ADME/TK Evaluation (K10260) of 2-Hydroxy-4-methoxybenzophenone (131-57-7) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration, Intravenous Injection or Dermal Application
Radiolabel Description:
Carbon-14; 2-Hydroxy-4-methoxybenzophenone, [benzene-14C(U)]-
Vehicles:
Intravenous, water:ethanol:alkamuls (3:5:2 by v:v:v); Oral, corn oil; Dermal, acetone, coconut oil, ethanol:coconut oil (1:1), ethanol, light Paraffin oil, or lotion which is olive oil:emulsifying wax:water (15:15:70 v:w:v).
DOI:
https://doi.org/10.22427/NTP-DATA-002-01338-0023-0000-2
Data Summary - Male Rats
- Dermal Single Dose (0.1 mg/kg in Paraffin Oil, Study Duration 72 hours) (48KB)
- Dermal Single Dose (1 mg/kg in Ethanol, Study Duration 72 hours) (48KB)
- Dermal Single Dose (10 mg/kg in Coconut Oil, Study Duration 72 hours) (47KB)
- Dermal Single Dose (10 mg/kg in Ethanol, Study Duration 72 hours) (67KB)
- Dermal Single Dose (10 mg/kg in Ethanol-Coconut Oil, Study Duration 72 hours) (54KB)
- Dermal Single Dose (10 mg/kg in Lotion, Study Duration 72 hours) (54KB)
- Dermal Single Dose (10 mg/kg in Paraffin Oil, Study Duration 72 hours) (53KB)
- Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (38KB)
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (45KB)
- Gavage Single Dose (100 mg/kg, Study Duration 2 hours) (50KB)
- Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (81KB)
- Gavage Single Dose (500 mg/kg, Study Duration 72 hours) (47KB)
- Gavage and IV Toxicokinetics for Male and Female Rats (170KB)
- IV Single Dose (10 mg/kg, Bile Study Duration 6 hours) (74KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (60KB)
Data Summary - Female Rats
- Dermal Single Dose (15 mg/kg in Lotion, Study Duration 72 hours) (49KB)
- Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (47KB)
- Gavage and IV Toxicokinetics for Male and Female Rats (170KB)
Data Summary - Male Mice
- Dermal Single Dose (1 mg/kg in Ethanol, Study Duration 72 hours) (48KB)
- Dermal Single Dose (10 mg/kg in Acetone Study Duration 72 hours) (47KB)
- Dermal Single Dose (10 mg/kg in Ethanol Repeat, Study Duration 72 hours) (30KB)
- Dermal Single Dose (10 mg/kg in Lotion, Study Duration 72 hours) (48KB)
- Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (32KB)
- Gavage Single Dose (500 mg/kg, Study Duration 72 hours) (46KB)
- IV Single Dose (10 mg/kg, Study Duration 72 hours) (29KB)