ADME Evaluation (K11054) of Sulfolane (126-33-0) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration, Intravenous Injection, or Dermal Application
Radiolabel Description:
Carbon-14 in the C-2 and C-5 position of the ring; sulfolane, [2,5-14C]-
Vehicles:
Intravenous, saline; oral, water; dermal, 95% ethanol.
DOI:
https://doi.org/10.22427/NTP-DATA-002-03276-0008-0000-8
Waidyanatha S, Black SR, Blystone CR, Patel PR, Watson SL, Snyder RW, Fennell TR.
Disposition and metabolism of sulfolane in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans.
Xenobiotica. 2019 Jul 5:1-12. doi: https://doi.org/10.1080/00498254.2019.1630786. [Epub ahead of print] PMID: 31184953
Data Summary – Male Rats
- Dermal Single Dose (100 mg/kg, Covered, Study Duration 48 hours) (56KB)
- Dermal Single Dose (100 mg/kg, Uncovered, Study Duration 48 hours) (59KB)
- Dermal Single Dose (100 mg/kg, with Breath Traps, Covered, Study Duration 48 hours) (43KB)
- Gavage Single Dose (100 mg/kg, Study Duration 24 hours) (49KB)
- Gavage Single Dose (100 mg/kg, Study Duration 48 hours) (51KB)
- Gavage Single Dose (30 mg/kg, Study Duration 72 hours) (62KB)
- Gavage Single Dose (300 mg/kg, Study Duration 72 hours) (64KB)
- IV Single Dose (100 mg/kg, Study Duration 48 hours) (51KB)
Data Summary – Female Rats
- Dermal Single Dose (100 mg/kg, Covered, Study Duration 48 hours) (56KB)
- Gavage Single Dose (100 mg/kg, Study Duration 48 hours) (51KB)
Data Summary – Male Mice
- Dermal Single Dose (100 mg/kg, Covered, Study Duration 48 hours) (58KB)
- IV Single Dose (100 mg/kg, Study Duration 48 hours) (51KB)