Person Details: Bruce D. Hammock

Superfund Research Program

Bruce D. Hammock

University of California-Davis
Department of Entomology
90 Briggs Hall
One Shields Avenue
Davis, California 95616
Phone: 530-752-7519
Fax: 530-752-1537
Email: bdhammock@ucdavis.edu

Projects

University of California-Davis: Administrative Core (1995-2023)
University of California-Davis: Analytical Chemistry Core (1995-2023)
University of California-Davis: Immunoassays for Human and Environmental Health Monitoring (1995-2023)

Research Briefs

310 - New Tool Monitors a Flame Retardant in Sediment
283 - Researchers Identify Compounds that Reduce Abnormal Blood Vessel Growth in the Eye
241 - SRP Researchers Determine that Triclosan Promotes Liver Tumor Growth in Mice
213 - Widely Used Antibacterial Agents May Lead to Significant Health Concerns
181 - Enhanced Detection of Toxic Substances with Phage Library-Enhanced Immunoassays
142 - Nanoparticle Immunoassays - Advances & Spin-offs
55 - Potent Inhibitors are Discovered for Soluble Epoxide Hydrolases, Enzymes That Have an Important Role in the Metabolism of Environmental Contaminants

Patents

Hazardous Waste Sites

Frontier Fertilizer

University of California-Davis: Immunoassays for Human and Environmental Health Monitoring

Sulphur Bank Mercury Mine

University of California-Davis: Immunoassays for Human and Environmental Health Monitoring

Publications

McReynolds C, Morisseau C, Wagner KM, Hammock BD. Epoxy Fatty Acids Are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation. In: Druggable Lipid Signaling Pathways. Springer, pp.71-99.

2024

Abdalla HB, Puhl L, Rivas CA, Wu Y, Rojas P, Trindade da Silva CA, Hammock BD, Maddipati KR, Soares MQ, Clemente-Napimoga JT, Kantarci A, Napimoga MH, Van Dyke TE. 2024. Modulating the sEH/EETs axis restrains specialized proresolving mediator impairment and regulates T cell imbalance in experimental periodontitis. J Immunol 212(3):433-445. doi:10.4049/jimmunol.2300650 PMID:38117781
Fang X, Liu T, Xue C, Xue G, Wu M, Liu P, Hammock BD, Lai W, Peng J, Zhang C. 2024. Competitive ratiometric fluorescent lateral flow immunoassay based on dual emission signal for sensitive detection of chlorothalonil. Food Chem 433:137200. doi:10.1016/j.foodchem.2023.137200 PMID:37678117
Gao Q, Chen L, An Z, Wang Y, Yang D, Wang Z, Kang J, Barnych B, Hammock BD, Huo J, Zhang J. 2024. Development of an immunoassay based on a specific antibody for the detection of diphenyl ether herbicide fomesafen. Sci Total Environ 914:169858. doi:10.1016/j.scitotenv.2023.169858 PMID:38190900
Gao S, Abd El-Aty AM, Xu L, Zhao J, Li J, Lei X, Zhao Y, She Y, Jin F, Wang J, Yuan S, Jin M, Zheng L, Hammock BD. 2024. Rapid detection of prometryn residues in agricultural samples: Method comparison of the ic-ELISA and colloidal gold immunochromatographic test strips. ACS Agric Sci Technol doi:10.1021/acsagscitech.3c00490
Kelly A, Wang W, Rothenberger E, Yang J, Gilligan MM, Kipper FC, Attaya A, Gartung A, Hwang SH, Gillespie M, Bayer R, Quinlivan K, Torres K, Huang S, Mitsiades N, Yang H, Hammock BD, Panigrahy D. 2024. Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 121(7):doi:10.1073/pnas.2314085121 PMID:38330013
Li P, Abd El-Aty AM, Jiang H, Shen J, Wang Z, Wen K, Li J, Wang S, Wang J, Hammock BD, Jin M. 2024. Immunoassays and emerging analytical techniques of fipronil and its metabolites for food safety: A review. J Agric Food Chem 72(4):2059-2076. doi:10.1021/acs.jafc.3c07428 PMID:38252458
Naeem Z, Zukunft S, Huard A, Hu J, Hammock BD, Weigert A, Frömel T, Fleming I. 2024. Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli. Biomed Pharmacother 171:116127. doi:10.1016/j.biopha.2024.116127 PMID:38198951 PMCID:10857809
Trindade-da-Silva C, Yang J, Fonseca F, Pham H, Napimoga M, Abdalla HB, Aver G, De Oliveira M, Hammock BD, Clemente-Napimoga J. 2024. Eicosanoid profiles in an arthritis model: Effects of a soluble epoxide hydrolase inhibitor. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1869(2):159432. doi:10.1016/j.bbalip.2023.159432 PMID:37984607 PMCID:10842726
Wang Y, Zhou H, Fu Y, Wang Z, Gao Q, Yang D, Kang J, Chen L, An Z, Hammock BD, Zhang J, Huo J. 2024. Establishment of an indirect competitive immunoassay for the detection of dicamba based on a highly specific nanobody. Sci Total Environ 917:170567. doi:10.1016/j.scitotenv.2024.170567 PMID:38296098
Warner J, Hardesty JE, Song Y, Floyd A, Deng Z, Jebet A, He L, Zhang XH, McClain CJ, Hammock BD, Warner D, Kirpich IA. 2024. Hepatic transcriptome and its regulation following soluble epoxide hydrolase inhibition in alcohol-associated liver disease. Am J Pathol 194(1):71-84. doi:10.1016/j.ajpath.2023.09.016 PMID:37925018 PMCID:10768534

2023

Angelia J, Weng X, Solomatov A, Chin C, Fernandez A, Hudson PK, Morisseau C, Hammock BD, Kandasamy R, Pecic S. 2023. Structure-activity relationship studies of benzothiazole-phenyl analogs as multi-target ligands to alleviate pain without affecting normal behavior. Prostaglandins Other Lipid Mediat 164:106702. doi:10.1016/j.prostaglandins.2022.106702 PMID:36529320 PMCID:PMC9879382
Atone J, Wagner KM, Koike S, Yang J, Hwang SH, Hammock BD. 2023. Inhibition of soluble epoxide hydrolase reduces paraquat neurotoxicity in rodents. Environ Toxicol Pharmacol 98:104070. doi:10.1016/j.etap.2023.104070 PMID:36682504 PMCID:PMC9992278
Basting RT, Napimoga M, Trindade da Silva CA, Abdalla HB, Durso BC, Martins LH, Cavalcanti Hd, Hammock BD, Clemente-Napimoga JT. 2023. Soluble epoxide hydrolase inhibitor blockage microglial cell activation in subnucleus caudalis in a persistent model of arthritis. Int Immunopharmacol 120:110320. doi:10.1016/j.intimp.2023.110320 PMID:37230034
Chen Y, Chen L, Xu H, Cao R, Morisseau C, Zhang M, Shi Y, Hammock BD, Wang J, Zhuang J, Liu Z, Chen G. 2023. Structure-directed discovery of potent soluble epoxide hydrolase inhibitors for the treatment of inflammatory disease. J Med Chem 66(4):2979-3009. doi:10.1021/acs.jmedchem.2c01996 PMID:36689364 PMCID:PMC9974930
Deans J, Deol P, Titova N, Radi S, Vuong L, Evans J, Pan S, Fahrmann J, Yang J, Hammock BD, Fiehn O, Fekry B, Eckel-Mahan K, Sladek FM. 2023. HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver. Front. Endocrinol 14:1266527. doi:10.3389/fendo.2023.1266527 PMID:38111711 PMCID:10726135
Dover M, Moseley T, Biskaduros A, Paulchakrabarti M, Hwang SH, Hammock BD, Choudhury B, Kaczor-Urbanowicz KE, Urbanowicz A, Morselli M, Dang J, Pellegrini M, Paul K, Bentolila LA, Fiala M. 2023. Polyunsaturated fatty acids mend macrophage transcriptome, glycome, and phenotype in the patients with neurodegenerative diseases, including Alzheimer's disease. Journal of Alzheimers Disease 91(1):245-261. doi:10.3233/JAD-220764 PMID:36373322 PMCID:PMC9881025
El-Sheikh EA, Li D, Hamed I, Ashour M, Hammock BD. 2023. Residue analysis and risk exposure assessment of multiple pesticides in tomato and strawberry ad their products from markets. Foods 12(10):1936. doi:10.3390/foods12101936 PMID:37238754 PMCID:PMC1021775
Gao Q, Huo J, Chen L, Yang D, Zhang W, Jia B, Xu X, Barnych B, Zhang J, Hammock BD. 2023. Development of immunoassay based on a specific antibody for sensitive detection of nicosulfuron in environment. Sci Total Environ 859(Pt1):160247. doi:10.1016/j.scitotenv.2022.160247 PMID:36400293 PMCID:PMC10042444
He Q, McCoy MR, Qi M, Morisseau C, Yang H, Xu C, Shey R, Goodman MC, Zhao S, Hammock BD. 2023. The generation of a nanobody-based ELISA for human microsomal epoxide hydrolase. Int J Mol Sci 24(19):14698. doi:10.3390/ijms241914698 PMID:37834144 PMCID:PMC10572367
He Q, McCoy MR, Yang H, Lin M, Cui X, Zhao S, Morisseau C, Li D, Hammock BD. 2023. Mix-and-read nanobody-based sandwich homogeneous split-luciferase assay for the rapid detection of human soluble epoxide hydrolase. Anal Chem 95(14):6038-6045. doi:10.1021/acs.analchem.3c00079 PMID:36972550 PMCID:PMC10335774
Kulkarni R, Mehta R, Goswami SK, Hammock BD, Morisseau C, Hwang SH, Mallappa O, Azeemuddin MM, Rafiq M, N MS. 2023. Neuroprotective effect of herbal extracts inhibiting soluble epoxide hydrolase (sEH) and cyclooxygenase (COX) against chemotherapy-induced cognitive impairment in mice. Biochem Biophys Res Commun 667:64-72. doi:10.1016/j.bbrc.2023.05.008 PMID:37209564
Lei X, Abd El-Aty AM, Xu L, Zhao J, Li J, Gao S, Zhao Y, She Y, Jin F, Wang J, Zheng L, Jin M, Hammock BD. 2023. Production of a monoclonal antibody for the detection of forchlorfenuron: application in an indirect enzyme-linked immunosorbent assay and immunochromatographic strip. Biosensors 13(2):239. doi:10.3390/bios13020239 PMID:36832005 PMCID:PMC9954037
Leuillier M, Duflot T, Menoret S, Messaoudi H, Djerada Z, Groussard D, Denis RG, Chevalier L, Karoui A, Panthu B, Thiebaut P, Schmitz-Afonso I, Nobis S, Campart C, Henry T, Sautreuil C, Luquet SH, Beseme O, Feliu C, Peyret H, Nicol L, Henry J, Renet S, Mulder P, Wan D, Tesson L, Heslan J, Duche A, Jacques S, Ziegler F, Brunel V, Rautureau GJ, Monteil C, do Rego J, do Rego J, Afonso C, Hammock BD, Madec A, Pinet F, Richard V, Anegon I, Guignabert C, Morisseau C, Bellien J. 2023. CRISPR/Cas9-mediated inactivation of the phosphatase activity of soluble epoxide hydrolase prevents obesity and cardiac ischemic injury. J. Adv. Res 43:163-174. doi:10.1016/j.jare.2022.03.004 PMID:36585106 PMCID:PMC9811321
Li J, Wu G, Li L, Wang L, Liang Y, Fang R, Zhang Q, Xie L, Shen X, Shen Y, Xu Z, Wang H, Hammock BD. 2023. Structural insights into the stability and recognition mechanism of the antiquinalphos nanobody for the detection of quinalphos in foods. Anal Chem 95(30):11306-11315. doi:10.1021/acs.analchem.3c01370 PMID:37428097
Liu M, Chen Z, Huang X, Wang H, Zhao J, Shen Y, Luo L, Wen X, Hammock BD, Xu Z. 2023. A bispecific nanobody with high sensitivity/efficiency for simultaneous determination of carbaryl and its metabolite 1-naphthol in the soil and rice samples. Environ Pollut 335:122265. doi:10.1016/j.envpol.2023.122265 PMID:37517641
Liu M, He X, Xu Z, Deng H, Shen Y, Luo L, Shen X, Chen Z, Hammock BD, Wang H. 2023. Development of a biotinylated nanobody-based gold nanoparticle immunochromatographic assay for the detection of procymidone in crops. J Agric Food Chem 71(35):13137-13146. doi:10.1021/acs.jafc.3c03408 PMID:37611148
Luo A, Wu Z, Li S, McReynolds C, Wang D, Liu H, Huang C, He T, Zhang X, Wang Y, Liu C, Hammock BD, Hashimoto K, Yang CZ. 2023. The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. J Transl Med 21(1):71. doi:10.1186/s12967-023-03917-x PMID:36732752 PMCID:PMC9896784
McReynolds C, Hammock BD, Morisseau C. 2023. Regulatory lipid vicinal diols counteract the biological activity of epoxy fatty acids and can act as biomarkers and mechanisms for disease progression. Pharmacol Ther 248:108454. doi:10.1016/j.pharmthera.2023.108454 PMID:37268114
Oh YT, Yang J, Morriseau C, He Q, Hammock BD, Youn JH. 2023. Effects of individual circulating FFAs on plasma and hepatic FFA epoxides, diols, and epoxide-diol ratios as indices of soluble epoxide hydrolase activity. Int J Mol Sci 24(13):10760. doi:10.3390/ijms241310760 PMID:37445935 PMCID:PMC10341844
Oh YT, Yang J, Stefanovski D, Hammock BD, Youn JH. 2023. Determinants of meal-induce changes in circulating FFA epoxides, diols, and diol-to-epoxide ratios as indices of soluble epoxide hydrolase activity. Int J Mol Sci 24(24):17351. doi:10.3390/ijms242417351 PMID:38139180 PMCID:PMC10743433
Pan S, Karey E, Nieves-Cintron M, Chen Y, Hwang SH, Hammock BD, Pinkerton KE, Chen C. 2023. Effects of chronic secondhand smoke exposure on cardiovascular regulation and the role of soluble epoxide hydrolase in mice. Front Physiol 14:1185744. doi:10.3389/fphys.2023.1185744 PMID:37362438 PMCID:PMC10285070
Peyman M, Barroso E, Turcu AL, Estrany F, Smith D, Jurado-Aguilar J, Rada P, Morisseau C, Hammock BD, Valverde AM, Palomer X, Galdeano C, Vazquez S, Vazquez-Carrera M. 2023. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. Biomed Pharmacother 168:115667. doi:10.1016/j.biopha.2023.115667 PMID:37826940
Pu Y, Cheng R, Zhang Q, Huang T, Lu C, Tang Z, Zhong Y, Wu L, Hammock BD, Hashimoto K, Luo Y, Liu Y. 2023. Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Clin Immunol 257:doi:10.1016/j.clim.2023.109850 PMID:38013165 PMCID:10872286
Ravindran R, Kang H, McReynolds C, Sanghar GK, Chang W, Ramasamy S, Kolloli A, Kumar R, Subbian S, Hammock BD, Hartigan-O'Connor DJ, Ikram A, Haczku A, Khan IH. 2023. Dynamics of temporal immune responses in nonhuman primates and humans immunized with COVID-19 vaccines. PLoS One 18(10):e0287377. doi:10.1371/journal.pone.0287377 PMID:37856429 PMCID:PMC10586671
Richter FC, Friedrich M, Kampschulte N, Piletic K, Alsaleh G, Zummach R, Hecker J, Pohin M, Ilott N, Guschina I, Wideman SK, Johnson E, Borsa M, Hahn P, Morriseau C, Hammock BD, Schipper HS, Edwards CM, Zechner R, Siegmund B, Weidinger C, Schebb N, Powrie F, Simon AK. 2023. Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10. EMBO J e112202. doi:10.15252/embj.2022112202 PMID:36795015 PMCID:PMC10015370
Shen Q, Yang J, Zamora D, Horowitz M, Faurot KR, MacIntosh BA, Mann JD, Hammock BD, Ramsden CE, Taha AY. 2023. Associations between plasma lipid mediators and chronic daily headache outcomes in patients randomized to a low linoleic acid diet with or without added omega-3 fatty acids. Metabolites 13(6):690. doi:10.3390/metabo13060690 PMID:37367848 PMCID:PMC10304617
Sun S, Ding Z, Gao L, Hammock BD, Huang X, Xu ZP, Wang X, Cheng Q, Mo F, Shi W, Xie S, Liu A, Li H, Yang X, Lu X. 2023. A dendritic/tumor fusion cell vaccine enhances efficacy of nanobody-based CAR-T cells against solid tumor. Thno 13(14):5099-5113. doi:10.7150/thno.84946 PMID:37771772 PMCID:PMC10526666
Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad MJ, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. 2023. Chronic diclofenac exposure increases mitochondrial oxidative stress, inflammatory mediators, and cardiac dysfunction. Cardiovasc Drugs Ther 37(1):25-37. doi:10.1007/s10557-021-07253-4 PMID:34499283 PMCID:PMC8904649
Vazquez J, Ginex T, Herrero A, Morisseau C, Hammock BD, Luque FJ. 2023. Screening and biological evaluation of soluble epoxide hydrolase inhibitors: Assessing the role of hydrophobicity in the pharmacophore-guided search of novel hits. J Chem Inf Model 63(10):3209-3225. doi:10.1021/acs.jcim.3c00301 PMID:37141492 PMCID:PMC10207366
Wang W, Wagner KM, Wagner YM, Singh N, Yang J, He Q, Morisseau C, Hammock BD. 2023. Soluble epoxide hydrolase contributes to cell senescence and ER stress in aging mice colon. Int J Mol Sci 24(5):4570. doi:10.3390/ijms24054570 PMID:36901999 PMCID:PMC1000356
Wang W, Wang Y, Wagner KM, Lee RD, Hwang SH, Morisseau C, Wulff H, Hammock BD. 2023. Aflatoxin B1 increases soluble epoxied hydrolase in the brain and induces neuroinflammation and dopaminergic neurotoxicity. Int J Mol Sci 24(12):9938. doi:10.3390/ijms24129938 PMID:37373086 PMCID:PMC10298596
Wang W, Wang Y, Yang J, Wagner KM, Hwang SH, Cheng J, Singh N, Edwards PC, Morisseau C, Zhang G, Panigrahy D, Hammock BD. 2023. Aflatoxin B1 exposure disrupts the intestinal immune function via a soluble epoxide hydrolase-mediated manner. Ecotoxicol Environ Saf 249:114417. doi:10.1016/j.ecoenv.2022.114417 PMID:36525946 PMCID:PMC9879385
Wang Y, Abd El-Aty AM, Wang S, Cui X, Zhao J, Lei X, Xu L, She Y, Jin F, Eun J, Shim J, Wang J, Jin M, Hammock BD. 2023. Competitive fluorescent immunosensor based on catalytic hairpin self-assembly for multiresidue detection of organophosphate pesticides in agricultural products. Food Chem 413:135607. doi:10.1016/j.foodchem.2023.135607 PMID:36773354 PMCID:PMC10013200
Wang Y, Liu P, Ye Y, Hammock BD, Zhang C. 2023. An integrated approach to improve the assay performance of quantum dot-based lateral flow immunoassays by using silver deposition. Microchemical Journal 192:108932. doi:10.1016/j.microc.2023.108932
Wang Y, Morisseau C, Takamura A, Wan D, Li D, Sidoli S, Yang J, Wolan DW, Hammock BD, Kitamura S. 2023. PROTAC-mediated selective degradation of cytosolic soluble epoxide hydrolase enhances ER stress reduction. ACS Chem Biol doi:10.1021/acschembio.3c00017 PMID:36947831
Wu S, Tian J, Xue X, Ma F, Morisseau C, Hammock BD, Xu T. 2023. Biosynthesis of magnetosome-nanobody complex in Magnetospirillum gryphiswaldense MSR-1 and a magnetosome-nanobody-based enzyme-linked immunosorbent assay for the detection of tetrabromobisphenol A in water. Anal Bioanal Chem doi:10.1007/s00216-023-05005-x PMID:37934249
Xu L, Abd El-Aty AM, Cao Z, Lei X, Zhao J, Li J, Gao S, Zhao Y, She Y, Jin F, Wang J, Jin M, Hammock BD. 2023. Generating monoclonal antibodies against buprofezin and developing immunoassays for its residue detection in tea samples. J Agric Food Chem 71(41):14967-14978. doi:10.1021/acs.jafc.3c03263 PMID:37803933
Yang H, Qi M, He Q, Hwang SH, Yang J, McCoy MR, Morisseau C, Zhao S, Hammock BD. 2023. Quantification of soluble epoxide hydrolase inhibitors in experimental and clinical samples using the nanobody-based ELISA. J Pharm Anal 13(9):1013-1023. doi:10.1016/j.jpha.2023.05.006 PMID:37842656 PMCID:10568103
Yang H, Vasylieva N, Wang J, Li Z, Duan W, Chen S, Wen K, Meng H, Yu X, Shen J, Hammock BD, Wang Z. 2023. Precise isolation and structural origin of an ultra-specific nanobody against chemical compound. J Hazard Mater 458:131958. doi:10.1016/j.jhazmat.2023.131958 PMID:37429192
Yang JC, Xu P, Ning S, Wasielewski LJ, Adomat H, Hwang SH, Morisseau C, Gleave M, Corey E, Gao AC, Lara Jr PN, Evans CP, Hammock BD, Liu C. 2023. Novel inhibition of AKR1C3 and androgen receptor axis by PTUPB synergizes enzalutamide treatment in advanced prostate cancer. Oncogene doi:10.1038/s41388-022-02566-6 PMID:36596844 PMCID:PMC9975039
Yin Z, He Q, Yang H, Morisseau C, El-Sheikh EA, Li D, Hammock BD. 2023. Development of a sandwich ELISA for the specific quantitation of hemagglutinin (HA)-tagged proteins during their inducible expression in Escherichia coli. Anal Bioanal Chem doi:10.1007/s00216-023-04846-w PMID:37505234
Zhang J, Luan Z, Huo X, Zhang M, Morisseau C, Sun C, Hammock BD, Ma X. 2023. Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury. Int J Biol Sci 19(1):294-310. doi:10.7150/ijbs.78097 PMID:36594097 PMCID:PMC9760444
Zhang J, Zhang M, Huo X, Ning J, Yu Z, Morisseau C, Sun C, Hammock BD, Ma X. 2023. Macrophage inactivation by small molecule wedelolactone via targeting sEH for the treatment of LPS-induced acute lung injury. ACS Cent Sci 9(3):440-456. doi:10.1021/acscentsci.2c01424
Zhang J, Zhang W, Morisseau C, Zhang M, Dong H, Zhu Q, Huo X, Sun C, Hammock BD, Ma X. 2023. Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase attenuated particulate matter 2.5 exposure mediated lung injury. J Hazard Mater 458:131890. doi:10.1016/j.jhazmat.2023.131890 PMID:37406527

