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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Patent Detail: Linoleic Acid Diol and Glucuronide Conjugate Levels as Diagnostic Markers of Disorders of Abnormal Regulation of Cytochrome P450 Metabolism of Unsaturated Fatty Acids

Patent Detail

Superfund Research Program

Linoleic Acid Diol and Glucuronide Conjugate Levels as Diagnostic Markers of Disorders of Abnormal Regulation of Cytochrome P450 Metabolism of Unsaturated Fatty Acids

Number: 6,756,210
Year: 2004
Patent Status: Issued
Authors: Hammock, B.D., G. Zurek, S.J. Gee, J.W. Newman, J. Zheng

The invention provides methods of using dihydroxy unsaturated fatty acids as markers for identifying patients with a disorder associated with abnormal regulation of the cytochrome P450 metabolism or oxidation of unsaturated fatty acids. For example, linoleic acid diols, including leukotoxindiol, can be used as a diagnostic tool for identifying patients with pre-eclampsia, eclampsia, and pregnancy-induced hypertension.

Associated Projects:

  • University of California-Davis: Immunoassays for Human and Environmental Health Monitoring
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