ADME/TK Evaluation (K04089) of Nanoscale material ([13C]-Fullerene-C60) (99685-96-8) in F344 Rats Exposed via Intratracheal Instillation or Intravenous Injection

Radiolabel Description:
Carbon-13; [¹³C]-Fullerene-C60

Vehicles:
Intravenous, stable suspensions of PBS/1% Tween 80; intratracheal instillation, stable suspensions of PBS/1% Tween 80.

Shipkowski KA, Sanders JM, McDonald JD, Walker NJ, Waidyanatha S.
Disposition of fullerene C60 in rats following intratracheal or intravenous administration.
Xenobiotica. 2019 Sep;49(9):1078-1085. doi: https://doi.org/10.1080/00498254.2018.1528646. Epub 2019 Apr 12. PMID: 30257131

Data Summary - Male Rats

Radiolabel Description:
Carbon-13; N-[1-¹³C]-Fullerene-C60

Vehicles:
Intravenous, stable suspensions of PBS/1% Tween 80; intratracheal instillation, stable suspensions of PBS/1% Tween 80.

• IV Single Dose (5 mg/kg, Study Duration 168 hours) (91KB)
• Intratracheal instillation Single Dose (1 mg/kg, Study Duration 168 hours) (73KB)
• Intratracheal instillation Single Dose (5 mg/kg, Study Duration 168 hours) (73KB)