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Short-Term Individual Animal Non Neoplastic Diagnosis

Study Information:

Chemical Name: Perfluorodecanoic Acid
CASRN: ="335-76-2"
Study Number: C20615
Exposure Route: GAVAGE
TDMS Number: 2061501
Sex: Female
Strain and Species: HSD Rats

Female Individual Animal Non Neoplastic Diagnoses
System Organ Site Treatment Group Number Examined Cage Number Animal Number Days on Study Lesion Found Lesion Name Lesion Qualifier Removal Reason
Alimentary System Esophagus Periesoph Tiss 2.5 mg/kg 10 160 967 29 1 Inflammation Moderate, Granulomatous Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 155 941 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 155 942 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 155 944 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 155 945 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 156 946 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 156 947 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 156 948 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 0.625 mg/kg 10 156 950 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 951 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 952 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 953 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 954 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 955 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 956 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 957 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 958 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 959 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 960 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 961 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 962 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 963 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 964 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 965 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 966 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 967 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 968 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 969 29 1 Cytoplasmic Alteration Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 970 29 1 Cytoplasmic Alteration Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 951 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 952 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 954 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 157 955 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 957 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 958 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 959 29 1 Hypertrophy Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 960 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 961 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 962 29 1 Hypertrophy Mild Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 963 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 964 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 965 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 966 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 967 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 968 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 969 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 970 29 1 Hypertrophy Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 959 29 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 966 29 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 968 29 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 969 29 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 970 29 1 Necrosis Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 1.25 mg/kg 10 158 959 29 1 Vacuolization Cytoplasmic Minimal Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 961 29 1 Vacuolization Cytoplasmic Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 962 29 1 Vacuolization Cytoplasmic Marked Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 963 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 964 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 159 965 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 966 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 967 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 968 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 969 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Hepatocyte 2.5 mg/kg 10 160 970 29 1 Vacuolization Cytoplasmic Moderate Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 149 912 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 149 913 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver Vehicle Control 10 149 915 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 1.25 mg/kg 10 157 953 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 2.5 mg/kg 10 159 961 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Alimentary System Liver 2.5 mg/kg 10 159 964 29 1 Infiltration Cellular Minimal, Mixed Cell Terminal Sacrifice
Cardiovascular System Heart Epicardium Vehicle Control 10 150 918 29 1 Fibrosis Minimal Terminal Sacrifice
Cardiovascular System Heart Epicardium Vehicle Control 10 150 918 29 1 Infiltration Cellular Mild, Mixed Cell Terminal Sacrifice
Cardiovascular System Heart Epicardium 2.5 mg/kg 10 159 961 29 1 Inflammation Moderate, Granulomatous Terminal Sacrifice
Cardiovascular System Heart Epicardium 2.5 mg/kg 10 160 967 29 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Genital System Uterus Bilateral Vehicle Control 10 150 916 29 1 Dilation Mild Terminal Sacrifice
Genital System Uterus Bilateral Vehicle Control 10 150 917 29 1 Dilation Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 159 961 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 159 962 29 1 Hypocellularity Moderate Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 159 963 29 1 Hypocellularity Moderate Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 159 964 29 1 Hypocellularity Minimal Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 159 965 29 1 Hypocellularity Moderate Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 160 966 29 1 Hypocellularity Moderate Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 160 967 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 160 968 29 1 Hypocellularity Moderate Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 160 969 29 1 Hypocellularity Mild Terminal Sacrifice
Hematopoietic System Bone Marrow 2.5 mg/kg 10 160 970 29 1 Hypocellularity Moderate Terminal Sacrifice
Hematopoietic System Lymph Node Mediastinal 0.312 mg/kg 1 153 934 29 1 Inflammation Marked, Granulomatous Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 159 961 29 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 159 962 29 1 Atrophy Marked Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 159 963 29 1 Atrophy Marked Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 159 965 29 1 Atrophy Minimal Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 160 966 29 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 160 968 29 1 Atrophy Moderate Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 160 969 29 1 Atrophy Mild Terminal Sacrifice
Hematopoietic System Thymus 2.5 mg/kg 10 160 970 29 1 Atrophy Marked Terminal Sacrifice
Respiratory System Lung Bronchiole 2.5 mg/kg 10 160 967 29 1 Inflammation Mild, Granulomatous Terminal Sacrifice
Respiratory System Lung Interstitium Vehicle Control 10 149 912 29 1 Inflammation Minimal, Granulomatous Terminal Sacrifice
Respiratory System Lung Serosa Vehicle Control 10 150 918 29 1 Fibrosis Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith 0.156 mg/kg 10 151 923 29 1 Degeneration Minimal Terminal Sacrifice
Respiratory System Nose Respirat Epith 0.156 mg/kg 10 151 923 29 1 Hyperplasia Mild Terminal Sacrifice
Respiratory System Nose Respirat Epith Vehicle Control 10 149 911 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 0.156 mg/kg 10 151 923 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 0.156 mg/kg 10 152 926 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 0.625 mg/kg 10 156 947 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 0.625 mg/kg 10 156 948 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 0.625 mg/kg 10 156 950 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 157 953 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Respiratory System Nose Respirat Epith 1.25 mg/kg 10 157 954 29 1 Inflammation Minimal, Chronic Active Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 149 911 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 149 912 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 149 914 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 149 915 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney Vehicle Control 10 150 916 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.156 mg/kg 10 151 921 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.156 mg/kg 10 151 923 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.156 mg/kg 10 152 926 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.156 mg/kg 10 152 927 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.156 mg/kg 10 152 928 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.156 mg/kg 10 152 929 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.156 mg/kg 10 152 930 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.312 mg/kg 10 153 931 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.312 mg/kg 10 153 932 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.312 mg/kg 10 153 933 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.312 mg/kg 10 154 937 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.312 mg/kg 10 154 938 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.312 mg/kg 10 154 940 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.625 mg/kg 10 155 942 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.625 mg/kg 10 155 944 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.625 mg/kg 10 155 945 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.625 mg/kg 10 156 948 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.625 mg/kg 10 156 949 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 0.625 mg/kg 10 156 950 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 157 951 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 157 952 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 157 953 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 157 955 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice
Urinary System Kidney 1.25 mg/kg 10 158 958 29 1 Nephropathy Minimal, Chronicprogr Terminal Sacrifice