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National Institute of Environmental Health Sciences

 

Research Highlights

The vision of the NIEHS is to use environmental health sciences to understand human disease and improve human health. Below are some research highlights from NIEHS scientists since its founding in 1966.

Click on the buttons below to sort by year or title. Click on the tags below each highlight to filter by tag.

August 1, 2012 – NIEHS director introduces the 2012-2017 strategic plan for NIEHS, "Advancing Science Improving Health: A Plan for Environmental Health Research." NIEHS, with the help of its stakeholders, lays out a plan that has descriptive strategic themes and 11 goals that are identified as priority areas for the field. As the NIEHS moves forward, our overall goal is to make the institute, including the National Toxicology Program (NTP), the foremost trus


Tags: Toxicity children's health genes lung

On June 10, 2011, the U.S. Department of Health and Human Services added eight substances to its Report on Carcinogens, a science-based document that identifies chemicals and biological agents that may put people at increased risk for cancer.


The industrial chemical formaldehyde and a botanical known as aristolochic acids are listed as known human carcinogens. Six other substances - captafol, cobalt-tungsten carbide (in powder or hard metal form)


Tags: National Toxicology Program Report on Carcinogens cancer carcinogens

Testing the safety of chemicals is becoming more efficient and less reliant on animals thanks to a federal collaboration known as Tox 21. Tox 21 brings together scientists from the National Institutes of Health (NIH), NIEHS, the National Toxicology Program (NTP), the Environmental Protection Agency (EPA), and most recently the Food and Drug Administration (FDA) to test the safety of chemicals using state-of-the-art robotic technology that will reduce the rel


Tags: National Toxicology Program Report on Carcinogens notable NIEHS program toxicity

An NIEHS-led interagency effort identified 11 key categories of diseases and other health consequences of global climate change. As part of an ad hoc interagency working group on climate change and health, NIEHS teamed up with other government and international researchers to address public health concerns and vulnerability related to climate change. Discussions demonstrated that climate change mitigation strategies, in addition to reducing greenhou


Tags: breast cancer genes

Genetic tests are available for the two principal alleles of CYP2C9. Researchers found a null allele of CYP2C9 that decreases metabolism of both warfarin and phenytoin and a second deleterious allele reported in African-Americans on warfarin. Collaborative clinical studies have shown that metabolism of tolbutamide, phenytoin, and warfarin are altered in people with genetic polymorphisms of CYP2C9, affecting dosage requirements and sometimes causing dangerous


Tags: genes