ADME/TK Evaluation (K03021) of Ionic Liquid (1-Butyl-1-methylpyrrolidinium chloride) (479500-35-1) in F344 Rats Exposed via Gavage Administration, Intravenous Injection or Dermal Application

Radiolabel Description:
Carbon-14; N-[1-¹⁴C]Butyl-1-methylpyrrolidinium chloride

Vehicles:
Intravenous, not specified; oral, 0.9% sodium chloride; dermal, water or ethanol:water (63.7:37.3) or dimethylformamide: water (63.7:37.3).

Additional Information:
Study was conducted in male rats only. Dermal dose site was covered.

Data Summary - Male Rats

• Dermal Single Dose (5 mg/kg in DMF, Study Duration 48 hours) (42KB)
• Dermal Single Dose (5 mg/kg in Ethanol, Study Duration 48 hours) (41KB)
• Dermal Single Dose (5 mg/kg in Nanopure Water, Study Duration 72 hours) (38KB)
• Gavage Multiple Dose 5-Day (50 mg/kg, Study Duration 24 hours) (38KB)
• Gavage Single Dose (0.5, 5, and 50 mg/kg, Study Duration 72 hours) (39KB)
• Gavage Single Dose (50 mg/kg, Study Duration 24 hours) (36KB)
• Gavage and IV Toxicokinetics for Male Rats (146KB)
• IV Single Dose (5 mg/kg, Study Duration 48 hours) (33KB)