ADME Evaluation (K94150) of Bisphenol S (80-09-1) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration or Intravenous Injection

Radiolabel Description:
Carbon-14 uniformly on the rings; Bisphenol S [¹⁴C(U)]-  

Vehicles:
Intravenous, ethanol:Cremophor:water (10:20:70); Oral, Cremophor.

Waidyanatha S, Black SR, Snyder RW, Yueh YL, Sutherland V, Patel PR, Watson SL, Fennell TR.
Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans.
Toxicol Appl Pharmacol. 2018 Jul 15;351:32-45. doi: https://doi.org/10.1016/j.taap.2018.05.008 . Epub 2018 May 18. PMID: 29753715

Summary Data - Male Rats

• Gavage Single Dose (150 mg/kg, Excreta with Bile Study Duration 24 hours) (35KB)
• Gavage Single Dose (150 mg/kg, Study Duration 24 hours) (67KB)
• Gavage Single Dose (150 mg/kg, Study Duration 72 hours) (55KB)
• Gavage Single Dose (50 mg/kg, Study Duration 72 hours) (56KB)
• Gavage Single Dose (500 mg/kg, Study Duration 72 hours) (62KB)
• IV Single Dose (50 mg/kg, Study Duration 72 hours) (77KB)

Summary Data - Female Rats

• Gavage Single Dose (150 mg/kg, Study Duration 72 hours) (56KB)

Summary Data - Male Mice

• Gavage Single Dose (150 mg/kg, Study Duration 72 hours) (79KB)

Summary Data - Female Mice

• Gavage Single Dose (150 mg/kg, Study Duration 72 hours) (65KB)

Supplemental Material

• Formation of BPS from BPS derivatives (326KB)
• Concentration Data BPS (21KB)