Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
143 |
881 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
143 |
882 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
143 |
883 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
143 |
884 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
143 |
885 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
144 |
886 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
144 |
887 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
144 |
888 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
144 |
889 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
144 |
890 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
891 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
892 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
893 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
894 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
895 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
896 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
897 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
898 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
899 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
900 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
901 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
903 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
905 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
907 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
910 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
144 |
889 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
144 |
890 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
891 |
29 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
892 |
29 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
893 |
29 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
894 |
29 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
895 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
896 |
29 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
897 |
29 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
898 |
29 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
899 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
900 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
901 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
903 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
905 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
907 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
910 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.156 mg/kg |
10 |
140 |
866 |
29 |
1 |
Necrosis |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
0.625 mg/kg |
10 |
143 |
881 |
29 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
892 |
29 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
893 |
29 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
894 |
29 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
905 |
29 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
891 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
892 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
893 |
29 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
894 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
145 |
895 |
29 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
896 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
897 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
899 |
29 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.25 mg/kg |
10 |
146 |
900 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
901 |
29 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
903 |
29 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
147 |
905 |
29 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
907 |
29 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Vacuolization Cytoplasmic |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
2.5 mg/kg |
10 |
148 |
910 |
29 |
1 |
Vacuolization Cytoplasmic |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
137 |
851 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
138 |
856 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
138 |
857 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
Epithelium |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
Epithelium |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
|
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
|
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
|
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Ulcer |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
138 |
860 |
29 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
Duct |
Vehicle Control |
10 |
138 |
860 |
29 |
1 |
Exfoliated Germ Cell |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
Duct |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Exfoliated Germ Cell |
Marked |
Terminal Sacrifice |
Genital System |
Epididymis |
Duct |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Exfoliated Germ Cell |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
Duct |
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Exfoliated Germ Cell |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
Duct |
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Exfoliated Germ Cell |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
10 |
138 |
857 |
29 |
1 |
Granuloma Sperm |
Moderate |
Terminal Sacrifice |
Genital System |
Epididymis |
|
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Hypospermia |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
10 |
138 |
860 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Degeneration |
Marked |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
145 |
891 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
145 |
894 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
145 |
895 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
146 |
896 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
146 |
897 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
146 |
898 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
146 |
899 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
1.25 mg/kg |
10 |
146 |
900 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
147 |
901 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
147 |
903 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
147 |
905 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
148 |
907 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Interstit Cell |
2.5 mg/kg |
10 |
148 |
910 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Spermatid Retention |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Spermatid Retention |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Spermatid Retention |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Spermatid Retention |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
147 |
901 |
29 |
1 |
Hypocellularity |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Hypocellularity |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
147 |
903 |
29 |
1 |
Hypocellularity |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Hypocellularity |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
147 |
905 |
29 |
1 |
Hypocellularity |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Hypocellularity |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
148 |
907 |
29 |
1 |
Hypocellularity |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Hypocellularity |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Hypocellularity |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
2.5 mg/kg |
10 |
148 |
910 |
29 |
1 |
Hypocellularity |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
145 |
892 |
29 |
1 |
Apoptosis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
145 |
893 |
29 |
1 |
Apoptosis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
145 |
895 |
29 |
1 |
Apoptosis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
146 |
896 |
29 |
1 |
Apoptosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
146 |
897 |
29 |
1 |
Apoptosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
146 |
898 |
29 |
1 |
Apoptosis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
146 |
899 |
29 |
1 |
Apoptosis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Lymphocyte |
1.25 mg/kg |
10 |
146 |
900 |
29 |
1 |
Apoptosis |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
147 |
901 |
29 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
147 |
904 |
29 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
147 |
905 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
148 |
907 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
148 |
908 |
29 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
148 |
909 |
29 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
2.5 mg/kg |
10 |
148 |
910 |
29 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
137 |
855 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
138 |
857 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
138 |
860 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
139 |
865 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
140 |
866 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
140 |
868 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
140 |
870 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
141 |
873 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
877 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
878 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
879 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
880 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
886 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
888 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
889 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
890 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
138 |
857 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
138 |
860 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
141 |
873 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
877 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
878 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
879 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
880 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
886 |
29 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
888 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
889 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
890 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
138 |
857 |
29 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
138 |
860 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
139 |
865 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
140 |
866 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
140 |
867 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
140 |
868 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.156 mg/kg |
10 |
140 |
870 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
141 |
873 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
877 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
878 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
879 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.312 mg/kg |
10 |
142 |
880 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
886 |
29 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
888 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
889 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
0.625 mg/kg |
10 |
144 |
890 |
29 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
137 |
852 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
137 |
853 |
29 |
1 |
Nephropathy |
Mild, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
137 |
855 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
138 |
857 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
138 |
858 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
138 |
860 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
139 |
862 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
139 |
863 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
139 |
864 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
139 |
865 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
140 |
867 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
140 |
868 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
140 |
869 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.156 mg/kg |
10 |
140 |
870 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.312 mg/kg |
10 |
141 |
871 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.312 mg/kg |
10 |
141 |
873 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.312 mg/kg |
10 |
142 |
876 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.312 mg/kg |
10 |
142 |
877 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.312 mg/kg |
10 |
142 |
880 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.625 mg/kg |
10 |
143 |
882 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.625 mg/kg |
10 |
143 |
883 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.625 mg/kg |
10 |
143 |
884 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.625 mg/kg |
10 |
143 |
885 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.625 mg/kg |
10 |
144 |
887 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
0.625 mg/kg |
10 |
144 |
888 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.25 mg/kg |
10 |
145 |
891 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.25 mg/kg |
10 |
145 |
892 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.25 mg/kg |
10 |
146 |
896 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.25 mg/kg |
10 |
146 |
897 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.25 mg/kg |
10 |
146 |
898 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.25 mg/kg |
10 |
146 |
899 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.25 mg/kg |
10 |
146 |
900 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.5 mg/kg |
10 |
147 |
901 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.5 mg/kg |
10 |
147 |
902 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2.5 mg/kg |
10 |
148 |
906 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |