Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
21 |
101 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
21 |
102 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
21 |
103 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
21 |
104 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
21 |
105 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
22 |
106 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
22 |
107 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
22 |
109 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
300 mg/kg |
10 |
22 |
110 |
92 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Centrilobular, Hepatocyte |
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Fatty Change |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
23 |
113 |
3 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
23 |
115 |
4 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
15 |
73 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
16 |
78 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
16 |
79 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
18 |
88 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
19 |
91 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
20 |
96 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Hepatodiaphragmatic Nodule |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
13 |
65 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
67 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
68 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
69 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
14 |
70 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
15 |
71 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
15 |
72 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
15 |
73 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
15 |
74 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
15 |
75 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
10 mg/kg |
10 |
16 |
77 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
17 |
82 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
17 |
83 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
17 |
84 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
17 |
85 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
18 |
87 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
18 |
88 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
18 |
89 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 mg/kg |
10 |
18 |
90 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
19 |
92 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
19 |
93 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
19 |
94 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
20 |
98 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
20 |
99 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
21 |
101 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
21 |
102 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
21 |
103 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
21 |
104 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
21 |
105 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
22 |
106 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
22 |
107 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
22 |
109 |
92 |
1 |
Inflammation |
Mild, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
300 mg/kg |
10 |
22 |
110 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
21 |
101 |
92 |
1 |
Depletion Secretory |
Mild |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
21 |
102 |
92 |
1 |
Depletion Secretory |
Mild |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
21 |
103 |
92 |
1 |
Depletion Secretory |
Minimal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
21 |
104 |
92 |
1 |
Depletion Secretory |
Minimal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
21 |
105 |
92 |
1 |
Depletion Secretory |
Mild |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
22 |
106 |
92 |
1 |
Depletion Secretory |
Mild |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
22 |
107 |
92 |
1 |
Depletion Secretory |
Minimal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Depletion Secretory |
Minimal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
22 |
109 |
92 |
1 |
Depletion Secretory |
Minimal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
300 mg/kg |
10 |
22 |
110 |
92 |
1 |
Depletion Secretory |
Mild |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Depletion Secretory |
Moderate |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Depletion Secretory |
Moderate |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Depletion Secretory |
Moderate |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Depletion Secretory |
Moderate |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Depletion Secretory |
Moderate |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Depletion Secretory |
Moderate |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
Submandibul Gl |
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Depletion Secretory |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
600 mg/kg |
10 |
23 |
115 |
4 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
10 |
21 |
104 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
10 |
22 |
106 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
10 |
22 |
107 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
300 mg/kg |
10 |
22 |
110 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular, Epithelium |
600 mg/kg |
10 |
23 |
115 |
4 |
1 |
Necrosis |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
61 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
63 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
13 |
65 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
69 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
14 |
70 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Genital System |
Ovary |
|
10 mg/kg |
1 |
15 |
74 |
92 |
1 |
Cyst |
Minimal |
Terminal Sacrifice |
Genital System |
Ovary |
|
30 mg/kg |
2 |
17 |
84 |
92 |
1 |
Cyst |
Minimal |
Terminal Sacrifice |
Genital System |
Ovary |
|
30 mg/kg |
2 |
18 |
90 |
92 |
1 |
Cyst |
Minimal |
Terminal Sacrifice |
Genital System |
Ovary |
|
100 mg/kg |
1 |
19 |
94 |
92 |
1 |
Cyst |
Minimal |
Terminal Sacrifice |
Genital System |
Ovary |
|
300 mg/kg |
1 |
22 |
108 |
92 |
1 |
Cyst |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
10 |
14 |
70 |
92 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Depletion Lymphoid |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Necrosis |
Moderate, Lymphoid |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
Cortex |
600 mg/kg |
10 |
23 |
113 |
3 |
1 |
Necrosis |
Minimal, Lymphoid |
Natural Death |
Hematopoietic System |
Thymus |
Cortex |
600 mg/kg |
10 |
23 |
115 |
4 |
1 |
Necrosis |
Marked, Lymphoid |
Natural Death |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
10 |
13 |
62 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
Vehicle Control |
10 |
13 |
65 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
10 mg/kg |
10 |
15 |
71 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
10 mg/kg |
10 |
15 |
72 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
10 mg/kg |
10 |
15 |
74 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
10 mg/kg |
10 |
15 |
75 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
10 mg/kg |
10 |
16 |
76 |
92 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
17 |
81 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
17 |
84 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
17 |
85 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
18 |
86 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
18 |
87 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
18 |
88 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
18 |
89 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
30 mg/kg |
10 |
18 |
90 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
19 |
93 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
19 |
94 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
19 |
95 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
20 |
100 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
20 |
96 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
20 |
97 |
92 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
20 |
98 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
100 mg/kg |
10 |
20 |
99 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
21 |
101 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
21 |
102 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
21 |
103 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
21 |
104 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
21 |
105 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
22 |
107 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
22 |
109 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
300 mg/kg |
10 |
22 |
110 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
18 |
88 |
92 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
62 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
65 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
10 mg/kg |
10 |
15 |
71 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
10 mg/kg |
10 |
15 |
73 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
10 mg/kg |
10 |
15 |
74 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
10 mg/kg |
10 |
15 |
75 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
10 mg/kg |
10 |
16 |
76 |
92 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
10 mg/kg |
10 |
16 |
78 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
17 |
81 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
17 |
85 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
18 |
86 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
18 |
87 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
18 |
88 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
18 |
89 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/kg |
10 |
18 |
90 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
10 |
19 |
93 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
10 |
19 |
95 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
10 |
20 |
100 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
10 |
20 |
96 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
10 |
20 |
97 |
92 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
10 |
20 |
98 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 mg/kg |
10 |
20 |
99 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
21 |
101 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
21 |
102 |
92 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
21 |
103 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
21 |
104 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
21 |
105 |
92 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
22 |
106 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
22 |
107 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
22 |
108 |
92 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
22 |
109 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
300 mg/kg |
10 |
22 |
110 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
13 |
64 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
10 |
13 |
61 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
10 |
13 |
62 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
10 |
13 |
64 |
92 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
10 |
14 |
68 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
Vehicle Control |
10 |
14 |
70 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
13 |
64 |
92 |
1 |
Accumulation, Hyaline Droplet |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
14 |
68 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
10 |
13 |
62 |
92 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
Vehicle Control |
10 |
13 |
65 |
92 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Antr Chamber |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Exudate |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
600 mg/kg |
10 |
23 |
115 |
4 |
1 |
Inflammation |
Minimal, Acute |
Natural Death |
Special Senses System |
Eye |
Postr Chamber |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Exudate |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Retina |
600 mg/kg |
10 |
24 |
116 |
92 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Special Senses System |
Eye |
|
10 mg/kg |
1 |
15 |
71 |
92 |
1 |
Hemorrhage |
Moderate |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
Acinus |
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
13 |
64 |
92 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Dilatation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
61 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
62 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
63 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
64 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
66 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
68 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
69 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
70 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
23 |
114 |
4 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
23 |
113 |
3 |
1 |
Mineralization |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
23 |
111 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
23 |
112 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
24 |
117 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
24 |
119 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
24 |
120 |
92 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
13 |
65 |
92 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
69 |
92 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
14 |
70 |
92 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
23 |
113 |
3 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
600 mg/kg |
10 |
24 |
118 |
92 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |