NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Date: 05/30/02 Route: DOSED WATER Time: 08:14:56 FINAL/RATS Facility: Southern Research Institute Chemical CAS #: 71133-14-7 Lock Date: 06/29/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Date: 05/30/02 Route: DOSED WATER Time: 08:14:56 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Natural Death 1 Survivors Terminal Sacrifice 9 10 10 10 10 10 Animals Examined Microscopically 10 4 6 5 5 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (3) (1) (10) Hematopoietic Cell Proliferation 2 (20%) Hepatodiaphragmatic Nodule 2 (67%) 1 (100%) 1 (10%) Inflammation, Chronic, Focal 4 (40%) 3 (30%) Mesentery (1) (1) (1) Fat, Necrosis, Focal 1 (100%) 1 (100%) 1 (100%) Pancreas (10) (10) Acinus, Atrophy, Focal 1 (10%) 1 (10%) Salivary Glands (10) (10) Parotid Gland, Basophilic Focus 3 (30%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy, Focal 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (1) (1) (10) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Date: 05/30/02 Route: DOSED WATER Time: 08:14:56 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Cyst 1 (100%) 1 (100%) Ovary (10) (1) (2) (10) Cyst 1 (100%) 2 (100%) 3 (30%) Uterus (10) (1) (3) (2) (10) Hydrometra 1 (10%) 1 (100%) 3 (100%) 2 (100%) 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (3) (1) (4) (3) (1) (6) Mediastinal, Hemorrhage 1 (33%) 1 (25%) 1 (17%) Mediastinal, Hyperplasia, Lymphoid 1 (25%) 1 (33%) 1 (17%) Pancreatic, Hemorrhage 2 (67%) 1 (100%) 2 (50%) 1 (33%) 4 (67%) Pancreatic, Hyperplasia, Lymphoid 1 (17%) Pancreatic, Inflammation, Granulomatous 1 (33%) 1 (17%) Lymph Node, Mesenteric (10) (10) Hyperplasia, Lymphoid 2 (20%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Inflammation, Chronic, Focal 1 (10%) 1 (10%) Alveolus, Hemorrhage 1 (10%) Alveolus, Infiltration Cellular, Focal, Histiocyte 2 (20%) Nose (10) (10) Olfactory Epithelium, Septum, Cyst 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Date: 05/30/02 Route: DOSED WATER Time: 08:14:56 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Inflammation, Chronic 1 (10%) Nephropathy 1 (10%) 1 (10%) Cortex, Cyst 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Date: 05/30/02 Route: DOSED WATER Time: 08:14:56 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 5 2 2 3 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (1) (1) (1) (10) Hematopoietic Cell Proliferation 2 (20%) 1 (10%) Hepatodiaphragmatic Nodule 1 (100%) 1 (100%) 1 (100%) 1 (10%) Inflammation, Chronic, Focal 3 (30%) 3 (30%) Mesentery (1) Fat, Necrosis, Focal 1 (100%) Pancreas (10) (1) (10) Acinus, Atrophy, Focal 1 (100%) 1 (10%) Salivary Glands (10) (10) Parotid Gland, Basophilic Focus 7 (70%) 4 (40%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy, Focal 7 (70%) 9 (90%) ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) Accessory Adrenal Cortical Nodule 1 (10%) Vacuolization Cytoplasmic, Focal 1 (10%) Adrenal Medulla (10) (10) Hyperplasia, Focal 1 (10%) Pituitary Gland (10) (10) Pars Distalis, Cyst 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Date: 05/30/02 Route: DOSED WATER Time: 08:14:56 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) Inflammation, Chronic 1 (10%) Testes (10) (10) Atrophy 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) (2) (1) (1) (2) (4) Mediastinal, Hemorrhage 1 (50%) Mediastinal, Hyperplasia, Lymphoid 1 (50%) Pancreatic, Hemorrhage 1 (100%) 1 (50%) 1 (100%) 1 (50%) 4 (100%) Lymph Node, Mesenteric (10) (1) (1) (10) Hyperplasia, Lymphoid 1 (100%) 1 (100%) 1 (10%) Inflammation, Chronic, Granulomatous 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Inflammation, Chronic, Focal 1 (10%) Metaplasia, Osseous 1 (10%) Alveolus, Infiltration Cellular, Focal, Histiocyte 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Date: 05/30/02 Route: DOSED WATER Time: 08:14:56 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Nephropathy 4 (40%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------