If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Long-Term Individual Animal Neoplastic Diagnosis

Study Information:

Chemical Name: Tetrabromobisphenol A
CASRN: ="79-94-7"
Study Number: C20320
Exposure Route: GAVAGE
TDMS Number: 2032003
Sex: Female
Strain and Species: Wistar Han Rats

Female Individual Animal Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Intestine Large Cecum 500 mg/kg 50 97 332 729 1 Leiomyoma Terminal Sacrifice
Alimentary System Intestine Large Colon 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Intestine Small Duodenum Vehicle Control 60 85 272 729 1 Leiomyosarcoma Terminal Sacrifice
Alimentary System Intestine Small Jejunum 1000 mg/kg 60 108 386 729 1 Leiomyoma Terminal Sacrifice
Alimentary System Intestine Small 250 mg/kg 50 92 307 527 1 Leiomyosarcoma Metastatic Natural Death
Alimentary System Liver 500 mg/kg 50 106 376 642 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Liver 500 mg/kg 50 98 337 321 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Liver 500 mg/kg 50 106 377 600 1 Adenocarcinoma Metastatic Natural Death
Alimentary System Liver 1000 mg/kg 60 112 406 615 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Liver 1000 mg/kg 60 114 418 607 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Liver Vehicle Control 60 79 244 730 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 250 mg/kg 50 87 285 729 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 250 mg/kg 50 89 294 729 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 1000 mg/kg 60 112 409 730 1 Hepatocellular Adenoma Terminal Sacrifice
Alimentary System Liver 500 mg/kg 50 102 356 729 1 Leukemia Mononuclear Terminal Sacrifice
Alimentary System Liver 250 mg/kg 50 91 304 656 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Alimentary System Liver 250 mg/kg 50 92 308 658 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Alimentary System Mesentery 250 mg/kg 8 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Mesentery 500 mg/kg 5 106 376 642 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Mesentery 500 mg/kg 5 98 337 321 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Mesentery 1000 mg/kg 4 112 406 615 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Mesentery 1000 mg/kg 4 114 418 607 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Mesentery 250 mg/kg 8 92 307 527 1 Leiomyosarcoma Metastatic Natural Death
Alimentary System Mesentery 500 mg/kg 5 103 362 697 1 Leiomyosarcoma Metastatic Natural Death
Alimentary System Mesentery 250 mg/kg 8 91 304 656 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Alimentary System Mesentery 250 mg/kg 8 92 308 658 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Alimentary System Pancreas 250 mg/kg 50 91 302 548 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Pancreas 250 mg/kg 50 94 316 713 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Pancreas 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Pancreas 500 mg/kg 50 106 376 642 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Pancreas 1000 mg/kg 60 112 406 615 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Pancreas 1000 mg/kg 60 114 418 607 1 Adenocarcinoma Metastatic Moribund Sacrifice
Alimentary System Pancreas 1000 mg/kg 60 116 426 730 1 Adenocarcinoma Metastatic Terminal Sacrifice
Alimentary System Pancreas Vehicle Control 60 86 278 548 1 Granulosa Cell Tumor Malignant Metastatic Moribund Sacrifice
Alimentary System Pancreas 250 mg/kg 50 92 307 527 1 Leiomyosarcoma Metastatic Natural Death
Alimentary System Pancreas 250 mg/kg 50 91 304 656 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Alimentary System Pancreas 250 mg/kg 50 92 308 658 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Alimentary System Pancreas 250 mg/kg 50 96 328 664 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Alimentary System Stomach Glandular Vehicle Control 60 80 249 729 1 Leiomyosarcoma Terminal Sacrifice
Alimentary System Stomach Glandular 500 mg/kg 50 103 362 697 1 Leiomyosarcoma Natural Death
Alimentary System Stomach Glandular 250 mg/kg 50 92 308 658 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Cardiovascular System Heart Endocardium Vehicle Control 60 80 248 730 1 Schwannoma Benign Terminal Sacrifice
Endocrine System Adrenal Cortex 250 mg/kg 50 91 302 548 1 Adenocarcinoma Metastatic Moribund Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 60 77 234 729 1 Adenoma Terminal Sacrifice
Endocrine System Adrenal Cortex 1000 mg/kg 60 117 431 728 1 Adenoma Terminal Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 60 77 234 729 1 Carcinoma Terminal Sacrifice
Endocrine System Adrenal Medulla Vehicle Control 60 77 233 729 1 Pheochromocytoma Benign Terminal Sacrifice
Endocrine System Adrenal Medulla Vehicle Control 60 86 276 729 1 Pheochromocytoma Benign Terminal Sacrifice
Endocrine System Adrenal Medulla 1000 mg/kg 60 114 416 688 1 Pheochromocytoma Malignant Moribund Sacrifice
Endocrine System Islets Pancreatic 500 mg/kg 50 100 350 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 76 227 364 1 Adenoma Dosing Accident
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 75 222 656 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 75 224 726 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 76 229 464 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 79 241 545 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 79 242 545 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 83 262 713 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 85 271 604 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 85 273 546 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 76 228 668 1 Adenoma Natural Death
