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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Mark E. Hahn

Woods Hole Oceanographic Institution
Biology Department, MS-32
Woods Hole, MA 02543-1049
Phone: 508-289-3242
Fax: 508-457-2134
Email:

Projects

Research Briefs

Hazardous Waste Sites

Atlantic Wood Site, Elizabeth River

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

New Bedford Harbor Coast Guard Removal

  • Boston University: Mechanisms and Impacts of Dioxin Resistance in Fish

Publications

2014
  • Lowe, Margaret M., Jeff E. Mold, Bittoo Kanwar, Yong Huang, Alexander Louie, Michael P. Pollastri, Cuihua Wang, Gautam Patel, Diana G. Franks, Jennifer J. Schlezinger, David H. Sherr, Allen E. Silverstone, Mark E. Hahn, and Joseph M. McCune. 2014. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS ONE.   9(2):15. doi:10.1371/journal.pone.0087877  
  • Parks, Ashley, Michael P. Pollastri, Mark E. Hahn, Elizabeth A. Stanford, Olga Novikov, Diana G. Franks, Sarah E. Haigh, Supraja Narasimhan, Trent D. Ashton, Timothy G. Hopper, Dmytro Kozakov, Dmitri Beglov, Sandor Vajda, Jennifer J. Schlezinger, and David H. Sherr. 2014. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Molecular Pharmacology.   86(5):593-608. doi:10.1124/mol.114.093369  
  • Reitzel, Adam M., Sibel I. Karchner, Diana G. Franks, Brad R. Evans, Diane E. Nacci, Denise Champlin, Veronica M. Vieira, and Mark E. Hahn. 2014. Genetic variation at aryl hydrocarbon receptor (AHR) loci in populations of Atlantic killifish (Fundulus heteroclitus) inhabiting polluted and reference habitats. BMC Evolutionary Biology. 14:6. doi:10.1186/1471-2148-14-6  
2013
  • Bainy, Afonso C., Akira Kubota, Jared V. Goldstone, Roger Lille-Langoy, Sibel I. Karchner, Malin C. Celander, Mark E. Hahn, Anders Goksoyr, and John J. Stegeman. 2013. Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquatic Toxicology.   142-143:447-457. doi:10.1016/j.aquatox.2013.09.014  
  • Fraccalvieri, Domenico, Anatoly A. Soshilov, Sibel I. Karchner, Diana G. Franks, Alessandro Pandini, Laura Bonati, Mark E. Hahn, and Michael S. Denison. 2013. Comparative analysis of homology models of the AH receptor ligand binding domain: Verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry.   52:714-725. doi:10.1021/bi301457f  
  • Harbeitner, Rachel C., Mark E. Hahn, and Alicia R. Timme-Laragy. 2013. Differential sensitivity to pro-oxidant exposure in two populations of killifish (Fundulus heteroclitus). Ecotoxicology. 22:387-401. doi:10.1007/s10646-012-1033-x  
  • Timme-Laragy, Alicia R., Jared V. Goldstone, Barry R. Imhoff, John J. Stegeman, Mark E. Hahn, and Jason M. Hansen. 2013. Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free Radical Biology and Medicine.   65:89-101. doi:10.1016/j.freeradbiomed.2013.06.011  
  • Williams, Larissa M., Alicia R. Timme-Laragy, Jared V. Goldstone, A.G. McArthur, John J. Stegeman, Roxanna M. Smolowitz, and Mark E. Hahn. 2013. Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS ONE.   doi:10.1371/journal.pone.0079574  
2011
2010
  • Aluru, N., Sibel I. Karchner, and Mark E. Hahn. 2010. Role of DNA methylation of AHR1 and AHR2 promoters in differential sensitivity to PCBs in Atlantic Killifish, Fundulus heteroclitus. Aquatic Toxicology.   101:288-94. doi:10.1016/j.aquatox.2010.10.010  
  • Greytak, Sarah R., Ann M. Tarrant, Diane E. Nacci, Mark E. Hahn, and Gloria V. Callard. 2010. Estrogen responses in killifish (Fundulus heteroclitus) from polluted and unpolluted environments are site- and gene-specific. Aquatic Toxicology.   99(2):291-299. doi:10.1016/j.aquatox.2010.05.009  
