ADME/TK Evaluation (K08002) of Bisphenol AF (1478-61-1) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration or Intravenous Injection

Radiolabel Description:
Carbon-14 uniformly on the rings; Bisphenol AF [ring-U-¹⁴C]-

Vehicles:
Intravenous, PEG400:isotonic saline:ethanol (50:40:10); oral, Cremophor.

Waidyanatha S, Mathews JM, Patel PR, Black SR, Snyder RW, Fennell TR.
Disposition of bisphenol AF, a bisphenol A analogue, in hepatocytes in vitro and in male and female Harlan Sprague-Dawley rats and B6C3F1/N mice following oral and intravenous administration.
Xenobiotica. 2015;45(9):811-9. doi: https://doi.org/10.3109/00498254.2015.1021732. Epub 2015 Jun 12. PMID: 25923777

Data Summary – Male Rats

• Gavage Single Dose (3.4 mg/kg, Study Duration 72 hours) (51KB)
• Gavage Single Dose (34 mg/kg, Study Duration 72 hours) (49KB)
• Gavage Single Dose (340 mg/kg, Bile Study Duration 24 hours) (29KB)
• Gavage Single Dose (340 mg/kg, Study Duration 72 hours) (48KB)
• IV Single Dose (34 mg/kg, Study Duration 72 hours) (50KB)

Data Summary – Female Rats

• Gavage Single Dose (34 mg/kg, Study Duration 24 hours) (45KB)
• Gavage Single Dose (34 mg/kg, Study Duration 72 hours) (51KB)
• IV Single Dose (34 mg/kg, Study Duration 72 hours) (50KB)

Data Summary – Male Mice

• Gavage Single Dose (34 mg/kg, Study Duration 72 hours) (52KB)
• IV Single Dose (34 mg/kg, Study Duration 72 hours) (50KB)

Data Summary – Female Mice

• Gavage Single Dose (34 mg/kg, Study Duration 72 hours) (51KB)
• IV Single Dose (34 mg/kg, Study Duration 72 hours) (52KB)

Individual Animal Data

• Individual Animal Data (277KB)