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 86 277 662 1 Adenoma Natural Death
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 78 238 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 80 246 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 81 255 729 Multiple Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 82 259 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 83 261 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 83 265 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 84 267 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 84 268 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 85 272 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis Vehicle Control 60 86 276 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 88 286 652 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 89 291 624 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 91 302 548 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 91 303 693 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 92 308 658 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 94 316 713 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 94 317 636 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 94 320 492 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 96 328 664 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 87 281 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 87 283 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 87 284 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 88 287 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 88 288 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 90 296 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 90 297 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 90 298 728 Multiple Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 90 300 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 92 306 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 92 309 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 95 322 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 95 324 728 Multiple Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 95 325 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 96 326 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 96 327 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 96 329 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 250 mg/kg 50 96 330 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 100 349 705 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 101 355 637 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 104 370 561 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 105 372 639 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 105 375 529 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 97 331 545 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 97 334 607 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 98 339 488 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 103 362 697 1 Adenoma Natural Death
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 100 347 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 100 350 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 102 356 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 104 367 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 106 378 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 106 380 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 98 340 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 99 342 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 mg/kg 50 99 345 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 109 393 603 1 Adenoma Dosing Accident
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 107 385 531 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 110 397 545 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 111 403 729 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 114 417 686 1 Adenoma Moribund Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 116 429 630 1 Adenoma Natural Death
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 107 382 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 109 391 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 110 396 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 110 400 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 111 401 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 112 408 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 112 410 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 117 431 728 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 117 435 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 118 436 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 1000 mg/kg 60 116 428 730 1 Carcinoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed Vehicle Control 60 75 225 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed Vehicle Control 60 78 239 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed Vehicle Control 60 79 243 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed Vehicle Control 60 82 256 730 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed 250 mg/kg 50 93 314 729 1 Adenoma Terminal Sacrifice
