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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Pentabromodiphenyl Oxide (Technical) (DE 71)
CASRN: ="32534-81-9"
Study Number: C20209
Exposure Route: GAVAGE
TDMS Number: 2020901
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Liver Hepatocyte 0.01 MG/KG 10 15 71 93 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.01 MG/KG 10 16 76 93 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 MG/KG 10 17 81 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 MG/KG 10 17 82 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 MG/KG 10 17 83 93 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 MG/KG 10 17 84 93 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 5 MG/KG 10 18 86 93 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 19 91 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 19 92 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 19 93 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 19 94 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 19 95 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 20 100 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 20 96 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 20 97 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 20 98 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 20 99 93 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 101 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 102 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 103 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 104 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 105 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 106 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 107 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 108 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 109 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 110 93 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 111 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 112 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 113 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 114 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 115 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 116 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 117 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 118 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 119 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 120 93 1 Hypertrophy Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 19 91 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 19 95 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 50 MG/KG 10 20 98 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 101 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 102 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 103 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 104 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 21 105 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 106 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 107 93 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 108 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 109 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 100 MG/KG 10 22 110 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 111 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 112 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 113 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 114 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 23 115 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 116 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 117 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 118 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 119 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 500 MG/KG 10 24 120 93 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver 500 MG/KG 10 23 112 93 1 Basophilic Focus Terminal Sacrifice
Alimentary System Liver 100 MG/KG 10 21 101 93 1 Hepatodiaphragmatic Nodule Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 14 66 93 1 Necrosis Minimal, Focal Terminal Sacrifice
Alimentary System Liver 50 MG/KG 10 20 99 93 1 Necrosis Minimal, Focal Terminal Sacrifice
Alimentary System Mesentery Fat 0.01 MG/KG 1 16 79 93 1 Necrosis Mild Terminal Sacrifice
Alimentary System Stomach Glandular 500 MG/KG 10 23 112 93 1 Erosion Minimal Terminal Sacrifice
Alimentary System Stomach Glandular 500 MG/KG 10 23 115 93 1 Erosion Minimal Terminal Sacrifice
Alimentary System Stomach Glandular 500 MG/KG 10 24 120 93 1 Erosion Minimal Terminal Sacrifice
Alimentary System Stomach Glandular, Glands 0.01 MG/KG 10 16 76 93 1 Dilatation Minimal Terminal Sacrifice
Alimentary System Stomach Glandular, Glands 100 MG/KG 10 22 110 93 1 Dilatation Minimal Terminal Sacrifice
Cardiovascular System Heart Vehicle Control 10 14 66 93 1 Cardiomyopathy Minimal Terminal Sacrifice
Endocrine System Adrenal Cortex Vehicle Control 10 14 69 93 1 Accessory Adrenal Cortical Nodule Minimal Terminal Sacrifice
Endocrine System Pituitary Gland Pars Distalis 500 MG/KG 10 23 113 93 1 Cyst Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 19 91 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 19 92 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 19 94 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 20 100 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 20 96 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 20 97 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 20 98 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 50 MG/KG 10 20 99 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 21 101 93 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 21 102 93 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 21 103 93 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 21 104 93 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 21 105 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 22 106 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 22 107 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 22 108 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 100 MG/KG 10 22 110 93 1 Hypertrophy Minimal Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 23 111 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 23 112 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 23 113 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 23 114 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 23 115 93 1 Hypertrophy Mild Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 24 116 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 24 117 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 24 118 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 24 119 93 1 Hypertrophy Moderate Terminal Sacrifice
Endocrine System Thyroid Gland Follicle 500 MG/KG 10 24 120 93 1 Hypertrophy Moderate Terminal Sacrifice
Genital System Clitoral Gland 500 MG/KG 10 23 114 93 1 Inflammation Moderate, Chronic Terminal Sacrifice
Genital System Clitoral Gland 500 MG/KG 10 24 116 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 5 MG/KG 10 18 90 93 1 Hemorrhage Moderate Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 50 MG/KG 10 20 99 93 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 100 MG/KG 10 21 101 93 1 Hemorrhage Minimal Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 100 MG/KG 10 22 110 93 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 5 MG/KG 10 18 90 93 1 Hyperplasia Minimal, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 50 MG/KG 10 20 99 93 1 Hyperplasia Moderate, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 100 MG/KG 10 21 101 93 1 Hyperplasia Marked, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 100 MG/KG 10 22 110 93 1 Hyperplasia Mild, Lymphoid Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 5 MG/KG 10 18 88 93 1 Hemorrhage Moderate Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 100 MG/KG 10 22 110 93 1 Hemorrhage Mild Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 5 MG/KG 10 18 88 93 1 Pigmentation Mild Terminal Sacrifice
Hematopoietic System Lymph Node Pancreatic 100 MG/KG 10 22 110 93 1 Pigmentation Minimal Terminal Sacrifice
Hematopoietic System Thymus 500 MG/KG 10 23 112 93 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus 500 MG/KG 10 23 114 93 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 500 MG/KG 10 23 115 93 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 500 MG/KG 10 24 116 93 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 5 MG/KG 10 18 88 93 1 Hemorrhage Mild Terminal Sacrifice
Respiratory System Lung 0.01 MG/KG 10 15 71 93 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 0.01 MG/KG 10 16 78 93 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 100 MG/KG 10 22 110 93 1 Hemorrhage Minimal Terminal Sacrifice
Respiratory System Lung 100 MG/KG 10 22 110 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 500 MG/KG 10 23 114 93 1 Infiltration Cellular Minimal, Histiocyte Terminal Sacrifice
Respiratory System Lung 500 MG/KG 10 24 116 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Respiratory System Lung 500 MG/KG 10 24 117 93 1 Inflammation Minimal, Chronic Terminal Sacrifice
Special Senses System Eye 100 MG/KG 1 22 107 93 1 Developmental Malformation Terminal Sacrifice
Urinary System Kidney 500 MG/KG 10 24 116 93 1 Infiltration Cellular Minimal, Mononuclear Cl Terminal Sacrifice