ADME/TK Evaluation (S0941) of Sodium Dichromate Dihydrate (VI) (7789-12-0) in F344 Rats and B6C3F1 Mice Exposed via Gavage Administration

Radiolabel Description:
Chromium-51; [⁵¹Cr]Sodium chromate (Na₂⁵¹CrO₄) and [⁵¹Cr]chromium III chloride (⁵¹CrCl₃)

Vehicles:
Oral, deionized water

Additional Information:
For the sodium dichromate dihydrate (VI) 4 umol CRVI gavage dose 24 hour studies, Study I is a repeat of Study C but at a lower radioactive dosage: I at 5.96 ± μCi and C at 8.84 ± 0.74 Ci. The experiment was repeated to investigate the possibility that the higher amount of radioactivity used in Study C affected the absorption of dose.

NOTE: The data below includes both Sodium dichromate dihydrate (VI) and CrCl3-6H2O (chromium trichloride hexahydrate).

Summary Data - Male Rats

• Gavage Single Dose (2 umol CrIII & CrVI, Study Duration 24 hours) (35KB)
• Gavage Single Dose (2 umol CrIII, Study Duration 24 hours) (35KB)
• Gavage Single Dose (2 umol CrVI, Study Duration 24 hours) (35KB)

Summary Data - Male Mice

For the Sodium Dichromate Dihydrate (VI) 4 umol CrVI gavage dose 24 hour studies, Study I is a repeat of Study C but at a lower radioactive dosage: I at 5.96 ± μCi and C at 8.84 ± 0.74 Ci.
The experiment was repeated to investigate the possibility that the higher amount of radioactivity used in Study C affected the absorption of dose.

• Gavage Single Dose (4 umol CrIII & CrVI, Study Duration 24 hours) (52KB)
• Gavage Single Dose (4 umol CrIII, Study Duration 24 hours) (35KB)
• Gavage Single Dose (4 umol CrVI, Study Duration 24 hours, high radioactivity) (59KB)
• Gavage Single Dose (4 umol CrVI, Study Duration 24 hours, low radioactivity) (35KB)