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Person Details

Superfund Research Program

Karl T Kelsey

Projects

• Brown University: Environment, Genetics and Epigenetics in a R.I. Birth Cohort (2009-2014)

Publications

2012

• Karagas, Margaret R., Angeline S. Andrew, Heather H. Nelson, Z. Li, Tracy Punshon, Alan R. Schned, Carmen J. Marsit, J. Steven Morris, Jason H. Moore, A.L. Tyler, Diane Gilbert-Diamond, Mary L. Guerinot, and Karl T. Kelsey. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Human Genetics.   131:453-461. doi:10.1007/s00439-011-1090-x  
• Nielsen, Susan S., Harvey Checkoway, Rondi A. Butler, Heather H. Nelson, Federico M. Farin, William T. Longstreth, Gary M. Franklin, Phillip D. Swanson, and Karl T. Kelsey. 2012. LINE-1 DNA Methylation, Smoking and Risk of Parkinson's Disease. Journal of Parkinson's Disease.   2(4):303-308. doi:10.3233/JPD-012129  

2011

• Avissar-Whiting, Michele, Devin C. Koestler, E. Andrés Houseman, Brock C. Christensen, Karl T. Kelsey, and Carmen J. Marsit. 2011. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics. 6:703-709. doi:10.4161/epi.6.6.16158   (Completed with ARRA Funds)
• Gui, Jiang, Angeline S. Andrew, Peter C. Andrews, H.M. Nelson, Karl T. Kelsey, Margaret R. Karagas, and Jason H. Moore. 2011. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Annals of Human Genetics.   75:20-8. doi:10.1111/j.1469-1809.2010.00624.x  
• Gui, Jiang, Angeline S. Andrew, Peter C. Andrews, Heather Nelson, Karl T. Kelsey, Margaret R. Karagas, and Jason H. Moore. 2011. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Annals of Human Genetics.   75(1):20-28. doi:10.1111/j.1469-1809.2010.00624.x   (Completed with ARRA Funds)
• Gui, Jiang, Jason H. Moore, Karl T. Kelsey, Carmen J. Marsit, Margaret R. Karagas, and Angeline S. Andrew. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Human Genetics.   129(1):101-110. doi:10.1007/s00439-010-0905-5   (Completed with ARRA Funds)
• Langevin, Scott M., E. Andrés Houseman, Brock C. Christensen, John K. Wiencke, Heather H. Nelson, Margaret R. Karagas, Carmen J. Marsit, and Karl T. Kelsey. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics. 6:908-919. doi:10.4161/epi.6.7.16431   (Completed with ARRA Funds)
• Marsit, Carmen J., Devin C. Koestler, Brock C. Christensen, Margaret R. Karagas, E. Andrés Houseman, and Karl T. Kelsey. 2011. DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer. Journal of Clinical Oncology.   29(9):1133-1139. doi:10.1200/JCO.2010.31.3577   (Completed with ARRA Funds)
• Pacheco, Sara E., Brock C. Christensen, Carmen J. Marsit, Karl T. Kelsey, Mark Sigman, and Kim Boekelheide. 2011. Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm. PLoS ONE.   6:doi:10.1371/journal.pone.0020280   (Completed with ARRA Funds)
• Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, and Carmen J. Marsit. 2011. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes & Control. 22:1205-1213. doi:10.1007/s10552-011-9788-6  
• Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and John K. Wiencke. 2011. Association of second hand smoke exposures with DNA methylation in bladder cancer cases. Cancer Causes & Control. 22(8):1205-1213. doi:10.1007/s10552-011-9788-6   (Completed with ARRA Funds)

