ADME/TK Evaluation (K06043) of N,N-Dimethylacetoacetamide (2044-64-6) in Wistar-Han Rats, F344 Rats and B6C3F1 Mice Exposed via Gavage Administration

Radiolabel Description:
Carbon-14; N,N-Dimethylacetoacetamide, [carbonyl-¹⁴C]-

Vehicles:
Oral, water.

Fennell T, Watson S, Snyder R, Jeffcoat R, Waidyanatha S.
Disposition and metabolism of N,N-dimethylacetoacetamide in male F344 and Wistar-Han rats and female B6C3F1 mice.
Xenobiotica. 2011 Nov;41(11):1013-20. doi: https://doi.org/10.3109/00498254.2011.599444. Epub 2011 Aug 6. PMID: 21819270

Data Summary - Male F344 Rats

• Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (61KB)
• Gavage Single Dose (130 mg/kg, Study Duration 24 hours) (60KB)

Data Summary - Male Wistar Han Rats

• Gavage Single Dose (130 mg/kg, Study Duration 24 hours) (43KB)
• Gavage Single Dose (8 mg/kg, Study Duration 24 hours) (61KB)

Data Summary - Female Mice

• Gavage Single Dose (8 mg/kg, Study Duration 24 hours) (62KB)