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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Karl T. Kelsey

Brown University
70 Ship St
Box G E5
Providence, RI 02912
Phone: 401-863-6420
Email:

Projects

Publications

2014
  • Sverrisson, Einar F., Michael S. Zens, Dennis L. Fei, Angeline Andrews, Alan R. Schned, David J. Robbins, Karl T. Kelsey, Hua Li, James DiRenzo, Margaret R. Karagas, and John D. Seigne. 2014. Clinicopathological correlates of Gli1 expression in a population-based cohort of patients with newly diagnosed bladder cancer. Urologic Oncology-Seminars and Original Investigations. 32(5):539-545. doi:10.1016/j.urolonc.2014.03.006  
2013
  • Eum, Ki-Do, Florence T. Wang, Joel Schwartz, Craig P. Hersh, Karl T. Kelsey, Robert O. Wright, Avron Spiro, III, David Sparrow, Howard Hu, and Marc G. Weisskopf. 2013. Modifying roles of glutathione S-transferase polymorphisms on the association between cumulative lead exposure and cognitive function. NeuroToxicology.   39C:65-71. doi:10.1016/j.neuro.2013.08.002  
  • Wyszynski, Asaf, Sam A. Tanyos, Judy R. Rees, Carmen J. Marsit, Karl T. Kelsey, Alan R. Schned, Eben M. Pendleton, Michael S. Zens, Margaret R. Karagas, and Angeline S. Andrew. 2013. Body mass and smoking are modifiable risk factors for recurrent bladder cancer. Cancer.   doi:10.1002/cncr.28394  
2012
  • Andrew, Angeline S., Ting Hu, Jian Gu, Jiang Gui, Yuanqing Ye, Carmen J. Marsit, Karl T. Kelsey, Alan R. Schned, Sam A. Tanyos, Eben M. Pendleton, Rebecca A. Mason, Elaine V. Morlock, Michael S. Zens, Zhongze Li, Jason H. Moore, Xifeng Wu, and Margaret R. Karagas. 2012. HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer. PLoS ONE.   7(12):e51301. doi:10.1371/journal.pone.0051301  
  • Karagas, Margaret R., Angeline S. Andrew, Heather H. Nelson, Z. Li, Tracy Punshon, Alan R. Schned, Carmen J. Marsit, J Steven Morris, Jason H. Moore, A.L. Tyler, Diane Gilbert-Diamond, Mary L. Guerinot, and Karl T. Kelsey. 2012. SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Human Genetics.   131:453-461. doi:10.1007/s00439-011-1090-x  
  • Nielsen, Susan S., Harvey Checkoway, Rondi A. Butler, Heather H. Nelson, Federico M. Farin, William T. Longstreth, Gary M. Franklin, Phillip D. Swanson, and Karl T. Kelsey. 2012. LINE-1 DNA Methylation, Smoking and Risk of Parkinson's Disease. Journal of Parkinson's Disease.   2(4):303-308. doi:10.3233/JPD-012129  
2011
  • Avissar-Whiting, Michele, Devin C. Koestler, E. Andrés Houseman, Brock C. Christensen, Karl T. Kelsey, and Carmen J. Marsit. 2011. Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma. Epigenetics. 6:703-709. doi:10.4161/epi.6.6.16158   (Completed with ARRA Funds)
  • Gui, Jiang, Angeline S. Andrew, Peter C. Andrews, Heather H. Nelson, Karl T. Kelsey, Margaret R. Karagas, and Jason H. Moore. 2011. A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Annals of Human Genetics.   75(1):20-28. doi:10.1111/j.1469-1809.2010.00624.x   (Completed with ARRA Funds)
  • Gui, Jiang, Jason H. Moore, Karl T. Kelsey, Carmen J. Marsit, Margaret R. Karagas, and Angeline S. Andrew. 2011. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Human Genetics.   129(1):101-110. doi:10.1007/s00439-010-0905-5   (Completed with ARRA Funds)
  • Langevin, Scott M., E. Andrés Houseman, Brock C. Christensen, John K. Wiencke, Heather H. Nelson, Margaret R. Karagas, Carmen J. Marsit, and Karl T. Kelsey. 2011. The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood. Epigenetics. 6:908-919. doi:10.4161/epi.6.7.16431   (Completed with ARRA Funds)