  • Howard, Gregory, Jennifer J. Schlezinger, Mark E. Hahn, and Thomas F. Webster. 2010. Generalized Concentration Addition Predicts Joint Effects of Aryl Hydrocarbon Receptor Agonists with Partial Agonists and Competitive Antagonists. Environmental Health Perspectives. 118:666-672. doi:10.1289/ehp.0901312  
2009
2008
  • Evans, Brad R., Sibel I. Karchner, Lenka L. Allan, Richard S. Pollenz, Robert L. Tanguay, Mark J. Jenny, David H. Sherr, and Mark E. Hahn. 2008. Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: Role of DNA binding and competition for AHR nuclear translocator. Molecular Pharmacology.   73(2):387-98.
  • Hansson, M.C. and Mark E. Hahn. 2008. Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms. Aquatic Toxicology.   86(2):121-30.
  • Matson, Cole W., Bryan W. Clark, Mark J. Jenny, Carrie R. Fleming, Mark E. Hahn, and Richard T. Di Giulio. 2008. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquatic Toxicology.   87(4):289-95. doi:10.1016/j.aquatox.2008.02.010  
2007
  • Burnett, Karen G., Lisa J. Bain, William S. Baldwin, Gloria V. Callard, Sarah Cohen, Richard T. Di Giulio, David H. Evans, Marta Gomez-Chiarri, Mark E. Hahn, Cindi A. Hoover, Sibel I. Karchner, Fumi Katoh, Deborah L. MacLatchy, William S. Marshall, Joel N. Meyer, Diane E. Nacci, Bernard B. Rees, Thomas D. Singer, John J. Stegeman, David W. Towle, Peter A. van Veld, Wolfgang K. Vogelbein, Andrew Whitehead, Richard N. Winn, Douglas L. Crawford, and Marjorie F. Oleksiak. 2007. Fundulus as the premier teleost model in environmental biology: Opportunities for new insights using genomics. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics.   2(4):257-286. doi:10.1016/j.cbd.2007.09.001  
  • Carvan, M.J., Evan P. Gallagher, Anders Goksoyr, Mark E. Hahn, and D.G. Joakim. 2007. Fish models in toxicology. Zebrafish.   4:9-20.
  • Hahn, Mark E. and E.V. Hestermann. 2007. Receptor-mediated mechanisms of toxicity. Chapter 5 in: The Toxicology of Fishes   . Taylor & Francis, Boca Raton, FL. pp.235-272.
  • Jonsson, Maria E., Mark J. Jenny, Bruce R. Woodin, Mark E. Hahn, and John J. Stegeman. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences.   100(1):180-93.
  • Reddy, C.M., John J. Stegeman, and Mark E. Hahn. 2007. Organic Pollutants: Presence and Effects in Humans and Marine Animals. Chapter 7 in: Oceans and Human Health: Risks and Remedies from the Seas. pp.121-144.
2006
  • Goldstone, Jared V., A. Hamdoun, B.J. Cole, M. Howard-Ashby, Daniel W. Nebert, M. Scally, M. Dean, D. Epel, Mark E. Hahn, and John J. Stegeman. 2006. The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology.   300(1):366-84. doi:10.1016/j.ydbio.2006.08.066  
  • Hahn, Mark E., Sibel I. Karchner, Brad R. Evans, Diana G. Franks, Rebeka R. Merson, and J.M. Lapseritis. 2006. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomic. Journal of Experimental Zoology. 305(9):693-706.
  • Merson, Rebeka R., Diana G. Franks, Sibel I. Karchner, and Mark E. Hahn. 2006. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 142:85-94.
  • Tarrant, Ann M., Sarah R. Greytak, Gloria V. Callard, and Mark E. Hahn. 2006. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. Journal of Molecular Endocrinology.   37(1):105-20.
2005
  • Evans, Brad R., Sibel I. Karchner, Diana G. Franks, and Mark E. Hahn. 2005. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: Structure, function, evolution, and AHR-dependent regulation in vivo. Archives of Biochemistry and Biophysics.   441(2):151-167.
  • Yang, Xinhai, Donghui Liu, Tessa J. Murray, Geoffrey C. Mitchell, Eli V. Hesterman, Sibel I. Karchner, Rebeka R. Merson, Mark E. Hahn, and David H. Sherr. 2005. The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene.   24(53):7869-7881.
