ADME/TK Evaluation (K08035) of L-beta-Methylaminoalanine (15920-93-1) in Harlan Sprague-Dawley Rats and B6C3F1/N Mice Exposed via Gavage Administration and Intravenous Injection

Vehicles:
Intravenous, normal saline; Oral, ultrapurified water.

Additional Information:
While L-beta_Methylaminoalanine (15920-93-1) was nominated, L-beta-Methylaminoalanine hydrochloride was used in this study (CAS 16012-55-8) due to solubility issues.

Waidyanatha S, Ryan K, Sanders JM, McDonald JD, Wegerski CJ, Doyle-Eisle M, Garner CE.
Disposition of β-N-methylamino-l-alanine (L-BMAA), a neurotoxin, in rodents following a single or repeated oral exposure.
Toxicol Appl Pharmacol. 2018 Jan 15;339:151-160. doi: https://doi.org/10.1016/j.taap.2017.12.008. Epub 2017 Dec 15. PMID: 29248465

Data Summary - Male Rats

• Gavage Multiple Dose 1,5,10-Day (1 mg/kg, Study Duration 24 hours) (67KB)
• Gavage Multiple Dose 10-Day (1 mg/kg, Study Duration 24 hours) (70KB)
• Gavage Multiple Dose 10-Day (1 mg/kg, Study Duration 72 hours) (58KB)
• Gavage Multiple Dose 5-Day (1 mg/kg, Study Duration 24 hours) (92KB)
• Gavage Single Dose (1 mg/kg, Study Duration 24 hours) (71KB)
• Gavage Single Dose (10 mg/kg, Study Duration 120 hours) (55KB)
• Gavage Single Dose (10 mg/kg, Study Duration 168 hours) (75KB)
• Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (89KB)
• Gavage Single Dose (10 mg/kg, Study Duration 72 hours) (57KB)
• Gavage Single Dose (100 mg/kg, Study Duration 24 hours) (77KB)
• IV Single Dose (1 mg/kg, Study Duration 24 hours) (50KB)

Summary Data - Female Rats

• Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (72KB)

Summary Data - Male Mice

• Gavage Single Dose (1 mg/kg, Study Duration 24 hours) (52KB)
• Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (70KB)
• Gavage Single Dose (100 mg/kg, Study Duration 24 hours) (52KB)
• IV Single Dose (1 mg/kg, Study Duration 24 hours) (52KB)

Summary Data - Female Mice

• Gavage Single Dose (10 mg/kg, Study Duration 24 hours) (52KB)