  • Marsit, Carmen J., Devin C. Koestler, Brock C. Christensen, Margaret R. Karagas, E. Andrés Houseman, and Karl T. Kelsey. 2011. DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DNA Methylation Associated With Bladder Cancer. Journal of Clinical Oncology.   29(9):1133-1139. doi:10.1200/JCO.2010.31.3577   (Completed with ARRA Funds)
  • Pacheco, Sara E., Brock C. Christensen, Carmen J. Marsit, Karl T. Kelsey, Mark Sigman, and Kim Boekelheide. 2011. Integrative DNA Methylation and Gene Expression Analyses Identify DNA Packaging and Epigenetic Regulatory Genes Associated with Low Motility Sperm. PLoS ONE.   6:doi:10.1371/journal.pone.0020280   (Completed with ARRA Funds)
  • Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, and Carmen J. Marsit. 2011. Association of secondhand smoke exposures with DNA methylation in bladder carcinomas. Cancer Causes & Control. 22:1205-1213. doi:10.1007/s10552-011-9788-6  
  • Wilhelm-Benartzi, Charlotte, Brock C. Christensen, Devin C. Koestler, E. Andrés Houseman, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and John K. Wiencke. 2011. Association of second hand smoke exposures with DNA methylation in bladder cancer cases. Cancer Causes & Control. 22(8):1205-1213. doi:10.1007/s10552-011-9788-6   (Completed with ARRA Funds)
2010
  • Christensen, Brock C., A. Smith, Shichun Zheng, Devin C. Koestler, E Andres Houseman, Carmen J. Marsit, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas, Margaret R. Wrensch, Karl T. Kelsey, and John K. Wiencke. 2010. DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma. Journal of the National Cancer Institute.   103:143-153.
  • Gee, Gretchen V., Devin C. Koestler, Brock C. Christensen, David J. Sugarbaker, David J. Ugolini, Giovanni P. Ivaldi, Murray B. Resnick, E Andres Houseman, Karl T. Kelsey, and Carmen J. Marsit. 2010. Downregulated MicroRNAs in the differential diagnosis of malignant pleural mesothelioma. International Journal of Cancer.   127(12):2859–2869. doi:10.1002/ijc.25285  
  • Greene, Casey S., Daniel S. Himmelstein, Heather H. Nelson, Karl T. Kelsey, Scott M. Williams, Angeline S. Andrew, Margaret R. Karagas, and Jason H. Moore. 2010. Enabling personal genomics with an explicit test of epistasis. Pacific Symposium on Biocomputing. 327-36. doi:10.1142/9789814295291_0035  
  • Gui, Jiang, Angeline S. Andrew, Peter C. Andrews, H.A. Nelson, Karl T. Kelsey, Margaret R. Karagas, and Jason H. Moore. 2010. A simple and computationally efficient sampling approach to covariate adjustment for multifactor dimensionality reduction analysis of epistasis. Human Heredity. 70:219-225. doi:10.1159/000319175  
  • Koestler, Devin C., Carmen J. Marsit, Brock C. Christensen, Margaret R. Karagas, Raphael Bueno, David J. Sugarbaker, Karl T. Kelsey, and E. Andrés Houseman. 2010. Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics.   26(20):2578-2585. doi:10.1093/bioinformatics/btq470   (Completed with ARRA Funds)
  • Kwong, Ryan C., Margaret R. Karagas, Karl T. Kelsey, Rebecca A. Mason, Sam A. Tanyos, Alan R. Schned, Carmen J. Marsit, and Angeline S. Andrew. 2010. Arsenic exposure predicts bladder cancer survival in a US population. World Journal of Urology.   28:487-92. doi:10.1007/s00345-009-0477-y   (Completed with ARRA Funds)
  • Marsit, Carmen J., E. Andrés Houseman, Brock C. Christensen, Luc A. Gagne, Margaret R. Wrensch, Heather H. Nelson, Joseph L. Wiemels, Shichun Zheng, John K. Wiencke, Angeline S. Andrew, Alan R. Schned, Margaret R. Karagas, and Karl T. Kelsey. 2010. Identification of Methylated Genes Associated with Aggressive Bladder Cancer. PLoS ONE.   5:e12334. doi:10.1371/journal.pone.0012334  
  • Wilhelm, Charlotte S., Karl T. Kelsey, Rondi A. Butler, Silvia Plaza, Luc A. Gagne, Michael S. Zens, Angeline S. Andrew, Steven Morris, Heather H. Nelson, Alan R. Schned, Margaret R. Karagas, and Carmen J. Marsit. 2010. Implications of LINE1 methylation for bladder cancer risk in women. Clinical Cancer Research.   16:1682-1689. doi:10.1158/1078-0432.ccr-09-2983  
