ADME/TK Evaluation (K10022) of Hydroquinone (123-31-9) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration, Intravenous Injection or Dermal Application
Radiolabel Description:
Carbon-14 uniformly in the ring; Hydroquinone, [ring-14C(U)]-
Vehicles:
Intravenous, saline; Oral, distilled water; Dermal, 95% ethanol
Black SR, Fennell TR, Mathews JM, Snyder RW, Patel PR, Watson SL, Sutherland V, Waidyanatha S.
Disposition of [14C]hydroquinone in Harlan Sprague-Dawley rats and B6C3F1/N mice: species and route comparison.
Xenobiotica. 2018 Nov;48(11):1128-1141. doi: https://doi.org/10.1080/00498254.2017.1398847. Epub 2017 Nov 22. PMID: 29166815
Data Summary - Male Rats
- Dermal Single Dose (10% Covered, Study Duration 72 hours) (62KB)
- Dermal Single Dose (2% Covered, Study Duration 72 hours) (69KB)
- Dermal Single Dose (2% Uncovered, Study Duration 72 hours) (70KB)
- Dermal Single Dose (20% Covered, Study Duration 72 hours) (82KB)
- Gavage Single Dose (0.5 mg/kg, Study Duration 72 hours) (57KB)
- Gavage Single Dose (5 mg/kg, Study Duration 24 hours) (61KB)
- Gavage Single Dose (50 mg/kg, Study Duration 72 hours) (86KB)
- IV Single Dose (5 mg/kg, Study Duration 72 hours) (66KB)
Data Summary - Female Rats
- Dermal Single Dose (2% Covered, Study Duration 72 hours) (77KB)
- IV Single Dose (5 mg/kg, Study Duration 72 hours) (58KB)
Data Summary - Male Mice
- Dermal Single Dose (10% Covered, Study Duration 72 hours) (68KB)
- Dermal Single Dose (2% Covered, Study Duration 72 hours) (69KB)
- Dermal Single Dose (2% Uncovered, Study Duration 72 hours) (61KB)
- Dermal Single Dose (20% Covered, Study Duration 72 hours) (91KB)
- Gavage Single Dose (0.5 mg/kg, Study Duration 72 hours) (68KB)
- Gavage Single Dose (5 mg/kg, Study Duration 24 hours) (76KB)
- Gavage Single Dose (5 mg/kg, Study Duration 72 hours) (67KB)
- Gavage Single Dose (50 mg/kg, Study Duration 72 hours) (72KB)
- IV Single Dose (5 mg/kg, Study Duration 72 hours) (57KB)
Data Summary - Female Mice
- Dermal Single Dose (2% Covered, Study Duration 72 hours) (70KB)
- Gavage Single Dose (5 mg/kg, Study Duration 72 hours) (65KB)