ADME/TK Evaluation (K20084) of Dimethylethanolamine (108-01-0) and Choline (67-48-1) in Wistar Han Rats, Sprague-Dawley Rats and B6C3F1 Mice Exposed via Gavage Administration or Intravenous Injection

Radiolabel Description:
Carbon-14 located on both carbons of the ethanol; Dimethylethanolamine, [ethanol-¹⁴C(U)]-; Carbon-14 located on methyl carbon; Choline chloride, [methyl-¹⁴C]-

Vehicles:
Intravenous, 0.85% saline for Dimethylethanolamine and water for Choline chloride; Oral, water

Shipkowski KA, Sanders JM, McDonald JD, Garner CE, Doyle-Eisele M, Wegerski CJ, Waidyanatha S.
Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.
Toxicol Appl Pharmacol. 2019 Sep 1;378:114592. doi: https://doi.org/10.1016/j.taap.2019.05.011. Epub 2019 May 14. PMID: 31100288

Choline

Summary Data - Female Wistar Han Rats

• Choline Gavage Single Dose (160 mg/kg with Vehicle Pretreatment, Study Duration 24 hours) (45KB)
• Choline Gavage Single Dose (160 mg/kg, with 100 mg/kg DMAE Pretreatment, Study Duration 24 hours) (55KB)
• Choline Gavage Single Dose (160 mg/kg, with 500 mg/kg DMAE Pretreatment, Study Duration 24 hours) (71KB)
• Choline IV Single Dose (160 mg/kg, Study Duration 24 hours) (44KB)

Summary Data - Female B6C3F1 Mice

• Choline Gavage Single Dose (160 mg/kg, Study Duration 24 hours) (45KB)
• Choline Gavage Single Dose (160 mg/kg, with 500 mg/kg DMAE Pretreatment, Study Duration 24 hours) (64KB)

Summary Data - Male Wistar Han Rats

• Choline Gavage Single Dose (160 mg/kg, Study Duration 24 hours) (45KB)
• Choline Gavage Single Dose (160 mg/kg, with 100 mg/kg DMAE Pretreatment, Study Duration 24 hours) (54KB)
• Choline Gavage Single Dose (160 mg/kg, with 500 mg/kg DMAE Pretreatment, Study Duration 24 hours) (54KB)
• Choline Gavage Single Dose (160 mg/kg, with Multiple (3x)100 mg/kg DMAE Pretreatments, Study Duration 24 hours) (44KB)
• Choline IV Single Dose (16 mg/kg, Study Duration 24 hours) (70KB)

Dimethylethanolamine

Summary Data - Male Wistar Han Rats

• DMAE Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (40KB)
• DMAE Gavage Single Dose (100 mg/kg, Study Duration 2 hours) (32KB)
• DMAE Gavage Single Dose (100 mg/kg, Study Duration 24 hours) (43KB)
• DMAE Gavage Single Dose (500 mg/kg, Study Duration 168 hours) (46KB)
• DMAE Gavage Single Dose (500 mg/kg, Study Duration 2 hours) (47KB)
• DMAE Gavage Single Dose (500 mg/kg, Study Duration 24 hours) (45KB)
• DMAE Gavage Single Dose (500 mg/kg, Study Duration 72 hours) (43KB)
• DMAE IV Single Dose (10 mg/kg, Study Duration 24 hours) (45KB)

Summary Data - Female Wistar Han Rats

• DMAE Gavage Single Dose (500 mg/kg, Study Duration 24 hours) (40KB)

Summary Data - Male Sprague-Dawley Rats

• DMAE Gavage Single Dose (500 mg/kg, Study Duration 24 hours) (48KB)

Summary Data - Male B6C3F1 Mice

• DMAE Gavage Single Dose (500 mg/kg, Study Duration 24 hours, Outlier) (44KB)
• DMAE Gavage Single Dose (500 mg/kg, Study Duration 24 hours, Repeat) (78KB)

Summary Data - Female B6C3F1 Mice

• DMAE Gavage Single Dose (100 mg/kg, Study Duration 24 hours) (51KB)
• DMAE Gavage Single Dose (500 mg/kg, Study Duration 24 hours) (44KB)
• DMAE Gavage Single Dose (500 mg/kg, Study Duration 72 hours) (45KB)