ADME/TK Evaluation (K07051) of Dimethylamine Borane (74-94-2) in Harlan Sprague-Dawley Rats Exposed via Gavage Administration, Intravenous Injection or Dermal Application
Radiolabel Description:
Carbon-14 located on one or both carbons attached to the N depending on the batch; [14C]Dimethylethanolamine
Vehicles:
Intravenous, saline; Oral, distilled water; Dermal, 95% ethanol.
Mathews JM, Watson SL, Patel PR, Black SR, Hong Y, Levine KE, Ross G, Germolec DR, Thakur SA, Waidyanatha S.
Metabolism and disposition of [(14)C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application.
Xenobiotica. 2014 Jan;44(1):36-47. doi: https://doi.org/10.3109/00498254.2013.800662. Epub 2013 Jun 20. PMID: 23786350
Data Summary - Male Rats
- Dermal Single Dose (0.15 mg/kg, Study Duration 72 hours) (72KB)
- Dermal Single Dose (1.5 mg/kg, Study Duration 72 hours) (70KB)
- Dermal Single Dose (15 mg/kg, Study Duration 72 hours) (70KB)
- Gavage Single Dose (1.5 mg/kg, Study Duration 72 hours) (62KB)
- IV Single Dose (1.5 mg/kg, Study Duration 72 hours) (66KB)