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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Publication Detail

Title: The effect of oxidative stress polymorphisms on the association between long-term black carbon exposure and lung function among elderly men.

Authors: Mordukhovich, Irina; Lepeule, Johanna; Coull, Brent A; Sparrow, David; Vokonas, Pantel; Schwartz, Joel

Published In Thorax, (2015 Feb)

Abstract: BACKGROUND: Black carbon (BC) is a pro-oxidant, traffic-related pollutant linked with lung function decline. We evaluated the influence of genetic variation in the oxidative stress pathway on the association between long-term BC exposure and lung function decline. METHODS: Lung function parameters (FVC and FEV1) were measured during one or more study visits between 1995 and 2011 (n=651 participants) among an elderly cohort: the Normative Aging Study. Residential BC exposure levels were estimated using a spatiotemporal land use regression model. We evaluated whether oxidative stress variants, combined into a genetic score, modify the association between 1-year and 5-year moving averages of BC exposure and lung function levels and rates of decline, using linear mixed models. RESULTS: We report stronger associations between long-term BC exposure and increased rate of lung function decline, but not baseline lung function level, among participants with higher oxidative stress allelic risk profiles compared with participants with lower risk profiles. Associations were strongest when evaluating 5-year moving averages of BC exposure. A 0.5 µg/m(3) increase in 5-year BC exposure was associated with a 0.1% yearly increase in FVC (95% CI -0.5 to 0.7) among participants with low genetic risk scores and a 1.3% yearly decrease (95% CI -1.8 to -0.8) among those with high scores (p-interaction=0.0003). DISCUSSION: Our results suggest that elderly men with high oxidative stress genetic scores may be more susceptible to the effects of BC on lung function decline. The results, if confirmed, should inform air-quality recommendations in light of a potentially susceptible subgroup.

PubMed ID: 25414198 Exiting the NIEHS site

MeSH Terms: Aged; Catalase/genetics; Forced Expiratory Volume/genetics*; Glutamate-Cysteine Ligase/genetics; Glutathione S-Transferase pi/genetics; Glutathione Transferase/genetics; Heme Oxygenase-1/genetics; Humans; Lung/physiopathology*; Male; NAD(P)H Dehydrogenase (Quinone)/genetics; Occupational Exposure/adverse effects*; Oxidative Stress/genetics*; Polymorphism, Genetic; Soot/toxicity*; Time Factors; Vital Capacity/genetics*

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