Endocrine System Pituitary Gland Pars Intermed 1000 mg/kg 60 109 395 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Bilateral, C Cell Vehicle Control 60 75 224 726 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland Bilateral, Follicular Cel Vehicle Control 60 79 244 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 60 83 262 713 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 60 78 238 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 60 78 239 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 60 80 248 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 60 82 260 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell Vehicle Control 60 85 274 728 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 89 291 624 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 94 316 713 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 87 281 728 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 88 287 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 88 288 728 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 89 292 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 90 297 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 91 301 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 250 mg/kg 50 96 329 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 500 mg/kg 50 102 359 496 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell 500 mg/kg 50 106 379 572 1 Adenoma Natural Death
Endocrine System Thyroid Gland C Cell 500 mg/kg 50 100 348 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 500 mg/kg 50 104 369 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 500 mg/kg 50 97 332 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 1000 mg/kg 60 110 398 614 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland C Cell 1000 mg/kg 60 108 389 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland C Cell 1000 mg/kg 60 112 409 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel Vehicle Control 60 86 277 662 1 Adenoma Natural Death
Endocrine System Thyroid Gland Follicular Cel Vehicle Control 60 85 272 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 250 mg/kg 50 90 300 729 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 250 mg/kg 50 92 309 730 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 250 mg/kg 50 95 321 728 1 Adenoma Terminal Sacrifice
Endocrine System Thyroid Gland Follicular Cel 500 mg/kg 50 105 372 639 1 Adenoma Moribund Sacrifice
Endocrine System Thyroid Gland Follicular Cel 500 mg/kg 50 101 351 730 1 Adenoma Terminal Sacrifice
Genital System Ovary 250 mg/kg 50 94 316 713 1 Adenocarcinoma Metastatic Moribund Sacrifice
Genital System Ovary 500 mg/kg 50 106 376 642 1 Adenocarcinoma Metastatic Moribund Sacrifice
Genital System Ovary 1000 mg/kg 60 112 406 615 1 Adenocarcinoma Moribund Sacrifice
Genital System Ovary 1000 mg/kg 60 114 418 607 1 Adenocarcinoma Metastatic Moribund Sacrifice
Genital System Ovary Vehicle Control 60 86 278 548 1 Granulosa Cell Tumor Malignant Moribund Sacrifice
Genital System Ovary 250 mg/kg 50 91 304 656 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Genital System Ovary Vehicle Control 60 77 234 729 1 Sex Cord Stromal Tumor, Benign Mixed Cell Terminal Sacrifice
Genital System Ovary Vehicle Control 60 78 239 730 1 Sex Cord Stromal Tumor, Benign Mixed Cell Terminal Sacrifice
Genital System Ovary 1000 mg/kg 60 109 394 684 1 Sex Cord Stromal Tumor, Benign Mixed Cell Natural Death
Genital System Uterus Cervix 500 mg/kg 50 100 347 730 1 Sarcoma Stromal Terminal Sacrifice
Genital System Uterus Cervix 250 mg/kg 50 91 304 656 1 Squamous Cell Carcinoma Moribund Sacrifice
Genital System Uterus Vehicle Control 60 83 262 713 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus Vehicle Control 60 80 249 729 Multiple Adenocarcinoma Terminal Sacrifice
Genital System Uterus Vehicle Control 60 83 261 730 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 250 mg/kg 50 91 302 548 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 250 mg/kg 50 94 316 713 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 250 mg/kg 50 95 323 583 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 500 mg/kg 50 105 374 636 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 500 mg/kg 50 106 376 642 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 500 mg/kg 50 98 337 321 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 500 mg/kg 50 106 377 600 Multiple Adenocarcinoma Natural Death
Genital System Uterus 500 mg/kg 50 100 346 730 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 102 356 729 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 104 367 730 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 98 336 729 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 112 406 615 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 1000 mg/kg 60 113 412 684 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 1000 mg/kg 60 114 417 686 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 1000 mg/kg 60 114 418 607 1 Adenocarcinoma Moribund Sacrifice
Genital System Uterus 1000 mg/kg 60 108 388 729 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 110 400 728 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 115 425 729 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 116 426 730 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 116 430 730 1 Adenocarcinoma Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 102 358 728 1 Adenoma Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 103 364 729 1 Adenoma Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 97 335 730 1 Adenoma Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 118 440 625 1 Adenoma Moribund Sacrifice
Genital System Uterus 1000 mg/kg 60 109 394 684 1 Adenoma Natural Death
Genital System Uterus 1000 mg/kg 60 108 386 729 1 Adenoma Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 113 414 730 1 Adenoma Terminal Sacrifice