  • Wilhelm-Benartzi, Charlotte, Devin C. Koestler, Brock C. Christensen, John K. Wiencke, Alan R. Schned, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, and E Andres Houseman. 2010. DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer. Carcinogenesis.   31:1972-1976. doi:10.1093/carcin/bgq178   (Completed with ARRA Funds)
2009
  • Baris, Dalsu, Margaret R. Karagas, Castine Verrill, Alison Johnson, Angeline S. Andrew, Carmen J. Marsit, Joanne S. Colt, Sai Cherala, Claudine Samanic, Richard Waddell, Kenneth P. Cantor, Alan R. Schned, Nathaniel Rothman, Jay H. Lubin, Joseph F. Fraumeni, Robert N. Hoover, Karl T. Kelsey, Debra T. Silverman, and Molly Schwenn. 2009. A case-control study of smoking and bladder cancer risk: Emergent patterns over time. Journal of the National Cancer Institute.   101(22):1553-61. doi:10.1093/jnci/djp361  
  • Christensen, Brock C., E. Andrés Houseman, Carmen J. Marsit, Shichun Zheng, Margaret R. Wrensch, Joseph L. Wiemels, Heather H. Nelson, Margaret R. Karagas, J. Padbury, Raphael Bueno, David J. Sugarbaker, Ru-Fang Yeh, John K. Wiencke, and Karl T. Kelsey. 2009. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genetics.   5(8):e1000602. doi:10.1371/journal.pgen.1000602  
  • Dietrich, K., Alan R. Schned, J. Fortuny, John A. Heaney, Carmen J. Marsit, Karl T. Kelsey, and Margaret R. Karagas. 2009. Glucocorticoid therapy and risk of bladder cancer. British Journal of Cancer.   101(8):1316-20. doi:10.1038/sj.bjc.6605314  
  • Mason, Rebecca A., Elaine V. Morlock, Margaret R. Karagas, Karl T. Kelsey, Carmen J. Marsit, Alan R. Schned, and Angeline S. Andrew. 2009. EGFR pathway polymorphisms in bladder cancer susceptibility and prognosis. Carcinogenesis.   30(7):1155-1160. doi:10.1093/carcin/bgp077  
  • Stern, Mariana C., Jie Lin, Jonine D. Figueroa, Karl T. Kelsey, Anne E. Kiltie, Jian-Min Yuan, Giuseppe Matullo, Tony Fletcher, Simone Benhamou, Jack A. Taylor, Donatella Placidi, Zuo-feng Zhang, Gunnar Steineck, Nathaniel Rothman, Manolis Kogevinas, Debra T. Silverman, Nuria Malats, Stephen J. Chanock, Xifeng Wu, Margaret R. Karagas, Angeline S. Andrew, Heather H. Nelson, David T. Bishop, Sei Chung Sak, Ananya Choudhury, Jennifer H. Barrett, Faye Elliot, Roman Corral, Amit D. Joshi, Manuela Gago-Dominguez, Victoria K. Cortessis, Yu-Tang Gao, Yong-Bing Xiang, Paolo Vineis, Carlotta Sacerdote, Simonetta Guarrera, Silvia Polidoro, Alessandra Allione, Eugen Gurzau, Kvetoslava Koppova, Rajiv Kumar, Peter Rudnai, Stefano Porru, Angela Carta, Marcello Campagna, Cecilia Arici, Sung Shim Park, and Montserrat Garcia-Closas. 2009. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: Findings from the International Consortium of Bladder Cancer. Cancer Research.   69(17):6857-64. doi:10.1158/0008-5472.CAN-09-1091  
2008
  • Houseman, E.Andrés, Brock C. Christensen, Ru-Fang Yeh, Carmen J. Marsit, Margaret R. Karagas, Margaret R. Wrensch, Heather H. Nelson, Joseph L. Wiemels, Shichun Zheng, John K. Wiencke, and Karl T. Kelsey. 2008. Model-based clustering of DNA methylation array data: A recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Biochemistry.   9:365. doi:10.1186/1471-2105-9-365  
2007
  • Andrew, Angeline S., Margaret R. Karagas, Heather H. Nelson, Simonetta Guarrera, Silvia Polidoro, Sara Gamberini, Carlotta Sacerdote, Jason H. Moore, Karl T. Kelsey, Eugene Demidenko, Paolo Vineis, and Giuseppe Matullo. 2007. DNA repair polymorphisms modify bladder cancer risk: A multi-factor analytic strategy. Cancer Epidemiology Biomarkers & Prevention.   65(2):105-118. doi:10.1159/000108942