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National Institute of Environmental Health Sciences


Research Highlights

Low-calorie diet slows bladder cancer

broccoli on a fork

Low-calorie diets can slow the development of bladder cancer in mice by reducing the level of a key hormone called insulin-like growth factor 1, NIEHS research showed. This research established the role of caloric restriction in the prevention of certain cancers, and identified insulin-like growth factor 1 as a key risk factor in the development and progression of cancer.




Hursting SD, Switzer BR, French JE, Kari FW. 1993. The growth hormone: insulin-like growth factor 1 axis is a mediator of diet restriction-induced inhibition of mononuclear cell leukemia in Fischer rats. Cancer Res 53(12):2750-2757. [Abstract]  [Full Text] 

Doll R, Peto R. 1981. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66(6):1191-1308. [Abstract]