2010

• Christensen, Brock C., A. Smith, Shichun Zheng, Devin C. Koestler, E.A. Houseman, Carmen J. Marsit, Joseph L. Wiemels, Heather Nelson, Margaret R. Karagas, Margaret R. Wrensch, Karl T. Kelsey, and John K. Wiencke. 2010. DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma. Journal of the National Cancer Institute.   103:143-153.
• Gee, G.V., Devin C. Koestler, Brock C. Christensen, D.J. Sugarbaker, D. Ugolini, G.P. Ivaldi, M.B. Resnick, E.A. Houseman, Karl T. Kelsey, and Carmen J. Marsit. 2010. Downregulated MicroRNAs in the differential diagnosis of malignant pleural mesothelioma. International Journal of Cancer.   127(12):2859–2869. doi:10.1002/ijc.25285  
• Greene, Casey S., Daniel S. Himmelstein, Heather H. Nelson, Karl T. Kelsey, Scott M. Williams, Angeline S. Andrew, Margaret R. Karagas, and Jason H. Moore. 2010. Enabling personal genomics with an explicit test of epistasis. Pacific Symposium on Biocomputing. 327-36. doi:10.1142/9789814295291_0035  
• Gui, Jiang, Angeline S. Andrew, Peter C. Andrews, H.A. Nelson, Karl T. Kelsey, Margaret R. Karagas, and Jason H. Moore. 2010. A Simple and Computationally Efficient Sampling Approach to Covariate Adjustment for Multifactor Dimensionality Reduction Analysis of Epistasis. Human Heredity. 70:219-225. doi:10.1159/000319175  
• Koestler, D., Carmen J. Marsit, B.C. Christensen, Margaret R. Karagas, R. Bueno, D.J. Sugarbaker, Karl T. Kelsey, and E. Andrés Houseman. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics.   26(20):2578-2585. doi:10.1093/bioinformatics/btq470   (Completed with ARRA Funds)
• Kwong, Ryan C., Margaret R. Karagas, Karl T. Kelsey, Rebecca A. Mason, Sam A. Tanyos, Alan R. Schned, Carmen J. Marsit, and Angeline S. Andrew. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World Journal of Urology.   28:487-92. doi:10.1007/s00345-009-0477-y   (Completed with ARRA Funds)
• Marsit, Carmen J., E. Andrés Houseman, B.C. Christensen, L. Gagne, Margaret R. Wrensch, Heather H. Nelson, Joseph L. Wiemels, S. Zheng, John K. Wiencke, Angeline S. Andrew, Alan R. Schned, Margaret R. Karagas, and Karl T. Kelsey. 2010. Identification of Methylated Genes Associated with Aggressive Bladder Cancer. PLoS ONE.   5:e12334. doi:10.1371/journal.pone.0012334  
• Wilhelm, C.S., Karl T. Kelsey, R. Butler, S. Plaza, L. Gagne, Michael S. Zens, A.S. Andrew, S. Morris, Heather H. Nelson, Alan R. Schned, Margaret R. Karagas, and Carmen J. Marsit. 2010. Implications of LINE1 Methylation for Bladder Cancer Risk in Women. Clinical Cancer Research.   16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983  
• Wilhelm-Benartzi, Charlotte, D. Koestler, B.C. Christensen, John K. Wiencke, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and E.A. Houseman. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis.   31:1972-1976. doi:10.1093/carcin/bgq178   (Completed with ARRA Funds)

2009

• Baris, Dalsu, Margaret R. Karagas, Castine Verrill, Angeline S. Andrew, Carmen J. Marsit, Molly Schwenn, Joanne S. Colt, Sai Cherala, Claudine Samanic, Richard Waddell, Kenneth P. Cantor, Alan R. Schned, Nathaniel Rothman, Jay H. Lubin, Joseph F. Fraumeni, Robert N. Hoover, Karl T. Kelsey, and Debra T. Silverman. 2009. A Case-Control Study of Smoking and Bladder Cancer Risk: Emergent Patterns Over Time. Journal of the National Cancer Institute.   101(22):1553-61. doi:10.1093/jnci/djp361  
• Christensen, B.C., E. Andrés Houseman, Carmen J. Marsit, S. Zheng, Margaret R. Wrensch, Joseph L. Wiemels, H.H. Nelson, Margaret R. Karagas, J. Padbury, R. Bueno, D.J. Sugarbaker, Ru-Fang Yeh, John K. Wiencke, and Karl T. Kelsey. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genetics.   5(8):e1000602. doi:10.1371/journal.pgen.1000602  
• Dietrich, K., Alan R. Schned, J. Fortuny, John A. Heaney, Carmen J. Marsit, Karl T. Kelsey, and Margaret R. Karagas. 2009. Glucocorticoid therapy and risk of bladder cancer. British Journal of Cancer.   101(8):1316-20. doi:10.1038/sj.bjc.6605314  
• Mason, Rebecca A., Elaine Morlock, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, Alan R. Schned, and Angeline S. Andrew. 2009. EGFR pathway polymorphisms in bladder cancer susceptibility and prognosis. Carcinogenesis.   30(7):1155-1160. doi:10.1093/carcin/bgp077  
• Stern, Mariana C., Jie Lin, Jonine D. Figueroa, Karl T. Kelsey, Anne E. Kiltie, Jian-Min Yuan, G. Matullo, Tony Fletcher, Simone Benhamou, Jack A. Taylor, Donatella Placidi, Zuo-feng Zhang, Gunnar Steineck, Nathaniel Rothman, Manolis Kogevinas, Debra T. Silverman, Nuria Malats, Stephen Chanock, Xifeng Wu, Margaret R. Karagas, Angeline S. Andrew, Heather H. Nelson, D.T. Bishop, Sei Chung Sak, Ananya Choudhury, Jennifer H. Barrett, Faye Elliot, Roman Corral, Amit D. Joshi, Manuela Gago-Dominguez, Victoria K. Cortessis, Yu-Tang Gao, Yong-Bing Xiang, Paolo Vineis, C. Sacerdote, S. Guarrera, S. Polidoro, Alessandra Allione, Eugen Gurzau, Kvetoslava Koppova, Rajiv Kumar, Peter Rudnai, Stefano Porru, Angela Carta, Marcello Campagna, Cecilia Arici, Sung Shim Park, and Montserrat Garcia-Closas. 2009. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer. Cancer Research.   69(17):6857-64. doi:10.1158/0008-5472.CAN-09-1091