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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Carmen J. Marsit

Brown University
Laboratories of Molecular Medicine
70 Ship St., Room 537
Providence, RI 02912
Phone: 401-863-6508
Email:

Projects

Publications

2014
  • Koestler, Devin C., Jing Li, John A. Baron, Gregory J. Tsongalis, Lynn F. Butterly, Martha Goodrich, Corina Lesseur, Margaret R. Karagas, Carmen J. Marsit, Jason H. Moore, Angeline S. Andrew, and Amitabh Srivastava. 2014. Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Modern Pathology. 27:145-155. doi:10.1038/modpathol.2013.104  
2012
  • Andrew, Angeline S., Ting Hu, Jian Gu, Jiang Gui, Yuanqing Ye, Carmen J. Marsit, Karl T. Kelsey, Alan R. Schned, Sam A. Tanyos, Eben M. Pendleton, Rebecca A. Mason, Elaine V. Morlock, Michael S. Zens, Zhongze Li, Jason H. Moore, Xifeng Wu, and Margaret R. Karagas. 2012. HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS ONE.   7(12):e51301. doi:10.1371/journal.pone.0051301  
  • Karagas, Margaret R., Angeline S. Andrew, Heather H. Nelson, Z. Li, Tracy Punshon, Alan R. Schned, Carmen J. Marsit, J Steven Morris, Jason H. Moore, A.L. Tyler, Diane Gilbert-Diamond, Mary L. Guerinot, and Karl T. Kelsey. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Human Genetics.   131:453-461. doi:10.1007/s00439-011-1090-x  
  • Lesseur, Corina, Diane Gilbert-Diamond, Angeline S. Andrew, R.M. Ekstrom, Z. Li, Karl T. Kelsey, Carmen J. Marsit, and Margaret R. Karagas. 2012. A case-control study of polymorphisms in zenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicology Letters.   210:100-106. doi:10.1016/j.toxlet.2012.01.015  
2011
  • Avissar-Whiting, Michele, Devin C. Koestler, E. Andrés Houseman, Brock C. Christensen, Karl T. Kelsey, and Carmen J. Marsit. 2011. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics. 6:703-709. doi:10.4161/epi.6.6.16158   (Completed with ARRA Funds)
  • Banister, Carolyn E., Devin C. Koestler, Matthew A. Maccani, E. Andrés Houseman, James F. Padbury, and Carmen J. Marsit. 2011. Infant growth restriction is associated with distinct patterns of DNA methylation in human placentas. Epigenetics. 6:920-927. doi:10.4161/epi.6.7.16079   (Completed with ARRA Funds)
  • Filiberto, Amanda C., Matthew A. Maccani, Devin C. Koestler, Charlotte Wilhelm-Benartzi, Luc A. Gagne, and Carmen J. Marsit. 2011. Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics. 6(5):566-572. doi:10.4161/epi.6.5.15236  
  • Gui, Jiang, Jason H. Moore, Karl T. Kelsey, Carmen J. Marsit, Margaret R. Karagas, and Angeline S. Andrew. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Human Genetics.   129(1):101-110. doi:10.1007/s00439-010-0905-5   (Completed with ARRA Funds)
  • Langevin, Scott M., E. Andrés Houseman, Brock C. Christensen, John K. Wiencke, Heather H. Nelson, Margaret R. Karagas, Carmen J. Marsit, and Karl T. Kelsey. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics. 6:908-919. doi:10.4161/epi.6.7.16431   (Completed with ARRA Funds)
  • Maccani, Matthew A., James F. Padbury, and Carmen J. Marsit. 2011. miR-16 and miR-21 Expression in the Placenta Is Associated with Fetal Growth. PLoS ONE.   6:doi:10.1371/journal.pone.0021210   (Completed with ARRA Funds)
  • Marsit, Carmen J., Devin C. Koestler, Brock C. Christensen, Margaret R. Karagas, E. Andrés Houseman, and Karl T. Kelsey. 2011. DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer. Journal of Clinical Oncology.   29(9):1133-1139. doi:10.1200/JCO.2010.31.3577   (Completed with ARRA Funds)
  • Pacheco, Sara E., Brock C. Christensen, Carmen J. Marsit, Karl T. Kelsey, Mark Sigman, and Kim Boekelheide. 2011. Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm. PLoS ONE.   6:doi:10.1371/journal.pone.0020280   (Completed with ARRA Funds)
  • Robins, J., Carmen J. Marsit, J. Padbury, and Surendra Sharma. 2011. Endocrine disruptors, environmental oxygen, epigenetics and pregnancy. Frontiers in Bioscience.   3:690-700. (Completed with ARRA Funds)
  • Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, and Carmen J. Marsit. 2011. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes & Control. 22:1205-1213. doi:10.1007/s10552-011-9788-6  
  • Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and John K. Wiencke. 2011. Association of second hand smoke exposures with DNA methylation in bladder cancer cases. Cancer Causes & Control. 22(8):1205-1213. doi:10.1007/s10552-011-9788-6   (Completed with ARRA Funds)
2010
  • Avissar-Whiting, Michele, Keila R. Veiga, Kristen M. Uhl, Matthew A. Maccani, Luc A. Gagne, Erika L. Moen, and Carmen J. Marsit. 2010. Bisphenol A exposure leads to specific microRNA alterations in placental cells. Reproductive Toxicology.   29(4):401-406. doi:10.1016/j.reprotox.2010.04.004  
  • Christensen, Brock C., A. Smith, Shichun Zheng, Devin C. Koestler, E Andres Houseman, Carmen J. Marsit, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas, Margaret R. Wrensch, Karl T. Kelsey, and John K. Wiencke. 2010. DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma. Journal of the National Cancer Institute.   103:143-153.
  • Gee, Gretchen V., Devin C. Koestler, Brock C. Christensen, David J. Sugarbaker, David J. Ugolini, Giovanni P. Ivaldi, Murray B. Resnick, E Andres Houseman, Karl T. Kelsey, and Carmen J. Marsit. 2010. Downregulated MicroRNAs in the differential diagnosis of malignant pleural mesothelioma. International Journal of Cancer.   127(12):2859–2869. doi:10.1002/ijc.25285  
  • Koestler, Devin C., Carmen J. Marsit, Brock C. Christensen, Margaret R. Karagas, Raphael Bueno, David J. Sugarbaker, Karl T. Kelsey, and E. Andrés Houseman. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics.   26(20):2578-2585. doi:10.1093/bioinformatics/btq470   (Completed with ARRA Funds)
  • Kwong, Ryan C., Margaret R. Karagas, Karl T. Kelsey, Rebecca A. Mason, Sam A. Tanyos, Alan R. Schned, Carmen J. Marsit, and Angeline S. Andrew. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World Journal of Urology.   28:487-92. doi:10.1007/s00345-009-0477-y   (Completed with ARRA Funds)
  • Maccani, Matthew A., Michele Avissar-Whiting, Carolyn E. Banister, Bethany McGonnigal, J. Padbury, and Carmen J. Marsit. 2010. Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta. Epigenetics. 5(7):583-589. doi:10.4161/epi.5.7.12762  
  • Marsit, Carmen J., E. Andrés Houseman, Brock C. Christensen, Luc A. Gagne, Margaret R. Wrensch, Heather H. Nelson, Joseph L. Wiemels, Shichun Zheng, John K. Wiencke, Angeline S. Andrew, Alan R. Schned, Margaret R. Karagas, and Karl T. Kelsey. 2010. Identification of Methylated Genes Associated with Aggressive Bladder Cancer. PLoS ONE.   5:e12334. doi:10.1371/journal.pone.0012334  
  • Wilhelm, Charlotte S., Karl T. Kelsey, Rondi A. Butler, Silvia Plaza, Luc A. Gagne, Michael S. Zens, Angeline S. Andrew, Steven Morris, Heather H. Nelson, Alan R. Schned, Margaret R. Karagas, and Carmen J. Marsit. 2010. Implications of LINE1 methylation for bladder cancer risk in women. Clinical Cancer Research.   16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983  
  • Wilhelm-Benartzi, Charlotte, Devin C. Koestler, Brock C. Christensen, John K. Wiencke, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and E Andres Houseman. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis.   31:1972-1976. doi:10.1093/carcin/bgq178   (Completed with ARRA Funds)
2009
  • Andrew, Angeline S., Jiang Gui, Arthur Sanderson, Rebecca A. Mason, Elaine V. Morlock, Alan R. Schned, Karl Kelsey, Carmen J. Marsit, Jason H. Moore, and Margaret R. Karagas. 2009. Bladder cancer SNP panel predicts susceptibility and survival. Human Genetics.   125(5-6):527-539. doi:10.1007/s00439-009-0645-6  
  • Andrew, Angeline S., Rebecca A. Mason, Karl Kelsey, Alan R. Schned, Carmen J. Marsit, Heather H. Nelson, and Margaret R. Karagas. 2009. DNA repair genotype interacts with arsenic exposure to increase bladder cancer risk. Toxicology Letters.   187(1):10-14. doi:10.1016/j.toxlet.2009.01.013  
  • Baris, Dalsu, Margaret R. Karagas, Castine Verrill, Alison Johnson, Angeline S. Andrew, Carmen J. Marsit, Joanne S. Colt, Sai Cherala, Claudine Samanic, Richard Waddell, Kenneth P. Cantor, Alan R. Schned, Nathaniel Rothman, Jay H. Lubin, Joseph F. Fraumeni, Robert N. Hoover, Karl T. Kelsey, Debra T. Silverman, and Molly Schwenn. 2009. A case-control study of smoking and bladder cancer risk: Emergent patterns over time. Journal of the National Cancer Institute.   101(22):1553-61. doi:10.1093/jnci/djp361  
