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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Cobalt
CASRN: ="7440-48-4"
Study Number: C60311
Exposure Route: RESPIRATORY EXPOSURE WHOLE BODY
TDMS Number: 6031101
Sex: Female
Strain and Species: F 344/N Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Nervous System Brain 20 MG/M3 5 10 901 5 1 Hemorrhage Moderate Natural Death
Nervous System Brain 20 MG/M3 5 10 905 13 1 Hemorrhage Minimal Natural Death
Nervous System Brain 40 MG/M3 5 12 1101 6 1 Hemorrhage Mild Natural Death
Nervous System Brain 40 MG/M3 5 12 1105 7 1 Hemorrhage Mild Natural Death
Respiratory System Lung Alveolar Epith 20 MG/M3 5 10 901 5 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolar Epith 20 MG/M3 5 10 904 7 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolar Epith 40 MG/M3 5 12 1101 6 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolar Epith 40 MG/M3 5 12 1103 6 1 Hyperplasia Minimal Natural Death
Respiratory System Lung Alveolus 20 MG/M3 5 10 901 5 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 20 MG/M3 5 10 904 7 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 20 MG/M3 5 10 905 13 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 20 MG/M3 5 10 902 16 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 20 MG/M3 5 10 903 16 1 Infiltration Cellular Mild, Histiocyte Terminal Sacrifice
Respiratory System Lung Alveolus 40 MG/M3 5 12 1101 6 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 12 1102 5 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 12 1103 6 1 Infiltration Cellular Minimal, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 12 1104 6 1 Infiltration Cellular Mild, Histiocyte Natural Death
Respiratory System Lung Alveolus 40 MG/M3 5 12 1105 7 1 Infiltration Cellular Moderate, Histiocyte Natural Death
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 4 303 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 502 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 701 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 702 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 703 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 704 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 901 5 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 904 7 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 902 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 12 1101 6 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 12 1102 5 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 40 MG/M3 5 12 1104 6 1 Necrosis Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 4 301 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 4 302 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 4 304 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 2.5 MG/M3 5 4 305 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 501 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 502 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 503 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 504 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 5 MG/M3 5 6 505 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 701 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 702 16 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 703 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 704 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 10 MG/M3 5 8 705 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 905 13 1 Vacuolization Cytoplasmic Minimal Natural Death
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 902 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Bronchiole, Epithelium 20 MG/M3 5 10 903 16 1 Vacuolization Cytoplasmic Mild Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 8 701 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 8 702 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 8 703 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 10 MG/M3 5 8 704 16 1 Fibrosis Minimal Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 10 905 13 1 Fibrosis Moderate Natural Death
Respiratory System Lung Interstitium 20 MG/M3 5 10 902 16 1 Fibrosis Moderate Terminal Sacrifice
Respiratory System Lung Interstitium 20 MG/M3 5 10 903 16 1 Fibrosis Moderate Terminal Sacrifice
Respiratory System Lung 20 MG/M3 5 10 901 5 1 Hemorrhage Mild Natural Death
Respiratory System Lung 20 MG/M3 5 10 904 7 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 20 MG/M3 5 10 905 13 1 Hemorrhage Minimal Natural Death
Respiratory System Lung 40 MG/M3 5 12 1101 6 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 40 MG/M3 5 12 1102 5 1 Hemorrhage Mild Natural Death
Respiratory System Lung 40 MG/M3 5 12 1103 6 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 40 MG/M3 5 12 1104 6 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 40 MG/M3 5 12 1105 7 1 Hemorrhage Moderate Natural Death
Respiratory System Lung 20 MG/M3 5 10 901 5 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 20 MG/M3 5 10 904 7 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 12 1101 6 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 12 1102 5 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 12 1103 6 1 Inflammation Minimal, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 12 1104 6 1 Inflammation Mild, Acute Natural Death
Respiratory System Lung 40 MG/M3 5 12 1105 7 1 Inflammation Minimal, Acute Natural Death
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 301 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 302 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 303 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 304 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 305 16 1 Atrophy Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 501 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 502 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 503 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 504 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 505 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 701 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 702 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 703 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 704 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 705 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 901 5 1 Atrophy Mild Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 905 13 1 Atrophy Moderate Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 902 16 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 903 16 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1105 7 1 Atrophy Mild Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 903 16 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1105 7 1 Metaplasia Minimal, Squamous Natural Death
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 301 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 302 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 303 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 304 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 2.5 MG/M3 5 4 305 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 501 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 502 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 5 MG/M3 5 6 503 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 701 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 702 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 703 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 704 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 10 MG/M3 5 8 705 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 901 5 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 904 7 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 905 13 1 Necrosis Minimal Natural Death
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 902 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Olfactory Epi 20 MG/M3 5 10 903 16 1 Necrosis Mild Terminal Sacrifice
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1101 6 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1102 5 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1103 6 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1104 6 1 Necrosis Moderate Natural Death
Respiratory System Nose Olfactory Epi 40 MG/M3 5 12 1105 7 1 Necrosis Moderate Natural Death
Respiratory System Nose Respirat Epith 5 MG/M3 5 6 503 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 701 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 10 MG/M3 5 8 703 16 1 Atrophy Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 903 16 1 Atrophy Moderate Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 902 16 1 Metaplasia Minimal, Squamous Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 901 5 1 Necrosis Mild Natural Death
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 904 7 1 Necrosis Mild Natural Death
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 905 13 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 902 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 20 MG/M3 5 10 903 16 1 Necrosis Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1101 6 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1102 5 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1103 6 1 Necrosis Minimal Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1104 6 1 Necrosis Mild Natural Death
Respiratory System Nose Respirat Epith 40 MG/M3 5 12 1105 7 1 Necrosis Mild Natural Death
Respiratory System Nose 20 MG/M3 5 10 902 16 1 Foreign Body Terminal Sacrifice
Respiratory System Nose 40 MG/M3 5 12 1103 6 1 Inflammation Minimal, Acute Natural Death