004 03/25/03 590.00 No
53 12500 PPM Mass Head, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
53 12500 PPM Eye Abnormality 12/01/2004 03/25/03 618.00 No
53 12500 PPM Eye Abnormality 12/29/2004 03/25/03 646.00 No
53 12500 PPM Nasal/Eye Discharge 12/29/2004 03/25/03 646.00 No
53 12500 PPM Mass Head, Small (1mm-5mm) 1 12/29/2004 03/25/03 646.00 No
53 12500 PPM Eye Abnormality 01/26/2005 03/25/03 674.00 No
53 12500 PPM Mass Head, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
53 12500 PPM Eye Abnormality 02/23/2005 03/25/03 702.00 No
53 12500 PPM Mass Head, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
53 12500 PPM Mass Head, Small (1mm-5mm) 1 03/24/2005 03/25/03 731.00 Yes
53 12500 PPM Eye Abnormality 03/24/2005 03/25/03 731.00 Yes
84 12500 PPM Mass Appendage, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
84 12500 PPM Mass Appendage, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
84 12500 PPM Mass Appendage, Medium (6mm-15mm) 1 03/23/2005 03/25/03 730.00 Yes
92 12500 PPM Eye Abnormality 07/14/2004 03/25/03 478.00 No
92 12500 PPM Nasal/Eye Discharge 07/14/2004 03/25/03 478.00 No
92 12500 PPM Nasal/Eye Discharge 08/11/2004 03/25/03 506.00 No
92 12500 PPM Eye Abnormality 08/11/2004 03/25/03 506.00 No
92 12500 PPM Mass Head, Small (1mm-5mm) 1 09/08/2004 03/25/03 534.00 No
92 12500 PPM Nasal/Eye Discharge 09/08/2004 03/25/03 534.00 No
92 12500 PPM Eye Abnormality 09/08/2004 03/25/03 534.00 No
92 12500 PPM Eye Abnormality 10/06/2004 03/25/03 562.00 No
92 12500 PPM Mass Head, Small (1mm-5mm) 1 10/06/2004 03/25/03 562.00 No
92 12500 PPM Nasal/Eye Discharge 10/06/2004 03/25/03 562.00 No
92 12500 PPM Mass Head, Medium (6mm-15mm) 1 11/03/2004 03/25/03 590.00 No
92 12500 PPM Eye Abnormality 11/03/2004 03/25/03 590.00 No
92 12500 PPM Nasal/Eye Discharge 11/03/2004 03/25/03 590.00 No
92 12500 PPM Mass Head, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
92 12500 PPM Eye Abnormality 12/01/2004 03/25/03 618.00 No
92 12500 PPM Nasal/Eye Discharge 12/01/2004 03/25/03 618.00 No
92 12500 PPM Eye Abnormality 12/29/2004 03/25/03 646.00 No
92 12500 PPM Nasal/Eye Discharge 12/29/2004 03/25/03 646.00 No
92 12500 PPM Mass Head, Medium (6mm-15mm) 1 12/29/2004 03/25/03 646.00 No
92 12500 PPM Nasal/Eye Discharge 01/26/2005 03/25/03 674.00 No
92 12500 PPM Mass Head, Medium (6mm-15mm) 1 01/26/2005 03/25/03 674.00 No
92 12500 PPM Eye Abnormality 01/26/2005 03/25/03 674.00 No
92 12500 PPM Eye Abnormality 02/23/2005 03/25/03 702.00 No
92 12500 PPM Nasal/Eye Discharge 02/23/2005 03/25/03 702.00 No
92 12500 PPM Mass Head, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
92 12500 PPM Mass Head, Medium (6mm-15mm) 1 03/24/2005 03/25/03 731.00 Yes
92 12500 PPM Eye Abnormality 03/24/2005 03/25/03 731.00 Yes
94 12500 PPM Mass Head, Small (1mm-5mm) 1 05/21/2003 03/25/03 58.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 1 07/14/2004 03/25/03 478.00 No
94 12500 PPM Mass Appendage, Small (1mm-5mm) 1 08/11/2004 03/25/03 506.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 1 09/08/2004 03/25/03 534.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 1 10/06/2004 03/25/03 562.00 No
94 12500 PPM Nasal/Eye Discharge 11/03/2004 03/25/03 590.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 1 11/03/2004 03/25/03 590.00 No
94 12500 PPM Eye Abnormality 11/03/2004 03/25/03 590.00 No
94 12500 PPM Nasal/Eye Discharge 12/01/2004 03/25/03 618.00 No
94 12500 PPM Eye Abnormality 12/01/2004 03/25/03 618.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 2 12/29/2004 03/25/03 646.00 No
94 12500 PPM Eye Abnormality 12/29/2004 03/25/03 646.00 No
94 12500 PPM Eye Abnormality 01/26/2005 03/25/03 674.00 No
94 12500 PPM Nasal/Eye Discharge 01/26/2005 03/25/03 674.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 2 01/26/2005 03/25/03 674.00 No
94 12500 PPM Nasal/Eye Discharge 02/23/2005 03/25/03 702.00 No