2022

Abdalla HB, Alvarez C, Wu Y, Rojas P, Hammock BD, Maddipati KR, Trindade-da-Sillva CA, Soares MQ, Clemente-Napimoga JT, Kantarci A, Napimoga M, Van Dyke TE. 2022. Soluble epoxide hydrolase inhibition enhances production of specialized pro-resolving lipid mediator and promotes macrophage plasticity. Br J Pharmacol 16009. doi:10.1111/bph.16009 PMID:36508312
Abdalla HB, Napimoga M, Teixeira JM, Trindade da Silva CA, Pieroni VL, Araujo FS, Hammock BD, Clemente-Napimoga JT. 2022. Soluble epoxide hydrolase inhibition avoid formalin-induced inflammatory hyperalgesia in the temporomandibular joint. Inflammopharmacology doi:10.1007/s10787-022-00965-5 PMID:35303234
Bergmann CB, McReynolds C, Wan D, Singh N, Goetzman H, Caldwell CC, Supp DM, Hammock BD. 2022. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury. Proc Natl Acad Sci U S A 119:doi:10.1073/pnas.2120691119 PMID:35312372 PMCID:PMC9060469
Chen Z, Wu H, Shen Y, Wang H, Zhang Y, Hammock BD, Li Z, Luo L, Lei H, Xu Z. 2022. Phosphate-triggered ratiometric fluoroimmunoassay based on nanobody-alkaline phosphatase fusion for sensitive detection of 1-naphthol for the exposure assessment of pesticide carbaryl. J Hazard Mater 424:doi:10.1016/j.jhazmat.2021.127411 PMID:34629198
Chen Z, Zhang Y, Chen J, Lin Z, Wu M, Shen Y, Luo L, Wang H, Wen X, Hammock BD, Lei H, Xu Z. 2022. Production and characterization of biotinylated anti-fenitrothion nanobodies and development of sensitive fluoroimmunoassay. J Agric Food Chem 4102-4111. doi:10.1021/acs.jafc.2c00826 PMID:35333506
Codony S, Entrena JM, Calvo-Tusell C, Jora B, Gonzalez-Cano R, Osuna S, Corpas R, Morisseau C, Perez B, Barniol-Xicota M, Grinan-Ferre C, Perez C, Rodriguez-Franco M, Martinez AL, Loza MI, Pallas M, Verhelst SH, Sanfeliu C, Feixas F, Hammock BD, Brea J, Cobos EJ, Vasquez S. 2022. Synthesis, in vitro profiling, and in vivo evaluation of benzohomoadamantane-based ureas for visceral pain: a new indication for soluble epoxide hydrolase inhibitors. J Med Chem 65(20):13660-13680. doi:10.1021/acs.jmedchem.2c00515 PMID:36222708 PMCID:PMC9620236
Codony S, Pont C, Grinan-Ferre C, Pede-Mattatelli AD, Calvo-Tusell C, Feixas F, Osuna S, Jarne-Ferrer J, Naldi M, Bartolini M, Loza MI, Brea J, Perez B, Bartra C, Sanfeliu C, Juarez-Jimenez J, Morisseau C, Hammock BD, Pallas M, Vasquez S, Munoz-Torrero D. 2022. Discovery and in vivo proof of concept of a highly potent dual inhibitor of soluble epoxide hydrolase and acetylcholinesterase for the treatment of Alzheimers disease. J Med Chem 65(6):4909-4925. doi:10.1021/acs.jmedchem.1c02150 PMID:35271276 PMCID:PMC8958510
Ding Y, Cui P, Chen H, Li J, Huang L, Gonzalez-Sapienza GG, Hammock BD, Wang M, Hua X. 2022. Ready-to-use immunosensor for the detection of small molecules with fast readout. Biosens Bioelectron 209:doi:10.1016/j.bios.2022.113968 PMID:35007993
Du F, Cao R, Chen L, Sun J, Shi Y, Fu Y, Hammock BD, Zheng Z, Liu Z, Chen G. 2022. Structure-guided discovery of potent and oral soluble epoxide hydrolase inhibitors for the treatment of neuropathic pain. Acta Pharm Sin B 12:1377-1389. doi:10.1016/j.apsb.2021.09.018 PMID:35530144 PMCID:PMC9072249
Escolano C, Bagan A, Turcu AL, Morisseau C, Loza MI, Brea J, Bartra C, Sanfeliu C, Hammock BD, Vazquez S. 2022. A new family of subnanomolar inhibitors of soluble epoxide hydrolase. FASEB J 36(S1):doi:10.1096/fasebj.2022.36.S1.R2281
Gowler PR, Turnbull J, Shahtaheri M, Gohir S, Kelly T, McReynolds C, Yang J, Jha RR, Fernandes GS, Zhang W, Doherty M, Walsh DA, Hammock BD, Valdes AM, Barrett DA, Chapman V. 2022. Clinical and preclinical evidence for roles of soluble epoxide hydrolase in osteoarthritis knee pain. Arthritis Rheumatol 74(4):doi:10.1002/art.42000 PMID:34672113 PMCID:PMC8957539
He Q, Yang L, Lin M, Yang H, Cui X, McCoy MR, Hammock BD, Fang Y, Zhao S. 2022. Generation of bioluminescent enzyme immunoassay for ferritin by single-chain variable fragment and its NanoLuc luciferase fusion. Anal Bioanal Chem doi:10.1007/s00216-022-04261-7 PMID:35945290
Mao X, Wang Y, Jiang L, Zhang H, Zhao Y, Liu P, Liu J, Hammock BD, Zhang C. 2022. A polydopamine-coated gold nanoparticles quenching quantum dots-based dual-readout lateral flow immunoassay for sensitive detection of carbendazim in agriproducts. Biosensors 12(2):doi:10.3390/bios12020083 PMID:35200343 PMCID:PMC8869244
Matsumoto N, Singh N, Lee KS, Barnych B, Morisseau C, Hammock BD. 2022. The epoxy fatty acid pathway enhances cAMP in mammalian cells through multiple mechanisms. Prostaglandins Other Lipid Mediat 162:doi:10.1016/j.prostaglandins.2022.106662 PMID:35779854
Montecillo-Aguado M, Tirado-Rodriguez B, Antonio-Andres G, Morales-Martinez M, Tong Z, Yang J, Hammock BD, Hernandez-Pando R, Huerta-Yepez S. 2022. Omega-6 polyunsaturated fatty acids enhance tumor aggressiveness in experimental lung cancer model: Important role of oxylipins. Int J Mol Sci doi:10.3390/ijms23116179 PMID:35682855 PMCID:PMC9181584
Naeem Z, Zukunft S, Gunther S, Liebner S, Weigert A, Hammock BD, Fromel T, Fleming I. 2022. Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth. Pflugers Arch doi:10.1007/s00424-022-02709-4 PMID:35648219
Nguyen N, Morisseau C, Li D, Yang J, Lam E, Woodside DB, Hammock BD, Shih P. 2022. Soluble epoxide hydrolase is associated with postprandial anxiety decrease in healthy adult women. Int J Mol Sci 23(19):11798. doi:10.3390/ijms231911798 PMID:36233100 PMCID:PMC9569757
Pang Q, Chen Y, Mukhtar H, Xiong J, Wang X, Xu T, Hammock BD, Wang J. 2022. Camelization of a murine single-domain antibody against aflatoxin B1 and its antigen-binding analysis. Mycotoxin Res 38:51-60. doi:10.1007/s12550-021-00433-z PMID:35023020 PMCID:PMC8754551
Salvador J, Vasylieva N, Gonzalez-Garcia I, Jin M, Caster RW, Siegel JB, Hammock BD. 2022. Nanobody-based lateral flow immunoassay for the rapid detection of aflatoxin B1 in almond milk. ACS Food Sci Technol 2(8):1276-1282. doi:10.1021/acsfoodscitech.2c00118
Singh N, Li D, McReynolds C, Morisseau C, Hammock BD. 2022. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer. Analytical Methods doi:10.1039/d2ay00272h PMID:35481804 PMCID:PMC9116231
Song J, He K, Xing B, Pei Y, Wang D, Wang Y, Li S, Li J, Huan W, Zhang Y, Hammock BD. 2022. Rapid measurement of residual kanamycin using highly specific biomimetic recognition paper-based chip. Anal Chem 94(50):17567-17576. doi:10.1021/acs.analchem.2c03932 PMID:36458677
Song M, Wu Q, Liu B, Li P, Jiang L, Wang Y, Dong S, Xiong Y, Hammock BD, Zhang C. 2022. Using a quantum dot bead-based lateral flow immunoassay to broadly detect the adulteration of PDE-5 inhibitors in functional foods. Analytical Methods 10:doi:10.1039/d2ay00580h PMID:35723455
Sun C, Zhou J, Yu Z, Huo X, Zhang J, Morisseau C, Hammock BD, Ma X. 2022. Kurarinone alleviated Parkinsons disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc Natl Acad Sci U S A 119:doi:10.1073/pnas.2118818119 PMID:35217618 PMCID:PMC8892522
Wan D, Morisseau C, Hammock BD, Yang J. 2022. A fast and selective approach for profiling vicinal diols using liquid chromatography-post column derivatization-double precursor ion scanning mass spectrometry. Molecules 27(1):283. doi:10.3390/molecules27010283 PMID:35011515 PMCID:PMC8747065
Wang F, Yang Y, Wan D, Li J, Liang Y, Li Z, Shen Y, Xu Z, Yang J, Wang H, Gettemans J, Hammock BD, Sun Y. 2022. Nanobodies for accurate recognition of iso-tenuazonic acid and development of sensitive immunoassay for contaminant detection in foods. Food Control 136:doi:10.1016/j.foodcont.2022.108835
Wang Y, Abd El-Aty AM, Chen G, Jia H, Cui X, Xu L, Cao Z, She Y, Jin F, Zhang Y, Hacimuftuoglu A, Lamu S, Wang J, Zheng L, Jin M, Hammock BD. 2022. A competitive immunoassay for detecting triazophos based on fluorescent catalytic hairpin self-assembly. Microchimica Acta 189:doi:10.1007/s00604-022-05217-5 PMID:35190860
Xu J, Qiu X, Yu G, Ly M, Yang J, Silva RM, Zhang X, Yu M, Wang Y, Hammock BD, Pinkerton KE, Zhao D. 2022. Soluble epoxide hydrolase inhibitor can protect the femoral head against tobacco smoke exposure-induced osteonecrosis in spontaneously hypertensive rats. Toxicology 465(15):doi:10.1016/j.tox.2021.153045 PMID:34801612
Xu L, Abd El-Aty AM, Eun J, Shim J, Zhao J, Lei X, Gao S, She Y, Jin F, Wang J, Jin M, Hammock BD. 2022. Recent advances in rapid detection techniques for pesticide residue: a review. J Agric Food Chem 70(41):13093-13117. doi:10.1021/acs.jafc.2c05284 PMID:36210513
Xu L, Abd El-Aty AM, Shim J, Eun J, Lei X, Zhao J, Zhang X, Cui X, She Y, Jin F, Zheng L, Wang J, Jin M, Hammock BD. 2022. Design and characterization of a novel hapten and preparation of monoclonal antibody for detecting atrazine. Foods 11(12):doi:10.3390/foods11121726 PMID:35741925 PMCID:PMC9223028
Xu L, Abd El-Aty AM, Zhao J, Lei X, Zhang X, Zhao Y, Cui X, She Y, Jin F, Wang J, Jin M, Hammock BD. 2022. Obtaining a monoclonal antibody against a novel prometryn-like hapten and characterization of its selectivity for triazine herbicides. Biosensors 13(1):22. doi:10.3390/bios13010022 PMID:36671858 PMCID:PMC9855386
Xu L, Zhang X, Abd El-Aty AM, Wang Y, Cao Z, Jia H, Salvador J, Hacimuftuoglu A, Cui X, Zhang Y, Wang K, She Y, Jin F, Zheng L, Pujia B, Wang J, Jin M, Hammock BD. 2022. A highly sensitive bio-barcode immunoassay for multi-residue detection of organophosphate pesticides based on fluorescence anti-quenching. J Pharm Anal 12(4):637-644. doi:10.1016/j.jpha.2022.05.004 PMID:36105157 PMCID:PMC9463527
Zhang C, Li W, Li X, Wan D, Mack S, Zhang J, Wagner KM, Wang C, Tan B, Chen J, Wu C, Tsuji K, Takeuchi M, Chen Z, Hammock BD, Pinkerton KE, Yang J. 2022. Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor. PLoS One 17(4):doi:10.1371/journal.pone.0266608 PMID:35443010 PMCID:PMC9020733
Zhou H, He C, Li Z, Huo J, Xue Y, Xu X, Qi M, Chen L, Hammock BD, Zhang J. 2022. Development of a rapid gold nanoparticle immunochromatographic strip based on the nanobody for detecting 2,4-dichlorophenoxyacetic acid. Biosensors 12(2):doi:10.3390/bios12020084 PMID:35200344 PMCID:PMC8869386

2021

Bergmann CB, Hammock BD, Wan D, Gogolla F, Goetzman H, Caldwell CC, Supp DM. 2021. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Sci Rep 11(1):16555. doi:10.1038/s41598-021-96014-2 PMID:34400718 PMCID:PMC8368302
Buchholz BA, Ahn K, Huang H, Gee SJ, Stewart BJ, Ognibene T, Hammock BD. 2021. Pharmacokinetics, metabolite measurement, and biomarker identification of dermal exposure to permethrin using accelerator mass spectrometry. Toxicol Sci 183:49-59. doi:10.1093/toxsci/kfab082 PMID:34460930 PMCID:PMC8404990
Chen G, Liu G, Jia H, Cui X, Wang Y, Li D, Zheng W, She Y, Xu D, Huang X, Abd El-Aty AM, Sun J, Liu H, Zou Y, Wang J, Jin M, Hammock BD. 2021. A sensitive bio-barcode immunoassay based on bimetallic Au@Pt nanozyme for detection of organophosphate pesticides in various agro-products. Food Chem 362:130118. doi:10.1016/j.foodchem.2021.130118 PMID:34082296
Codony S, Calvo-Tusell C, Valverde E, Osuna S, Morisseau C, Loza MI, Brea J, Perez C, Rodriguez-Franco M, Pizarro-Delgado J, Corpas R, Grinan-Ferre C, Pallas M, Sanfeliu C, Vazquez-Carrera M, Hammock BD, Feixas F, Vazquez S. 2021. From the design to the in vivo evaluation of benzohomoadamantane-derived soluble epoxide hydrolase inhibitors for the treatment of acute pancreatitis. J Med Chem 64:doi:10.1021/acs.jmedchem.0c01601 PMID:33945278
Cui X, Abd El-Aty AM, Liu H, Jia H, Wang Y, Cao Z, Salvador J, She Y, Jin F, Wang J, Jin M, Hammock BD, Zhang C, Xu L. 2021. Enhanced bio-barcode immunoassay using droplet digital PCR for multiplex detection of organophosphate pesticides. J Agric Food Chem 69(37):PMID:34494438
Deng J, Yang H, Haak VM, Yang J, Kipper FC, Barksdale C, Hwang SH, Gartung A, Bielenberg DR, Subbian S, Ho K, Ye X, Fan D, Sun Y, Hammock BD, Panigrahy D. 2021. Eicosanoid regulation of debris-stimulated metastasis. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2107771118 PMID:34607951 PMCID:PMC8521662
Dong J, Li Z, Wang Y, Jin M, Shen Y, Xu Z, El-Aty AA, Gee SJ, Hammock BD, Sun Y, Wang H. 2021. Generation of functional single-chain fragment variable from hybridoma and development of chemiluminescence enzyme immunoassay for determination of total malachite green in tilapia fish. Food Chem 337:127780. doi:10.1016/j.foodchem.2020.127780 PMID:32799164 PMCID:PMC7541715 (ahead of print)
Du F, Sun W, Morisseau C, Hammock BD, Bao X, Liu Q, Wang C, Zhang T, Yang H, Zhou J, Xiao W, Zhongbo L, Chen G. 2021. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis. Eur J Med Chem 223(14):PMID:34218083
Fishbein A, Hammock BD, Serhan CN, Panigrahy D. 2021. Carcinogenesis: failure of resolution of inflammation?. Pharmacol Ther 218:107670. doi:10.1016/j.pharmthera.2020.107670 PMID:32891711 PMCID:PMC7470770
Fu H, Chen Z, Wang H, Luo L, Wang Y, Huang R, Xu Z, Hammock BD. 2021. Development of a sensitive non-competitive immunoassay via immunocomplex binding peptide for the determination of ethyl carbamate in wine samples. J Hazard Mater 406:124288. doi:10.1016/j.jhazmat.2020.124288 PMID:33525128
Hashimoto K, Hammock BD. 2021. Reply to Reeves and Dunn: Risk for autism in offspring after maternal glyphosate exposure. Proc Natl Acad Sci U S A 118:doi:10.1073/pnas.2016496118 PMID:33443192 PMCID:PMC7812790
Jamieson KL, Darwesh AM, Sosnowski DK, Zhang H, Shah S, Zhabyeyev P, Yang J, Hammock BD, Edin ML, Zeldin DC, Oudit GY, Kassiri Z, Seubert JM. 2021. Soluble epoxide hydrolase in aged female mice and human explanted hearts following ischemic injury. Int J Mol Sci 22:doi:10.3390/ijms22041691 PMID:33567578
Jankiewicz WK, Barnett SD, Stavniichuk A, Hwang SH, Hammock BD, Belayet JB, Khan AH, Imig JD. 2021. Dual sEH/COX-2 inhibition using PTUPB - a promising approach to antiangiogensis-induced nephrotoxicity. Front Pharmacol 12:doi:10.3389/fphar.2021.744776 PMID:34955823 PMCID:PMC8695932
Jonnalagadda D, Wan D, Chun J, Hammock BD, Kihara Y. 2021. A soluble epoxide hydrolase inhibitor, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, ameliorates experimental autoimmune encephalomyelitis. Int J Mol Sci 22(9):4650. doi:10.3390/ijms22094650 PMID:33925035
Koike S, Hsu M, Bettaieb A, Chu B, Matsumoto N, Morisseau C, Havel PJ, Huising MO, Hammock BD, Haj FG. 2021. Genetic deficiency or pharmacological inhibition of soluble epoxide hydrolase ameliorates high fat diet-induced pancreatic beta-cell dysfunction and loss. Free Radic Biol Med 172:48-57. doi:10.1016/j.freeradbiomed.2021.05.029 PMID:34038767
Martin-Lopez J, Codony S, Bartra C, Morisseau C, Loza MI, Sanfeliu C, Hammock BD, Brea J, Vazquez S. 2021. 2-(Piperidin-4-yl)acetamides as potent inhibitors of soluble epoxide hydrolase with anti-inflammatory activity. Pharmaceuticals 14(12):doi:10.3390/ph14121323 PMID:34959721 PMCID:PMC8703317
Mavangira V, Kuhn MJ, Abuelo A, Morisseau C, Hammock BD, Sordillo L. 2021. Activity of sEH and oxidant status during systemic bovine coliform mastitis. Antioxidants (Basel) doi:10.3390/antiox10050812 PMID:34065244 PMCID:PMC8161397
McReynolds C, Cortes-Puch I, Hammock BD, Shih P, Hammock BG, Yang J, Khan IH, Ravindran R. 2021. Plasma linoleate diols are potential biomarkers for severe COVID-19 infections. Front Physiol doi:10.3389/fphys.2021.663869 PMID:33868029 PMCID:PMC8047414
McReynolds C, Yang J, Guedes AP, Morisseau C, Garcia R, Knych H, Tearney C, Hamamoto B, Hwang SH, Wagner KM, Hammock BD. 2021. Species differences in metabolism of soluble epoxide hydrolase inhibitor, EC1728, highlight the importance of clinically relevant screening mechanisms in drug development. Molecules 26(16):5034. doi:10.3390/molecules26165034 PMID:34443621 PMCID:PMC8399023
Mello A, Hsu M, Koike S, Chu B, Cheng J, Yang J, Morisseau C, Torok NJ, Hammock BD, Haj FG. 2021. Soluble epoxide hydrolase hepatic deficiency ameliorates alcohol-associated liver disease. Cell Mol Gastroenterol Hepatol 11:815-830. doi:10.1016/j.jcmgh.2020.10.002 PMID:33068774 PMCID:PMC7851189
Mo F, Duan S, Jiang X, Yang X, Hou X, Shi W, Carlos CJ, Liu A, Yin S, Wang W, Yao H, Yu Z, Tang Z, Xie S, Ding Z, Zhao X, Hammock BD, Lu X. 2021. Nanobody-based chimeric antigen receptor T cells designed by CRISPR/Cas9 technology for solid tumor immunotherapy. Signal Transduct Target Ther 6:80. doi:10.1038/s41392-021-00462-1 PMID:33627635 PMCID:PMC7904846
Morisseau C, Kodani SD, Kamita SG, Yang J, Lee KS, Hammock BD. 2021. Relative importance of soluble and microsomal epoxide hydrolases for the hydrolysis of epoxy-fatty acids in human tissues. Int J Mol Sci 22:doi:10.3390/ijms22094993 PMID:34066758 PMCID:PMC8125816
Pu Y, Ma L, Shan J, Wan X, Hammock BD, Hashimoto K. 2021. Autism-like behaviors in male juvenile offspring after maternal glyphosate exposure. Clin Psychopharmacol Neurosci 19:554-558. doi:10.9758/cpn.2021.19.3.554 PMID:34294625
Ravindran R, McReynolds C, Yang J, Hammock BD, Ikram A, Ali A, Bashir A, Zohra T, Chang W, Hartigan-O'Connor DJ, Rashidi HH, Khan IH. 2021. Immune response dynamics in COVID-19 patients to SARS-CoV-2 and other human coronaviruses. PLoS One 16:e0254367. doi:10.1371/journal.pone.0254367 PMID:34242356
Rudant J, Marisseau C, Chung W, Zammouri J, Auclair M, Baujat G, Caupel E, Moulin C, Wang Y, Yang J, Hammock BD, Cerame B, Phan F, Feve B, Vigouroux C, Andreelli F, Jeru I. 2021. EPHX1 mutations cause a lipoatrophic diabetes syndrome due to impaired epoxide hydrolysis and increased cellular senescence. Elife 10:doi:10.7554/eLife.68445 PMID:34342583 PMCID:PMC8331186
Singh N, Barnych B, Wagner KM, Wan D, Morisseau C, Hammock BD. 2021. Adrenic acid-derived epoxy fatty acids are naturally occurring lipids and their methyl ester prodrug reduces endoplasmic reticulum stress and inflammatory pain. ACS Omega 6:7165-7174. doi:10.1021/acsomega.1c00241 PMID:33748630 PMCID:PMC7970556
Singh N, Vik A, Lybrand DB, Morisseau C, Hammock BD. 2021. New alkoxy- analogues of expoxyeicosatrienoic acids attenuate cisplatin nephrotoxicity in vitro via reduction of mitochondrial dysfunction, oxidative stress, mitogen-activated protein kinase signaling, and caspase activation. Chem Res Toxicol 34:2579-2591. doi:10.1021/acs.chemrestox.1c00347 PMID:34817988
Su B, Zhang Z, Sun Z, Tang Z, Xie X, Chen Q, Cao H, Yu X, Xu Y, Liu X, Hammock BD. 2021. Fluonanobody-based nanosensor via fluorescence resonance energy transfer for ultrasensitive detection of ochratoxin A. J Hazard Mater 422:PMID:34411960
Sun C, Zhang X, Morisseau C, Hee-Hwang S, Zhang Z, Hammock BD, Ma X. 2021. Discovery of soluble epoxide hydrolase inhibitors from chemical synthesis and natural products. J Med Chem 64:184-215. doi:10.1021/acs.jmedchem.0c01507 PMID:33369424 PMCID:PMC7942193
Sun C, Zhang X, Zhou J, Huo X, Yu Z, Morisseau C, Hammock BD, Ma X. 2021. Inhibition of sEH via stabilizing the level of EETs alleviated Alzheimer's disease through GSK3 beta signaling pathway. Food Chem Toxicol 156:PMID:34411643
Tiwari S, Yang J, Morisseau C, Durbin-Johnson BP, Hammock BD, Gomes AV. 2021. Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Sci Rep 11:7042. doi:10.1038/s41598-021-86284-1 PMID:33782432 PMCID:PMC8007717
Wagner KM, Yang J, Morisseau C, Hammock BD. 2021. Soluble epoxide hydrolase deletion limits high-fat diet-induced inflammation. Front Pharmacol 12:778470. doi:10.3389/fphar.2021.778470 PMID:34975481 PMCID:PMC8719166
Wang F, Li Z, Wan D, Vasylieva N, Shen Y, Xu Z, Yang J, Gettemans J, Wang H, Hammock BD, Sun Y. 2021. Enhanced non-toxic immunodetection of Alternaria mycotoxin tenuazonic acid based on ferritin-displayed anti-idiotypic nanobody-nanoluciferase multimers. J Agric Food Chem 69:4911-4917. doi:10.1021/acs.jafc.1c01128 PMID:33870684
Wang F, Wan D, Shen Y, Tian Y, Xiao Z, Xu Z, Yang J, Sun Y, Hammock BD, Wang H. 2021. Development of a chemiluminescence immunoassay for detection of tenuazonic acid mycotoxin in fruit juices with a specific camel polyclonal antibody dagger. Analytical Methods 8:doi:10.1039/d1ay00200g PMID:33885655
Wang S, Ishima T, Qu Y, Shan J, Chang L, Wei Y, Zhang J, Pu Y, Fujita Y, Tan Y, Wang X, Ma L, Wan X, Hammock BD, Hashimoto K. 2021. Ingestion of Faecalibaculum rodentium causes depression-like phenotypes in resilient Ephx2 knock-out mice: A role of brain-gut-microbiota axis via the subdiaphragmatic vagus nerve. J Affect Disord 292:565-573. doi:10.1016/j.jad.2021.06.006 PMID:34147969 PMCID:PMC8282729
Wang Y, Du P, Abd El-Aty AM, Chen G, Jia H, Cui X, Oz E, Zhang X, Zhang Y, Qin G, Yan F, Wang J, Jin M, Hammock BD. 2021. A visual bio-barcode immunoassay for sensitive detection of triazophos based on biochip silver staining signal amplification. Food Chem 347:129024. doi:10.1016/j.foodchem.2021.129024 PMID:33461115
Wang Y, Wagner KM, Morisseau C, Hammock BD. 2021. Inhibition of the soluble epoxide hydrolase as an analgesic strategy: A review of preclinical evidence. J Pain Res 14:61-72. doi:10.2147/JPR.S241893 PMID:33488116 PMCID:PMC7814236
Wilt S, Kodani SD, Valencia L, Hudson PK, Sanchez S, Quintana T, Morisseau C, Hammock BD, Kandasamy R, Pecic S. 2021. Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. Bioorg Med Chem 51:116507. doi:10.1016/j.bmc.2021.116507 PMID:34794001
Xu B, Wang K, Vasylieva N, Zhou H, Xue X, Wang B, Li QX, Hammock BD, Xu T. 2021. Development of a nanobody-based ELISA for the detection of the insecticides cyantraniliprole and chlorantraniliprole in soil and the vegetable bok choy. Anal Bioanal Chem 413(9):2503-2511. doi:10.1007/s00216-021-03205-x PMID:33580830
Yang Y, Xu X, Wu H, Yang J, Chen J, Morisseau C, Hammock BD, Bettaieb A, Zhao L. 2021. Differential effects of 17,18-EEQ and 19,20-EDP combined with soluble epoxide hydrolase inhibitor t-TUCB on diet-induced obesity in mice. Int J Mol Sci 22(15):8267. doi:10.3390/ijms22158267 PMID:34361032 PMCID:PMC8347952
Yu S, Li Z, Li J, Zhao S, Wu S, Liu H, Bi X, Li D, Dong J, Duan S, Hammock BD. 2021. Generation of dual functional nanobody-nanoluciferase fusion and its potential in bioluminescence enzyme immunoassay for trace glypican-3 in serum. Sens Actuators B Chem 336:doi:10.1016/j.snb.2021.129717
Zhang C, Wu X, Li D, Hu J, Wan D, Zhang Z, Hammock BD. 2021. Development of nanobody-based flow-through dot ELISA and lateral-flow immunoassay for rapid detection of 3-phenoxybenzoic acid. Analytical Methods doi:10.1039/d1ay00129a PMID:33861243
Zhao Y, Ruan X, Song Y, Smith JN, Vasylieva N, Hammock BD, Lin Y, Du D. 2021. Smartphone-based dual-channel immunochromatographic test strip with polymer quantum dot labels for simultaneous detection of cypermethrin and 3-phenoxybenzoic acid. Anal Chem 93:PMID:34591463
Zhao Y, Wang M, Zhang M, Yang X, Li Z, Vasylieva N, Tan G, Wang B, Hammock BD. 2021. Development of a direct competitive enzyme-linked immunosorbent assay for quantitation of sodium saccharin residue in food. J Food Sci 10:doi:10.1111/1750-3841.15767 PMID:34309034