Genital System Uterus 250 mg/kg 50 92 307 527 1 Leiomyosarcoma Natural Death
Genital System Uterus 250 mg/kg 50 91 304 656 1 Malignant Mixed Mullerian Tumor Moribund Sacrifice
Genital System Uterus 250 mg/kg 50 92 308 658 1 Malignant Mixed Mullerian Tumor Moribund Sacrifice
Genital System Uterus 250 mg/kg 50 96 328 664 1 Malignant Mixed Mullerian Tumor Moribund Sacrifice
Genital System Uterus 250 mg/kg 50 88 287 729 1 Malignant Mixed Mullerian Tumor Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 112 406 615 1 Malignant Mixed Mullerian Tumor Moribund Sacrifice
Genital System Uterus 1000 mg/kg 60 115 425 729 1 Malignant Mixed Mullerian Tumor Terminal Sacrifice
Genital System Uterus Vehicle Control 60 80 247 729 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus Vehicle Control 60 80 249 729 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus 250 mg/kg 50 91 303 693 1 Polyp Stromal Moribund Sacrifice
Genital System Uterus 250 mg/kg 50 89 293 730 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus 250 mg/kg 50 92 306 730 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus 250 mg/kg 50 95 322 730 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 100 346 730 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 100 348 730 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus 500 mg/kg 50 103 364 729 1 Polyp Stromal Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 110 398 614 1 Polyp Stromal Moribund Sacrifice
Genital System Uterus 250 mg/kg 50 93 313 614 1 Sarcoma Stromal Natural Death
Genital System Uterus 250 mg/kg 50 93 315 730 1 Sarcoma Stromal Terminal Sacrifice
Genital System Uterus 1000 mg/kg 60 114 417 686 1 Sarcoma Stromal Moribund Sacrifice
Genital System Vagina 250 mg/kg 1 89 295 729 1 Granular Cell Tumor Malignant Terminal Sacrifice
Genital System Vagina Vehicle Control 1 79 242 545 1 Leiomyoma Moribund Sacrifice
Genital System Vagina 1000 mg/kg 1 110 397 545 1 Polyp Moribund Sacrifice
Hematopoietic System Lymph Node Mediastinal 500 mg/kg 50 106 376 642 1 Adenocarcinoma Metastatic Moribund Sacrifice
Hematopoietic System Lymph Node Mesenteric Vehicle Control 60 85 275 730 1 Hemangiosarcoma Terminal Sacrifice
Hematopoietic System Spleen 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Hematopoietic System Spleen 500 mg/kg 50 106 376 642 1 Adenocarcinoma Metastatic Moribund Sacrifice
Hematopoietic System Spleen 1000 mg/kg 60 114 418 607 1 Adenocarcinoma Metastatic Moribund Sacrifice
Hematopoietic System Spleen 500 mg/kg 50 102 356 729 1 Leukemia Mononuclear Terminal Sacrifice
Hematopoietic System Spleen 250 mg/kg 50 91 304 656 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Hematopoietic System Thymus 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Hematopoietic System Thymus Vehicle Control 60 85 273 546 1 Sarcoma Moribund Sacrifice
Hematopoietic System Thymus Vehicle Control 60 78 239 730 1 Thymoma Benign Terminal Sacrifice
Hematopoietic System Thymus 500 mg/kg 50 101 351 730 1 Thymoma Benign Terminal Sacrifice
Hematopoietic System Thymus 500 mg/kg 50 104 368 730 1 Thymoma Benign Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 75 224 726 1 Adenocarcinoma Moribund Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 118 440 625 1 Adenocarcinoma Moribund Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 109 395 730 1 Adenocarcinoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 117 432 729 1 Adenocarcinoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 75 224 726 Multiple Adenoma Moribund Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 76 226 728 1 Adenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 83 265 730 1 Adenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 84 267 729 1 Adenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 89 291 624 1 Adenoma Moribund Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 94 316 713 1 Adenoma Moribund Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 94 317 636 1 Adenoma Moribund Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 94 319 722 1 Adenoma Moribund Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 96 327 730 1 Adenoma Terminal Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 101 355 637 1 Adenoma Moribund Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 100 347 730 1 Adenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 83 262 713 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 81 253 725 1 Fibroadenoma Natural Death
Integumentary System Mammary Gland Vehicle Control 60 77 234 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 79 244 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 82 256 730 Multiple Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 82 257 728 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 83 264 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland Vehicle Control 60 85 272 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 91 303 693 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 92 308 658 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 96 328 664 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 88 287 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 89 292 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 89 293 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 89 294 729 Multiple Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 89 295 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 90 296 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 90 298 728 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 90 300 729 Multiple Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 93 312 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 93 315 730 Multiple Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 95 325 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 250 mg/kg 50 96 326 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 102 359 496 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 104 366 531 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 97 331 545 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 103 361 243 1 Fibroadenoma Natural Death
