NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 05/30/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 08:16:45 FINAL/RATS Facility: Southern Research Institute Chemical CAS #: 71133-14-7 Lock Date: 06/29/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 05/30/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 08:16:45 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Natural Death 1 Survivors Terminal Sacrifice 9 10 10 10 10 10 Animals Examined Microscopically 10 4 6 5 5 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (3) (1) (10) Hematopoietic Cell Proliferation 2 [1.0] Hepatodiaphragmatic Nodule 2 [2.0] 1 [2.0] 1 [2.0] Inflammation, Chronic, Focal 4 [1.3] 3 [1.0] Mesentery (1) (1) (1) Fat, Necrosis, Focal 1 [2.0] 1 [2.0] 1 [2.0] Pancreas (10) (10) Acinus, Atrophy, Focal 1 [1.0] 1 [1.0] Salivary Glands (10) (10) Parotid Gland, Basophilic Focus 3 [1.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy, Focal 1 [1.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (10) (1) (1) (10) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 05/30/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 08:16:45 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Cyst 1 [1.0] 1 [2.0] Ovary (10) (1) (2) (10) Cyst 1 [2.0] 2 [2.0] 3 [2.0] Uterus (10) (1) (3) (2) (10) Hydrometra 1 [2.0] 1 [2.0] 3 [2.0] 2 [2.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (3) (1) (4) (3) (1) (6) Mediastinal, Hemorrhage 1 [2.0] 1 [2.0] 1 [1.0] Mediastinal, Hyperplasia, Lymphoid 1 [1.0] 1 [2.0] 1 [2.0] Pancreatic, Hemorrhage 2 [1.0] 1 [1.0] 2 [1.5] 1 [2.0] 4 [1.3] Pancreatic, Hyperplasia, Lymphoid 1 [1.0] Pancreatic, Inflammation, Granulomatous 1 [2.0] 1 [2.0] Lymph Node, Mesenteric (10) (10) Hyperplasia, Lymphoid 2 [1.5] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Inflammation, Chronic, Focal 1 [1.0] 1 [1.0] Alveolus, Hemorrhage 1 [2.0] Alveolus, Infiltration Cellular, Focal, Histiocyte 2 [1.0] Nose (10) (10) Olfactory Epithelium, Septum, Cyst 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 05/30/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 08:16:45 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 FEMALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Inflammation, Chronic 1 [1.0] Nephropathy 1 [1.0] 1 [1.0] Cortex, Cyst 1 [1.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 05/30/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 08:16:45 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Survivors Terminal Sacrifice 10 10 10 10 10 10 Animals Examined Microscopically 10 5 2 2 3 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (1) (1) (1) (10) Hematopoietic Cell Proliferation 2 [1.0] 1 [1.0] Hepatodiaphragmatic Nodule 1 [2.0] 1 [2.0] 1 [1.0] 1 [2.0] Inflammation, Chronic, Focal 3 [1.0] 3 [1.0] Mesentery (1) Fat, Necrosis, Focal 1 [2.0] Pancreas (10) (1) (10) Acinus, Atrophy, Focal 1 [2.0] 1 [1.0] Salivary Glands (10) (10) Parotid Gland, Basophilic Focus 7 [1.1] 4 [1.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (10) (10) Cardiomyopathy, Focal 7 [1.0] 9 [1.0] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) Accessory Adrenal Cortical Nodule 1 [1.0] Vacuolization Cytoplasmic, Focal 1 [1.0] Adrenal Medulla (10) (10) Hyperplasia, Focal 1 [2.0] Pituitary Gland (10) (10) Pars Distalis, Cyst 1 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 05/30/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 08:16:45 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (10) (10) Inflammation, Chronic 1 [1.0] Testes (10) (10) Atrophy 1 [1.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) (2) (1) (1) (2) (4) Mediastinal, Hemorrhage 1 [2.0] Mediastinal, Hyperplasia, Lymphoid 1 [1.0] Pancreatic, Hemorrhage 1 [2.0] 1 [1.0] 1 [2.0] 1 [1.0] 4 [1.0] Lymph Node, Mesenteric (10) (1) (1) (10) Hyperplasia, Lymphoid 1 [2.0] 1 [2.0] 1 [2.0] Inflammation, Chronic, Granulomatous 1 [1.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) Inflammation, Chronic, Focal 1 [1.0] Metaplasia, Osseous 1 [1.0] Alveolus, Infiltration Cellular, Focal, Histiocyte 1 [1.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 6 NTP Experiment-Test: 96014-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 90-DAY WITH AVERAGE SEVERITY GRADES[b] Date: 05/30/02 Route: DOSED WATER WATER DISINFECTION BYPRODUCTS BROMODICHLOROACETIC ACID Time: 08:16:45 ____________________________________________________________________________________________________________________________________ RATS:FISCHER 344 MALE 0 MG/L 62.5 125 MG/L 250 MG/L 500 MG/L 1000 MG/L MG/L ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) Nephropathy 4 [1.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------