2020

An G, Lee K, Yang J, Hammock BD. 2020. Target-Mediated Drug Disposition-A Class Effect of Soluble Epoxide Hydrolase Inhibitors. J Clin Pharmacol doi:10.1002/jcph.1763 PMID:33078430 PMCID:PMC7969377
Atone J, Wagner KM, Hashimoto K, Hammock BD. 2020. Cytochrome P450 derived epoxidized fatty acids as a therapeutic tool against neuroinflammatory diseases. Prostaglandins Other Lipid Mediat 147:13. doi:10.1016/j.prostaglandins.2019.106385 PMID:31698143 PMCID:PMC7067627
Barnych B, Singh N, Negrel S, Zhang Y, Magis D, Roux C, Hua X, Ding Z, Morisseau C, Tantillo DJ, Siegel JB, Hammock BD. 2020. Development of potent inhibitors of the human microsomal epoxide hydrolase. Eur J Med Chem 193:doi:10.1016/j.ejmech.2020.112206 PMID:32203787
Brighty GJ, Botham RC, Li S, Nelson L, Mortenson DE, Li G, Morisseau C, Wang H, Hammock BD, Sharpless KB, Kelly JW. 2020. Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery. Nat Chem 12:doi:10.1038/s41557-020-0530-4 PMID:32868886 PMCID:PMC7541551
Bukhari IA, Alorainey BI, Al-Motrefi AA, Mahmoud A, Campbell WB, Hammock BD. 2020. 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor, lowers L-NAME-induced hypertension through suppression of angiotensin-converting enzyme in rats. Eur Rev Med Pharmacol Sci 24:8143-8150. doi:10.26355/eurrev_202008_22501 PMID:32767352 PMCID:PMC7990106
Burmistrov V, Morisseau C, DYachenko V, Karlov D, Butov GM, Hammock BD. 2020. Imidazolidine-2,4,5-and pirimidine-2,4,6-triones - New primary pharmacophore for soluble epoxide hydrolase inhibitors with enhanced water solubility. Bioorg Med Chem Lett 30(3):126908. doi:10.1016/j.bmcl.2019.126908 PMID:31870649 PMCID:PMC6957307
Burmistrov V, Morisseau C, Karlov D, Pitushkin D, Vernigora A, Rasskazova E, Butov GM, Hammock BD. 2020. Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 30:127430. doi:10.1016/j.bmcl.2020.127430 PMID:32736212 PMCID:PMC7494652
Chen Q, Sun D, Pei H, Su B, Bao K, Cao H, Zhang C, Hammock BD, Liu X. 2020. Development of a nanobody tagged with streptavidin-binding peptide and its application in a Luminex fluoroimmunoassay for alpha fetal protein in serum. RSC Adv 10:23767-23774. doi:10.1039/D0RA04210B
Chen Z, Liu X, Xiao Z, Fu H, Huang Y, Huang S, Shen Y, Fan H, Yang X, Hammock BD, Xu Z. 2020. Production of a specific monoclonal antibody for 1-naphthol based on novel hapten strategy and development of an easy-to-use ELISA in urine samples. Ecotoxicol Environ Saf 196:doi:10.1016/j.ecoenv.2020.110533 PMID:32247241
Codony S, Pujol E, Pizarro J, Feixas F, Valverde E, Loza I, Brea J, Saez E, Oyarzabal J, Pineda-Lucena A, Perez B, Perez C, Rodriguez-Franco M, Leiva R, Osuna S, Morisseau C, Hammock BD, Vasquez-Carrera M, Vazquez S. 2020. 2-Oxaadamant-1-yl Ureas as Soluble Epoxide Hydrolase Inhibitors: In Vivo Evaluation in a Murine Model of Acute Pancreatitis. J Med Chem 63:9237-9257. doi:10.1021/acs.jmedchem.0c00310 PMID:32787085 PMCID:PMC7755424
Dongyang L, Yonglian C, Morisseau C, Wagner KM, Cho Y, Hammock BD. 2020. Development of a Highly Sensitive Enzyme-Linked Immunosorbent Assay for Mouse Soluble Epoxide Hydrolase Detection by Combining a Polyclonal Capture Antibody with a Nanobody Tracer. Anal Chem doi:10.1021/acs.analchem.0c01511 PMID:32786492
Edin ML, Lih FB, Hammock BD, Thomson S, Zeldin DC, Bishop-Bailey D. 2020. Vascular lipidomic profiling of potential endogenous fatty acid PPAR ligands reveals the coronary artery as major producer of CYP450-derived epoxy fatty acids. Cells 9:15. doi:10.3390/cells9051096 PMID:32365470 PMCID:PMC7290345
El-Moghazy AY, Huo J, Amaly N, Vasylieva N, Hammock BD, Sun G. 2020. An innovative nanobody-based electrochemical immunosensor using decorated nylon nanofibers for point-of-care monitoring of human exposure to pyrethroid insecticides. ACS Appl Mater Interfaces 12:6159-6168. doi:10.1021/acsami.9b16193
Fishbein A, Wang W, Yang H, Yang J, Hallisey V, Deng J, Verheul S, Hwang SH, Gartung A, Wang Y, Bielenberg DR, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2020. Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression. Proc Natl Acad Sci U S A 117:21576-21587. doi:10.1073/pnas.2007412117 PMID:32801214 PMCID:PMC7474612
Fu H, Wang Y, Xiao Z, Wang H, Li Z, Shen Y, Lei H, Sun Y, Xu Z, Hammock BD. 2020. A rapid and simple fluorescence enzyme-linked immunosorbent assay for tetrabromobisphenol A in soil samples based on a bifunctional fusion protein. Ecotoxicol Environ Saf 188:109904. doi:10.1016/j.ecoenv.2019.109904
Grinan-Ferre C, Codony S, Pujol E, Yang J, Leiva R, Escolano C, Puigoriol-Illamola D, Companys-Alemany J, Corpas R, Sanfeliu C, Perez B, Loza MI, Brea J, Morisseau C, Hammock BD, Vazquez S, Pallas M, Galdeano C. 2020. Pharmacological inhibition of soluble epoxide hydrolase as a new therapy for Alzheimer's Disease. Neurotherapeutics doi:10.1007/s13311-020-00854-1 PMID:32488482
Hammock BD, Wang W, Gilligan MM, Panigrahy D. 2020. Eicosanoids The Overlooked Storm in Coronavirus Disease 2019 (COVID-19)?. Am J Pathol 190:1782-1788. doi:10.1016/j.ajpath.2020.06.010 PMID:32650004 PMCID:PMC7340586
He J, Ma S, Wu S, Xu J, Tian J, Li J, Gee SJ, Hammock BD, Li QX, Xu T. 2020. Construction of immunomagnetic particles with high stability in stringent conditions by site-directed immobilization of multivalent nanobodies onto bacterial magnetic particles for the environmental detection of tetrabromobisphenol-a. Anal Chem 92:1114-1121. doi:10.1021/acs.analchem.9b04177 PMID:31763820
Hildreth K, Kodani SD, Hammock BD, Zhao L. 2020. Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies. J Nutr Biochem 86:doi:10.1016/j.jnutbio.2020.108484 PMID:32827665 PMCID:PMC760679
Hongsibsong S, Prapamontol T, Xu T, Hammock BD, Wang H, Chen Z, Xu Z. 2020. Monitoring of the organophosphate pesticide chlorpyrifos in vegetable samples from local markets in northern Thailand by developed immunoassay. Int J Environ Res Public Health 17:doi:10.3390/ijerph17134723 PMID:32630084
Huerta-Yepez S, Tirado-Rodriguez A, Montecillo-Aguado M, Yang J, Hammock BD, Hankinson O. 2020. Aryl Hydrocarbon Receptor-Dependent inductions of omega-3 and omega-6 polyunsaturated fatty acid metabolism act inversely on tumor progression. Sci Rep 10:17. doi:10.1038/s41598-020-64146-6 PMID:32398692 PMCID:PMC7217871
Knuth M, Mahapatra D, Jima DD, Wan D, Hammock BD, Law M, Kullman SW. 2020. Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish. Sci Rep 10:doi:10.1038/s41598-020-72622-2 PMID:32994480 PMCID:PMC7524799
Kumar S, Vasylieva N, Singh V, Hammock BD, Singh SG. 2020. A facile, sensitive and rapid sensing platform based on CoZnO for detection of fipronil; an environmental toxin. Electroanalysis 10:doi:10.1002/elan.202000051
Lee KS, Ng JC, Yang J, Hwang SH, Morisseau C, Wagner KM, Hammock BD. 2020. Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain. Bioorg Med Chem 28:doi:10.1016/j.bmc.2020.115735 PMID:33007552
Li D, Morisseau C, McReynolds C, Duflot T, Bellien J, Nagra RM, Taha AY, Hammock BD. 2020. Development of improved double-nanobody sandwich ELISAs for human soluble epoxide hydrolase detection in peripheral blood mononuclear cells of diabetic patients and the prefrontal cortex of multiple sclerosis patients. Anal Chem 92:7334-7342. doi:10.1021/acs.analchem.0c01115 PMID:32253910 PMCID:PMC7744119
Li P, Yang C, Liu B, Wu Q, Wang Y, Dong S, Zhang H, Vasylieva N, Hammock BD, Zhang C. 2020. Sensitive immunochromatographic assay using highly luminescent quantum dot nanobeads as tracer for the detection of cyproheptadine hydrochloride in animal-derived food. Front Chem 8:575. doi:10.3389/fchem.2020.00575 PMID:32760698 PMCID:PMC7372008
Li Z, Dong J, Vasylieva N, Cui Y, Wan D, Hua X, Huo J, Yang D, Gee SJ, Hammock BD. 2020. Highly specific nanobody against herbicide 2,4-dichlorophenoxyacetic acid for monitoring of its contamination in environmental water. Sci Total Environ 753:doi:10.1016/j.scitotenv.2020.141950 PMID:32906044 PMCID:PMC7674261
Li Z, Wang Y, Vasylieva N, Wan D, Yin Z, Dong J, Hammock BD. 2020. An ultrasensitive bioluminescent enzyme immunoassay based on nanobody/nanoluciferase heptamer fusion for the detection of Tetrabromobisphenol A in sediment. Anal Chem 92:10083-10090. doi:10.1021/acs.analchem.0c01908 PMID:32559059
Liu G, Wu F, Jiang X, Que Y, Qin Z, Hu P, Lee K, Yang J, Zeng C, Hammock BD, Tong X. 2020. Inactivation of SERCA2 cysteine 674 increases blood pressure by induction of endoplasmic reticulum stress and soluble epoxide hydrolase. Br J Pharmacol 177(8):1793-1805. doi:10.1111/bph.14937
Matin N, Fisher C, Lansdell TA, Hammock BD, Yang J, Jackson WF, Dorrance AM. 2020. Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. Microcirculation 11:doi:10.1111/micc.12653 PMID:32767848 PMCID:PMC7990111
Overby HB, Yang Y, Xu X, Graham K, Hildreth K, Choi S, Wan D, Morisseau C, Zeldin DC, Hammock BD, Wang S, Bettaieb A, Zhao L. 2020. Soluble Epoxide Hydrolase Inhibition by t-TUCB Promotes Brown Adipogenesis and Reduces Serum Triglycerides in Diet-Induced Obesity. Int J Mol Sci 21:doi:10.3390/ijms21197039 PMID:32987880 PMCID:PMC7582898
Panigrahy D, Gilligan MM, Gartung A, Cortes-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD. 2020. Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?. Cancer Metastasis Rev 4:doi:10.1007/s10555-020-09889-4 PMID:32385712 PMCID:PMC7207990
Pu Y, Yang J, Chang L, Qu Y, Wang S, Zhang K, Xiong Z, Zhang J, Tan Y, Wang X, Fujita Y, Ishima T, Wan D, Hee-Hwang S, Hammock BD, Hashimoto K. 2020. Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 117:11753-11759. doi:10.1073/pnas.1922287117 PMID:32398374 PMCID:PMC7260984
Qi M, Huo J, Li Z, He C, Li D, Wang Y, Vasylieva N, Zhang J, Hammock BD. 2020. On-spot quantitative analysis of dicamba in field waters using a lateral flow immunochromatographic strip with smartphone imaging. Anal Bioanal Chem doi:10.1007/s00216-020-02833-z PMID:32737550
Ren W, Xu Y, Huang Z, Li YP, Tu Z, Zou L, He Q, Fu J, Liu S, Hammock BD. 2020. Single chain variable fragment antibody based immunochromatographic strip for rapid detection of fumonisin B-1 in maize samples. Food Chem 319:doi:10.1016/j.foodchem.2020.126546 PMID:32179370
Shihadih DS, Harris TR, Kodani SD, Hwang SH, Lee KS, Mavangira V, Hamamoto B, Guedes AP, Hammock BD, Morisseau C. 2020. Selection of Potent Inhibitors of Soluble Epoxide Hydrolase for Usage in Veterinary Medicine. Front Vet Sci 7:doi:10.3389/fvets.2020.00580 PMID:33005645 PMCID:PMC7479175
Singh N, Barnych B, Morisseau C, Wagner KM, Wan D, Takeshita A, Pham H, Xu T, Dandekar A, Liu J, Hammock BD. 2020. N-Benzyl-linoleamide, a constituent of Lepidium meyenii (Maca), is an orally bioavailable soluble epoxide hydrolase inhibitor that alleviates inflammatory pain. J Nat Prod 83:3689-3697. doi:10.1021/acs.jnatprod.0c00938 PMID:33320645
Sirish P, Thai PN, Lee JH, Yang J, Zhang X, Ren L, Li N, Timofeyev V, Lee KS, Nader CE, Rowland DJ, Yechikov S, Ganaga S, Young JN, Lieu DK, Yamoah EN, Hammock BD, Chiamvimonvat N. 2020. Suppression of inflammation and fibrosis using soluble epoxide hydrolase inhibitors enhances cardiac stem cell-based therapy. Stem Cells Transl Med doi:10.1002/sctm.20-0143 PMID:32790136
Spath J, Nording M, Lindberg R, Brodin T, Jansson S, Yang J, Wan D, Hammock BD, Fick J. 2020. Novel metabolomic method to assess the effect-based removal efficiency of advanced wastewater treatment techniques. Environ Chem 17:1-5. doi:10.1071/en19270
Stefanovski D, Shih P, Hammock BD, Watanabe RM, Youn JH. 2020. Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach. Prostaglandins Other Lipid Mediat 148:11. doi:10.1016/j.prostaglandins.2020.106410 PMID:31931080
Sun C, Zhang J, Zhao W, Yi J, Yan J, Wang Y, Morisseau C, Liu Z, Hammock BD, Ma X. 2020. Protostane type triterpenoids as natural soluble epoxide hydrolase inhibitors: Inhibition potentials and molecular dynamics. Biochemistry 96:doi:10.1016/j.bioorg.2020.103637 PMID:32032849
Tang Z, Liu X, Su B, Chen Q, Cao H, Yun Y, Xu Y, Hammock BD. 2020. Ultrasensitive and rapid detection of ochratoxin A in agro-products by a nanobody-mediated FRET-based immunosensor. J Hazard Mater 387:121678. doi:10.1016/j.jhazmat.2019.121678 PMID:31753666
Teixeira JM, Abdalla HB, Basting RT, Hammock BD, Napimoga MH, Clemente-Napimoga JT. 2020. Peripheral soluble epoxide hydrolase inhibition reduces hypernociception and inflammation in albumin-induced arthritis in temporomandibular joint of rats. Int Immunopharmacol 87:106841. doi:10.1016/j.intimp.2020.106841 PMID:32736189 PMCID:PMC8015648
Trindade da Silva CA, Clemente-Napimoga JT, Abdalla HB, Rosa S, Ueira-Vieira C, Morisseau C, Verri WA, Montalli V, Hammock BD, Napimoga MH. 2020. Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model. Faseb J doi:10.1096/fj.202000415R PMID:32400048
Tu M, Wang W, Zhang G, Hammock BD. 2020. omega-3 polyunsaturated fatty acids on colonic inflammation and colon cancer: roles of lipid-metabolizing enzymes involved. Nutrients 12(11):3301. doi:10.3390/nu12113301 PMID:33126566 PMCID:PMC7693568
Wagner KM, Atone J, Hammock BD. 2020. Soluble epoxide hydrolase inhibitor mediated analgesia lacks tolerance in rat models. Brain Res 1728:doi:10.1016/j.brainres.2019.146573 PMID:31790682 PMCID:PMC6996511
Wagner KM, Gomes AV, McReynolds C, Hammock BD. 2020. Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics doi:10.1007/s13311-020-00916-4 PMID:32875445
Wang F, Li Z, Yang Y, Wan D, Vasylieva N, Zhang Y, Cai J, Wang H, Shen Y, Xu Z, Hammock BD. 2020. Chemiluminescent enzyme immunoassay and bioluminescent enzyme immunoassay for tenuazonic acid mycotoxin by exploitation of nanobody and nanobody-nanoluciferase fusion. Anal Chem 92:11935-11942. doi:10.1021/acs.analchem.0c02338 PMID:32702970
Wang L, Zhao D, Tang L, Li H, Liu Z, Gao J, Edin ML, Zhang H, Chen J, Zhu X, Wang D, Zeldin DC, Hammock BD, Wang J, Huang H. 2020. Soluble epoxide hydrolase deficiency attenuates lipotoxic cardiomyopathy via upregulation of AMPK-mTORC mediated autophagy. J Mol Cell Cardiol 154:80-91. doi:10.1016/j.yjmcc.2020.12.013 PMID:33378686 PMCID:PMC8068623
Wang Y, Yang J, Wang W, Sanidad KZ, Cinelli MA, Wan D, Hee-Hwang S, Kim D, Lee KS, Xiao H, Hammock BD, Zhang G. 2020. Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation. Proc Natl Acad Sci U S A 117:8431-8436. doi:10.1073/pnas.1916189117 PMID:32220957 PMCID:PMC7165420
Wilt S, Kodani SD, Le TN, Nguyen L, Vo N, Ly T, Rodriguez M, Hudson PK, Morrisseau C, Hammock BD, Pecic S. 2020. Development of multitarget inhibitors for the treatment of pain: Design, synthesis, biological evaluation and molecular modeling studies. Bioorg Chem 103:17. doi:10.1016/j.bioorg.2020.104165 PMID:32891856 PMCID:PMC7723751
Wu N, Hammock BD, Lee KS, An G. 2020. Simultaneous target-mediated drug disposition model for two small-molecule compounds competing for their pharmacological target: Soluble epoxide hydrolase. J Pharmacol Exp Ther 374:223-232. doi:10.1124/jpet.120.265330 PMID:32238455 PMCID:PMC7318792
Xie M, Yang J, Zhang J, Sherman HL, Zhang Z, Minter LM, Hammock BD, Park Y, Zhang G. 2020. Effects of linoleic acid-rich diet on plasma profiles of eicosanoids and development of colitis in Il-10(-/-) mice. J Agric Food Chem 68:7641-7647. doi:10.1021/acs.jafc.0c03024 PMID:32594738
Yang H, Duan J, Liu S, Xiong J, Guan X, Zhong W, Sun C, Zhang C, Luo X, Zhang Y, Chen P, Hammock BD, Hwang SH, Jiang J, Zhou Y, Guan C. 2020. A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation. Thno 10:4749-4761. doi:10.7150/thno.43108
Zhang J, Tan Y, Chang L, Hammock BD, Hashimoto K. 2020. Increased expression of soluble epoxide hydrolase in the brain and liver from patients with major psychiatric disorders: A role of brain - liver axis. J Affect Disord 270:131-134. doi:10.1016/j.jad.2020.03.070 PMID:32339103
Zhang X, Du P, Cui X, Chen G, Wang Y, Zhang Y, El-Aty AA, Hacimuftuoglu A, Wang J, He H, Jin M, Hammock BD. 2020. A sensitive fluorometric bio barcodes immunoassay for detection of triazophos residue in agricultural products and water samples by iterative cycles of DNA RNA hybridization and dissociation of fluorophores by Ribonuclease H. Sci Total Environ 717:doi:10.1016/j.scitotenv.2020.137268 PMID:32084695

2019

Burmistrov V, Morisseau C, DYachenko V, Rybakov V, Butov GM, Hammock BD. 2019. Fluoroaromatic fragments on 1,3-disubstituted ureas enhance soluble epoxide hydrolase inhibition. J Fluor Chem 220:48-53. doi:10.1016/j.jfluchem.2019.02.005 PMID:32132741 PMCID:PMC7055688
Chen H, Ding Y, Yang Q, Barnych B, Gonzalez-Sapienza GG, Hammock BD, Wang M, Hua X. 2019. Fluorescent turn off-on small-molecule-monitoring nanoplatform based on dendrimer-like peptides as competitors. ACS Appl Mater Interfaces 11(36):33380-33389. doi:10.1021/acsami.9b13111 PMID:31433617 PMCID:PMC7059760
Codony S, Valverde E, Leiva R, Brea J, Loza I, Morisseau C, Hammock BD, Vazquez S. 2019. Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors. Bioorg Med Chem 27(20):115078. doi:10.1016/j.bmc.2019.115078 PMID:31488357 PMCID:PMC6892585
de Oliveira GS, Adriani PP, Ribeiro JA, Morisseau C, Hammock BD, Dias MV, Chambergo FS. 2019. The molecular structure of an epoxide hydrolase from trichoderma reesei in complex with urea or amide-based inhibitors. Int J Biol Macromol 129:653-658. doi:10.1016/j.ijbiomac.2019.02.070 PMID:30771398 PMCID:PMC6447457
Deol P, Yang J, Morisseau C, Hammock BD, Sladek FM. 2019. Dimethyl sulfoxide decreases levels of oxylipin diols in mouse liver. Front Pharmacol 10:580. doi:10.3389/fphar.2019.00580 PMID:31191316 PMCID:PMC6548860
Dileepan M, Rastle-Simpson S, Greenberg Y, Wijesinghe D, Kumar N, Yang J, Hwang SH, Hammock BD, Sriramarao P, Rao S. 2019. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Front Pharmacol 10:1118. doi:10.3389/fphar.2019.01118 PMID:31611798 PMCID:PMC6777353
Ding Y, Hua X, Chen H, Gonazlez-Sapienza GG, Barnych B, Liu F, Wang M, Hammock BD. 2019. A dual signal immunochromatographic strip for the detection of imidaclothiz using a recombinant fluorescent-peptide tracer and gold nanoparticles. Sens Actuators B Chem 297:7. doi:10.1016/j.snb.2019.126714
Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hee-Hwang S, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. 2019. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A 116:1698-1703. doi:10.1073/pnas.1803999116 PMID:30647111 PMCID:PMC6358686
He J, Tao X, Wang K, Ding G, Li J, Li QX, Gee SJ, Hammock BD, Xu T. 2019. One-step immunoassay for the insecticide carbaryl using a chicken single-chain variable fragment (scFv) fused to alkaline phosphatase. Anal Biochem 572:9-15. doi:10.1016/j.ab.2019.02.022 PMID:30831096
Hiesinger K, Kramer JS, Achenbach J, Moser D, Weber J, Wittmann SK, Morisseau C, Angioni C, Geisslinger G, Kahnt AS, Kaiser A, Proschak A, Steinhilber D, Pogoryelov D, Wagner KM, Hammock BD, Proschak E. 2019. Computer-aided selective optimization of side activities of talinolol. ACS Med Chem Lett 10(6):899-903. doi:10.1021/acsmedchemlett.9b00075 PMID:31223445 PMCID:PMC6580380
Hongsibsong S, Prapamontol T, Dong J, Bever C, Xu Z, Gee SJ, Hammock BD. 2019. Exposure of consumers and farmers to organophosphate and synthetic pyrethroid insecticides in Northern Thailand. J Verbrauch Lebensm 14(1):17-23. doi:10.1007/s00003-019-01207-7
Hrdlicka J, Neckar J, Papousek F, Huskova Z, Kikerlova S, Vanourkova Z, Vernerova Z, Akat F, Vasinova J, Hammock BD, Hwang SH, Imig JD, Falck JR, Cervenka L, Kolar F. 2019. Epoxyeicosatrienoic acid-based therapy attenuates the progression of postischemic heart failure in normotensive Sprague-Dawley but not in hypertensive Ren-2 transgenic rats. Front Pharmacol 10:12. doi:10.3389/fphar.2019.00159 PMID:30881303 PMCID:PMC6406051
Huo J, Barnych B, Li Z, Wan D, Li D, Vasylieva N, Knezevic SZ, Osipitan OA, Scott JE, Zhang J, Hammock BD. 2019. Hapten synthesis, antibody development, and a highly sensitive indirect competitive chemiluminescent enzyme immunoassay for detection of dicamba. J Agric Food Chem 67:5711-5719. doi:10.1021/acs.jafc.8b07134 PMID:31042038 PMCID:PMC6873229
Hye Khan A, Kolb L, Skibba M, Yeboah MM, Chesnik MA, Hwang SH, Hammock BD, Imig JD. 2019. A novel dual soluble epoxide hydrolase inhibitor/cyclooxygenase-2 inhibitor treats Type 2 Diabetic complications in complications in obese ZSF1 rats. FASEB J 33:
Joshi U, Pearson A, Evans JE, Langlois H, Saltiel N, Ojo J, Klimas N, Sullivan K, Keegan AP, Oberlin S, Darcey T, Cseresznye A, Raya B, Paris D, Hammock BD, Vasylieva N, Hongsibsong S, Stern LJ, Crawford F, Mullan M, Abdullah L. 2019. A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness. Brain Behav Immun 81:545-559. doi:10.1016/j.bbi.2019.07.015
Klocke J, Ulu A, Wu K, Rudolph B, Dragun D, Gollasch M, Schunck W, Hammock BD, Riemekasten G, Enghard P. 2019. Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice. Sci Rep 9(1):8993. doi:10.1038/s41598-019-45299-5 PMID:31222024 PMCID:PMC6586931
Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knoll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati E, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E. 2019. Discovery of the first in vivo active inhibitors of the soluble epoxide hydrolase phosphatase domain. J Med Chem 62:8443-8460. doi:10.1021/acs.jmedchem.9b00445
Lee KS, Yang J, Niu J, Ng CJ, Wagner KM, Dong H, Kodani SD, Wan D, Morisseau C, Hammock BD. 2019. Drug-target residence time affects in vivo target occupancy through multiple pathways. ACS Cent Sci 5:1614-1624. doi:10.1021/acscentsci.9b00770 PMID:31572788 PMCID:PMC6764161
Liang Z, Zhang B, Xu M, Morisseau C, Hwang SH, Hammock BD, Li QX. 2019. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea, a selective and potent dual inhibitor of soluble epoxide hydrolase and p38 kinase intervenes in Alzheimer's signaling in human nerve cells. ACS Chem Neurosci 10:4018-4030. doi:10.1021/acschemneuro.9b00271 PMID:31378059 PMCID:PMC7028313
Liu Z, Wang K, Wang Z, Ding G, Hao X, Li QX, Li J, Gee SJ, Hammock BD, Xu T. 2019. Development of an immunoassay for the detection of carbaryl in cereals based on a camelid variable heavy-chain antibody domain. Journal of the Science of Food and Agriculture 99(9):4383-4390. doi:10.1002/jsfa.9672 PMID:30851058 PMCID:PMC7061733
Luo L, Wei X, Jia B, Yang J, Shen Y, Hammock BD, Dong J, Wang H, Lei H, Xu Z. 2019. Modulating linker composition of haptens resulted in improved immunoassay for histamine. Biomolecules 9:10. doi:10.3390/biom9100597 PMID:31614550 PMCID:PMC6843301
Luo Y, Wu M, Deng B, Huang J, Hwang SH, Li M, Zhou C, Zhang Q, Yu H, Zhao D, Zhang G, Qin L, Peng A, Hammock BD, Liu J. 2019. Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK. Proc Natl Acad Sci U S A 116(11):5154-5159. doi:10.1073/pnas.1815746116 PMID:30804206 PMCID:PMC6421466
Ma M, Ren Q, Yang J, Zhang K, Xiong Z, Ishima T, Pu Y, Hwang SH, Toyoshima M, Iwayama Y, Hisano Y, Yoshikawa T, Hammock BD, Hashimoto K. 2019. Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation. Proc Natl Acad Sci U S A 116(14):7083-7088. doi:10.1073/pnas.1819234116 PMID:30890645 PMCID:PMC6452650
McReynolds C, Hee-Hwang S, Yang J, Wan D, Wagner KM, Morisseau C, Li D, Schmidt WK, Hammock BD. 2019. Pharmaceutical effects of inhibiting the soluble epoxide hydrolase in canine osteoarthritis. Front Pharmacol 10:12. doi:10.3389/fphar.2019.00533 PMID:31214021 PMCID:PMC6554663
Minaz N, Razdan R, Hammock BD, Mujwar S, Goswami SK. 2019. Impact of diabetes on male sexual function in streptozotocin-induced diabetic rats: Protective role of soluble epoxide hydrolase inhibitor. Biomed Pharmacother 115:108897. doi:10.1016/j.biopha.2019.108897 PMID:31102913 PMCID:PMC6893866
Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. 2019. Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis 40:1731-1739. doi:10.1002/elps.201900059 PMID:31021001 PMCID:PMC7036291
Mukhtar H, Ma L, Pang Q, Zhou Y, Wang X, Xu T, Hammock BD, Wang J. 2019. Cyclic peptide: a safe and effective alternative to synthetic aflatoxin B1-competitive antigens. Anal Bioanal Chem 411(17):3881-3890. doi:10.1007/s00216-019-01862-7
Otoki Y, Metherel AH, Pedersen TL, Yang J, Hammock BD, Bazinet RP, Newman JW, Taha AY. 2019. Acute hypercapnia/ischemia alters the esterification of arachidonic acid and docosahexaenoic acid epoxide metabolites in rat brain neutral lipids. Lipids 55(1):7-22. doi:10.1002/lipd.12197
Panigrahy D, Gartung A, Yang J, Yang H, Gilligan MM, Sulciner ML, Bhasin SS, Bielenberg DR, Chang J, Schmidt BA, Piwowarski J, Fishbein A, Soler-Ferran D, Sparks MA, Staffa SJ, Sukhatme V, Hammock BD, Kieran MW, Huang S, Bhasin M, Serhan CN, Sukhatme VP. 2019. Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases. J Clin Invest 129(7):2964-2979. doi:10.1172/JCI127282 PMID:31205032 PMCID:PMC6597207
Pardeshi R, Bolshette N, Gadhave K, Arfeen M, Ahmed S, Jamwal R, Hammock BD, Lahkar M, Goswami SK. 2019. Docosahexaenoic Acid Increases the Potency of Soluble Epoxide Hydrolase Inhibitor in Alleviating Streptozotocin-Induced Alzheimers Disease-Like Complications of Diabetes. Front Pharmacol 10:288. doi:10.3389/fphar.2019.00288 PMID:31068802 PMCID:PMC6491817
Qiu Y, Li P, Liu B, Liu Y, Wang Y, Tao T, Xu J, Hammock BD, Liu X, Guan R, Zhang C. 2019. Phage-displayed nanobody based double antibody sandwich chemiluminescent immunoassay for the detection of Cry2A toxin in cereals. Food Agric Immunol 30:924-936. doi:10.1080/09540105.2019.1642307
Rand AA, Rajamani A, Kodani SD, Harris TR, Schlatt L, Barnych B, Passerini AG, Hammock BD. 2019. Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2. J Lipid Res 60:1996-2005. doi:10.1194/jlr.M094219 PMID:31641036 PMCID:PMC6889709
Ren W, Li Z, Xu Y, Wan D, Barnych B, Li Y, Tu Z, He Q, Fu J, Hammock BD. 2019. One-Step Ultrasensitive Bioluminescent Enzyme Immunoassay Based on Nanobody/Nanoluciferase Fusion for Detection of Aflatoxin B1 in Cereal. J Agric Food Chem 67:5221-5229. doi:10.1021/acs.jafc.9b00688
Riangrungroj P, Bever C, Hammock BD, Polizzi K. 2019. A label-free optical whole-cell Escherichia coli biosensor for the detection of pyrethroid insecticide exposure. Sci Rep doi:10.1038/s41598-019-48907-6 PMID:31462650 PMCID:PMC6713742
Shen Y, Peng W, Chen Q, Hammock BD, Liu J, Li D, Yang J, Ding J, Wang X. 2019. Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model. Brain Behav Immun 81:535-544. doi:10.1016/j.bbi.2019.07.014 PMID:31306773 PMCID:PMC6873816
Shu M, Xu Y, Dong J, Zhong C, Hammock BD, Wang W, Wu G. 2019. Development of a noncompetitive idiometric nanobodies phage immunoassay for the determination of fumonisin B1. Food Agric Immunol 30(1):510-21. doi:10.1080/09540105.2019.1604637
Tang Z, Liu X, Wang Y, Chen Q, Hammock BD, Xu Y. 2019. Nanobody-based fluorescence resonance energy transfer immunoassay for noncompetitive and simultaneous detection of ochratoxin a and ochratoxin B. Environ Pollut 251:238-245. doi:10.1016/j.envpol.2019.04.135
Tang Z, Mo F, Liu A, Siliang D, Xiaomei Y, Liang L, Hou X, Yin S, Jiang X, Vasylieva N, Dong J, Barnych B, Hammock BD, Lu X. 2019. A nanobody against cytotoxic t-lymphocyte associated antigen-4 increases the anti-tumor effects of specific CD8(+) T cells. J Biomed Nanotechnol 15:2229-2239. doi:10.1166/jbn.2019.2859 PMID:31847937
Vackova S, Kopkan L, Kikerlova S, Huskova Z, Sadowski J, Kompanowska-Jezierska E, Hammock BD, Imig JD, Taborsky M, Melenovsky V, Cervenka L. 2019. Pharmacological blockade of soluble epoxide hydrolase attenuates the progression of congestive heart failure combined with chronic kidney disease: insights from studies with fawn-hooded hypertensive rats. Front Pharmacol 10:16. doi:10.3389/fphar.2019.00018 PMID:30728778 PMCID:PMC6351500
Vasquez S, Codony S, Pizarro J, Loza MI, Brea J, Morisseau C, Hammock BD, Vasquez-Carrera M. 2019. Synthesis of a new family soluble epoxid hydrolase inhibitors, in vitro profiling and in vivo evaluation in a murine model of acute pancreatitis. FASEB J 33:
Vasylieva N, Kitamura S, Dong J, Barnych B, Hvorecny KL, Madden DR, Gee SJ, Wolan DW, Morisseau C, Hammock BD. 2019. Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif). Anal Chim Acta 1057:106-113. doi:10.1016/j.aca.2018.12.060 PMID:30832908 PMCID:PMC6426448
Wan D, Yang J, McReynolds C, Barnych B, Wagner KM, Morisseau C, Hee-Hwang S, Sun J, Blocher R, Hammock BD. 2019. In vitro and in vivo metabolism of a potent inhibitor of soluble epoxide hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea. Front Pharmacol 10:464. doi:10.3389/fphar.2019.00464 PMID:31143115 PMCID:PMC6520522
Wang J, Deng K, Zhou C, Fang Z, Meyer C, Deshpande K, Li Z, Mi X, Luo Q, Hammock BD, Tan C, Chen Y, Pan T. 2019. Microfluidic cap-to-dispense (muCD): a universal microfluidic robotic interface for automated pipette-free high-precision liquid handling. Lab Chip 19(20):3405-3415. doi:10.1039/c9lc00622b PMID:31501848 PMCID:PMC6785371
Wang K, Liu Z, Ding G, Li J, Vasylieva N, Li QX, Li D, Gee SJ, Hammock BD, Xu T. 2019. Development of a one-step immunoassay for triazophos using camel single-domain antibody-alkaline phosphatase fusion protein. Anal Bioanal Chem 411(6):1287-1295. doi:10.1007/s00216-018-01563-7
Wang K, Vasylieva N, Wan D, Eads DA, Yang J, Tretten T, Barnych B, Li J, Li QX, Gee SJ, Hammock BD, Xu T. 2019. Quantitative detection of fipronil and fipronil-sulfone in sera of black-tailed prairie dogs and rats after oral exposure to fipronil by camel single-domain antibody-based immunoassays. Anal Chem 91:1532-1540. doi:10.1021/acs.analchem.8b04653
Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song C, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih P, Sing K, Lee S, Minter LM, Kim D, Xiao H, Liu J, Hammock BD, Zeldin DC, Zhang G. 2019. Targeted Metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis. Cancer Res 79:1822-1830. doi:10.1158/0008-5472.CAN-18-3221 PMID:30803995 PMCID:PMC6467714
Wang Y, Li Z, Barnych B, Huo J, Wan D, Vasylieva N, Xu J, Li P, Liu B, Zhang C, Hammock BD. 2019. Investigation of the small size of nanobodies for a sensitive fluorescence polarization immunoassay for small molecules: 3-phenoxybenzoic acid, an exposure biomarker of pyrethroid insecticides as a model. J Agric Food Chem 67(41):11536-11541. doi:10.1021/acs.jafc.9b04621
Wang Y, Xu J, Qiu Y, Li P, Liu B, Yang L, Barnych B, Hammock BD, Zhang C. 2019. Highly specific monoclonal antibody and sensitive quantum dot beads-based fluorescence immunochromatographic test strip for tebuconazole assay in agricultural products. J Agric Food Chem 67:9096-9103. doi:10.1021/acs.jafc.9b02832 PMID:31356079 PMCID:PMC7069222
Xia R, Sun L, Liao J, Li H, You X, Xu D, Yang J, Hee-Hwang S, Jones R, Hammock BD, Yang G. 2019. Inhibition of Pancreatic Carcinoma Growth Through Enhancing omega-3 Epoxy Polyunsaturated Fatty Acid Profile by Inhibition of Soluble Epoxide Hydrolase. Anticancer Res 39(7):3651-3660. doi:10.21873/anticanres.13513
Yang J, Bruun DA, Wang C, Wan D, McReynolds C, Phu K, Inceoglu B, Lein PJ, Hammock BD. 2019. Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. Toxicol Appl Pharmacol 382:114749. doi:10.1016/j.taap.2019.114749 PMID:31521729 PMCID:PMC6957308
Zarriello S, Tuazon JP, Corey S, Schimmel S, Rajani M, Gorsky A, Incontri D, Hammock BD, Borlongan CV. 2019. Humble beginnings with big goals: small molecule soluble epoxide hydrolase inhibitors for treating CNS disorders. Prog Neurobiol 172:23-39. doi:10.1016/j.pneurobio.2018.11.001 PMID:30447256 PMCID:PMC6993804
Zhang C, Duan J, Yang H, Sun C, Zhong W, Tao J, Guan X, Jiang H, Hammock BD, Hee-Hwang S, Zhou Y, Guan C. 2019. COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence. FEBS Lett 287(8):doi:10.1111/febs.15105 (ahead of print)
Zhu M, Wang L, Wu X, Na R, Wang Y, Li QX, Hammock BD. 2019. A novel and simple imidazo[1,2-a]pyridin fluorescent probe for the sensitive and selective imaging of cysteine in living cells and zebrafish. Anal Chim Acta 1058:155-165. doi:10.1016/j.aca.2019.01.023