2004
  • Hahn, Mark E., Sibel I. Karchner, Diana G. Franks, and Rebeka R. Merson. 2004. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenetics and Genomics.   14(2):131-143.
  • Powell, Wade H., Hilary G. Morrison, E. Jennifer Weil, Sibel I. Karchner, Mitchell L. Sogin, John J. Stegeman, and Mark E. Hahn. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Marine Environmental Research.   58(2-5):119-124.
2003
  • Meyer, Joel N., Deena M. Wassenberg, Sibel I. Karchner, Mark E. Hahn, and Richard T. Di Giulio. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental Toxicology and Chemistry.   22(10):2337-2343.
2002
  • Bard, Shannon Mala, Susan M. Bello, Mark E. Hahn, and John J. Stegeman. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquatic Toxicology.   59(3-4):237-251.
  • Karchner, Sibel I., Diana G. Franks, Wade H. Powell, and Mark E. Hahn. 2002. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. Journal of Biological Chemistry.   277:6949-6959.
  • Powell, Wade H. and Mark E. Hahn. 2002. Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants. Journal of Experimental Zoology. 294(1):17-29.
2001
  • Bello, Susan M., Diana G. Franks, John J. Stegeman, and Mark E. Hahn. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine Superfund site: In vivo and in vitro studies on the inducibility of xenobiotic-metabolizing enzymes. Toxicological Sciences.   60(1):77-91.
  • Hahn, Mark E. 2001. Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models. Marine Biotechnology.   3:S224-S238.
  • Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology.   53(2):127-138.
2000
  • Betka, Marlies, Alice Welenc, Diana G. Franks, Mark E. Hahn, and Gloria V. Callard. 2000. Characterization of two aryl hydrocarbon receptor (AHR) mRNA forms in Squalus acanthias and stage-dependent expression during spermatogenesis. The Bulletin: Mount Desert Island Biological Laboratory. 39:65-67.
  • Karchner, Sibel I., Sean W. Kennedy, Suzanne Trudeau, and Mark E. Hahn. 2000. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Marine Environmental Research.   50(1-5):51-56.
  • Powell, Wade H., Rachel Bright, Susan M. Bello, and Mark E. Hahn. 2000. Developmental and Tissue-specific Expression of AHR1, AHR2, and ARNT2 in Dioxin-sensitive and -resistant Populations of the Marine Fish, Fundulus heteroclitus. Toxicological Sciences.   57(2):229-239.
  • Powell, Wade H. and Mark E. Hahn. 2000. The evolution of aryl hydrocarbon signaling proteins: Diversity of ARNT isoforms among fish species. Marine Environmental Research.   50(1-5):39-44.
  • Quadri, Shafat A., Ariful N. Qadri, Mark E. Hahn, Koren K. Mann, and David H. Sherr. 2000. The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor (AhR) Activation and Polycyclic Aromatic Hydrocarbon-induced Pre-B cell Apoptosis. Molecular Pharmacology.   58:515-525.
  • Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2000. TCDD induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology.  
1999
  • Betka, Marlies, Alice Welenc, Mark E. Hahn, and Gloria V. Callard. 1999. Stage-related distribution of two arylhydrocarbon receptor (AhR) mRNA variants and differential effects of Ah ligands on cell proliferation and death during spermatogenesis in the spiny dogfish shark (Squalus acanthias). In: Proceedings of the 1999 SETAC (Society of Environmental Toxcology and Chemistry) Annual Meeting.
  • Black, Virginia H., P.M. Shaw, Sibel I. Karchner, Wade H. Powell, and Mark E. Hahn. 1999. Differential expression of CYP1A1 and CYP1A2, but not AHR or ARNT, in guinea pig adrenal and liver. Endocrine Research. 24:631-632.
