ADME/TK Evaluation (K08036) of tris(4-Chlorophenyl)methane (27575-78-6) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration or Intravenous Injection
Radiolabel Description:
Carbon-14; Tris(4-chlorophenyl)methane, [14C(U)]-
Vehicles:
Intravenous, Cremophor:saline:ethanol (20:70:10); Oral, Cremophor:water (40:60).
Catlin NR, Waidyanatha S, Black SR, Mathews JM, Snyder RW, Patel PR, Watson SL, Fennell TR.
Disposition of tris(4-chlorophenyl)methanol and tris(4-chlorophenyl)methane in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration.
Xenobiotica. 2019 Apr;49(4):484-494. doi: https://doi.org/10.1080/00498254.2018.1463475. Epub 2018 May 3. PMID: 29659319
Data Summary - Male Rats
- Gavage Single Dose (1 mg/kg, Study Duration 72 hours) (57KB)
- Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (48KB)
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (57KB)
- Gavage Single Dose (100 mg/kg, Excreta with Bile, Study Duration 24 hours) (37KB)
- Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (57KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (58KB)
Data Summary - Female Rats
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (57KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (59KB)
Data Summary - Male Mice
- Gavage Single Dose (1 mg/kg, Study Duration 72 hours) (57KB)
- Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (64KB)
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (60KB)
- Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (65KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (67KB)
Data Summary - Female Mice
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (68KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (67KB)