2018

Bever C, Nording ML, Taft D, Kalanetra KM, Mills DA, Breck MA, Smilowitz JT, German JB, Hammock BD. 2018. Effects of triclosan in breast milk on the infant fecal microbiome. Chemosphere 203:467-473. doi:10.1016/j.chemosphere.2018.03.186 PMID:29635158 PMCID:PMC5915298
Burmistrov V, Morisseau C, Harris TR, Butov GM, Hammock BD. 2018. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorg Chem 76:510-527. doi:10.1016/j.bioorg.2017.12.024 PMID:29310082 PMCID:PMC5837815
Burmistrov V, Morisseau C, Pitushkin D, Karlov D, Fayzullin RR, Butov GM, Hammock BD. 2018. Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 28:2302-2313. doi:10.1016/j.bmcl.2018.05.024 PMID:29803731
Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, Gizzi P, Haber V, Mihaljevic VB, Tavcar B, Portelius E, Pannee J, Blennow K, Zetterberg H, Garbis SD, Auvray P, Gerber H, Fraering J, Fraering PC, Meijer L. 2018. Induction of amyloid-beta(42) production by fipronil and other pyrazole insecticides. Journal of Alzheimers Disease 62:1663-1681. doi:10.3233/jad-170875 PMID:29504531
Chabova VC, Kujal P, Skaroupkova P, Varnourkova Z, Vackova S, Huskova Z, Kikerlova S, Sadowski J, Kompanowska-Jezierska E, Baranowska I, Hwang SH, Hammock BD, Imig JD, Tesar V, Cervenka L. 2018. Combined inhibition of soluble epoxide hydrolase and renin-angiotensin system exhibits superior renoprotection to renin-angiotensin system blockade in 5/6 nephrectomized Ren-2 transgenic hypertensive rats with established chronic kidney disease. Kidney Blood Press Res 43:329-349. doi:10.1159/000487902 PMID:29529602 PMCID:PMC5985203
Chen H, Yang Q, Ding Y, Vasylieva N, Bever C, Hua X, Wang M, Hammock BD. 2018. Competitive and noncompetitive immunoassays for the detection of benzothiostrobin using magnetic nanoparticles and fluorescein isothiocyanate-labeled peptides. Anal Bioanal Chem 1-99. doi:10.1007/s00216-018-1478-8 PMID:30478514
Cui X, He Q, Shen D, Jiang Z, Chen Y, Zhao S, Hammock BD. 2018. Production and characterization of a single-chain variable fragment-alkaline phosphatase fusion protein for glycocholic acid detection in a one-step enzyme-linked immunosorbent assay. Analytical Methods 10:2629-2635. doi:10.1039/c8ay00848e
de Oliveira GS, Adriani PP, Wu H, Morisseau C, Hammock BD, Chambergo FS. 2018. Substrate and inhibitor selectivity, and biological activity of an epoxide hydrolase from Trichoderma reesei. Molecular Biology Reports 46(1):371-9. doi:10.1007/s11033-018-4481-4 PMID:30426381 PMCID:PMC6426676
Guedes AP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hee-Hwang S, Morisseau C, Hammock BD. 2018. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther 41:230-238. doi:10.1111/jvp.12463 PMID:29067696
Harris TR, Kodani SD, Rand AA, Yang J, Imai DM, Hwang SH, Hammock BD. 2018. Celecoxib does not protect against fibrosis and inflammation in a carbon tetrachloride-induced model of liver injury. Mol Pharmacol 94:834-841. doi:10.1124/mol.118.111831 PMID:29844231 PMCID:PMC6022802
He J, Tian J, Xu J, Wang K, Li J, Gee SJ, Hammock BD, Li QX, Xu T. 2018. Strong and oriented conjugation of nanobodies onto magnetosomes for the development of a rapid immunomagnetic assay for the environmental detection of tetrabromobisphenol-A. Anal Bioanal Chem 410(25):6633-6642. doi:10.1007/s00216-018-1270-9 PMID:30066195
Hennebelle M, Metherel AH, Kitson AP, Otoki Y, Yang J, Lee KS, Hammock BD, Bazinet RP, Taha AY. 2018. Brain oxylipin concentrations following hypercapnia/ischemia: effects of brain dissection and dissection time. J Lipid Res 60:671-682. doi:10.1194/jlr.D084228 PMID:30463986 PMCID:PMC6399504
Huo J, Li Z, Wan D, Li D, Qi M, Barnych B, Vasylieva N, Zhang J, Hammock BD. 2018. Development of a highly sensitive direct competitive fluorescence enzyme immunoassay based on a nanobody-alkaline phosphatase fusion protein for detection of 3-phenoxybenzoic acid in urine. J Agric Food Chem 66:11284-11290. doi:10.1021/acs.jafc.8b04521 PMID:30293433
Jeon J, Uthaman S, Lee J, Hwang H, Kim G, Yoo PJ, Hammock BD, Kim CS, Park Y, Park I. 2018. In-direct localized surface plasmon resonance (LSPR)-based nanosensors for highly sensitive and rapid detection of cortisol. Sens Actuators B Chem 266:710-716. doi:10.1016/j.snb.2018.03.167
Kala P, Sedlakova L, Skaroupkova P, Kopkan L, Vanourkova Z, Taborsky M, Nishiyama A, Hwang SH, Hammock BD, Sadowski J, Melenovsky V, Imig JD, Cervenka L. 2018. Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in ren-2 transgenic hypertensive rats with aorto-caval fistula. Physiol Res 67:401-415. PMID:29527914 PMCID:PMC6056335
Kodani SD, Bhakta S, Hee-Hwang S, Pakhomova S, Newcomer ME, Morisseau C, Hammock BD. 2018. Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg Med Chem 28:762-768. doi:10.1016/j.bmcl.2018.01.003 PMID:29366648 PMCID:PMC5837813
Kodani SD, Wan D, Wagner KM, Hwang SH, Morisseau C, Hammock BD. 2018. Design and potency of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors. ACS Omega 3(10):14076-14086. doi:10.1021/acsomega.8b01625 PMID:30411058 PMCID:PMC6210075
Lakkappa N, Krishnamurthy PT, Yamjala K, Hwang SH, Hammock BD, Babu B. 2018. Evaluation of anti-Parkinson activity of PTUPB by measuring dopamine and its metabolites in Drosophila melanogaster: LC-MS/MS method development. J Pharm Biomed Anal 149:457-464. doi:10.1016/j.jpba.2017.11.043 PMID:29169114
Lassabe G, Kramer K, Hammock BD, Gonzalez-Sapienza GG, Gonzalez-Techera A. 2018. Noncompetitive Homogeneous Detection of Small Molecules Using Synthetic Nanopeptamer-Based Luminescent Oxygen Channeling. Anal Chem 90(10):6187-6192. doi:10.1021/acs.analchem.8b00657 PMID:29694028 PMCID:PMC5963685
Minaz N, Razdan R, Hammock BD, Goswami SK. 2018. An inhibitor of soluble epoxide hydrolase ameliorates diabetes-induced learning and memory impairment in rats. Prostaglandins Other Lipid Mediat 136:84-89. doi:10.1016/j.prostaglandins.2018.05.004 PMID:29751149
Napimoga MH, Trindade-da-Silva C, Demasi AP, Martinez EF, Macedo CG, Abdalla HB, Bettaieb A, Haj FG, Clemente-Napimoga JT, Hammock BD. 2018. Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption. J Periodontal Res doi:10.1111/jre.12559 PMID:29851077
Pali M, Bever C, Vasylieva N, Hammock BD, Suni II. 2018. Impedance detection of 3-phenoxybenzoic acid with a noncompetitive two-site phage anti-immunocomplex assay. Electroanalysis 30:2653-2659. doi:10.1002/elan.201800457
Pecic S, Zeki AA, Xu X, Jin GY, Zhang S, Kodani SD, Halim M, Morisseau C, Hammock BD, Deng S. 2018. Novel piperidine-derived amide sEH inhibitors as mediators of lipid metabolism with improved stability. Prostaglandins Other Lipid Mediat 136:90-95. doi:10.1016/j.prostaglandins.2018.02.004 PMID:29567338 PMCID:PMC5970965
Qiu Y, Li P, Dong S, Zhang X, Yang Q, Wang Y, Ge J, Hammock BD, Zhang C, Liu X. 2018. Phage-mediated competitive chemiluminescent immunoassay for detecting Cry1Ab toxin by using an anti-idiotypic camel nanobody. J Agric Food Chem 66:950-956. doi:10.1021/acs.jafc.7b04923 PMID:29293334
Rand AA, Helmer PO, Inceoglu B, Hammock BD, Morisseau C. 2018. LC-MS/MS analysis of the epoxides and diols derived from the endocannabinoid arachidonoyl ethanolamide. Methods Mol Biol 1730:123-133. doi:10.1007/978-1-4939-7592-1_10 PMID:29363071
Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa K, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K. 2018. Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease. Proc Natl Acad Sci U S A 115:E5815-E5823. doi:10.1073/pnas.1802179115 PMID:29735655 PMCID:PMC6016799
Taha AY, Hennebelle M, Yang J, Zamora D, Rapoport SI, Hammock BD, Ramsden CE. 2018. Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins Leukot Essent Fatty Acids 138:71-80. doi:10.1016/j.plefa.2016.05.004 PMID:27282298 PMCID:PMC5106341
Tu R, Armstrong J, Lee KS, Hammock BD, Sapirstein A, Koehler RC. 2018. Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep 8:5279. doi:10.1038/s41598-018-23504-1 PMID:29588470 PMCID:PMC5869703
Wang F, zhang H, Ma A, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin T, Malfatti MA, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan C. 2018. COX-2/sEH dual inhibitor PTUPB potentiates the antitumor efficacy of cisplatin. Mol Cancer Ther 17:474-483. doi:10.1158/1535-7163.MCT-16-0818 PMID:29284644 PMCID:PMC5824635
Wang W, Yang J, Zhang J, Wang Y, Hee-Hwang S, Qi W, Wan D, Kim D, Sun J, Sanidad KZ, Yang H, Park Y, Liu J, Zhao X, Zheng X, Liu Z, Hammock BD, Zhang G. 2018. Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A 115:5283-5288. doi:10.1073/pnas.1721711115 PMID:29717038 PMCID:PMC5960306
Yamanashi H, Boeglin WE, Morisseau C, Davis RW, Sulikowski GA, Hammock BD, Brash AR. 2018. Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function. J Lipid Res 59:684-695. doi:10.1194/jlr.M082701 PMID:29459481 PMCID:PMC5880498
Yang Y, Sun D, Kandhi S, Froogh G, Zhuge J, Huang W, Hammock BD, Huang A. 2018. Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation. Proc Natl Acad Sci U S A 115:613-618. doi:10.1073/pnas.1716016115 PMID:29295935 PMCID:PMC5776989
Červenka L, Huskova Z, Kopkan L, Kikerlova S, Sedlakova L, Vanourkova Z, Alanova P, Kolar F, Hammock BD, Hee-Hwang S, Imig JD, Falck JR, Sadowski J, Kompanowska-Jezierska E, Neckar J. 2018. Two pharmacological epoxyeicosatrienoic acid-enhancing therapies are effectively antihypertensive and reduce the severity of ischemic arrhythmias in rats with angiotensin II-dependent hypertension. J Hypertens 36:doi:10.1097/hjh.0000000000001708 PMID:29570510 PMCID:PMC7375140 (accepted for publication)

2017

Barnych B, Rand A, Cajka T, Lee KS, Hammock BD. 2017. Synthesis of cylooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11-and 15-hydroxy 8,9-EETs. Org Biomol Chem 15:4308-4313. doi:10.1039/c7ob00789b PMID:28470279
Bettaieb A, Koike S, Chahed S, Bachaalany S, Hashoush N, Graham J, Fatima H, Havel PJ, Gruzdev A, Zeldin DC, Hammock BD, Haj FG, Zhao Y. 2017. Podocyte-specific soluble exposide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J 284(13):1970-1986. doi:10.1111/febs.14100 PMID:28485854 PMCID:PMC5515292
Bettaieb A, Koike S, Hsu M, Ito Y, Chahed S, Bachaalany S, Gruzdev A, Calvo-Rubio M, Lee KS, Inceoglu B, Imig JD, Villalba JM, Zeldin DC, Hammock BD, Haj FG. 2017. Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochim Biophys Acta 1861:2758-2765. doi:10.1016/j.bbagen.2017.07.021 PMID:28757338
Cui X, Vasylieva N, Wu P, Barnych B, Yang J, Shen D, He Q, Gee SJ, Zhao S, Hammock BD. 2017. Development of an indirect competitive enzyme-linked immunosorbent assay for glycocholic acid based on chicken single-chain variable fragment antibodies. Anal Chem 89:11091-11097. doi:10.1021/acs.analchem.7b03190 PMID:28942640
Deng B, Luo Y, Kang X, Li C, Morisseau C, Yang J, Lee KS, Huang J, Hu D, Wu M, Peng A, Hammock BD, Liu J. 2017. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3 beta signaling. Proc Natl Acad Sci U S A 114:12608-12613. doi:10.1073/pnas.1705615114 PMID:29109264 PMCID:PMC5703276
Fischer GJ, Bacon W, Yang J, Palmer JM, Dagenais T, Hammock BD, Keller NP. 2017. Lipoxygenase activity accelerates programmed spore germination in aspergillus fumigatus. Front Microbiol 8:831. doi:10.3389/fmicb.2017.00831 PMID:28536571 PMCID:PMC5422543
Flitter B, Hvorecny KL, Ono E, Eddens TJ, Yang J, Kwak D, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls J, Levy BD, Madden DR, Bomberger JM. 2017. Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators. Proc Natl Acad Sci U S A 114(1):136-141. doi:10.1073/pnas.1610242114 PMID:27980032 PMCID:PMC5224368
Goswami SK, Rand A, Wan DB, Yang J, Inceoglu B, Thomas M, Morisseau C, Yang G, Hammock BD. 2017. Pharmacological inhibition of soluble epoxide hydrolase or genetic deletion reduces diclofenac-induced gastric ulcers. Life Sciences 180:114-122. doi:10.1016/j.lfs.2017.05.018 PMID:28522175 PMCID:PMC5659729
Guedes AP, Galuppo L, Hood D, Hwang SH, Morisseau C, Hammock BD. 2017. Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis. Equine Vet J 49(3):345-351. doi:10.1111/evj.12603 PMID:27338788
Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KS, Hammock BD, Schunck W, Connor KM. 2017. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A 114:e7545-e7553. doi:10.1073/pnas.1620898114 PMID:28827330 PMCID:PMC5594641
Hennebelle M, Otoki Y, Yang J, Hammock BD, Levitt AJ, Taha AY, Swardfager W. 2017. Altered soluble epoxide hydrolase-derived oxylipins in patients with seasonal major depression: An exploratory study. Psychiatry Res 252:94-101. doi:10.1016/j.psychres.2017.02.056 PMID:28259037
Hennebelle M, Zhang Z, Metherel AH, Kitson AP, Otoki Y, Richardson CE, Yang J, Lee KS, Hammock BD, Zhang L, Bazinet RP, Taha AY. 2017. Linoleic acid participates in the response to ischemic brain injury through oxidized metabolites that regulate neurotransmission. Sci Rep 7:4342. doi:10.1038/s41598-017-02914-7 PMID:28659576 PMCID:PMC5489485
Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. 2017. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:1382-1391. doi:10.1016/j.bbadis.2017.02.004 PMID:28185955
Hvorecny KL, Bahl CD, Kitamura S, Lee KS, Hammock BD, Morisseau C, Madden DR. 2017. Active-site flexibility and substrate specificity in a bacterial virulence factor: Crystallographic snapshots of an epoxide hydrolase. Structure 25(5):697-707. doi:10.1016/j.str.2017.03.002 PMID:28392259
Hwang SH, Wagner KM, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee K, Hammock BD. 2017. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorg Med Chem Lett 27(3):620-625. doi:10.1016/j.bmcl.2016.12.002 PMID:28025003
Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. 2017. Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat 133:68-78. doi:10.1016/j.prostaglandins.2017.08.003 PMID:28847566 PMCID:PMC5584617
Islam O, Patil P, Goswami SK, Razdan R, Inamdar MN, Rizwan M, Mathew J, Inceoglu B, Stephen Lee KS, Hwang SH, Hammock BD. 2017. Inhibitors of soluble epoxide hydrolase minimize ischemia-reperfusion-induced cardiac damage in normal, hypertensive, and diabetic rats. Cardiovasc Ther 35(3):e12259. doi:10.1111/1755-5922.12259 PMID:28296232
Kandhi S, Zhang B, Froogh G, Qin J, Alruwaili N, Le Y, Yang Y, Hwang SH, Hammock BD, Wolin MS, Huang A, Sun D. 2017. EETs promote hypoxic pulmonary vasoconstriction via constrictor prostanoids. Am J Physiol Lung Cell Mol Physiol 313:L350-L359. PMID:28450284
Kitamura S, Morisseau C, Harris TR, Inceoglu B, Hammock BD. 2017. Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales. PLoS One 12(5):e0176571. doi:10.1371/journal.pone.0176571 PMID:28472063 PMCID:PMC5417501
Kodani SD, Barthelemy M, Kamita SG, Hammock BD, Morisseau C. 2017. Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts. Anal Biochem 539:81-89. doi:10.1016/j.ab.2017.10.014 PMID:29054529 PMCID:PMC5696082
Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. 2017. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Arch Biochem Biophys 613:1-11. doi:10.1016/j.abb.2016.10.017 PMID:27983948 PMCID:PMC5172606
Li D, Cui Y, Morisseau C, Gee SJ, Bever C, Liu X, Wu J, Hammock BD, Ying Y. 2017. Nanobody based immunoassay for human soluble epoxide hydrolase detection using Polymeric Horseradish Peroxidase (PolyHRP) for signal enhancement: The rediscovery of PolyHRP?. Anal Chem 89(11):6248-6256. doi:10.1021/acs.analchem.7b01247 PMID:28460522 PMCID:PMC5611449
Liu X, Tang Z, Duan Z, He Z, Shu M, Wang X, Gee SJ, Hammock BD, Xu Y. 2017. Nanobody-based enzyme immunoassay for ochratoxin A in cereal with high resistance to matrix interference. Talanta 164:154-158. doi:10.1016/j.talanta.2016.11.039 PMID:28107910 PMCID:PMC5862147
Orcholski ME, Khurshudyan A, Shamskhou EA, Yuan K, Chen IY, Kodani SD, Morisseau C, Hammock BD, Hong EM, Alexandrova L, Alastalo T, Berry G, Zamanian RT, de Jesus Perez VA. 2017. Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 313:L252-L266. doi:10.1152/ajplung.00453.2016 PMID:28473326
Rand A, Barnych B, Morisseau C, Cajka T, Lee KS, Panigrahy D, Hammock BD. 2017. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids. Proc Natl Acad Sci U S A 114:4370-4375. doi:10.1073/pnas.1616893114 PMID:28396419 PMCID:PMC5410821
Richardson CE, Hennebelle M, Otoki Y, Zamora D, Yang J, Hammock BD, Taha AY. 2017. Lipidomic analysis of oxidized fatty acids in plant and algae oils. J Agric Food Chem 65(9):1941-1951. doi:10.1021/acs.jafc.6b05559 PMID:28157307
Trindade-da-Silva C, Bettaieb A, Napimoga M, Stephen Lee KS, Inceoglu B, Ueira-Vieira C, Bruun DA, Goswami SK, Haj FG, Hammock BD. 2017. Soluble epoxide hydrolase pharmacological inhibition decreases alveolar bone loss by modulating host inflammatory response, RANK-related signaling, endoplasmic reticulum stress, and apoptosis. J Pharmacol Exp Ther 361(3):408-416. doi:10.1124/jpet.116.238113 PMID:28356494 PMCID:PMC5443319
Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD. 2017. Sensitive immunoassay for detection and quantification of the neurotoxin, tetramethylenedisulfotetramine. Anal Chem 89(10):5612-5619. doi:10.1021/acs.analchem.7b00846 PMID:28398746
Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. 2017. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environ Int 103:91-98. doi:10.1016/j.envint.2017.03.012 PMID:28343720 PMCID:PMC5432128
Wagner KM, Gilda JE, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. 2017. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res 326:69-76. doi:10.1016/j.bbr.2017.02.048 PMID:28259677 PMCID:PMC5409858
Wagner KM, McReynolds C, Schmidt WK, Hammock BD. 2017. Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacol Ther 180:62-76. doi:10.1016/j.pharmthera.2017.06.006 PMID:28642117 PMCID:PMC5677555
Wagner SD, Kurobe T, Hammock BG, Lam CH, Wu G, Vasylieva N, Gee SJ, Hammock BD, Teh SJ. 2017. Developmental effects of fipronil on Japanese Medaka (Oryzias latipes) embryos. Chemosphere 166:511-520. doi:10.1016/j.chemosphere.2016.09.069 PMID:27710886
Wan D, Yang J, Barnych B, Hwang SH, Lee KS, Cui Y, Niu J, Watsky MA, Hammock BD. 2017. A new sensitive LC/MS/MS analysis of vitamin D metabolites using a click derivatizatization reagent, 2-nitrosopyridine. J Lipid Res 58(4):798-808. doi:10.1194/jlr.D073536 PMID:28148721 PMCID:PMC5392736
Wang W, Yang J, Qi W, Yang H, Wang C, Tan B, Hammock BD, Park Y, Kim D, Zhang G. 2017. Lipidomic profiling of high-fat diet-induced obesity in mice: importance of cytochrome P450-derived fatty acid epoxides. Obesity (Silver Spring) 25(1):132-140. doi:10.1002/oby.21692 PMID:27891824 PMCID:PMC5182168
Xu Z, Li Y, Sun Y, Beier RC, Lei H, Gee SJ, Hammock BD, Shen Y, Yang J, Wang H. 2017. Immunochemical techniques for multianalyte analysis of chemical residues in food and the environment: a review. Trends in Analytical Chemistry 88:25-40. doi:10.1016/j.trac.2016.12.010
Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. 2017. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem 49:8-14. doi:10.1016/j.jnutbio.2017.07.006 PMID:28863368
Zhang Y, Hong G, Lee K, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. 2017. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. J Neurochem 140(5):814-825. doi:10.1111/jnc.13933 PMID:28002622 PMCID:PMC5310989

