ADME/TK Evaluation (K06049) of 2-Methoxy-4-nitroaniline (97-52-9) in Harlan Sprague-Dawley Rats and B6C3F1 Mice Exposed via Gavage Administration, Intravenous Injection or Dermal Application

Radiolabel Description:
Carbon-14; 2-Methoxy-4-nitroaniline, [ring-¹⁴C(U)]- 

Vehicles:
Intravenous, PEG400:ethanol:saline (60:10:30); Oral, Cremophor; Dermal, acetone.

Mathews JM, Zhan Q, Etheridge AS, Patel PR, Black SR, Banks TT, Fennell TR, Snyder RW, Burgess JP, Warren SD, Surh I, Waidyanatha S.
Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice.
Xenobiotica. 2012 Dec;42(12):1213-24. doi: https://doi.org/10.3109/00498254.2012.697211. Epub 2012 Jun 23. PMID: 22725680

Data Summary - Male Rats

• Dermal Single Dose (15 mg/kg, Study Duration 24 hours) (58KB)
• Gavage Single Dose (15 mg/kg, Study Duration 24 hours) (48KB)
• Gavage Single Dose (15 mg/kg, Study Duration 72 hours) (56KB)
• Gavage Single Dose (150 mg/kg, Bile Study Duration 4 hours) (23KB)
• Gavage Single Dose (150 mg/kg, Study Duration 72 hours) (55KB)
• Gavage Single Dose (2 mg/kg, Study Duration 72 hours) (59KB)
• IV Single Dose (15 mg/kg, Study Duration 24 hours) (47KB)
• IV Single Dose (15 mg/kg, Study Duration 72 hours) (50KB)

Data Summary - Female Rats

• Gavage Single Dose (15 mg/kg, Study Duration 72 hours) (50KB)
• IV Single Dose (15 mg/kg, Study Duration 72 hours) (50KB)

Data Summary - Male Mice

• Dermal Single Dose (15 mg/kg, Study Duration 24 hours) (57KB)
• Gavage Single Dose (15 mg/kg, Study Duration 72 hours) (57KB)
• IV Single Dose (15 mg/kg, Study Duration 72 hours) (49KB)

Data Summary - Female Mice

• Gavage Single Dose (15 mg/kg, Study Duration 72 hours) (57KB)
• IV Single Dose (15 mg/kg, Study Duration 72 hours) (49KB)