ADME/TK Evaluation (S0819) of o-Chloropyridine (109-09-1) in F344 Rats and B6C3F1 Mice Exposed via Gavage Administration, Intravenous Injection, or Intraperitoneal Injection
Radiolabel Description:
Carbon-14 in the C-2 and C-6 position of the ring; 2-Chloropyridine, [Ring-2,6-14C]-
Vehicles:
Intravenous, Alkamuls EL-620/L (no more than 15% of the dose) and distilled deionized water; Oral, Alkamuls EL-620/L (no more than 15% of the dose) and distilled deionized water; Intraperitoneal, Alkamuls EL-620/L (no more than 15% of the dose) and distilled deionized water.
Summary Data - Male Rats
- Gavage Single Dose (0.11 mg/kg, Study Duration 72 hours) (60KB)
- Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (56KB)
- Gavage Single Dose (10.4 mg/kg, Study Duration 72 hours) (59KB)
- Intraperitoneal Single Dose (50 mg/kg, Excreta with Bile, Study Duration 4 hours) (43KB)
- Individual Animal Data (Toxicokinetics) (18KB)