2016

Ahn K, Ranganathan A, Bever C, Hwang SH, Holland EB, Morisseau K, Pessah IN, Hammock BD, Gee SJ. 2016. Detection of the antimicrobial triclosan in environmental samples by immunoassay. Environ Sci Technol 50(7):3754-3761. doi:10.1021/acs.est.5b05357 PMID:26937944 PMCID:PMC4821808
Akintoye E, Wu JH, Hou T, Song X, Yang J, Hammock BD, Mozaffarian D. 2016. Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery. J Lipid Res 57(3):492-498. doi:10.1194/jlr.P062398 PMID:26749073 PMCID:PMC4766998
Bever C, Dong J, Vasylieva N, Barnych B, Cui Y, Hammock BD, Gee SJ. 2016. VHH antibodies: emerging reagents for the analysis of environmental chemicals. Anal Bioanal Chem 408(22):5985-6002. doi:10.1007/s00216-016-9585-x PMID:27209591 PMCID:PMC4983233
Ghosh R, Goswami SK, Feitoza LB, Hammock BD, Gomes AV. 2016. Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol 223:923-935. doi:10.1016/j.ijcard.2016.08.233 PMID:27589040 PMCID:PMC5076377
Gong Y, Fu Z, Edin ML, Liu C, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellstrom A, Hammock BD, Zeldin DC, Smith LE. 2016. Cytochrome P450 oxidase 2C inhibition adds to omega-3 long-chain polyunsaturated fatty acids protection against retinal and choroidal neovascularization. Arterioscler Thromb Vasc Biol 36(9):1919-1927. doi:10.1161/ATVBAHA.116.307558 PMID:27417579 PMCID:PMC5010176
Goswami SK, Wan D, Yang J, Trindade da Silva CA, Morisseau C, Kodani SD, Yang G, Inceoglu B, Hammock BD. 2016. Anti-ulcer efficacy of soluble epoxide hydrolase inhibitor TPPU on diclofenac-induced intestinal ulcers. J Pharmacol Exp Ther 357(3):529-536. doi:10.1124/jpet.116.232108 PMID:26989141 PMCID:PMC4885505
Harris TR, Kodani SD, Yang J, Imai DM, Hammock BD. 2016. An ω-3-enriched diet alone does not attenuate CCl4-induced hepatic fibrosis. J Nutr Biochem 38:93-101. doi:10.1016/j.jnutbio.2016.08.010 PMID:27732914 PMCID:PMC5102762
Hye Khan A, Hwang SH, Sharma A, Corbett JA, Hammock BD, Imig JD. 2016. A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat. Prostaglandins Other Lipid Mediat 125:40-47. doi:10.1016/j.prostaglandins.2016.07.003 PMID:27432695 PMCID:PMC5035206
Kamita SG, Mulligan S, Cornel AJ, Hammock BD. 2016. Quantification of GST and esterase activities in pyrethrin-resistant mosquitoes using pyrethroid-like fluorescent substrates. Int J Pest Manag 62:276-283. doi:10.1080/09670874.2016.1175685 PMID:28736488 PMCID:PMC5516934
Kim J, Ulu A, Wan DB, Yang J, Hammock BD, Weiss RH. 2016. Addition of DHA synergistically enhances the efficacy of regorafenib for kidney cancer therapy. Mol Cancer Ther 15(5):890-898. doi:10.1158/1535-7163.MCT-15-0847 PMID:26921392 PMCID:PMC4873345
Kitamura S, Hvorecny KL, Niu J, Hammock BD, Madden DR, Morisseau C. 2016. Rational design of potent and selective inhibitors of an epoxide hydrolase virulence factor from Pseudomonas aeruginosa. J Med Chem 59(10):4790-4799. doi:10.1021/acs.jmedchem.6b00173 PMID:27120257 PMCID:PMC4957648
Kodani SD, Overby HB, Morisseau C, Chen J, Zhao L, Hammock BD. 2016. Parabens inhibit fatty acid amide hydrolase: a potential role in paraben-enhanced 3T3-L1 adipocyte differentiation. Toxicol Lett 262:92-99. doi:10.1016/j.toxlet.2016.09.011 PMID:27659731 PMCID:PMC5096949
Li D, Liu Y, Zhang X, Lv H, Pang W, Sun X, Gan L, Hammock BD, Ai D, Zhu Y. 2016. Inhibition of soluble epoxide hydrolase alleviated atherosclerosis by reducing monocyte infiltration in Ldlr(-/-) mice. J Mol Cell Cardiol 98:128-137. doi:10.1016/j.yjmcc.2016.08.001 PMID:27496380
Liu J, Morisseau C, Huang H, Hammock BD. 2016. Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use. J Ethnopharmacol 194:475-482. doi:10.1016/j.jep.2016.09.044 PMID:27702689
McLellan GJ, Aktas Z, Hennes-Beean E, Kolb AW, Larsen IV, Schmitz EJ, Clausius HR, Yang J, Hwang SH, Morisseau C, Inceoglu B, Hammock BD, Brandt CR. 2016. Effect of a soluble epoxide hydrolase inhibitor, UC1728, on LPS-induced uveitis in the rabbit. J Ocul Biol 4(1):PMID:28066796 PMCID:PMC5218821
Mouchlis VD, Morisseau C, Hammock BD, Li S, McCammon JA, Dennis EA. 2016. Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2. Bioorg Med Chem 24(20):4801-4811. doi:10.1016/j.bmc.2016.05.009 PMID:27320659 PMCID:PMC5053890
Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang J, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. 2016. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proc Natl Acad Sci U S A 113(13):E1944-E1952. doi:10.1073/pnas.1601532113 PMID:26976569 PMCID:PMC4822604
Sharma A, Hye Khan A, Levick SP, Sing K, Hammock BD, Imig JD. 2016. Novel omega-3 fatty acid epoxygenase metabolite reduces kidney fibrosis. Int J Mol Sci 17(5):751. doi:10.3390/ijms17050751 PMID:27213332 PMCID:PMC4881572
Shih P, Yang J, Morisseau C, German JB, Zeeland AA, Armando AM, Quehenberger O, Bergen AW, Magistretti P, Berrettini W, Halmi KA, Schork N, Hammock BD, Kaye W. 2016. Dysregulation of soluble epoxide hydrolase and lipidomic profiles in anorexia nervosa. Mol Psychiatry 21(4):537-546. doi:10.1038/mp.2015.26 PMID:25824304 PMCID:PMC4591075
Sirish P, Li N, Timofeyev V, Zhang X, Wang L, Yang J, Lee KS, Bettaieb A, Ma S, Lee JH, Su D, Lau V, Myers R, Lieu DK, Lopez JE, Young JN, Yamoah EN, Haj FG, Ripplinger C, Hammock BD, Chiamvimonvat N. 2016. Molecular mechanisms and new treatment paradigm for atrial fibrillation. Circ Arrhythm Electrophysiol 9(5):e003721-e003740. doi:10.1161/CIRCEP.115.003721 PMID:27162031 PMCID:PMC4869994
Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Sing K, Lee S, Hammock BD, Sadoshima J, Cohen RA, Zeng C. 2016. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol 92:30-40. doi:10.1016/j.yjmcc.2016.01.020 PMID:26812119 PMCID:PMC5008453
Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. 2016. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol 6(3):1000300. doi:10.4172/2161-0495.1000300 PMID:28255523 PMCID:PMC5328659
Wagner KM, Lee KS, Yang J, Hammock BD. 2016. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. Eur J Pain 21:456-465. doi:10.1002/ejp.939 PMID:27634339 PMCID:PMC5300894
Wu X, Yang J, Morisseau C, Robertson LW, Hammock BD, Lehmler H. 2016. 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) decreases hepatic and systemic ratios of epoxide to diol metabolites of unsaturated fatty acids in male rats. Toxicol Sci 152(2):309-322. doi:10.1093/toxsci/kfw084 PMID:27208083 PMCID:PMC4960907
Xu J, Morisseau C, Yang J, Lee KS, Kamita SG, Hammock BD. 2016. Ingestion of the epoxide hydrolase inhibitor AUDA modulates immune responses of the mosquito, Culex quinquefasciatus during blood feeding. Insect Biochem Mol Biol 76:62-69. doi:10.1016/j.ibmb.2016.06.011 PMID:27369469 PMCID:PMC5010450
Zhao Y, Wan D, Yang J, Hammock BD, Ortiz de Montellano P. 2016. Catalytic activities of tumor-specific human cytochrome P450 CYP2W1 toward endogenous substrates. Drug Metab Dispos 44(5):771-780. doi:10.1124/dmd.116.069633 PMID:26936974 PMCID:PMC4851306

2015

Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR. 2015. Inhibiting an epoxide hydrolase virulence factor from Pseudomonas aeruginosa protects CFTR. Angew Chem Int Ed Engl 54(34):9881-9885. doi:10.1002/anie.201503983 PMID:26136396 PMCID:PMC4556431
Berthelot CC, Kamita SG, Sacchi R, Yang J, Nording ML, Georgi K, Karbowski CH, German JB, Weiss RH, Hogg RJ, Hammock BD, Zivkovic AM. 2015. Changes in PTGS1 and ALOX12 gene expression in peripheral blood mononuclear cells are associated with changes in arachidonic acid, oxylipins, and oxylipin/fatty acid ratios in response to omega-3 fatty acid supplementation. PLoS One 10(12):e0144996. doi:10.1371/journal.pone.0144996 PMID:26672987 PMCID:PMC4681469
Bettaieb A, Chahed S, Bachaalany S, Griffey S, Hammock BD, Haj FG. 2015. Soluble epoxide hydrolase pharmacological inhibition ameliorates experimental acute pancreatitis in mice. Mol Pharmacol 88(2):281-290. doi:10.1124/mol.114.097501 PMID:25993999 PMCID:PMC4518092
Burmistrov V, Morisseau C, Danilov D, Harris TR, Dalinger I, Vatsadze I, Shkineva T, Butov GM, Hammock BD. 2015. 1,3-Disubstituted and 1,3,3-trisubstituted adamantyl-ureas with isoxazole as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 25(23):5514-5519. doi:10.1016/j.bmcl.2015.10.066 PMID:26520661 PMCID:PMC4654407
Cui Y, Li D, Morisseau C, Dong J, Yang J, Wan D, Rossotti MA, Gee SJ, Gonzalez-Sapienza GG, Hammock BD. 2015. Heavy chain single-domain antibodies to detect native human soluble epoxide hydrolase. Anal Bioanal Chem 407(24):7275-7283. doi:10.1007/s00216-015-8889-6 PMID:26229025 PMCID:PMC4573264
Fahrmann J, Grapov D, Yang J, Hammock BD, Fiehn O, Bell GI, Hara M. 2015. Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia. Am J Physiol Endocrinol Metab 308(11):E978-E989. doi:10.1152/ajpendo.00019.2015 PMID:25852003 PMCID:PMC4451288
Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ. 2015. Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. Neurotoxicol Teratol 47:36-45. doi:10.1016/j.ntt.2014.10.008 PMID:25446016 PMCID:PMC4291292
Goswami SK, Inceoglu B, Yang J, Wan D, Kodani SD, Trindade da Silva CA, Morisseau C, Hammock BD. 2015. Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model. Toxicol Appl Pharmacol 289(3):419-427. doi:10.1016/j.taap.2015.10.018 PMID:26522832 PMCID:PMC4666679
Hammock BD, Hobbs JA, Slater SB, Acuna S, Teh SJ. 2015. Contaminant and food limitation stress in an endangered estuarine fish. Sci Total Environ 532:316-326. doi:10.1016/j.scitotenv.2015.06.018 PMID:26081734 PMCID:PMC4843802
Harris TR, Bettaieb A, Kodani SD, Dong H, Myers R, Chiamvimonvat N, Haj FG, Hammock BD. 2015. Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice. Toxicol Appl Pharmacol 286(2):102-111. doi:10.1016/j.taap.2015.03.022 PMID:25827057 PMCID:PMC4458210
Hua X, Zhou L, Feng L, Ding Y, Shi H, Wang L, Gee SJ, Hammock BD, Wang M. 2015. Competitive and noncompetitive phage immunoassays for the determination of benzothiostrobin. Anal Chim Acta 890:150-156. doi:10.1016/j.aca.2015.07.056 PMID:26347177 PMCID:PMC4791039
Hwang VJ, Kim J, Rand A, Yang C, Sturdivant S, Hammock BD, Bell P, Guay-Woodford LM, Weiss RH. 2015. The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate. Am J Physiol Renal Physiol 309(6):F492-F498. doi:10.1152/ajprenal.00238.2015 PMID:26155843 PMCID:PMC4572393
Inceoglu B, Bettaieb A, Trindade da Silva CA, Lee KS, Haj FG, Hammock BD. 2015. Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain. Proc Natl Acad Sci U S A 112(29):9082-9087. doi:10.1073/pnas.1510137112 PMID:26150506 PMCID:PMC4517273
Kim J, Yoon SP, Toews ML, Imig JD, Hwang SH, Hammock BD, Padanilam BJ. 2015. Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy. Am J Physiol Renal Physiol 308(2):F131-F139. doi:10.1152/ajprenal.00531.2014 PMID:25377915 PMCID:PMC4338924
Kitamura S, Morisseau C, Inceoglu B, Kamita SG, De Nicola GR, Nyegue M, Hammock BD. 2015. Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo. PLoS One 10(2):e0117438. doi:10.1371/journal.pone.0117438 PMID:25659109 PMCID:PMC4319826
Liu X, Xu Y, Wan D, Xiong Y, He Z, Wang X, Gee SJ, Ryu D, Hammock BD. 2015. Development of a nanobody-alkaline phosphatase fusion protein and its application in a highly sensitive direct competitive fluorescence enzyme immunoassay for detection of ochratoxin A in cereal. Anal Chem 87(2):1387-1394. doi:10.1021/ac504305z PMID:25531426 PMCID:PMC4476795
Lopez-Vicario C, Alcaraz-Quiles J, Garcia-Alonso V, Rius B, Hwang SH, Titos E, Lopategi A, Hammock BD, Arroyo V, Claria J. 2015. Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides. Proc Natl Acad Sci U S A 112(2):536-541. doi:10.1073/pnas.1422590112 PMID:25550510 PMCID:PMC4299190
Nording M, Yang J, Hoang L, Zamora V, Uyeminami DL, Espiritu I, Pinkerton KE, Hammock BD, Luria A. 2015. Bioactive lipid profiling reveals drug target engagement of a soluble epoxide hydrolase inhibitor in a murine model of tobacco smoke exposure. Metabolomics 1:doi:10.7243/2059-0008-1-1 PMID:27076918 PMCID:PMC4827720
Ostermann AI, Herbers J, Willenberg I, Chen R, Hwang SH, Greite R, Morisseau C, Gueler F, Hammock BD, Schebb N. 2015. Oral treatment of rodents with soluble epoxide hydrolase inhibitor 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU): Resulting drug levels and modulation of oxylipin pattern. Prostaglandins Other Lipid Mediat 121(PtA):131-137. doi:10.1016/j.prostaglandins.2015.06.005 PMID:26117215 PMCID:PMC4688279
Ranganathan A, Gee SJ, Hammock BD. 2015. An immunoassay for the detection of triclosan-O-glucuronide, a primary human urinary metabolite of triclosan. Anal Bioanal Chem 407(24):7263-7273. doi:10.1007/s00216-015-8918-5 PMID:26255293 PMCID:PMC4580343
Rossotti MA, Pirez M, Gonzalez-Techera A, Cui Y, Bever C, Lee KS, Morisseau C, Leizagoyen C, Gee SJ, Hammock BD, Gonzalez-Sapienza GG. 2015. Method for sorting and pairwise selection of nanobodies for the development of highly sensitive sandwich immunoassays. Anal Chem 87(23):11907-11914. doi:10.1021/acs.analchem.5b03561 PMID:26544909 PMCID:PMC4666776
Samokhvalov V, Zlobine I, Jamieson KL, Jurasz P, Chen C, Lee KS, Hammock BD, Seubert JM. 2015. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Toxicol Lett 232(1):10-20. doi:10.1016/j.toxlet.2014.09.029 PMID:25300478 PMCID:PMC4486642
Sasso O, Wagner KM, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. 2015. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacol Res 97:7-15. doi:10.1016/j.phrs.2015.04.001 PMID:25882247 PMCID:PMC4464910
Shihadih DS, Harris TR, Yang J, Merzlikin O, Lee KS, Hammock BD, Morisseau C. 2015. Identification of potent inhibitors of the chicken soluble epoxide hydrolase. Bioorg Med Chem Lett 25(2):276-279. doi:10.1016/j.bmcl.2014.11.053 PMID:25479771 PMCID:PMC4277729
Vasylieva N, Ahn K, Barnych B, Gee SJ, Hammock BD. 2015. Development of an immunoassay for the detection of the phenylpyrazole insecticide fipronil. Environ Sci Technol 49(16):10038-10047. doi:10.1021/acs.est.5b01005 PMID:26196357 PMCID:PMC4605820
Walkowska A, Kuczeriszka M, Sadowski J, Olszyñski KH, Dobrowolski L, Červenka L, Hammock BD, Kompanowska-Jezierska E. 2015. High salt intake increases blood pressure in normal rats: putative role of 20-HETE and no evidence on changes in renal vascular reactivity. Kidney Blood Press Res 40(3):323-334. doi:10.1159/000368508 PMID:26067851 PMCID:PMC4583220
Wang J, Majkova Z, Bever C, Yang J, Gee SJ, Li J, Xu T, Hammock BD. 2015. One-step immunoassay for tetrabromobisphenol a using a camelid single domain antibody-alkaline phosphatase fusion protein. Anal Chem 87(9):4741-4748. doi:10.1021/ac504735p PMID:25849972 PMCID:PMC4476793
Wecksler AT, Hwang SH, Liu J, Wettersten HI, Morisseau C, Wu J, Weiss RH, Hammock BD. 2015. Biological evaluation of a novel sorafenib analogue, t-CUPM. Cancer Chemother Pharmacol 75(1):161-171. doi:10.1007/s00280-014-2626-2 PMID:25413440 PMCID:PMC4400119
Xu J, Morisseau C, Yang J, Mamatha DM, Hammock BD. 2015. Epoxide hydrolase activities and epoxy fatty acids in the mosquito Culex quinquefasciatus. Insect Biochem Mol Biol 59:41-49. doi:10.1016/j.ibmb.2015.02.004 PMID:25686802 PMCID:PMC4387068
Yang J, Bratt J, Franzi L, Liu J, Zhang G, Zeki AA, Vogel CF, Williams K, Dong H, Lin Y, Hwang SH, Kenyon NJ, Hammock BD. 2015. Soluble epoxide hydrolase inhibitor attenuates inflammation and airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol 52(1):46-55. doi:10.1165/rcmb.2013-0440OC PMID:24922186 PMCID:PMC4370250

2014

Bettaieb A, Chahed S, Tabet G, Yang J, Morisseau C, Griffey S, Hammock BD, Haj FG. 2014. Effects of soluble epoxide hydrolase deficiency on acute pancreatitis in mice. PLoS One 9(11):e113019. doi:10.1371/journal.pone.0113019 PMID:25402489 PMCID:PMC4234494
Bever C, Majkova Z, Radhakrishnan R, Suni II, McCoy MR, Wang Y, Dechant JE, Gee SJ, Hammock BD. 2014. Development and utilization of camelid VHH antibodies from alpaca for 2,2',4,4'-tetrabrominated diphenyl ether detection. Anal Chem 86(15):7875-7882. doi:10.1021/ac501807j PMID:25005746 PMCID:PMC4144723
Burmistrov V, Morisseau C, Lee KS, Shihadih DS, Harris TR, Butov GM, Hammock BD. 2014. Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 24(9):2193-2197. doi:10.1016/j.bmcl.2014.03.016 PMID:24685540 PMCID:PMC4019751
Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P. 2014. Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc Natl Acad Sci U S A 111(22):8167-8172. doi:10.1073/pnas.1402965111 PMID:24843165 PMCID:PMC4050620
Chen A, Wang R, Bever C, Xing S, Hammock BD, Pan T. 2014. Smartphone-interfaced lab-on-a-chip devices for field-deployable enzyme-linked immunosorbent assay. Biomicrofluidics 8(6):064101. doi:10.1063/1.4901348 PMID:25553178 PMCID:PMC4241779
Despa S, Sharma S, Harris TR, Dong H, Li N, Chiamvimonvat N, Taegtmeyer H, Margulies KB, Hammock BD, Despa F. 2014. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model. J Am Heart Assoc 3(4):doi:10.1161/JAHA.114.001015 PMID:25146704 PMCID:PMC4310392
Dong J, Xu C, Wang H, Xiao Z, Gee SJ, Li Z, Wang F, Wu W, Shen Y, Yang J, Sun Y, Hammock BD. 2014. Enhanced sensitive immunoassay: noncompetitive phage anti-immune complex assay for the determination of malachite green and leucomalachite green. J Agric Food Chem 62(34):8752-8758. doi:10.1021/jf5019824 PMID:25077381 PMCID:PMC4150606
Hua X, Yin W, Shi H, Li M, Wang Y, Wang H, Ye Y, Kim H, Gee SJ, Wang M, Liu F, Hammock BD. 2014. Development of phage immuno-loop-mediated isothermal amplification assays for organophosphorus pesticides in agro-products. Anal Chem 86(16):8441-8447. doi:10.1021/ac5020657 PMID:25135320 PMCID:PMC4139188
Kim J, Imig JD, Yang J, Hammock BD, Padanilam BJ. 2014. Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation. Am J Physiol Renal Physiol 307(8):F971-F980. doi:10.1152/ajprenal.00256.2014 PMID:25164080 PMCID:PMC4200297
Kujal P, Chabova VC, Skaroupkova P, Huskova Z, Vernerova Z, Kramer HJ, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kitada K, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Cervenka L. 2014. Inhibition of soluble epoxide hydrolase is renoprotective in 5/6 nephrectomized Ren-2 transgenic hypertensive rats. Clin Exp Pharmacol Physiol 41(3):227-237. doi:10.1111/1440-1681.12204 PMID:24471737 PMCID:PMC4038339
Lee KS, Liu J, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD. 2014. Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem 57(16):7016-7030. doi:10.1021/jm500694p PMID:25079952 PMCID:PMC4148150
Liu X, Xu Y, Xiong Y, Tu Z, Li Y, He Z, Qiu Y, Fu J, Gee SJ, Hammock BD. 2014. VHH phage-based competitive real-time immuno-polymerase chain reaction for ultrasensitive detection of ochratoxin A in cereal. Anal Chem 86(15):7471-7477. doi:10.1021/ac501202d PMID:24992514 PMCID:PMC4306448
Morisseau C, Wecksler AT, Deng C, Dong H, Yang J, Lee KS, Kodani SD, Hammock BD. 2014. Effect of soluble epoxide hydrolase polymorphism on substrate and inhibitor selectivity and dimer formation. J Lipid Res 55(6):1131-1138. doi:10.1194/jlr.M049718 PMID:24771868 PMCID:PMC4031944
Ono E, Dutile S, Kazani S, Weschsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland E, Castro M, Jarjour NN, Israel E, Levy BD. 2014. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med 190(8):886-897. doi:10.1164/rccm.201403-0544OC PMID:25162465 PMCID:PMC4299578
Radhakrishnan R, Suni II, Bever C, Hammock BD. 2014. Impedance biosensors: applications to sustainability and remaining technical challenges. ACS Sustain Chem Eng 2(7):1649-1655. doi:10.1021/sc500106y PMID:25068095 PMCID:PMC4105195
Schebb N, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH. 2014. Metabolic activation of the antibacterial agent triclocarban by cytochrome P450 1A1 yielding glutathione adducts. Drug Metab Dispos 42(7):1098-1102. doi:10.1124/dmd.114.058206 PMID:24733789 PMCID:PMC4170114
Schebb N, Ostermann AI, Yang J, Hammock BD, Hahn A, Schuchardt J. 2014. Comparison of the effects of long-chain omega-3 fatty acid supplementation on plasma levels of free and esterified oxylipins. Prostaglandins Other Lipid Mediat 113-115:21-29. doi:10.1016/j.prostaglandins.2014.05.002 PMID:24880049 PMCID:PMC4247815
Schuchardt J, Schmidt S, Kressel G, Willenberg I, Hammock BD, Hahn A, Schebb N. 2014. Modulation of blood oxylipin levels by long-chain omega-3 fatty acid supplementation in hyper- and normolipidemic men. Prostaglandins Leukot Essent Fatty Acids 90:27-37. doi:10.1016/j.plefa.2013.12.008 PMID:24411718 PMCID:PMC4130704
Schuchardt J, Schneider I, Willenberg I, Yang J, Hammock BD, Hahn A, Schebb N. 2014. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA. Prostaglandins Other Lipid Mediat 109-111:23-31. doi:10.1016/j.prostaglandins.2014.03.001 PMID:24667634 PMCID:PMC4172375
Sporkova A, Jichova S, Huskova Z, Kopkan L, Nishiyama A, Hwang SH, Hammock BD, Imig JD, Kompanowska-Jezierska E, Sadowski J, Kramer HJ, Cervenka L. 2014. Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats. Clin Exp Pharmacol Physiol 41(12):1003-1013. doi:10.1111/1440-1681.12310 PMID:25224811 PMCID:PMC4347520
Thiphom S, Prapamontol T, Chantara S, Mangklabruks A, Suphavilai C, Ahn K, Gee SJ, Hammock BD. 2014. Determination of the pyrethroid insecticide metabolite 3-PBA in plasma and urine samples from farmer and consumer groups in northern Thailand. J Environ Sci Health B 49(1):15-22. doi:10.1080/03601234.2013.836862 PMID:24138464 PMCID:PMC4020914
Trunnelle KJ, Bennett DH, Ahn K, Schenker MB, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hammock BD. 2014. Concentrations of the urinary pyrethroid metabolite 3-phenoxybenzoic acid in farm worker families in the MICASA study. Environ Res 131:153-159. doi:10.1016/j.envres.2014.03.003 PMID:24721133 PMCID:PMC4152318
Ulu A, Lee S, Miyabe C, Yang J, Hammock BG, Dong H, Hammock BD. 2014. An omega-3 epoxide of docosahexaenoic acid lowers blood pressure in angiotensin-II-dependent hypertension. J Cardiovasc Pharmacol 64(1):87-99. doi:10.1097/FJC.0000000000000094 PMID:24691274 PMCID:PMC4092041
Wagner KM, Vito S, Inceoglu B, Hammock BD. 2014. The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling. Prostaglandins Other Lipid Mediat 113-115:2-12. doi:10.1016/j.prostaglandins.2014.09.001 PMID:25240260 PMCID:PMC4254344
Wagner KM, Yang J, Inceoglu B, Hammock BD. 2014. Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy. J Pain 15(9):907-914. doi:10.1016/j.jpain.2014.05.008 PMID:24924124 PMCID:PMC4150748
Wang J, Bever C, Majkova Z, Dechant JE, Yang J, Gee SJ, Xu T, Hammock BD. 2014. Heterologous antigen selection of camelid heavy chain single domain antibodies against tetrabromobisphenol A. Anal Chem 86(16):8296-8302. doi:10.1021/ac5017437 PMID:25068372 PMCID:PMC4139172
Wang W, Zhu J, Lyu F, Panigrahy D, Ferrara KW, Hammock BD, Zhang G. 2014. ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat 113-115:13-20. doi:10.1016/j.prostaglandins.2014.07.002 PMID:25019221 PMCID:PMC4306447
Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. 2014. Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs 25(4):433-446. doi:10.1097/CAD.0000000000000079 PMID:24525589 PMCID:PMC3947856
Xu J, Morisseau C, Hammock BD. 2014. Expression and characterization of an epoxide hydrolase from Anopheles gambiae with high activity on epoxy fatty acids. Insect Biochem Mol Biol 54:42-52. doi:10.1016/j.ibmb.2014.08.004 PMID:25173592 PMCID:PMC4252830
Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proc Natl Acad Sci U S A 111(48):17200-17205. doi:10.1073/pnas.1419119111 PMID:25404284 PMCID:PMC4260592
Zhang G, Kodani SD, Hammock BD. 2014. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer. Prog Lipid Res 53:108-123. doi:10.1016/j.plipres.2013.11.003 PMID:24345640 PMCID:PMC3914417
Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu J, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2014. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A 111(30):11127-11132. doi:10.1073/pnas.1410432111 PMID:25024195 PMCID:PMC4121808

