Skip Navigation
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

National Institute of Environmental Health Sciences

Use this QR code to view the newest version of this document
Use this QR code to view the newest version of this document

Your Environment. Your Health.

Person Details: Cindy McReynolds

Superfund Research Program

Cindy McReynolds

University of California-Davis
Center for Integrative Toxicology
One Shields Ave
Davis, California 95616
Phone: 530-752-8465
Email: cbmcreynolds@ucdavis.edu

Publications

  • McReynolds C, Morisseau C, Wagner KM, Hammock BD. Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation. In: Druggable Lipid Signaling Pathways. Springer, pp.71-99.

2023

  • Luo A, Wu Z, Li S, McReynolds C, Wang D, Liu H, Huang C, He T, Zhang X, Wang Y, Liu C, Hammock BD, Hashimoto K, Yang CZ. 2023. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. J Transl Med 21(1):71. doi:10.1186/s12967-023-03917-x PMID:36732752 PMCID:PMC9896784
  • McReynolds C, Hammock BD, Morisseau C. 2023. Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression. Pharmacol Ther 248:108454. doi:10.1016/j.pharmthera.2023.108454 PMID:37268114
  • Ravindran R, Kang H, McReynolds C, Sanghar GK, Chang W, Ramasamy S, Kolloli A, Kumar R, Subbian S, Hammock BD, Hartigan-O'Connor DJ, Ikram A, Haczku A, Khan IH. 2023. Dynamics of temporal immune responses in nonhuman primates and humans immunized with COVID-19 vaccines. PLoS One 18(10):e0287377. doi:10.1371/journal.pone.0287377 PMID:37856429 PMCID:PMC10586671

2022

  • Bergmann CB, McReynolds C, Wan D, Singh N, Goetzman H, Caldwell CC, Supp DM, Hammock BD. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proc Natl Acad Sci U S A 119:doi:10.1073/pnas.2120691119 PMID:35312372 PMCID:PMC9060469
  • Gowler PR, Turnbull J, Shahtaheri M, Gohir S, Kelly T, McReynolds C, Yang J, Jha RR, Fernandes GS, Zhang W, Doherty M, Walsh DA, Hammock BD, Valdes AM, Barrett DA, Chapman V. 2022. Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain. Arthritis Rheumatol 74(4):doi:10.1002/art.42000 PMID:34672113 PMCID:PMC8957539
  • Singh N, Li D, McReynolds C, Morisseau C, Hammock BD. 2022. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Analytical Methods doi:10.1039/d2ay00272h PMID:35481804 PMCID:PMC9116231

2021

  • McReynolds C, Cortes-Puch I, Hammock BD, Shih P, Hammock BG, Yang J, Khan IH, Ravindran R. 2021. Plasma linoleate diols are potential biomarkers for severe COVID-19 infections. Front Physiol doi:10.3389/fphys.2021.663869 PMID:33868029 PMCID:PMC8047414
  • McReynolds C, Yang J, Guedes AP, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner KM, Hammock BD. 2021. Species differences in metabolism of soluble epoxide hydrolase inhibitor, EC1728, highlight the importance of clinically relevant screening mechanisms in drug development. Molecules 26(16):5034. doi:10.3390/molecules26165034 PMID:34443621 PMCID:PMC8399023
  • Ravindran R, McReynolds C, Yang J, Hammock BD, Ikram A, Ali A, Bashir A, Zohra T, Chang W, Hartigan-O'Connor DJ, Rashidi HH, Khan IH. 2021. Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses. PLoS One 16:e0254367. doi:10.1371/journal.pone.0254367 PMID:34242356

2020

  • Li D, Morisseau C, McReynolds C, Duflot T, Bellien J, Nagra RM, Taha AY, Hammock BD. 2020. Development of improved double-nanobody sandwich ELISAs for human soluble epoxide hydrolase detection in peripheral blood mononuclear cells of diabetic patients and the prefrontal cortex of multiple sclerosis patients. Anal Chem 92:7334-7342. doi:10.1021/acs.analchem.0c01115 PMID:32253910 PMCID:PMC7744119
  • Wagner KM, Gomes AV, McReynolds C, Hammock BD. 2020. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics doi:10.1007/s13311-020-00916-4 PMID:32875445

2019

  • McReynolds C, Hee-Hwang S, Yang J, Wan D, Wagner KM, Morisseau C, Li D, Schmidt WK, Hammock BD. 2019. Pharmaceutical effects of inhibiting the soluble epoxide hydrolase in canine osteoarthritis. Front Pharmacol 10:12. doi:10.3389/fphar.2019.00533 PMID:31214021 PMCID:PMC6554663
  • Wan D, Yang J, McReynolds C, Barnych B, Wagner KM, Morisseau C, Hee-Hwang S, Sun J, Blocher R, Hammock BD. 2019. In vitro and in vivo metabolism of a potent inhibitor of soluble epoxide hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Front Pharmacol 10:464. doi:10.3389/fphar.2019.00464 PMID:31143115 PMCID:PMC6520522
  • Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749 PMID:31521729 PMCID:PMC6957308

2017

Back
to Top