  • Christensen, Brock C., E. Andrés Houseman, Carmen J. Marsit, Shichun Zheng, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas, J. Padbury, Raphael Bueno, David J. Sugarbaker, Ru-Fang Yeh, John K. Wiencke, and Karl T. Kelsey. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genetics.   5(8):e1000602. doi:10.1371/journal.pgen.1000602  
  • Dietrich, K., Alan R. Schned, J. Fortuny, John A. Heaney, Carmen J. Marsit, Karl T. Kelsey, and Margaret R. Karagas. 2009. Glucocorticoid therapy and risk of bladder cancer. British Journal of Cancer.   101(8):1316-20. doi:10.1038/sj.bjc.6605314  
  • Maccani, Matthew A. and Carmen J. Marsit. 2009. Epigenetics and imprinting in the placenta. American Journal of Reproductive Immunology. 62(2):78-89. doi:10.1111/j.1600-0897.2009.00716.x  
  • Mason, Rebecca A., Elaine V. Morlock, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, Alan R. Schned, and Angeline S. Andrew. 2009. EGFR pathway polymorphisms in bladder cancer susceptibility and prognosis. Carcinogenesis.   30(7):1155-1160. doi:10.1093/carcin/bgp077  
2008
  • Houseman, E.Andrés, Brock C. Christensen, Ru-Fang Yeh, Carmen J. Marsit, Margaret R. Karagas, Margaret R. Wrensch, Heather H. Nelson, Joseph L. Wiemels, Shichun Zheng, John K. Wiencke, and Karl T. Kelsey. 2008. Model-based clustering of DNA methylation array data: A recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Biochemistry.   9:365. doi:10.1186/1471-2105-9-365  
  • Schned, Alan R., Angeline S. Andrew, Carmen J. Marsit, Karl T. Kelsey, Michael S. Zens, and Margaret R. Karagas. 2008. Histological classification and stage of newly diagnosed bladder cancer in a population-based study from the Northeastern United States. Scandinavian Journal of Urology and Nephrology.   42(3):237-42.
  • Wiemels, Joseph L., Jerry Hofmann, M. Kang, Rebecca Selzer, Roland Green, Mi Zhou, Sheng Zhong, Luoping Zhang, Martyn T. Smith, Carmen J. Marsit, Mignon L. Loh, Patricia A. Buffler, and Ru-Fang Yeh. 2008. Chromosome 12p Deletions in TEL-AML1 Childhood Acute Lymphoblastic Leukemia Are Associated with Retrotransposon Elements and Occur Postnatally. Cancer Research.   68:9935-9944. doi:10.1158/0008-5472.CAN-08-2139  
2007
  • Hsiung, D.T., Carmen J. Marsit, E. Andrés Houseman, Karen Eddy, C.S. Furniss, Michael D. McClean, and Karl T. Kelsey. 2007. Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiology Biomarkers & Prevention.   16(1):108-14.
2006
  • Marsit, Carmen J., Karen Eddy, and Karl T. Kelsey. 2006. MicroRNA responses to cellular stress. Cancer Research.   66(22):10843-10848.
  • Marsit, Carmen J., E. Andrés Houseman, Karen Eddy, Raphael Bueno, David J. Sugarbaker, Heather H. Nelson, Margaret R. Karagas, Karl T. Kelsey, and Brock C. Christensen. 2006. Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Research.   66(21):10621-9.
  • Marsit, Carmen J., Margaret R. Karagas, Hadi Danaee, Mei Liu, Angeline S. Andrew, Alan R. Schned, Heather H. Nelson, and Karl T. Kelsey. 2006. Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis.   27(1):112-116.
  • Marsit, Carmen J., Margaret R. Karagas, Alan R. Schned, and Karl T. Kelsey. 2006. Carcinogen exposure and epigenetic silencing in bladder cancer. Annals of the New York Academy of Sciences.   1076:810-21.
2005
  • Hirao, Shuya, Tomoko Hirao, Yoko Hirao, Carmen J. Marsit, Alan R. Schned, Tara Devi-Ashok, Heather H. Nelson, Angeline S. Andrew, Margaret R. Karagas, and Karl T. Kelsey. 2005. Loss of heterozygosity on chromosome 9q and p53 alterations in human bladder cancer. Cancer.   104(9):1918-1923.
  • Marsit, Carmen J., Margaret R. Karagas, Angeline S. Andrew, Mei Liu, Hadi Danaee, Alan R. Schned, Heather H. Nelson, and Karl T. Kelsey. 2005. Epigenetic Inactivation of SFRP Genes and TP53 Alteration Act Jointly as Markers of Invasive Bladder Cancer. Cancer Research.   65(16):7081-7085.
2003
  • Wiencke, John K., Shichun Zheng, Martyn T. Smith, Luoping Zhang, Xiaomei Ma, Joseph L. Wiemels, Carmen J. Marsit, Karl T. Kelsey, and Patricia A. Buffler. 2003. Methylation of transcribed PTEN pseudogene in pediatric leukemia is associated with subtypes of common ALL containing t(12;21) translocation. In: Proceedings of the Ninety Fourth Annual Meeting of the (AACR) American Association for Cancer Research, July 11-14, 2003, San Francisco. San Franciso, CA.

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