2013

Bettaieb A, Nagata N, AbouBechara D, Chahed S, Morisseau C, Hammock BD, Haj FG. 2013. Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue. J Biol Chem 288:14189-14199. doi:10.1074/jbc.M113.458414 PMID:23576437 PMCID:PMC3656275
Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock BD, Chorev M, Aktas BH. 2013. Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase. J Med Chem 56(23):9457-9470. doi:10.1021/jm400793v PMID:24261904 PMCID:PMC3938169
Falck D, Schebb N, Prihatiningtyas S, Zhang J, Heus F, Morisseau C, Kool J, Hammock BD, Niessen WM. 2013. Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures. Chromatographia 76:13-21. doi:10.1007/s10337-012-2343-0 PMID:23526703 PMCID:PMC3601784
Frolov A, Dong H, Jiang M, Yang L, Cook EC, Matnani R, Hammock BD, Crofford LJ. 2013. Niemann-pick type C2 deficiency in human fibroblasts confers robust and selective activation of prostaglandin E2 biosynthesis. J Biol Chem 288:23696-23703. doi:10.1074/jbc.M112.445916 PMID:23814065 PMCID:PMC3745317
Frolov A, Yang L, Dong H, Hammock BD, Crofford LJ. 2013. Anti-inflammatory properties of prostaglandin E2: deletion of microsomal prostaglandin E synthase-1 exacerbates non-immune inflammatory arthritis in mice. Prostaglandins Leukot Essent Fatty Acids 89(5):351-358. doi:10.1016/j.plefa.2013.08.003 PMID:24055573 PMCID:PMC3897272
Gardell AM, Yang J, Sacchi R, Fangue NA, Hammock BD, Kültz D. 2013. Tilapia (Oreochromis mossambicus) brain cells respond to hyperosmotic challenge by inducing myo-inositol biosynthesis. J Exp Biol 216(24):4615-4625. doi:10.1242/jeb.088906 PMID:24072790 PMCID:PMC3851147
Guedes AP, Morisseau C, Sole A, Soares JN, Ulu A, Dong H, Hammock BD. 2013. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet Anaesth Analg 40(4):440-448. doi:10.1111/vaa.12030 PMID:23463912 PMCID:PMC3956586
Han J, Kim H, Sudheendra L, Gee SJ, Hammock BD, Kennedy IM. 2013. Photonic crystal lab-on-a-chip for detecting staphylococcal entertoxin B at low attomolar concentration. Anal Chem 85(6):3104-3109. doi:10.1021/ac303016h PMID:23418954 PMCID:PMC3608201
Han J, Kim H, Sudheendra L, Hass EA, Gee SJ, Hammock BD, Kennedy IM. 2013. Electrophoretic build-up of multi nanoparticle array for a highly sensitive immunoassay. Biosens Bioelectron 41:302-308. doi:10.1016/j.bios.2012.08.042 PMID:23021853 PMCID:PMC3525773
Hwang SH, Wecksler AT, Wagner KM, Hammock BD. 2013. Rationally designed multitarget agents against inflammation and pain. Curr Med Chem 20(13):1783-1799. doi:10.2174/0929867311320130013 PMID:23410172 PMCID:PMC4113248
Hwang SH, Wecksler AT, Zhang G, Morisseau C, Nguyen LV, Fu SH, Hammock BD. 2013. Synthesis and biological evaluation of sorafenib- and regorafenib- like sEH inhibitors. Bioorg Med Chem Lett 23(13):3732-3737. doi:10.1016/j.bmcl.2013.05.011 PMID:23726028 PMCID:PMC3744640
Inceoglu B, Zolkowska D, Yoo H, Wagner KM, Yang J, Hackett E, Hwang SH, Lee KS, Rogawski MA, Morisseau C, Hammock BD. 2013. Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures. PLoS One 8(12):doi:10.1371/journal.pone.0080922 PMID:24349022 PMCID:PMC3862847
Kamita SG, Oshita GH, Wang P, Morisseau C, Hammock BD, Nandety R, Falk BW. 2013. Characterization of HOVI-MEH1, a microsomal epoxide hydrolase from the Glassy-Winged Sharpshooter Homalodisca vitripennis. Arch Insect Biochem Physiol 83(4):171-179. doi:10.1002/arch.21100 PMID:23704009 PMCID:PMC3846607
Kamita SG, Yamamoto K, Dadala MM, Pha K, Morisseau C, Escaich A, Hammock BD. 2013. Cloning and characterization of a microsomal epoxide hydrolase from Heliothis virescens. Insect Biochem Mol Biol 43(3):219-228. doi:10.1016/j.ibmb.2012.12.002 PMID:23276675 PMCID:PMC3577957
Lee KS, Morisseau C, Yang J, Wang P, Hwang SH, Hammock BD. 2013. Forster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase. Anal Biochem 434(2):259-268. doi:10.1016/j.ab.2012.11.015 PMID:23219719 PMCID:PMC3632402
Liu J, Lin Y, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD. 2013. Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models. European Journal of Pharmaceutical Sciences 48(4-5):619-627. doi:10.1016/j.ejps.2012.12.013 PMID:23291046 PMCID:PMC3596469
Morisseau C, Hammock BD. 2013. Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. Annu Rev Pharmacol Toxicol 53:37-58. doi:10.1146/annurev-pharmtox-011112-140244 PMID:23020295 PMCID:PMC3578707
Morisseau C, Pakhomova S, Hwang SH, Newcomer ME, Hammock BD. 2013. Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg Med Chem Lett 23(13):3818-3821. doi:10.1016/j.bmcl.2013.04.083 PMID:23684894 PMCID:PMC3703951
Morisseau C, Sahdeo S, Cortopassi GA, Hammock BD. 2013. Development of an HTS assay for EPHX2 phosphatase activity and screening of nontargeted libraries. Anal Biochem 434(1):105-111. doi:10.1016/j.ab.2012.11.017 PMID:23219563 PMCID:PMC3557602
Nording ML, Yang J, Georgi K, Karbowski CH, German JB, Weiss RH, Hogg RJ, Trygg J, Hammock BD, Zivkovic AM. 2013. Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids. PLoS One 8:e76575. doi:10.1371/journal.pone.0076575 PMID:24204640 PMCID:PMC3811983
Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. 2013. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 110(33):13528-13533. doi:10.1073/pnas.1311565110 PMID:23898174 PMCID:PMC3746918
Poli G, Corda E, Martino P, Dall'Ara P, Bareggi SR, Bondiolotti G, Iulini B, Mazza M, Casalone C, Hwang SH, Hammock BD, Inceoglu B. 2013. Therapeutic activity of inhibition of the soluble epoxide hydrolase in a mouse model of scrapie. Life Sciences 92(23):1145-1150. doi:10.1016/j.lfs.2013.04.014 PMID:23651659 PMCID:PMC3806320
Ranganathan A, Paradise GA, Hansen CA, McCoy MR, Gee SJ, Zhong P, Chang D, Hammock BD. 2013. Indirect homologous competitive enzyme-linked immunosorbent assay for the detection of a class of glycosylated dihydrochalcones. J Agric Food Chem 61(28):6964-6970. doi:10.1021/jf401302y PMID:23767873 PMCID:PMC3723731
Schuchardt J, Schmidt S, Kressel G, Dong H, Willenberg I, Hammock BD, Hahn A, Schebb N. 2013. Comparison of free serum oxylipin concentrations in hyper- vs. normolipidemic men. Prostaglandins Leukot Essent Fatty Acids 89(1):19-29. doi:10.1016/j.plefa.2013.04.001 PMID:23694766 PMCID:PMC4057063
Sirish P, Li N, Liu J, Lee KS, Hwang SH, Qiu H, Zhao C, Ma S, Lopez JE, Hammock BD, Chiamvimonvat N. 2013. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A 110(14):5618-5623. doi:10.1073/pnas.1221972110 PMID:23493561 PMCID:PMC3619365
Smilowitz JT, Zivkovic AM, Wan YY, Watkins SM, Nording M, Hammock BD, German JB. 2013. Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. Mol Nutr Food Res 57(8):1319-1335. doi:10.1002/mnfr.201200808 PMID:23818328 PMCID:PMC3806310
Stewart DN, Lango J, Nambiar KP, Falso MS, Fitzgerald PG, Rocke DM, Hammock BD, Buchholz BA. 2013. Carbon turnover in the water-soluble protein of the adult human lens. Mol Vis 19:463-475. PMID:23441119 PMCID:PMC3580966
Trunnelle KJ, Bennett DH, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hennessy-Burt TE, Hammock BD, Schenker MB. 2013. Pyrethroids in house dust from the homes of farm worker families in the MICASA study. Environ Int 61:57-63. doi:10.1016/j.envint.2013.09.007 PMID:24096042 PMCID:PMC4059492
Ulu A, Harris TR, Morisseau C, Miyabe C, Inoue H, Schuster G, Dong H, Iosif A, Liu J, Weiss RH, Chiamvimonvat N, Imig JD, Hammock BD. 2013. Anti-inflammatory effects of omega-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II dependent hypertension. J Cardiovasc Pharmacol 62(3):285-297. doi:10.1097/FJC.0b013e318298e460 PMID:23676336 PMCID:PMC3773051
Van Bogaert I, Zhang G, Yang J, Liu J, Ye Y, Soetaert W, Hammock BD. 2013. Preparation of 20- HETE using multifunctional enzyme type 2-negative Starmerella bombicola. J Lipid Res 54(11):3215-3219. doi:10.1194/jlr.D042226 PMID:23966667 PMCID:PMC3793626
Vanrell L, Gonzalez-Techera A, Hammock BD, Gonzalez-Sapienza GG. 2013. Nanopeptamers for the development of small-analyte lateral flow tests with a positive readout. Anal Chem 85(2):1177-1182. doi:10.1021/ac3031114 PMID:23214940 PMCID:PMC3904493
Wagner KM, Inceoglu B, Dong H, Yang J, Hwang SH, Jones PD, Morisseau C, Hammock BD. 2013. Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models. Eur J Pharmacol 700(1-3):93-101. doi:10.1016/j.ejphar.2012.12.015 PMID:23276668 PMCID:PMC3578047
Wang Y, Li P, Majkova Z, Bever C, Kim H, Zhang Q, Dechant JE, Gee SJ, Hammock BD. 2013. Isolation of alpaca anti-idiotypic heavy-chain single-domain antibody for the aflatoxin immunoassay. Anal Chem 85(17):8298-8303. doi:10.1021/ac4015885 PMID:23965250 PMCID:PMC3787825
Wang Y, Wang H, Li P, Zhang Q, Kim H, Gee SJ, Hammock BD. 2013. Correction to: Phage- displayed peptide that mimics aflatoxins and its application in immunoassay. J Agric Food Chem 61(16):3994. doi:10.1021/jf401235p
Wang Y, Wang H, Li P, Zhang Q, Kim H, Gee SJ, Hammock BD. 2013. Phage-displayed peptide that mimics aflatoxins and its application in immunoassay. J Agric Food Chem 61(10):2426–2433. doi:10.1021/jf4004048 PMID:23394544 PMCID:PMC3830680
Wettersten HI, Hwang SH, Li C, Shiu EY, Wecksler AT, Hammock BD, Weiss RH. 2013. A novel p21 attenuator which is structurally related to sorafenib. Cancer Biol Ther 14:278-285. doi:10.4161/cbt.23374 PMID:23298903 PMCID:PMC3595311
Yang J, Solaimani P, Dong H, Hammock BD, Hankinson O. 2013. Treatment of mice with 2,3,7,8-Tetrachlorodibenzo-p-dioxin markedly increases the levels of a number of cytochrome P450 metabolites of omega-3 polyunsaturated fatty acids in the liver and lung. Toxicol Sci 38(6):833-836. PMID:24213002 PMCID:PMC4068614
Zhang G, Panigrahy D, Mahakian LM, Yang J, Liu J, Lee KS, Wettersten HI, Ulu A, Hu X, Tam S, Hwang SH, Ingham ES, Kieran MW, Weiss RH, Ferrara KW, Hammock BD. 2013. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. Proc Natl Acad Sci U S A 110(16):6530-6535. doi:10.1073/pnas.1304321110 PMID:23553837 PMCID:PMC3631682
Zhang W, Li H, Dong H, Liao J, Hammock BD, Yang G. 2013. Soluble epoxide hydrolase deficiency inhibits dextran sulfate sodium-induced colitis and carcinogenesis in mice. Anticancer Res 33(12):5261-5271. PMID:24324059 PMCID:PMC4076172

2012

Ahn K, Kasagami T, Tsai H, Schebb N, Ogunyoku TA, Gee SJ, Young TM, Hammock BD. 2012. An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban. Environ Sci Technol 46:374-381. doi:10.1021/es202494d PMID:22077920 PMCID:PMC3258304 (Completed with ARRA Funds)
Cao Z, Hammock BD, McCoy MR, Rogawski MA, Lein PJ, Pessah IN. 2012. Tetramethylenedisulfotetramine alters Ca2+ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation. Toxicol Sci 130(2):362-372. doi:10.1093/toxsci/kfs244 PMID:22889812 PMCID:PMC3529644
Cherednichenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos G, Schebb N, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN. 2012. Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle. Proc Natl Acad Sci U S A 109(35):14158-14163. doi:10.1073/pnas.1211314109 PMID:22891308 PMCID:PMC3435154
Eiserich JP, Yang J, Morrissey BM, Hammock BD, Cross CE. 2012. Omics approaches in cystic fibrosis research: a focus on oxylipin profiling in airway secretions. Ann N Y Acad Sci 1259:1-9. doi:10.1111/j.1749-6632.2012.06580.x PMID:22758630 PMCID:PMC3403728
Han J, Sudheendra L, Kim H, Gee SJ, Hammock BD, Kennedy IM. 2012. Ultrasensitive on-chip immunoassays with a nanoparticle-assembled photonic crystal. ACS Nano 6(10):8570-8582. doi:10.1021/nn301656c PMID:22957818 PMCID:PMC3479307
Inceoglu AB, Clifton HL, Yang J, Hegedus C, Hammock BD, Schaefer S. 2012. Inhibition of soluble epoxide hydrolase limits niacin-induced vasodilation in mice. J Cardiovasc Pharmacol 60:70-75. doi:10.1097/FJC.0b013e3182580a5d PMID:22526297 PMCID:PMC3396292
Inceoglu B, Wagner KM, Yang J, Bettaieb A, Schebb N, Hwang SH, Morisseau C, Haj FG, Hammock BD. 2012. Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of Type I Diabetes. Proc Natl Acad Sci U S A 109(28):11390-11395. doi:10.1073/pnas.1208708109 PMID:22733772 PMCID:PMC3396532
Kim H, Majkova Z, Dechant JE, Gee SJ, Tabares-da Rosa S, Gonzalez-Sapienza GG, Hammock BD, McCoy MR. 2012. Isolation of alpaca anti-hapten heavy chain single domain antibodies for development of sensitive immunoassay. Anal Chem 84(2):1165-1171. doi:10.1021/ac2030255 PMID:22148739 PMCID:PMC3264785
Kim H, McCoy MR, Majkova Z, Dechant JE, Gee SJ, Tabares-da Rosa S, Gonzalez-Sapienza GG, Hammock BD. 2012. Correction to isolation of alpaca antihapten heavy chain single domain antibodies for development of sensitive immunioassay. Anal Chem 84(15):6919–6919. doi:10.1021/ac301927h PMID:22830304 PMCID:PMC3460544
Kim I, Nishi K, Kasagami T, Morisseau C, Liu J, Tsai H, Hammock BD. 2012. Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase. Bioorg Med Chem Lett 22(18):5889-5892. doi:10.1016/j.bmcl.2012.07.074 PMID:22901393 PMCID:PMC3432147
Lin Y, Ubels JL, Schotanus MP, Yin Z, Pintea V, Hammock BD, Watsky MA. 2012. Enhancement of vitamin D metabolites in the eye following vitamin D3 supplementation and UV-B irradiation. Curr Eye Res 37(10):871-878. doi:10.3109/02713683.2012.688235 PMID:22632164 PMCID:PMC3572765
McCoy MR, Yang Z, Fu X, Ahn K, Gee SJ, Bom DC, Zhong P, Chang D, Hammock BD. 2012. Monitoring of total type II pyrethroid pesticides in citrus oils and water by converting to a common product 3-phenoxybenzoic acid. J Agric Food Chem 60:5065-5070. doi:10.1021/jf2051653 PMID:22486225 PMCID:PMC3412423
Morisseau C, Schebb N, Dong H, Ulu A, Aronov PA, Hammock BD. 2012. Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids. Biochem Biophys Res Commun 419:796-800. doi:10.1016/j.bbrc.2012.02.108 PMID:22387545 PMCID:PMC3313618
Qiu H, Liu J, Wei D, Li N, Yamoah EN, Hammock BD, Chiamvimonvat N. 2012. Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia. Cardiovasc Res 95(3):336-345. doi:10.1093/cvr/cvs191 PMID:22707158 PMCID:PMC3400359
Schebb N, Ahn K, Dong H, Gee SJ, Hammock BD. 2012. Whole blood is the sample matrix of choice for monitoring systemic triclocarbon levels. Chemosphere 87(7):825-827. doi:10.1016/j.chemosphere.2011.12.077 PMID:22273184 PMCID:PMC3538789 (Completed with ARRA Funds)
Schebb N, Buchholz BA, Hammock BD, Rice RH. 2012. Metabolism of the antibacterial triclocarban by human epidermal keratinocytes to yield protein adducts. J Biochem Mol Toxicol 26(6):230-234. doi:10.1002/jbt.21411 PMID:22711420 PMCID:PMC3522462
Schebb N, Franze B, Maul R, Ranganathan A, Hammock BD. 2012. In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites. Drug Metab Dispos 40:25-31. doi:10.1124/dmd.111.042283 PMID:21953915 PMCID:PMC3250046 (Completed with ARRA Funds)
Thiphom S, Prapamontol T, Chantara S, Mangklabruks A, Suphavilai C, Ahn K, Gee SJ, Hammock BD. 2012. An enzyme-linked immunosorbent assay for detecting 3-phenoxybenzoic acid in plasma and its application to farmers and consumers. Analytical Methods 4:3772-3778. doi:10.1039/c2ay25642h PMID:23667388 PMCID:PMC3646417
Yang J, Eiserich JP, Cross CE, Morrissey BM, Hammock BD. 2012. Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radic Biol Med 53(1):160-171. doi:10.1016/j.freeradbiomed.2012.05.001 PMID:22580336 PMCID:PMC3412514
Yao H, Liu J, Samra AI, Kamita SG, Cornel AJ, Hammock BD, Huang H. 2012. Development of pyrethroid-like fluorescent substrates for glutathione S-transferase. Anal Biochem 431:77-83. doi:10.1016/j.ab.2012.09.011 PMID:23000005 PMCID:PMC3489985
Yueh MF, Li T, Evans RM, Hammock BD, Tukey RH. 2012. Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha. PLoS One 7(6):e37705. doi:10.1371/journal.pone.0037705 PMID:22761658 PMCID:PMC3376094 (Completed with ARRA Funds)
Zhang W, Yang AL, Liao J, Li H, Dong H, Chung Y, Bai H, Matkowskyj KA, Hammock BD, Yang G. 2012. Soluble epoxide hydrolase gene deficiency or inhibition attenuates chronic active inflammatory bowel disease in IL-10(-/-) mice. Dig Dis 57(10):2580-2591. doi:10.1007/s10620-012-2217-1 PMID:22588244 PMCID:PMC3664520
Zivkovic AM, Yang J, Georgi K, Hegedus C, Nording ML, O'Sullivan A, German JB, Hogg RJ, Weiss RH, Bay C, Hammock BD. 2012. Serum oxylipin profiles in lgA nephropathy patients reflect kidney functional alterations. Metabolomics 8(6):1102-1113. doi:10.1007/s11306-012-0417-5 PMID:23833568 PMCID:PMC3700377
Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA. 2012. Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine. J Pharmacol Exp Ther 341(2):435-446. doi:10.1124/jpet.111.190579 PMID:22328574 PMCID:PMC3336809

2011

Abdu E, Bruun DA, Yang DR, Yang J, Inceoglu B, Hammock BD, Alkayed NJ, Lein PJ. 2011. Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures. J Neurochem 117:632-642. doi:10.1111/j.1471-4159.2010.07139.x PMID:21155804 PMCID:PMC3081369
Ahn K, Gee SJ, Aronov PA, Vega H, Krieger RI, Hammock BD, Kim H. 2011. Immunochemical analysis of 3-phenoxybenzoic acid, a biomarker of forestry worker exposure to pyrethroid insecticides. Anal Bioanal Chem 401(4):1285-1293. doi:10.1007/s00216-011-5184-z PMID:21717113 PMCID:PMC3848323
Ahn K, Kim H, McCoy MR, Gee SJ, Hammock BD. 2011. Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides. J Agric Food Chem 59(7):2792-2802. doi:10.1021/jf1033569 PMID:21105656 PMCID:PMC3070843
Barhoumi R, Mouneimne Y, Hammock BD, Safe SH, Burghardt RC, Parrish AR, Ramos E. 2011. Multiphoton spectral analysis of benzo a pyrene uptake and metabolism in a rat liver cell line. Toxicol Appl Pharmacol 253:45-56. doi:10.1016/j.taap.2011.03.009 PMID:21420996 PMCID:PMC3081912
Charles RL, Burgoyne JR, Mayr M, Weldon SM, Hubner N, Dong H, Morisseau C, Hammock BD, Landar A, Eaton P. 2011. Redox regulation of soluble epoxide hydrolase by 15-Deoxy-AProstaglandin J2 controls coronary hypoxic vasodilation. Circ. Res. Circ Res 108:324-334. doi:10.1161/CIRCRESAHA.110.235879 PMID:21164107 PMCID:PMC3259859
Davis BB, Liu J, Tancredi DJ, Wang L, Simon SI, Hammock BD, Pinkerton KE. 2011. The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment. Biochem Biophys Res Commun 410:494-500. doi:10.1016/j.bbrc.2011.06.008 PMID:21683067 PMCID:PMC3166856
Gee SJ, Gonazlez-Sapienza GG, Hammock BD, Kim H, McCoy MR. 2011. Noncompetitive phage anti-immunocomplex real-time polymerase chain reaction for sensitive detection of small molecules. Anal Chem 83(1):246-253. doi:10.1021/ac102353z PMID:21141939 PMCID:PMC3031424
Honetschlagerova Z, Huskova Z, Vanourkova Z, Sporkova A, Kramer HJ, Hwang SH, Tsai H, Hammock BD, Imig JD, Cervenka L, Kopkan L. 2011. Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension. J Physiol 589(Pt1):207-219. doi:10.1113/jphysiol.2010.199505 PMID:21078594 PMCID:PMC3039270
Hwang SH, Wagner KM, Morisseau C, Liu J, Dong H, Wecksler AT, Hammock BD. 2011. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. J Med Chem 54:3037-3050. doi:10.1021/jm2001376 PMID:21434686 PMCID:PMC3281519
Inceoglu B, Wagner KM, Schebb N, Morisseau C, Jinks SL, Ulu A, Hegedus C, Rose TE, Hammock BD, Brosnan R. 2011. Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP. Proc Natl Acad Sci U S A 108(12):5093-5097. doi:10.1073/pnas.1101073108 PMID:21383170 PMCID:PMC3064364
Inoue H, Hwang SH, Wecksler AT, Hammock BD, Weiss RH. 2011. Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy. Cancer Biol Ther 12:827-836. doi:10.4161/cbt.12.9.17680 PMID:21878748 PMCID:PMC3225758
Kamita SG, Samra AI, Liu J, Cornel AJ, Hammock BD. 2011. Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene. PLoS One 6:doi:10.1371/journal.pone.0028392 PMID:22174797 PMCID:PMC3235118
Kim Y, Lee E, Kim K, Lee YT, Hammock BD, Lee H. 2011. Competitive immunochromatographic assay for the detection of the organophosphorus pesticide chlorpyrifos. Anal Chim Acta 693(1-2):106-113. doi:10.1016/j.aca.2011.03.011 PMID:21504817 PMCID:PMC3927651
Koeners MP, Wesseling S, Ulu A, Sepulveda R, Morisseau C, Braam B, Hammock BD, Joles JA. 2011. Soluble epoxide hydrolase in the generation and maintenance of high blood pressure in spontaneously hypertensive rats. Am J Physiol Endocrinol Metab 300:E691-698. doi:10.1152/ajpendo.00710.2010 PMID:21266668 PMCID:PMC3074945
Li YY, Liu J, Harris TR, Sirish P, Hammock BD, Chiamvimonvat N. 2011. Use of metabolomics profiling in the study of arachidonic acid metabolism in cardiovascular disease. American Journal of Cardiology 17:42-46. doi:10.1111/j.1751-7133.2010.00209.x PMID:21272227 PMCID:PMC3583533
Liu J, Qiu H, Moisseau C, Hwang SH, Tsai H, Ulu A, Chiamvimonvat N, Hammock BD. 2011. Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model. Toxicol Appl Pharmacol 255:200-206. doi:10.1016/j.taap.2011.06.017 PMID:21741984 PMCID:PMC3156297
Luria A, Bettaieb A, Xi Y, Shieh G, Liu H, Inoue H, Tsai H, Imig JD, Haj FG, Hammock BD. 2011. Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance. Proc Natl Acad Sci U S A 108(22):9038-9043. doi:10.1073/pnas.1103482108 PMID:21571638 PMCID:PMC3107315
Morisseau C, Bernay M, Escaich A, Sanborn JR, Lango J, Hammock BD. 2011. Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. Anal Biochem 414(1):154-162. doi:10.1016/j.ab.2011.02.038 PMID:21371418 PMCID:PMC3090455
Qiu H, Li N, Liu J, Harris TR, Hammock BD, Chiamvimonvat N. 2011. Soluble epoxide hydrolase inhibitors and heart failure. Cardiovasc Ther 29(2):99-111. doi:10.1111/j.1755-5922.2010.00150.x PMID:20433684 PMCID:PMC3325372
Schebb N, Huby M, Morisseau C, Hwang SH, Hammock BD. 2011. Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors. Anal Bioanal Chem 400(5):1359-1366. doi:10.1007/s00216-011-4861-2 PMID:21479549 PMCID:PMC3081056
Schebb N, Inceoglu B, Ahn K, Morisseau C, Gee SJ, Hammock BD. 2011. Investigation of human exposure to triclocarban after showering and preliminary evaluation of its biological effects. Environ Sci Technol 45:3109-3115. doi:10.1021/es103650m PMID:21381656 PMCID:PMC3470465 (Completed with ARRA Funds)
Schebb N, Inceoglu B, Rose TE, Wagner KM, Hammock BD. 2011. Development of an ultra fast online-solid phase extraction (SPE) liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) based approach for the determination of drugs in pharmacokinetic studies. Analytical Methods 3:420-428. doi:10.1039/c0ay00714e PMID:21660124 PMCID:PMC3110015
Schebb N, Kurobe T, Franze B, Ranganathan A, Hammock BD, Teh SJ, Flores I. 2011. Bioconcentration, metabolism and excretion of triclocarban in larval Qurt medaka (Oryzias latipes). Aquat Toxicol 105:448-454. doi:10.1016/j.aquatox.2011.07.020 PMID:21872556 PMCID:PMC3236035
Sporkova A, Kopkan L, Varcabova S, Huskova Z, Hwang SH, Hammock BD, Imig JD, Kramer HJ, Cervenka L. 2011. Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats. Am J Physiol Regul Integr Comp Physiol 300:R1468-R1475. doi:10.1152/ajpregu.00215.2010 PMID:21411763 PMCID:PMC3119161
Tabares-da Rosa S, Rossotti MA, Carleiza C, Carrion F, Pritsch O, Ahn K, Last JA, Hammock BD, Gonzalez-Sapienza GG. 2011. Competitive selection from single domain antibody libraries allows isolation of high-affinity antihapten antibodies that are not favored in the llama immune response. Anal Chem 83:7213-7220. doi:10.1021/ac201824z PMID:21827167 PMCID:PMC3193053
Wagner KM, Inceoglu B, Gill S, Hammock BD. 2011. Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction. J Agric Food Chem 59:2816-2824. doi:10.1021/jf102559q PMID:20958046 PMCID:PMC3483885
Wagner KM, Inceoglu B, Hammock BD. 2011. Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. Prostaglandins Other Lipid Mediat 96:76-83. doi:10.1016/j.prostaglandins.2011.08.001 PMID:21854866 PMCID:PMC3215909
Yang J, Dong H, Hammock BD. 2011. Profiling the regulatory lipids: another systemic way to unveil the biological mystery. Curr Opin Lipidol 22:197-203. doi:10.1097/MOL.0b013e3283468c10 PMID:21537174 PMCID:PMC3498048
Ye X, Zhou X, Furr J, Ahn K, Hammock BD, Gray EL, Calafat AM. 2011. Biomarkers of exposure to triclocarban in urine and serum. Toxicology 286(1-30):69-74. doi:10.1016/j.tox.2011.05.008 PMID:21635932 PMCID:PMC3534749 (Completed with ARRA Funds)
Yin Z, Pintea V, Lin Y, Hammock BD, Watsky MA. 2011. Vitamin D enhances corneal epithelial barrier function. Invest Ophthalmol Vis Sci 52:7359-7364. doi:10.1167/iovs.11-7605 PMID:21715350 PMCID:PMC3183972