94 12500 PPM Eye Abnormality 02/23/2005 03/25/03 702.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 2 02/23/2005 03/25/03 702.00 No
94 12500 PPM Mass Head, Small (1mm-5mm) 1 03/23/2005 03/25/03 730.00 Yes
94 12500 PPM Nasal/Eye Discharge 03/23/2005 03/25/03 730.00 Yes
94 12500 PPM Eye Abnormality 03/23/2005 03/25/03 730.00 Yes
94 12500 PPM Head Tilt 03/23/2005 03/25/03 730.00 Yes
99 12500 PPM Lethargic 06/03/2004 03/25/03 437.00 Yes
99 12500 PPM Thin 06/03/2004 03/25/03 437.00 Yes
103 25000 PPM Nasal/Eye Discharge 01/26/2005 03/25/03 674.00 No
103 25000 PPM Eye Abnormality 01/26/2005 03/25/03 674.00 No
103 25000 PPM Nasal/Eye Discharge 02/23/2005 03/25/03 702.00 No
103 25000 PPM Eye Abnormality 02/23/2005 03/25/03 702.00 No
103 25000 PPM Eye Abnormality 03/22/2005 03/25/03 729.00 Yes
103 25000 PPM Head Tilt 03/22/2005 03/25/03 729.00 Yes
115 25000 PPM Ulcer/Abscess Torso/Ventral 1 11/03/2004 03/25/03 590.00 No
115 25000 PPM Ulcer/Abscess Torso/Ventral 1 12/01/2004 03/25/03 618.00 No
115 25000 PPM Ulcer/Abscess Torso/Ventral 1 12/21/2004 03/25/03 638.00 Yes
115 25000 PPM Mass Torso/Ventral, Small (1mm-5mm) 1 12/21/2004 03/25/03 638.00 Yes
137 25000 PPM Mass Head, Small (1mm-5mm) 1 07/14/2004 03/25/03 478.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 08/11/2004 03/25/03 506.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 09/08/2004 03/25/03 534.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 10/06/2004 03/25/03 562.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 11/03/2004 03/25/03 590.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 12/29/2004 03/25/03 646.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
137 25000 PPM Mass Head, Small (1mm-5mm) 1 03/23/2005 03/25/03 730.00 Yes
138 25000 PPM Eye Abnormality 01/26/2005 03/25/03 674.00 No
138 25000 PPM Eye Abnormality 02/23/2005 03/25/03 702.00 No
138 25000 PPM Nasal/Eye Discharge 02/23/2005 03/25/03 702.00 No
138 25000 PPM Eye Abnormality 03/24/2005 03/25/03 731.00 Yes
140 25000 PPM Eye Abnormality 11/03/2004 03/25/03 590.00 No
140 25000 PPM Nasal/Eye Discharge 11/03/2004 03/25/03 590.00 No
140 25000 PPM Mass Head, Small (1mm-5mm) 1 11/03/2004 03/25/03 590.00 No
140 25000 PPM Mass Head, Small (1mm-5mm) 1 12/01/2004 03/25/03 618.00 No
140 25000 PPM Eye Abnormality 12/01/2004 03/25/03 618.00 No
140 25000 PPM Nasal/Eye Discharge 12/01/2004 03/25/03 618.00 No
140 25000 PPM Mass Head, Small (1mm-5mm) 1 12/29/2004 03/25/03 646.00 No
140 25000 PPM Eye Abnormality 01/26/2005 03/25/03 674.00 No
140 25000 PPM Mass Head, Small (1mm-5mm) 1 01/26/2005 03/25/03 674.00 No
140 25000 PPM Nasal/Eye Discharge 01/26/2005 03/25/03 674.00 No
140 25000 PPM Eye Abnormality 02/23/2005 03/25/03 702.00 No
140 25000 PPM Mass Head, Small (1mm-5mm) 1 02/23/2005 03/25/03 702.00 No
140 25000 PPM Eye Abnormality 03/22/2005 03/25/03 729.00 Yes
140 25000 PPM Mass Head, Small (1mm-5mm) 1 03/22/2005 03/25/03 729.00 Yes
142 25000 PPM Lethargic 02/14/2005 03/25/03 693.00 Yes
155 50000 PPM Lethargic 02/14/2005 03/25/03 693.00 Yes
162 50000 PPM Mass Torso/Ventral, Medium (6mm-15mm) 1 11/03/2004 03/25/03 590.00 No
164 50000 PPM Eye Abnormality 11/03/2004 03/25/03 590.00 No
164 50000 PPM Eye Abnormality 12/01/2004 03/25/03 618.00 No
164 50000 PPM Eye Abnormality 12/29/2004 03/25/03 646.00 No
164 50000 PPM Eye Abnormality 01/26/2005 03/25/03 674.00 No
164 50000 PPM Eye Abnormality 02/23/2005 03/25/03 702.00 No
164 50000 PPM Eye Abnormality 03/24/2005 03/25/03 731.00 Yes
172 50000 PPM Mass Torso/Ventral, Small (1mm-5mm) 1 09/08/2004 03/25/03 534.00 No
172 50000 PPM Mass Torso/Ventral, Medium (6mm-15mm) 1 10/06/2004 03/25/03 562.00 No
173 50000 PPM Thin 03/22/2005 03/25/03 729.00 Yes
173 50000 PPM Head Tilt 03/22/2005 03/25/03 729.00 Yes
176 50000 PPM Ulcer/Abscess Torso/Ventral 1 11/03/2004 03/25/03 590.00 No