  • Karchner, Sibel I., Wade H. Powell, and Mark E. Hahn. 1999. Structural and Functional Characterization of Two Highly Divergent Aryl Hydrocarbon Receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel class of ligand-binding basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) factors. Journal of Biological Chemistry.   274:33814-33824.
  • Mann, Koren K., Mark E. Hahn, Anthony F. Trombino, B. Paige Lawrence, Nancy I. Kerkvliet, and David H. Sherr. 1999. The Role of DMBA Metabolites in PreB Cell Apoptosis. Toxicological Sciences.   48(1-S):
  • Mann, Koren K., Raymond A. Matulka, Mark E. Hahn, Anthony F. Trombino, B. Paige Lawrence, Nancy I. Kerkvliet, and David H. Sherr. 1999. The Role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced Pre-B Cell Apoptosis. Toxicology and Applied Pharmacology.   161:10-22.
  • Powell, Wade H., Sibel I. Karchner, Rachel Bright, and Mark E. Hahn. 1999. Functional diversity of vertebrate ARNT proteins: Identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus. Archives of Biochemistry and Biophysics.   361(1):156-163.
1998
  • Bello, Susan M., Diana G. Franks, John J. Stegeman, and Mark E. Hahn. 1998. Dioxin Resistance in Killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund Site: In Vivo and In Vitro studies of CYP1A1 Inducibility. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC. pp.168.
  • Besselink, Harrie T., Michael S. Denison, Mark E. Hahn, Sibel I. Karchner, A. Dick Vethaak, Jan H. Koeman, and Abraham Brouwer. 1998. Low inducibility of CYPIA activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYPIA inhibition. Toxicological Sciences.   43(2):161-171.
  • Hahn, Mark E. 1998. Mechanisms of innate and acquired resistance to dioxin-like compounds. Reviews in Toxicology: Series B - Environmental Toxicology. 2:395-443.
  • Hahn, Mark E. 1998. The Aryl Hydrocarbon Receptor: A Comparative Perspective. Comparative Biochemistry and Physiology.   121(1-3):23-53.
  • Hahn, Mark E., Sibel I. Karchner, Miriam A. Shapiro, and Samanthi A. Perera. 1998. The aryl hydrocarbon receptor in early vertebrates. Marine Environmental Research.   46(1-5):41-44.
  • Powell, Wade H., Sibel I. Karchner, and Mark E. Hahn. 1998. Aryl Hydrocarbon Signaling Components in Fundulus heteroclitus: A Phylogenetic Perspective. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC.
1997
  • Bello, Susan M., John J. Stegeman, and Mark E. Hahn. 1997. Lack of cytochrome P450-1A inducibility in Fundulus heteroclitus from New Bedford Harbor: A case of dioxin resistance?. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • Hahn, Mark E., Sibel I. Karchner, Samanthi A. Perera, and Miriam A. Shapiro. 1997. Evolution of the Ah Receptor: Evidence for two AhR genes in early vertebrates. The Toxicologist.   36:242.
  • Hahn, Mark E., Sibel I. Karchner, Miriam A. Shapiro, and Samanthi A. Perera. 1997. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHRI and AHR2) and the PAS family. Proceedings of the National Academy of Sciences of the United States of America (PNAS).   94(25):13743-13748.
  • Karchner, Sibel I. and Mark E. Hahn. 1997. Molecular Characterization of Two Aryl Hydrocarbon (Ah) Receptors in the Mummichog Fundulus heteroclitus. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA. pp.426.
1996
  • Hahn, Mark E., Sibel I. Karchner, and Samanthi A. Perera. 1996. Molecular studies on the Ah receptor (AhR) in early vertebrates (bony and cartilaginous fish) and evidence for a second vertebrate AhR gene. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.232.

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