2010

Alihosseini F, Lango J, Ju K, Hammock BD, Sun G. 2010. Mutation of bacterium Vibrio gazogenes for selective preparation of colorants. Biotechnol Prog 26(2):352-360. doi:10.1002/btpr.346 PMID:19902486 PMCID:PMC2864118
Baumann A, Lohmann W, Rose TE, Ahn K, Hammock BD, Karst U, Schebb N. 2010. Electrochemistry-mass spectrometry unveils the formation of reactive triclocarban metabolites. Drug Metab Dispos 38(12):2130-2138. doi:10.1124/dmd.110.034546 PMID:20861155 PMCID:PMC2993458 (Completed with ARRA Funds)
Carlomagno M, Matho C, Cantou G, Sanborn JR, Last JA, Hammock BD, Roel A, Gonzalez D, Gonzalez-Sapienza GG. 2010. A clomazone immunoassay to study the environmental fate of the herbicide in rice (Oryza sativa) agriculture. J Agric Food Chem 58(7):4367-4371. doi:10.1021/jf9043259 PMID:20302341 PMCID:PMC2878771
Chabova VC, Walkowska A, Kompanowska-Jezierska E, Sadowski J, Kujal P, Vernerova Z, Vanourkova Z, Kopkan L, Kramer HJ, Imig JD, Hammock BD, Vaneckova I, Cervenka L, Falck JR. 2010. Combined inhibition of 20-hydroxyeicosatetraenoic acid formation and of epoxyeicosatrienoic acids degradation attenuates hypertension and hypertension-induced end-organ damage in Ren-2 transgenic rats. Clin Sci (Lond) 118(10):617-632. doi:10.1042/CS20090459 PMID:20050826 PMCID:PMC2854172
Garcia-Nieto E, Nichkova MJ, Yanez L, Costilla-Salazar R, Torres-Dosal A, Gee SJ, Hammock BD, Juarez-Santacruz L, Diaz-Barriga F. 2010. Assessment of dioxin-like soil contamination in Mexico by enzyme-linked immunosorbent assay. Arch Environ Contam Toxicol 58(4):918-926. doi:10.1007/s00244-009-9422-8 PMID:20091164 PMCID:PMC3033344
Hall LM, Kimlin M, Aronov PA, Hammock BD, Slusser J, Woodhouse L, Stephensen CB. 2010. Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J Nutr 140(3):542-550. doi:10.3945/jn.109.115253 PMID:20053937 PMCID:PMC2821886
Kim H, Rossotti MA, Ahn K, Gonzalez-Sapienza GG, Gee SJ, Musker R, Hammock BD. 2010. Development of a noncompetitive phage anti-immunocomplex assay for brominated diphenyl ether 47. Anal Biochem 401(1):38-46. doi:10.1016/j.ab.2010.01.040 PMID:20152791 PMCID:PMC2861364
Kubala L, Schmelzer KR, Klinke A, Kolarova H, Baldus S, Hammock BD, Eiserich JP. 2010. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. Free Radic Biol Med 48(10):1311-1320. doi:10.1016/j.freeradbiomed.2010.02.010 PMID:20156554 PMCID:PMC2856720
Liu J, Li N, Yang J, Li N, Qiu H, Ai D, Chiamvimonvat N, Zhu Y, Hammock BD. 2010. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events. Proc Natl Acad Sci U S A 107(39):17017-17022. doi:10.1073/pnas.1011278107 PMID:20837537 PMCID:PMC2947894
Morisseau C, Inceoglu B, Schmelzer KR, Tsai H, Jinks SL, Hegedus CM, Hammock BD. 2010. Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids. J Lipid Res 51:3481-3490. doi:10.1194/jlr.M006007 PMID:20664072 PMCID:PMC2975720
Nording ML, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD. 2010. Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: Electrospray tandem mass spectrometry. IEEE/ACM Trans Comput Biol Bioinform 10(1):123-130. doi:10.1109/JSEN.2009.2035736 PMID:21103452 PMCID:PMC2981865
Rayo J, Munoz L, Rosell G, Hammock BD, Guerrero A, Luque FJ, Pouplana R. 2010. Reactivity versus steric effects in fluorinated ketones as esterase inhibitors: a quantum mechanical and molecular dynamics study. J Mol Model 16(11):1753-1764. doi:10.1007/s00894-010-0807-4 PMID:20676708 PMCID:PMC3014912
Rose TE, Morisseau C, Liu J, Inceoglu B, Jones PD, Sanborn JR, Hammock BD. 2010. 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain. J Med Chem 53(19):7067-7075. doi:10.1021/jm100691c PMID:20812725 PMCID:PMC3285450
Rossotti MA, Carlomagno M, Gonzalez-Techera A, Hammock BD, Last JA, Gonzalez-Sapienza GG. 2010. Phage anti-immunocomplex assay for clomazone: two-site recognition increasing assay specificity and facilitating adaptation into an on-site format. Anal Chem 82(21):8838-8843. doi:10.1021/ac101476f PMID:20886819 PMCID:PMC3025275
Tsai H, Hwang SH, Morisseau C, Yang J, Jones PD, Kasagami T, Kim I, Hammock BD. 2010. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences 40(3):222-238. doi:10.1016/j.ejps.2010.03.018 PMID:20359531 PMCID:PMC3285443
Wang Y, Ulu A, Zhang L, Hammock BD. 2010. Soluble epoxide hydrolase in atherosclerosis. Curr Atheroscler Rep 12(3):174-183. doi:10.1007/s11883-010-0108-5 PMID:20425256 PMCID:PMC2857794

2009

Ahn K, Gee SJ, Tsai H, Bennett DH, Nishioka M, Blum A, Fishman E, Hammock BD. 2009. Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47. Environ Sci Technol 43(20):7784-7790. doi:10.1021/es9009037 PMID:19921894 PMCID:PMC3528349
Ai D, Pang W, Li N, Xu M, Jones PD, Yang J, Zhang Y, Chiamvimonvat N, Shyy JY, Hammock BD, Zhu Y. 2009. Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy. Proc Natl Acad Sci U S A 106(2):564-569. doi:10.1073/pnas.0811022106 PMID:19126686 PMCID:PMC2626743
Barbosa-Sicard E, Fromel T, Keseru B, Brandes RP, Morisseau C, Hammock BD, Braun T, Kruger M, Fleming I. 2009. Inhibition of the soluble epoxide hydrolase by tyrosine nitration. J Biol Chem 284:28156-28163. doi:10.1074/jbc.M109.054759 PMID:19704161 PMCID:PMC2788866
Chawengsub Y, Gauthier KM, Nithipatikom K, Hammock BD, Falck JR, Narsimhaswamy D, Campbell WB. 2009. Identification of 13-hydroxy-14,15-epoxyeicosatrienoic acid as an acid-stable endothelium-derived hyperpolarizing factor in rabbit arteries. J Biol Chem 284(45):31280-31290. doi:10.1074/jbc.M109.025627 PMID:19737933 PMCID:PMC2781526
Falck JR, Kodela R, Manne R, Atcha KR, Puli N, Dubasi N, Manthati VL, Capdevila JH, Yi X, Goldman DH, Morisseau C, Hammock BD, Campbell WB. 2009. 14,15-Epoxyeicosa-5,8,11-trienoic acid (14,15-EET) surrogates containing epoxide bioisosteres: influence upon vascular relaxation and soluble epoxide hydrolase inhibition. J Med Chem 52(16):5069-5075. doi:10.1021/jm900634w PMID:19653681 PMCID:PMC2888647
Huang H, Tanaka H, Hammock BD, Morisseau C. 2009. Novel and highly sensitive fluorescent assay for leucine aminopeptidases. Anal Biochem 391(1):11-16. doi:10.1016/j.ab.2009.05.004 PMID:19433052 PMCID:PMC2748848
Inceoglu AB, Waite T, Christiansen JA, McAbee RD, Kamita SG, Hammock BD, Cornel AJ. 2009. A rapid luminescent assay for measuring cytochrome P450 activity in individual larval Culex pipiens complex mosquitoes (Diptera: Culicidae). Journal of Medical Entomology 46(1):83-92. doi:10.1603/033.046.0111 PMID:19198521 PMCID:PMC3522461
Kasagami T, Kim I, Tsai H, Nishi K, Hammock BD, Morisseau C. 2009. Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities. Bioorg Med Chem Lett 19(6):1784-1789. doi:10.1016/j.bmcl.2009.01.069 PMID:19216074 PMCID:PMC2900318
Kim HJ, Ahn K, Gonzalez-Techera A, Gonzalez-Sapienza GG, Gee SJ, Hammock BD. 2009. Magnetic bead-based phage anti-immunocomplex assay (PHAIA) for the detection of the urinary biomarker 3-phenoxybenzoic acid to assess human exposure to pyrethroid insecticides. Anal Biochem 386(1):45-52. doi:10.1016/j.ab.2008.12.003 PMID:19101498 PMCID:PMC2863013
Li N, Liu J, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N. 2009. Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches. J Mol Cell Cardiol 47(6):835-845. doi:10.1016/j.yjmcc.2009.08.017 PMID:19716829 PMCID:PMC3290524
Liu J, Park S, Morisseau C, Hwang SH, Hammock BD, Weiss RH. 2009. Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo. Mol Cancer Ther 8(8):2193-2203. doi:10.1158/1535-7163.MCT-09-0119 PMID:19671760 PMCID:PMC2728155
Liu J, Tsai H, Hwang SH, Jones PD, Morisseau C, Hammock BD. 2009. Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation. Br J Pharmacol 156(2):284-296. doi:10.1111/j.1476-5381.2008.00009.x PMID:19154430 PMCID:PMC2697843
Lu C, Schoenfeld R, Shan Y, Tsai H, Hammock BD, Cortopassi GA. 2009. Frataxin deficiency induces Schwann cell inflammation and death. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792(11):1052-1061. doi:10.1016/j.bbadis.2009.07.011 PMID:19679182 PMCID:PMC3563672
Luria A, Morisseau C, Tsai H, Yang J, Inceoglu B, De Taeye B, Wiest MM, German JB, Hammock BD, Watkins SM. 2009. Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase. Am J Physiol Endocrinol Metab 297(2):E375-E383. doi:10.1152/ajpendo.00131.2009 PMID:19458064 PMCID:PMC2724109
Ma Z, Dosev D, Nichkova MJ, Dumas RK, Gee SJ, Hammock BD, Kennedy IM. 2009. Synthesis and characterization of multifunctional silica core-shell nanocomposites with magnetic and fluorescent functionalities. J Magn Magn Mater 321(10):1368-1371. doi:10.1016/j.jmmm.2009.02.040 PMID:20336173 PMCID:PMC2844650
Ma Z, Dosev D, Nichkova MJ, Gee SJ, Hammock BD, Kennedy IM. 2009. Synthesis and bio-functionalization of multifunctional magnetic Fe3O4@Y2O3:Eu nanocomposites. J Mater Chem 19:4695-4700. doi:10.1039/B901427F PMID:20357905 PMCID:PMC2847302
Matveeva EG, Morisseau C, Goodrow MH, Mullin C, Hammock BD. 2009. Tryptophan fluorescence quenching by enzyme inhibitors as a tool for enzyme active site structure investigation: epoxide hydrolase. Curr Pharm Biotechnol 10(6):589-599. doi:10.2174/138920109789069260 PMID:19619123 PMCID:PMC2861369
Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD. 2009. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environ Health Perspect 117(12):1867-1872. doi:10.1289/ehp.0900834 PMID:20049205 PMCID:PMC2799460
Nichkova MJ, Fu X, Yang Z, Zhong P, Sanborn JR, Chang D, Gee SJ, Hammock BD. 2009. Immunochemical screening of pesticides (simazine and cypermethrin) in orange oil. J Agric Food Chem 57(13):56735679. doi:10.1021/jf900652a PMID:19526986 PMCID:PMC3033343
Parrish AR, Chen G, Burghardt RC, Watanabe T, Hammock BD, Morisseau C. 2009. Attenuation of cisplatin nephrotoxicity by inhibition of soluble epoxide hydrolase. Cell Biol Toxicol 25(3):217-225. doi:10.1007/s10565-008-9071-0 PMID:18386137 PMCID:PMC3033346
Shen S, Zhang F, Zeng S, Tian Y, Chai X, Gee SJ, Hammock BD, Zheng J. 2009. Development of enantioselective polyclonal antibodies to detect styrene oxide protein adducts. Anal Chem 81(7):2668-2677. doi:10.1021/ac8023262 PMID:19245253 PMCID:PMC3463234
Yang J, Schmelzer KR, Georgi K, Hammock BD. 2009. Quantitative profiling method for oxylipin metabolome by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chem 81(19):8085-8093. doi:10.1021/ac901282n PMID:19715299 PMCID:PMC3290520

2008

Aronov PA, Hall LM, Dettmer K, Stephensen CB, Hammock BD. 2008. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem 391(5):1917-1930. doi:10.1007/s00216-008-2095-8 PMID:18437365 PMCID:PMC3587164
Aronova S, Wedaman K, Aronov PA, Fontes K, Ramos K, Hammock BD, Powers T. 2008. Regulation of ceramide biosynthesis by TOR complex 2. Cell Metab 7(2):148-158. doi:10.1016/j.cmet.2007.11.015 PMID:18249174 PMCID:PMC3882310
Barbosa-Sicard E, Popp R, Fisslthaler B, Hammock BD, Falck JR, Busse R, Fleming I, Keseru B, Dietrich A, Gudermann T, Weissmann N. 2008. Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response. FASEB J 22(12):4306-4315. doi:10.1096/fj.08-112821 PMID:18725458 PMCID:PMC2614611
Bradbury JA, Graves J, Degraff LM, Zhao X, Imig JD, Pedersen TL, Newman JW, Hammock BD, Conley AJ, Korach KS, Zeldin DC, Athirakul K, Ma J, Zhao Y, Couse JF, Quigley R, Harder DR, Coffman TM. 2008. Increased blood pressure in mice lacking cytochrome P450 2J5. FASEB J 22(12):4096-4108. doi:10.1096/fj.08-114413 PMID:18716027 PMCID:PMC2614614
Chawengsub Y, Aggarwal N, Nithipatikom K, Gauthier KM, Anjaiah S, Hammock BD, Falck JR, Campbell WB. 2008. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. Am J Physiol Heart Circ Physiol 294(3):H1348-H1356. doi:10.1152/ajpheart.01326.2007 PMID:18192225
Chen J, Ahn K, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL. 2008. Triclocarban enhances testosterone action: a new type of endocrine disruptor?. Endocrinology 149(3):1173-1179. doi:10.1210/en.2007-1057 PMID:18048496 PMCID:PMC2275366
Chen J, Ahn K, Zhao B, Denison MS, Lasley BL, Pessah IN, Kültz D, Chang DP, Gee SJ, Hammock BD, Cherednichenko G. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ Health Perspect 116:1203-1210. doi:10.1289/ehp.11200 PMID:18795164 PMCID:PMC2535623
Corenblum MJ, Wise VE, Georgi K, Hammock BD, Doris PA, Fornage M. 2008. Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat. Hypertension 51(2):567-73. PMID:18086949
Dreisbach AW, Rice JC, Japa S, Newman JW, Sigel A, Gill R, Hess AE, Cemo AC, Fonseca JP, Hammock BD, Lertora JJ, Hamm LL. 2008. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. Hypertension 51:755-761. PMID:18227407
Enayetallah AE, Luria A, Luo B, Tsai H, Sura P, Hammock BD, Grant DF. 2008. Opposite regulation of cholesterol levels by the phosphatase and hydrolase domains of soluble epoxide hydrolase. J Biol Chem 283(52):36592-36598. doi:10.1074/jbc.M806315200 PMID:18974052 PMCID:PMC2605982
Fife KL, Liu Y, Schmelzer KR, Tsai H, Kim I, Morisseau C, Hammock BD, Kroetz DL. 2008. Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation. J Pharmacol Exp Ther 327(3):707-715. doi:10.1124/jpet.108.142398 PMID:18815352 PMCID:PMC2761654
Gonzalez-Techera A, Umpierrez-Failache M, Cardozo S, Obal G, Last JA, Gee SJ, Hammock BD, Gonzalez-Sapienza GG, Pritsch O. 2008. High-throughput method for ranking the affinity of peptide ligands selected from phage display libraries. Bioconjug Chem 19(5):993-1000. doi:10.1021/bc700279y PMID:18393454 PMCID:PMC2863005
Gross GJ, Gauthier KM, Moore J, Falck JR, Hammock BD, Campbell WB, Nithipatikom K. 2008. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. Am J Physiol Heart Circ Physiol 294(6):H2838-H2844. doi:10.1152/ajpheart.00186.2008 PMID:18441205 PMCID:PMC2863006
Harris TR, Aronov PA, Hammock BD. 2008. Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence. DNA Cell Biol 27(9):467-477. doi:10.1089/dna.2008.0751 PMID:18554159 PMCID:PMC2858585
Hwang H, Park E, Young TM, Hammock BD. 2008. Occurrence of endocrine-disrupting chemicals in indoor dust. Sci Total Environ 404(1):26-35. doi:10.1016/j.scitotenv.2008.05.031 PMID:18632138 PMCID:PMC2858057
Inceoglu B, Jinks SL, Ulu A, Hegedus CM, Georgi K, Schmelzer KR, Wagner KM, Jones PD, Morisseau C, Hammock BD. 2008. Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways. Proc Natl Acad Sci U S A 105(48):18901-18906. doi:10.1073/pnas.0809765105 PMID:19028872 PMCID:PMC2596245
Jiang H, Zhu AG, Mamczur M, Morisseau C, Hammock BD, Falck JR, McGiff JC. 2008. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. J Pharmacol Exp Ther 326(1):330-337. doi:10.1124/jpet.107.134858 PMID:18445784 PMCID:PMC2732189
Kim HJ, Gonzalez-Techera A, Gonzalez-Sapienza GG, Ahn K, Gee SJ, Hammock BD. 2008. Phage-borne peptidomimetics accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites. Environ Sci Technol 42(6):2047-53. doi:10.1021/es702219a PMID:18409635
Morisseau C, Hammock BD. 2008. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Manag Sci 64(6):594-609. doi:10.1002/ps.1583 PMID:18383502
Morisseau C, Newman JW, Wheelock CE, Hill T, Morin D, Buckpitt AR, Hammock BD. 2008. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chem Res Toxicol 21(4):951-957. doi:10.1021/tx700446u PMID:18363382
Park E, Duarte Tagles H, Gee SJ, Hammock BD, Lee K, Schenker MB. 2008. Recruiting strategy and 24-hour biomonitoring of paraquat in agricultural workers. J Agromedicine 13(4):207-217. doi:10.1080/10599240802454528 PMID:19064412 PMCID:PMC2864554
Tanaka H, Kamita SG, Wolf NM, Harris TR, Wu Z, Morisseau C, Hammock BD. 2008. Transcriptional regulation of the human soluble epoxide hydrolase gene EPHX2. Biochim Biophys Acta 1779(1):17-27. doi:10.1016/j.bbagrm.2007.11.005 PMID:18078836 PMCID:PMC2699939
Van Emon JM, Chuang J, Lordo RA, Schrock ME, Nichkova MJ, Gee SJ, Hammock BD. 2008. An enzyme-linked immunosorbent assay for the determination of dioxins in contaminated sediment and soil samples. Chemosphere 72(1):95-103. doi:10.1016/j.chemosphere.2008.01.012 PMID:18313102 PMCID:PMC2858573
Wheelock CE, Forshed J, Goto S, Hammock BD, Newman JW. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chem Res Toxicol 21(3):583-590. doi:10.1021/tx7002454 PMID:18251509
Wheelock CE, Nishi K, Jones PD, Colvin ME, Olmstead MM, Hammock BD. 2008. Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorg Med Chem 16(4):2114-2130. doi:10.1016/j.bmc.2007.10.081 PMID:18023188 PMCID:PMC2720161
Wheelock CE, Phillips BM, Miller JL, Miller MG, Hammock BD. 2008. Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs). Rev Environ Contam Toxicol 195:117-178. PMID:18418956

2007

Ahn K, Lohstroh PN, Gee SJ, Gee NA, Lasley BL, Hammock BD. 2007. High-throughput automated luminescent magnetic particle-based immunoassay to monitor human exposure to pyrethroid insecticides. Anal Chem 79(23):8883-8890. doi:10.1021/ac070675l PMID:17983205
Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. 2007. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proc Natl Acad Sci U S A 104(21):9018-23. PMID:17495027
Akatsuka T, Ishikawa T, Kobayashi N, Saito T, Shindo M, Yamauchi M, Kurokohchi K, Miyazawa H, Duan H, Matsunaga T, Komoda T, Morisseau C, Hammock BD. 2007. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. J Autoimmun 28(1):7-18. doi:10.1016/j.jaut.2006.12.005 PMID:17296285 PMCID:PMC1892246
Chen J, Ahn K, Gee SJ, Gee NA, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol Appl Pharmacol 221(3):278-284. doi:10.1016/j.taap.2007.03.015 PMID:17481686 PMCID:PMC1978490
Chiamvimonvat N, Ho C, Tsai H, Hammock BD. 2007. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. J Cardiovasc Pharmacol 50(3):225-237. doi:10.1097/FJC.0b013e3181506445 PMID:17878749
Chiappe C, Leandri E, Hammock BD, Morisseau C. 2007. Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols. Green Chem 2007(9):162-168. doi:10.1039/b612106c PMID:18160974 PMCID:PMC2153531
Dettmer K, Aronov PA, Hammock BD. 2007. Mass spectrometry-based metabolomics. Mass Spectrom Rev 26(1):51-78. PMID:16921475
Dettmer K, Hanna D, Whetstone P, Hansen R, Hammock BD. 2007. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory. Anal Bioanal Chem 388(8):1643-1651. doi:10.1007/s00216-007-1301-4 PMID:17520243 PMCID:PMC4871698
Devonshire AL, Heidari R, Huang H, Hammock BD, Russell RJ, Oakeshott JG. 2007. Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases from Lucilia cuprina. Insect Biochem Mol Biol 37(9):891-902. doi:10.1016/j.ibmb.2007.04.011 PMID:17681228
Dosev D, Nichkova MJ, Dumas RK, Gee SJ, Hammock BD, Liu K, Kennedy IM. 2007. Magnetic/luminescent core/shell particles synthesized by spray pyrolysis and their application in immunoassays with internal standard. Nanotechnology 18(5):055102(6pp). PMID:18974844
Endsley MP, Aggarwal N, Isbell MA, Wheelock CE, Hammock BD, Flack JR, Nithipatikom K, Campbell WB. 2007. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: Location, hydrolysis and 12-lipoxygenase metabolism. Int J Cancer 121(5):984-991. doi:10.1002/ijc.22761 PMID:17443494 PMCID:PMC2565646
Fleming I, Rueben A, Popp R, Fisslthaler B, Sander A, Haendeler J, Falck JR, Morisseau C, Hammock BD, Busse R. 2007. Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arterioscler Thromb Vasc Biol 27(12):2612-2618. doi:10.1161/ATVBAHA.107.152074 PMID:17872452
Gonzalez-Techera A, Kim HJ, Gee SJ, Last JA, Hammock BD. 2007. Polyclonal antibody-based noncompetitive immunoassay for small analytes developed with short peptide loops isolated from phage libraries. Anal Chem 79(23):9191-9196. doi:10.1021/ac7016713 PMID:17973501 PMCID:PMC2556293
Gonzalez-Techera A, Vanrell L, Last JA, Hammock BD, Gonzalez-Sapienza GG. 2007. Phage anti-immune complex assay: general strategy for noncompetitive immunodetection of small molecules. Anal Chem 79(20):7799-7806. doi:10.1021/ac071323h PMID:17845007 PMCID:PMC2519879
Hillard CJ, Ho WS, Thompson J, Gauthier KM, Wheelock CE, Huang H, Hammock BD. 2007. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. Br J Pharmacol 152(5):691-8. PMID:17891162
Huang H, Nishi K, Tsai H, Hammock BD. 2007. Development of highly sensitive fluorescent assays for fatty acid amide hydrolase. Anal Biochem 363(1):12-21. PMID:17291440
Hwang SH, Tsai H, Liu J, Morisseau C, Hammock BD. 2007. Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50(16):3825-3840. doi:10.1021/jm070270t PMID:17616115 PMCID:PMC2596069
Inceoglu B, Schmelzer KR, Morisseau C, Jinks SL, Hammock BD. 2007. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins Other Lipid Mediat 82(1-4):42-49. PMID:17164131
Kim H, Gee SJ, Li QX, Hammock BD. 2007. Noncompetitive Fluorescent Immunoassay for the Detection of the Human Urinary Biomarker 3-Phenoxybenzoic Acid with Bench Top Immunosensor KinExATM 3000. Chapter 11in: Rational Environmental Management of Agrochemicals: Risk Assessment, Monitoring, and Remedial Action. pp.171185.
Kim HJ, Ahn K, Ma S, Gee SJ, Hammock BD. 2007. Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. J Agric Food Chem 55(10):3750-7. PMID:17455946
Kim I, Nishi K, Tsai H, Bradford T, Koda Y, Watanabe T, Morisseau C, Blanchfield J, Toth I, Hammock BD. 2007. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorg Med Chem 15(1):312-23. PMID:17046265
Kim I, Tsai H, Nishi K, Kasagami T, Morisseau C, Hammock BD. 2007. 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. J Med Chem 50(21):5217-5226. doi:10.1021/jm070705c PMID:17894481 PMCID:PMC2543935
Loch D, Hoey A, Morisseau C, Hammock BD, Brown L. 2007. Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. Cell Biochem Biophys 47:87-97. PMID:17406062
Luria A, Weldon SM, Kabcenell AK, Ingraham RH, Matera D, Jiang H, Gill R, Morisseau C, Newman JW, Hammock BD. 2007. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. J Biol Chem 282(5):2891-8. PMID:17135253
Newman JW, Kaysen GA, Hammock BD, Shearer GC. 2007. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. J Lipid Res 48:1792-1800. PMID:17496268
Nichkova MJ, Dosev D, Davies AE, Gee SJ, Kennedy IM, Hammock BD. 2007. Multiplexed immunoassays for biomonitoring of exposure to agrochemicals using quantum dots as fluorescent reporters. Proc SPIE Int Soc Opt Eng 6448:644817-1. doi:10.1117/12.699231
Nichkova MJ, Dosev D, Davies AE, Gee SJ, Kennedy IM, Hammock BD. 2007. Quantum dots as reporters in multiplexed immunoassays for biomarkers of exposure to agrochemicals. Anal Lett 40(7):1423-1433. doi:10.1080/00032710701327088 PMID:19079795 PMCID:PMC2600528
Nichkova MJ, Dosev D, Gee SJ, Hammock BD, Kennedy IM. 2007. Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration. Anal Biochem 369(a):34-40. PMID:17681270
Park E, Mak SK, Hammock BD, Kültz D. 2007. Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cells. J Toxicol Environ Health A 70(24):2092-5. PMID:18049999
Park E, Mak SK, Kültz D, Hammock BD. 2007. Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines. J Environ Sci Health B 43:71-74. PMID:18161576
Pedersen TL, Grekin RJ, Hammock BD, Ball DL, Vollmer A. 2007. Heparin, lipoproteins, and oxygenated fatty acids in blood: a cautionary note. Prostaglandins Leukot Essent Fatty Acids 77(5-6):363-366. doi:10.1016/j.plefa.2007.10.012 PMID:18036802 PMCID:PMC2705328
Thompson DA, Hammock BD. 2007. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. J Biosci 32(2):279-291. PMID:17435320 PMCID:PMC1904342
Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. 2007. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Mol Pharmacol 71(3):713-723. PMID:17167034
Wheelock CE, Goto S, Hammock BD, Newman JW. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics 3(2):137-145. doi:10.1007/s11306-007-0052-8 PMID:19079556 PMCID:PMC2597807
Yuan W, Chung JS, Gee SJ, Hammock BD, Zheng J. 2007. Development of polyclonal antibodies for the detection of styrene oxide modified proteins. Chem Res Toxicol 20(2):316-321. doi:10.1021/tx600340c PMID:17266334 PMCID:PMC2565645
Zhang W, Koerner IP, Noppens R, Grafe M, Tsai H, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ. 2007. Soluble epoxide hydrolase: a novel therapeutic target in stroke. J Cereb Blood Flow Metab 27(12):1931-1940. doi:10.1038/sj.jcbfm.9600494 PMID:17440491 PMCID:PMC2664093