Integumentary System Mammary Gland 500 mg/kg 50 106 379 572 Multiple Fibroadenoma Natural Death
Integumentary System Mammary Gland 500 mg/kg 50 105 373 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 97 332 729 Multiple Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 500 mg/kg 50 99 345 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 110 398 614 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 113 412 684 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 114 420 462 1 Fibroadenoma Moribund Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 109 394 684 1 Fibroadenoma Natural Death
Integumentary System Mammary Gland 1000 mg/kg 60 108 387 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 110 396 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 111 401 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 111 402 729 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 112 410 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 116 430 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Mammary Gland 1000 mg/kg 60 117 435 730 1 Fibroadenoma Terminal Sacrifice
Integumentary System Skin Subcut Tiss 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Integumentary System Skin Subcut Tiss Vehicle Control 60 77 234 729 1 Hemangiosarcoma Terminal Sacrifice
Integumentary System Skin Subcut Tiss 500 mg/kg 50 97 333 729 1 Lipoma Terminal Sacrifice
Integumentary System Skin Subcut Tiss 250 mg/kg 50 91 304 656 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Integumentary System Skin Subcut Tiss 250 mg/kg 50 92 308 658 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Integumentary System Skin Subcut Tiss 250 mg/kg 50 87 283 728 1 Sarcoma Terminal Sacrifice
Integumentary System Skin 250 mg/kg 50 89 292 730 1 Basal Cell Adenoma Terminal Sacrifice
Integumentary System Skin 250 mg/kg 50 88 289 383 1 Basal Cell Carcinoma Moribund Sacrifice
Integumentary System Skin 250 mg/kg 50 95 324 728 1 Fibroma Terminal Sacrifice
Integumentary System Skin 250 mg/kg 50 90 297 729 1 Squamous Cell Papilloma Terminal Sacrifice
Integumentary System Skin 500 mg/kg 50 105 374 636 1 Squamous Cell Papilloma Moribund Sacrifice
Musculoskeletal System Skeletal Muscle 250 mg/kg 2 94 316 713 1 Adenocarcinoma Metastatic Moribund Sacrifice
Musculoskeletal System Skeletal Muscle 500 mg/kg 1 98 337 321 1 Adenocarcinoma Metastatic Moribund Sacrifice
Musculoskeletal System Skeletal Muscle 250 mg/kg 2 92 307 527 1 Leiomyosarcoma Metastatic Natural Death
Nervous System Brain 500 mg/kg 50 102 359 496 1 Ependymoma Malignant Moribund Sacrifice
Nervous System Brain 500 mg/kg 50 102 360 377 1 Glioma Malignant Mixed Cell Natural Death
Nervous System Brain 500 mg/kg 50 98 336 729 1 Glioma Malignant Mixed Cell Terminal Sacrifice
Nervous System Brain 250 mg/kg 50 93 314 729 1 Granular Cell Tumor Benign Terminal Sacrifice
Respiratory System Lung Vehicle Control 60 83 262 713 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 250 mg/kg 50 91 302 548 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 250 mg/kg 50 94 316 713 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 250 mg/kg 50 96 328 664 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 500 mg/kg 50 98 337 321 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 1000 mg/kg 60 112 406 615 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 1000 mg/kg 60 114 418 607 1 Adenocarcinoma Metastatic Moribund Sacrifice
Respiratory System Lung 1000 mg/kg 60 108 388 729 1 Adenocarcinoma Metastatic Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 60 116 426 730 1 Adenocarcinoma Metastatic Terminal Sacrifice
Respiratory System Lung 1000 mg/kg 60 118 440 625 1 Alveolar/Bronchiolar Adenoma Moribund Sacrifice
Respiratory System Lung 1000 mg/kg 60 113 415 728 1 Alveolar/Bronchiolar Adenoma Terminal Sacrifice
Respiratory System Lung Vehicle Control 60 77 234 729 1 Carcinoma Metastatic Terminal Sacrifice
Respiratory System Lung Vehicle Control 60 86 278 548 1 Granulosa Cell Tumor Malignant Metastatic Moribund Sacrifice
Respiratory System Lung 250 mg/kg 50 91 304 656 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice
Respiratory System Lung Vehicle Control 60 85 271 604 1 Olfactory Neuroblastoma Metastatic Moribund Sacrifice
Respiratory System Nose Vehicle Control 60 85 271 604 1 Olfactory Neuroblastoma Moribund Sacrifice
Urinary System Kidney 250 mg/kg 50 91 302 548 1 Adenocarcinoma Metastatic Moribund Sacrifice
Urinary System Kidney 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Urinary System Kidney 1000 mg/kg 60 114 418 607 1 Adenocarcinoma Metastatic Moribund Sacrifice
Urinary System Kidney 500 mg/kg 50 100 346 730 1 Lipoma Terminal Sacrifice
Urinary System Urinary Bladder Transit Epithe Vehicle Control 60 78 236 729 1 Papilloma Terminal Sacrifice
Urinary System Urinary Bladder 250 mg/kg 50 95 323 583 1 Adenocarcinoma Metastatic Moribund Sacrifice
Urinary System Urinary Bladder Vehicle Control 60 86 278 548 1 Granulosa Cell Tumor Malignant Metastatic Moribund Sacrifice
Urinary System Urinary Bladder 250 mg/kg 50 92 308 658 1 Malignant Mixed Mullerian Tumor Metastatic Moribund Sacrifice