ADME/TK Evaluation (S0915) of Kawain (1635-33-2) in F344 Rats and B6C3F1 Mice Exposed via Gavage Administration or Intravenous Injection
Radiolabel Description:
Carbon-14 uniformly in the phenyl ring; (+)Kawain, [phenyl-14C(UL)]-
Vehicles:
Intravenous, plasma:Alkamuls (80:20, v,v); Oral, Alkamuls; Repeat Oral kava doses in Alkamuls:water (4:1, v:v).
Summary Data - Male Rats
- (+)Kawain Gavage Single Dose (100 mg/kg, Study Duration 72 hours) (33KB)
- (+)Kawain Gavage Single Dose (100 mg/kg, with 100 mg/kg Kavalactones Pretreatment for 7 Days, Study Duration 72 hours) (42KB)
- (+)Kawain IV Single Dose (7 mg/kg, Study Duration 72 hours) (33KB)
- Kavalactones Gavage Single Dose (100 mg/kg, with tracer (+)Kawain, Study Duration 72 hours) (52KB)
- Oral and IV Toxicokinetics for Male Rats (555KB)
- Individual Animal Data (Toxicokinetics) (20KB)