2006

Ahn K, Ma S, Tsai H, Gee SJ, Hammock BD. 2006. An immunoassay for a urinary metabolite as a biomarker of human exposure to the pyrethroid insecticide permethrin. Anal Bioanal Chem 384(3):713-722. PMID:16416099
Carkeet C, Dueker SR, Lango J, Buchholz BA, Miller JW, Green R, Hammock BD, Roth JR, Anderson PJ. 2006. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proc Natl Acad Sci U S A 103(15):5694-5699. PMID:16585531
Cummins CM, Koivunen ME, Stephanian A, Gee SJ, Hammock BD, Kennedy IM. 2006. Application of europium(III) chelate-dyed nanoparticle labels in a competitive atrazine fluoroimmunoassay on an ITO waveguide. Biosens Bioelectron 21(7):1077-1085. PMID:16368482
Davis BB, Morisseau C, Newman JW, Pedersen TL, Hammock BD, Weiss RH. 2006. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. J Pharmacol Exp Ther 316(2):815-821. PMID:16221742
Gomez GA, Morisseau C, Hammock BD, Christianson DW. 2006. Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Sci 15(1):58-64. doi:10.1110/ps.051720206 PMID:16322563 PMCID:PMC1762130
Harris TR, Morisseau C, Walzem RL, Ma S, Hammock BD. 2006. The cloning and characterization of a soluble epoxide hydrolase in chicken. Poultry Science 82(2):278-287. PMID:16523628
Huang H, Nishi K, Gee SJ, Hammock BD. 2006. Evaluation of chiral alpha-cyanoesters as general fluorescent substrates for screening enantioselective esterases. J Agric Food Chem 54(3):694-699. doi:10.1021/jf0526083 PMID:16448170 PMCID:PMC1444886
Hwang SH, Morisseau C, Do ZN, Hammock BD. 2006. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 16(22):5773-7. PMID:16949285
Inceoglu B, Jinks SL, Schmelzer KR, Waite T, Kim I, Hammock BD. 2006. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sciences 79(24):2311-2319. PMID:16962614
Inceoglu B, Lango J, Whetstone P, Hammock BD. 2006. The neutralizing effect of a polyclonal antibody raised against the N-terminal eighteen-aminoacid residues of birtoxin towards the whole venom of Parabuthus transvaalicus. Toxicology 47(2):144-149. PMID:16356521
Jones PD, Tsai H, Do ZN, Morisseau C, Hammock BD. 2006. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett 16(19):5212-5216. PMID:16870439
Koivunen ME, Dettmer K, Vermeulen R, Bakke B, Gee SJ, Hammock BD. 2006. Improved methods for urinary atrazine mercapturate analysis--assessment of an enzyme-linked immunosorbent assay (ELISA) and a novel liquid chromatography-mass spectrometry (LC-MS) method utilizing online solid phase extraction (SPE). Anal Chim Acta 572(2):180-189. doi:10.1016/j.aca.2006.05.037 PMID:17723476
Larsen BT, Miura H, Hatoum OA, Campbell WB, Hammock BD, Zeldin DC, Falck JR, Gutterman DD. 2006. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels: implications for soluble epoxide hydrolase inhibition. Am J Pathol 290(2):H491-H499. PMID:16258029
Lee CR, North KE, Bray MS, Fornage M, Seubert JM, Newman JW, Hammock BD, Couper DJ, Heiss G, Zeldin DC. 2006. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum Mol Genet 15(10):1640-1649. PMID:16595607
Morisseau C, Newman JW, Tsai H, Baecker PA, Hammock BD. 2006. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorg Med Chem Lett 16(20):5439-5444. doi:10.1016/j.bmcl.2006.07.073 PMID:16908134 PMCID:PMC1892215
Ng VY, Morisseau C, Falck JR, Hammock BD, Kroetz DL. 2006. Inhibition of smooth muscle proliferation by urea-based alkanoic acids via peroxisome proliferator-activated receptor alpha-dependent repression of cyclin D1. Arterioscler Thromb Vasc Biol 26(11):4262. PMID:16917105
Nichkova MJ, Dosev D, Perron R, Gee SJ, Hammock BD, Kennedy IM. 2006. Eu3+-doped Gd2O3 nanoparticles as reporters for optical detection and visualization of antibodies patterned by microcontact printing. Anal Bioanal Chem 384(3):631-637. PMID:16416096
Nishi K, Huang H, Kamita SG, Kim I, Morisseau C, Hammock BD. 2006. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys 445(1):115-123. PMID:16359636
Nording M, Nichkova MJ, Spinnel E, Persson Y, Gee SJ, Hammock BD, Haglund P. 2006. Rapid screening of dioxin-contaminated soil by accelerated solvent extraction/purification followed by immunochemical detection. Anal Bioanal Chem 385(2):357-366. PMID:16598456
Olearczyk JJ, Field MB, Kim I, Morisseau C, Hammock BD, Imig JD. 2006. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. J Pharmacol Exp Ther 318(3):1307-1314. PMID:16772540
Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR, Hammock BD, Kim I, Szelid Z, Vermeersch P, Gillijns H, Pellens M, Grimminger F, van Zonneveld A, Collen D, Busse R, Janssens S. 2006. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension 47(4):762-770. PMID:16505204
Schmelzer KR, Inceoglu B, Kubala L, Kim I, Jinks SL, Eiserich JP, Hammock BD. 2006. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A 103(37):13646-13651. PMID:16950874
Schmelzer KR, Wheelock AM, Dettmer K, Morin D, Hammock BD. 2006. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways. Environ Health Perspect 114(9):1354-1360. PMID:16966088 PMCID:PMC1570074
Seubert JM, Sinal CJ, Graves J, Degraff LM, Bradbury JA, Lee CR, Goralski K, Carey MA, Luria A, Newman JW, Hammock BD, Falck JR, Roberts H, Rockman HA, Murphy E, Zeldin DC. 2006. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circ Res 99(4):442-450. doi:10.1161/01.RES.0000237390.92932.37 PMID:16857962 PMCID:PMC2072806
Watanabe T, Schulz D, Morisseau C, Hammock BD. 2006. High-throughput pharmacokinetic method: cassette dosing in mice associated with minuscule serial bleedings and LC/MS/MS analysis. Anal Chim Acta 559(1):37-44. doi:10.1016/j.aca.2005.11.049 PMID:16636700 PMCID:PMC1447531
Wheelock AM, Miller JL, Miller MJ, Phillips BM, Huntley SA, Gee SJ, Tjeerdema RS, Hammock BD. 2006. Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations. Environ Toxicol Chem 25(4):973-984. PMID:16629136 PMCID:PMC1456014
Wolf NM, Morisseau C, Jones PD, Hock B, Hammock BD. 2006. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Anal Biochem 355(1):71-80. PMID:16729954
Xu D, Li N, He Y, Timofeyev V, Lu L, Tsai H, Kim I, Tuteja D, Mateo RP, Singapuri A, Davis BB, Low R, Hammock BD, Chiamvimonvat N. 2006. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proc Natl Acad Sci U S A 103(49):18733-18738. PMID:17130447
Zhao B, Baston DS, Hammock BD, Denison MS. 2006. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Mol Toxicol 20(3):103-113. PMID:16788953

2005

Ahn K, Gee SJ, Kim HJ, Nichkova MJ, Hammock BD. 2005. Progress in the development of biosensors for environmental and human monitoring of agrochemicals. Proceedings of the American Chemical Society Pacifichem 966:138-154.
Aronov PA, Dettmer K, Christiansen JA, Cornel AJ, Hammock BD. 2005. Development of a HPLC/tandem-MS method for the analysis of the larvicides methoprene, hydroprene, and kinoprene at trace levels using Diels-Alder derivatization. J Agric Food Chem 53(9):3306-3312. doi:10.1021/jf0485842 PMID:15853364 PMCID:PMC1479544
Dorrance AM, Rupp N, Pollock DM, Newman JW, Hammock BD, Imig JD. 2005. An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 46(6):842-848. PMID:16306811 PMCID:PMC1444897
Dosev D, Nichkova MJ, Liu M, Guo B, Liu G, Hammock BD, Kennedy IM. 2005. Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns. J Biomed Opt 10(6):064006. doi:10.1117/1.2136347 PMID:16409071
Dosev D, Nichkova MJ, Liu M, Guo B, Liu G, Xia Y, Hammock BD, Kennedy IM. 2005. Application of fluorescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns. Chapter 5699 in: Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications: III (Proceedings of SPIE). SPIE Society of Photo-Optical Instrumentation Engineering, San Jose, CA. pp.473-481.
Fang X, Hu S, Watanabe T, Weintraub NL, Snyder GD, Yao J, Liu Y, Shyy JY, Hammock BD, Spector AA. 2005. Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. J Pharmacol Exp Ther 314(1):260-270. doi:10.1124/jpet.105.085605 PMID:15798002
German JB, Hammock BD, Watkins SM. 2005. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics 1(1):3-9. PMID:16680201
Hennebold JD, Mah K, Perez W, Vance JE, Stouffer RL, Morisseau C, Hammock BD, Adashi EY. 2005. Identification and characterization of an ovary-selective isoform of epoxide hydrolase. Biol Reprod 72(4):968-975. doi:10.1095/biolreprod.104.035899 PMID:15601917
Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. 2005. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chem Res Toxicol 18(9):1371-1377. PMID:16167828
Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD. 2005. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chem Res Toxicol 18(3):516-527. doi:10.1021/tx049773h PMID:15777092
Imig JD, Zhao X, Zaharis CZ, Olearczyk JJ, Pollock DM, Newman JW, Kim I, Watanabe T, Hammock BD. 2005. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(4):975-981. doi:10.1161/01.HYP.0000176237.74820.75 PMID:16157792 PMCID:PMC1444888
Inceoglu B, Lango J, Pessah IN, Hammock BD. 2005. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon 45(6):727-733. PMID:15804521
Jones PD, Wolf NM, Morisseau C, Whetstone P, Hock B, Hammock BD. 2005. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Anal Biochem 343(1):66-75. PMID:15963942
Jung O, Brandes RP, Kim I, Schweda F, Schmidt R, Hammock BD, Busse R, Fleming I. 2005. Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. Hypertension 45(4):759-765. doi:10.1161/01.HYP.0000153792.29478.1d PMID:15699457
Kang K, Jones PD, Huang H, Zhang R, Mostovich LA, Wheelock CE, Watanabe T, Gulyaeva LF, Hammock BD. 2005. Evaluation of a-cyano ethers as fluorescent substrates for assay of cytochrome P450 enyzme activity. Anal Biochem 344(2):183-192. PMID:16083846
Kim I, Heirtzler FR, Morisseau C, Nishi K, Tsai H, Hammock BD. 2005. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. J Med Chem 48(10):3621-3629. doi:10.1021/jm0500929 PMID:15887969 PMCID:PMC1450255
Koivunen ME, Gee SJ, Park E, Lee K, Schenker MB, Hammock BD. 2005. Application of an enzyme-linked immunosorbent assay for the analysis of paraquat in human-exposure samples. Arch Environ Contam Toxicol 48(2):184-190. doi:10.1007/s00244-003-0251-x PMID:15696345
Liu Y, Zhang Y, Schmelzer KR, Lee T, Fang X, Zhu Y, Spector AA, Gill S, Morisseau C, Hammock BD, Shyy JY. 2005. The antiinflammatory effect of laminar flow: the role of PPAR, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proc Natl Acad Sci U S A 102(46):16747-16752. PMID:16267130
Mak SK, Shan G, Lee H, Watanabe T, Stoutamire DW, Gee SJ, Hammock BD. 2005. Development of a class selective immunoassay for the type II pyrethroid insecticides. Anal Chim Acta 534:109-120.
Morisseau C, Hammock BD. 2005. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annu Rev Pharmacol Toxicol 45:311-333. doi:10.1146/annurev.pharmtox.45.120403.095920 PMID:15822179
Newman JW, Morisseau C, Hammock BD. 2005. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog Lipid Res 44(1):1-50. PMID:15748653
Nichkova MJ, Dosev D, Gee SJ, Hammock BD, Kennedy IM. 2005. Microarray immunoassay for phenoxybenzoic acid using polymer encapsulated Eu:Gd2O3 nanoparticles as fluorescent labels. Anal Chem 77(21):6864-6873. doi:10.1021/ac050826p PMID:16255584
Nithipatikom K, Endsley MP, Isbell MA, Wheelock CE, Hammock BD, Campbell WB. 2005. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochem Biophys Res Commun 332(4):1028-1033. PMID:15919052
Schmelzer KR, Kubala L, Newman JW, Kim I, Eiserich JP, Hammock BD. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proc Natl Acad Sci U S A 102(28):9772-9777. PMID:15994227
Sellers KW, Sun C, Diez-Freire C, Waki H, Morisseau C, Falck JR, Hammock BD, Paton JF, Raizada MK. 2005. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB J 19:626-628. PMID:15659536
Shearer GC, Newman JW, Hammock BD, Kaysen GA. 2005. Graded effects of proteinuria on HDL structure in nephrotic rats. J Am Soc Nephrol 16(5):1309-1319. PMID:15788471
Smith KR, Pinkerton KE, Watanabe T, Pedersen TL, Ma S, Hammock BD. 2005. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proc Natl Acad Sci U S A 102(6):2186-2191. PMID:15684051
Tran KL, Aronov PA, Tanaka H, Newman JW, Hammock BD, Morisseau C. 2005. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry 44(36):12179-12187. PMID:16142916
Wheelock CE, Eder KJ, Werner I, Huang H, Jones PD, Brammell BF, Elskus AA, Hammock BD. 2005. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquat Toxicol 74(2):172-192. doi:10.1016/j.aquatox.2005.05.009 PMID:16011852 PMCID:PMC1444896
Wheelock CE, Miller JL, Miller MJ, Phillips BM, Gee SJ, Tjeerdema RS, Hammock BD. 2005. Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca. Aquat Toxicol 74(1):47-52. PMID:15951033

2004

Ahn K, Watanabe T, Gee SJ, Hammock BD. 2004. Hapten and antibody production for a sensitive immunoassay determinining a human urinary metabolite of the pyrethroid insecticide permethrin. J Agric Food Chem 52(15):4583-4594. PMID:15264887
Denison MS, Rogers WJ, Bohonowych JE, Zhao B, Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. 2004. Promiscuous ligand-dependent activation of the Ah receptor: chemicals in crude extracts from commercial and consumer products bind to and activate the Ah receptor and Ah receptor-dependent gene expression. Organohalogen Compounds 66:2966-2971.
Dey A, Williams RS, Pollock DM, Stepp DW, Newman JW, Hammock BD, Imig JD. 2004. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes Res 12(8):1278-1289. doi:10.1038/oby.2004.162 PMID:15340111
DuTeaux SB, Newman JW, Morisseau C, Fairbairn EA, Jelks K, Hammock BD, Miller MG. 2004. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicol Sci 78(2):187-195. PMID:14737000
Fang X, Weintraub NL, McCaw RB, Hu S, Harmon S, Rice JB, Hammock BD, Spector AA. 2004. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. Am J Physiol Cell Physiol 287:H2412-H2420. PMID:15284062
Gomez GA, Morisseau C, Hammock BD, Christianson DW. 2004. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochemistry 43(16):4716-4723. doi:10.1021/bi036189j PMID:15096040
Kennedy IM, Koivunen ME, Gee SJ, Cummins CM, Perron R, Dosev D, Hammock BD. 2004. Nanoscale fluoro-immuno assays with lanthanide oxide nanoparticles. Chapter 5593 in: Nanosensing: Materials and Devices (Proceedings of SPIE). SPIE Society of Photo-Optical Instrumentation Engineering, Bellingham, WA. pp.329-339.
Kim I, Morisseau C, Watanabe T, Hammock BD. 2004. Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility. J Med Chem 47(8):2110-2122. doi:10.1021/jm030514j PMID:15056008
Lee H, Shan G, Ahn K, Park E, Watanabe T, Gee SJ, Hammock BD. 2004. Development of an enzyme-linked Immunosorbent assay for the pyrethroid cypermethrin. J Agric Food Chem 52(2):1039-1043. PMID:14995094
Newman JW, Stok JE, Vidal JD, Corbin CJ, Huang Q, Hammock BD, Conley AJ. 2004. Cytochrome P450-dependent lipid metabolism in preovulatory follicles. Endocrinology 145(11):5097-5105. PMID:15308618
Nichkova MJ, Park E, Koivunen ME, Kamita SG, Gee SJ, Chuang J, Van Emon JM, Hammock BD. 2004. Immunochemical determination of dioxins in environmental and biological samples. Talanta 63:1213-1223. PMID:18969550
Park E, Kim J, Gee SJ, Watanabe T, Ahn K, Hammock BD. 2004. Determination of pyrethroid residues in agricultural products by an enzyme-linked immunosorbent assay. J Agric Food Chem 52(18):5572-5576. PMID:15373394
Rufo C, Hammock BD, Gee SJ, Last JA, Gonzalez-Sapienza GG. 2004. Robust and sensitive monoclonal enzyme-linked immunosorbent assay for the herbicide molinate. J Agric Food Chem 52(2):182-187. PMID:14733492
Seubert JM, Yang B, Bradbury JA, Graves J, Degraff LM, Gabel S, Gooch R, Foley J, Newman JW, Mao L, Rockman HA, Hammock BD, Murphy E, Zeldin DC. 2004. Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. Circ Res 95(5):506-514. PMID:15256482
Shan G, Huang H, Stoutamire DW, Gee SJ, Leng G, Hammock BD. 2004. A sensitive class specific immunoassay for the detection of pyrethroid metabolites in human urine. Chem Res Toxicol 17(2):218-225. PMID:14967009
Stok JE, Goloshchapov A, Song C, Wheelock CE, Derbel M, Morisseau C, Hammock BD. 2004. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Arch Biochem Biophys 430(2):247-255. PMID:15369824
Stok JE, Huang H, Jones PD, Wheelock CE, Morisseau C, Hammock BD. 2004. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. J Biol Chem 279(28):29863-29869. doi:10.1074/jbc.M403673200 PMID:15123619
Wheelock CE, Miller JL, Miller MJ, Gee SJ, Shan G, Hammock BD. 2004. Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity. Environ Toxicol Chem 23(11):2699-2708. PMID:15559286
Yu Z, Davis BB, Morisseau C, Hammock BD, Olson JL, Kroetz DL, Weiss RH. 2004. Vascular localization of soluble epoxide hydrolase in the human kidney. Am J Physiol Renal Physiol 286(4):F720-F726. PMID:14665429
Zhao X, Yamamoto T, Newman JW, Kim I, Watanabe T, Hammock BD, Stewart J, Imig JD. 2004. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J Am Soc Nephrol 15(5):1244-53. PMID:15100364

2003

Chen S, Yuen P, Collins SD, Smith R, Koivunen ME, Hammock BD. 2003. Time gated detection of europium nanoparticles in a microchannel-based environmental immunoassay. In: Proceedings of SPIE (The International Society for Optical Engineering).
Cho YA, Kim Y, Hammock BD, Lee YT, Lee H. 2003. Development of a microtiter plate ELISA and a dipstick ELISA for the determination of the organophosphorus insecticide fenthion. J Agric Food Chem 51(27):7854-7860. PMID:14690364
Denton DL, Wheelock CE, Murray SA, Deanovic LA, Hammock BD, Hinton DE. 2003. Joint acute toxicity of esfenvalerate and diazinon to fathead minnow (Pimephales promelas) larvae. Environ Toxicol Chem 22(2):336-341. PMID:12558165
Feng J, Mack JS, Shan G, Hammock BD. 2003. C60 nanoparticle quenching used as a biological label. In: Proceedings of SPIE (The International Society for Optical Engineering). pp.156-163.
Feng J, Shan G, Hammock BD, Kennedy IM. 2003. Fluorescence quenching competitive immunoassay in micro droplets. Biosens Bioelectron 18(8):1055-1063. PMID:12782469
Feng J, Shan G, Maquieira A, Koivunen ME, Guo B, Hammock BD. 2003. Functionalized europium oxide nanoparticles used as a fluorescent label in an immunoassay for atrazine. Anal Chem 75(19):5282-5286.
Inceoglu B, Lango J, Jing J, Chen L, Doymaz F, Pessah IN, Hammock BD. 2003. One scorpion, two venoms: prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proc Natl Acad Sci U S A 100(3):922-927. PMID:12552107
Kim Y, Cho YA, Lee H, Lee YT, Gee SJ, Hammock BD. 2003. Synthesis of haptens for immunoassay of organophosphorus pesticides and effect of heterology in hapten spacer arm length of immunoassay sensitivity. Anal Chim Acta 475(1-2):85-96.
Koivunen ME, Morisseau C, Newman JW, Horwath WR, Hammock BD. 2003. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens). Soil Biol Biochem 35(11):1433-1442.
Lee H, Watanabe T, Gee SJ, Hammock BD. 2003. Application of an enzyme-linked immunosorbent assay (ELISA) to determine deltamethrin residues in milk. Bull Environ Contam Toxicol 71(1):14-20. PMID:12945836
Lee JK, Ahn K, Stoutamire DW, Gee SJ, Hammock BD. 2003. Development of an enzyme-linked immunosorbent assay for the detection of the organophosphorus insecticide acephate. J Agric Food Chem 51(13):3695-3703. PMID:12797729
McElroy NR, Jurs PC, Morisseau C, Hammock BD. 2003. QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. J Med Chem 46(6):1066-1080. PMID:12620084
Morisseau C, Hammock BD. 2003. Measurements of soluble epoxide hydrolase (sEH) activity. Chapter 4 in: Current Protocals in Toxicology. John Wiley & Sons, NY. pp.1-4.
Newman JW, Morisseau C, Harris TR, Hammock BD. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A 100(4):1558-1563. PMID:12574510
Nichkova MJ, Feng J, Sanchez-Baeza F, Marco M, Hammock BD, Kennedy IM. 2003. Competitive quenching fluorescence immunoassy for chlorophenols based on laser-induced fluorescence detection in microdroplets. Anal Chem 75(1):83-90. PMID:12530822
Przybyla-Zawislak BD, Srivastava PK, Vazquez-Matias J, Mohrenweiser HW, Maxwell JE, Hammock BD, Bradbury JA, Enayetallah AE, Zeldin DC, Grant DF. 2003. Polymorphisms in human soluble epoxide hydrolase. Mol Pharmacol 64(2):482-490. PMID:12869654
Szekacs A, Le HM, Szurdoki F, Hammock BD. 2003. Optimization and validation of an enzyme immunoassay for the insect growth regulator fenoxycarb. Anal Chim Acta 487(1):15-29.
Taniai K, Inceoglu AB, Yukuhiro K, Hammock BD. 2003. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster. FEBS J 270(23):4696-4705. PMID:14622257
Viswanathan S, Hammock BD, Newman JW, Meerarani P, Toborek M, Hennig B. 2003. Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. J Am Coll Nutr 22(6):502-510. PMID:14684755
Watanabe T, Morisseau C, Newman JW, Hammock BD. 2003. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecyl-urea. Drug Metab Dispos 31(7):846-853. doi:10.1124/dmd.31.7.846 PMID:12814960
Wheelock CE, Nakagawa Y, Akamatsu M, Hammock BD. 2003. Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorg Med Chem 11(23):5101-5116. PMID:14604674
Wheelock CE, Wheelock AM, Zhang RH, Stok JE, Morisseau C, Le Valley SE, Green CE, Hammock BD. 2003. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Anal Biochem 315(2):208-222. PMID:12689831
Zhang RH, Kang K, Shan G, Hammock BD. 2003. Design, synthesis and evaluation of novel P450 fluorescent probes bearing -cyanoether. Tetrahedron Lett 44(23):4331-4334.

2002

Cho YA, Lee H, Park EY, Lee YT, Hammock BD, Ahn K, Lee JK. 2002. Development of an ELISA for the organophosphorus insecticide chlorpyrifos. Bulletin of the Korean Chemical Society 23(3):481-487.
Davis BB, Thompson DA, Howard LL, Morisseau C, Hammock BD, Weiss RH. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proc Natl Acad Sci U S A 99(4):2222-2227. PMID:11842228
Dedos SG, Szurdoki F, Szekacs A, Shiotsuki T, Hammock BD, Shimada J, Fugo H. 2002. Fenoxycarb levels and their effects on general and juvenile hormone esterase activity in the hemolymph of the silkworm, Bombyx mori. Pesticide Biochemistry and Physiology 73(3):174-187.
Denison MS, Nagy SR, Ziccardi MH, Clark GC, Chu MD, Brown DJ, Shan G, Sugawara Y, Gee SJ, Sanborn JR, Hammock BD. 2002. Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives. CRC Press Company, Boca Raton, FL. pp.483-494.
Fang X, Weintraub NL, Oltman CL, Stoll LL, Kaduce TL, Harmon S, Dellsperger KC, Morisseau C, Hammock BD, Spector AA. 2002. Human coronary endothelial cells convert 14,15-EET to a biologically active chain-shortened epoxide. Am J Physiol Heart Circ Physiol 283(6):H2306-H2314. doi:10.1152/ajpheart.00448.2002 PMID:12388281
Feng J, Shan G, Hammock BD, Kennedy IM. 2002. Fluorescence quenching competitive fluoroimmunoassay in micro droplets. In: Methods for Ultrasensitive Detection II, Proceedings of the International Society for Optical Engineering. SPIE, Bellingham, WA. pp.118-127.
Fornage M, Hinojos CA, Nurowska BW, Boerwinkle E, Hammock BD, Morisseau C, Doris PA. 2002. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Hypertension 40(4):485-490. PMID:12364351
Harcourt RL, Horne I, Sutherland TD, Hammock BD, Russell RJ, Oakeshott JG. 2002. Development of a simple and sensitive fluorimetric method for isolation of coumaphos-hydrolysing bacteria. Lett Appl Microbiol 34(4):263-268. PMID:1940156
Hennig B, Hammock BD, Slim RM, Toborek M, Viswanathan S, Robertson LW. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. Int J Hyg Environ Health 205(1-2):95-102. PMID:12018021
Imig JD, Zhao X, Capdevila JH, Morisseau C, Hammock BD. 2002. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension 39(2):690-694. PMID:11882632
Inceoglu B, Hayashida Y, Lango J, Ishida AT, Hammock BD. 2002. A single charged surface residue modifies the activity of ikitoxin, a beta-type Na⁺ channel toxin from Parabuthus transvaalicus. FEBS J 269(22):5369-5376. PMID:12423335
Kim K, Kim Y, Lee YT, Hammock BD, Lee H. 2002. Development of an enzyme-linked immunosorbent assay for the organophosphorus insecticide bromophos-ethyl. J Agric Food Chem 50(23):6675-6682. PMID:12405760
Lee H, Shan G, Watanabe T, Stoutamire DW, Gee SJ, Hammock BD. 2002. Enzyme-linked immunosorbent assay for the pyrethroid deltamethrin. J Agric Food Chem 50(20):5526-5532. PMID:12236674
Leppert VJ, Harvey AS, McCool GD, Quinlan FT, Feng J, Shan G, Stroeve P, Risbud SH, Hammock BD, Kennedy IM. 2002. Long-wavelength emitting nanocrystals for bioassay applications. In: Nanoscale Optics and Applications. Proceedings of SPIE, pp.110-121.
Morisseau C, Goodrow MH, Newman JW, Wheelock CE, Dowdy DL, Hammock BD. 2002. Structural refinement of inhibitors of urea based soluble epoxide hydrolases. Biochem Pharmacol 63(9):1599-1608. PMID:12007563
Morisseau C, Hammock BD. 2002. Epoxide Hydrolases. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY. pp.1194-1197.
Nagy SR, Sanborn JR, Hammock BD, Denison MS. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicol Sci 65(2):200-210. PMID:11812924
Newman JW, Watanabe T, Hammock BD. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. J Lipid Res 43(9):1563-1578. PMID:12235189
Park WC, Cho YA, Kim Y, Hammock BD, Lee YT, Lee H. 2002. Development of an enzyme-linked immunosorbent assay for the organophosphorus insecticide bromophos. Bulletin of the Korean Chemical Society 23(10):1399-1403.
Severson T, Goodrow MH, Morisseau C, Dowdy DL, Hammock BD. 2002. Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm(Manduca sexta: Sphingidae). Insect Biochem Mol Biol 32:1741-1756. PMID:12429126
Shelver WL, Shan G, Gee SJ, Stanker LH, Hammock BD. 2002. Comparison of immunoaffinity column recovery patterns of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans on columns generated with different monoclonal antibody clones and polyclonal antibodies. Anal Chim Acta 457:199-209.
Sugawara Y, Saito K, Ogawa M, Kobayashi S, Shan G, Sanborn JR, Hammock BD, Nakazawa H, Matsuki Y. 2002. Development of dioxin toxicity evaluation method in human milk by enzyme-linked immunosorbent assay--assay validation for human milk. Chemosphere 46(9-10):1471-1476. PMID:12002478
Szurdoki F, Szekacs A, Le HM, Hammock BD. 2002. Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb. J Agric Food Chem 50(1):29-40. PMID:11754538
Viswanathan S, Hammock BD, Meerarani P, Toborek M, Hennig B. 2002. Mechanisms of linoleic acid-induced endothelial activation: possible involvement of epoxide metabolites in mediating the inflammatory response. FASEB J 16:A157.
Wheelock CE, Colvin ME, Uemura I, Olmstead MM, Sanborn JR, Nakagawa Y, Jones AD, Hammock BD. 2002. Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. J Med Chem 45(25):5576-5593. PMID:12459025
Zurek G, Gee SJ, Hammock BD. 2002. Development of an enzyme immunoassay for linoleic acid diols in urine. Anal Chim Acta 466(2):247-256.

2001

Buchholz BA, Vogel JS, Gilman DS, Gee SJ, Hammock BD, Hui X, Wester RC, Maibach HI. 2001. Determining an occupational dermal exposure biomarker for atrazine through measurement of metabolites in human urine by HPLC-accelerator mass spectrometry. In: Toxicology of Skin. Taylor & Francis, Philadelphia, PA. pp.145-157.
Fang X, Kaduce TL, Weintraub NL, Harmon S, Teesch LM, Morisseau C, Thompson DA, Hammock BD, Spector AA. 2001. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells: implications for the vascular effects of soluble epoxide hydrolase inhibition. J Biol Chem 276(18):14867-14874. PMID:11278979
Hennig B, Slim RM, Toborek M, Hammock BD, Robertson LW. 2001. Cardiovascular disease: endothelial cells as a target for PCB toxicity. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.211-220.
Hennig B, Viswanathan S, Toborek M, Hammock BD. 2001. Mechanisms of fatty-acid mediated endothelial cell activation. J Am Coll Nutr 20:574.
Huang Q, Deveraux QL, Maeda S, Stennicke HR, Hammock BD, Reed JC. 2001. Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori. Biochim Biophys Acta 1499(3):191-198. PMID:11341966
Inceoglu B, Lango J, Wu J, Hawkins P, Southern J, Hammock BD. 2001. Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus transvaalicus (Buthidae). FEBS J 268(20):5407-5413. PMID:11606203
Lee JK, Ahn K, Park OS, Kang SY, Hammock BD. 2001. Development of an ELISA for the detection of the residues of the insecticide imidacloprid in agricultural and environmental samples. J Agric Food Chem 49(5):2159-2167. PMID:11368571
Matveeva EG, Gribkova EV, Sanborn JR, Gee SJ, Hammock BD, Savitsky AP. 2001. Development of a homogeneous phosphorescent immunoassay for the detection of polychlorinated dibenzo-p-dioxins. Anal Lett 34(13):2311-2320.
Matveeva EG, Shan G, Kennedy IM, Gee SJ, Hammock BD. 2001. Homogeneous fluoroimmunoassay of a pyrethroid metabolite in urine. Anal Chim Acta 444:103-117.
Miyashita M, Presley JM, Buchholz BA, Lam KS, Lee YM, Vogel JS, Hammock BD. 2001. Attomole level protein sequencing by Edman degradation coupled with accelerator mass spectrometry. Proc Natl Acad Sci U S A 98(8):4403-4408. PMID:11287636
Morisseau C, Newman JW, Dowdy DL, Goodrow MH, Hammock BD. 2001. Inhibition of microsomal epoxide hydrolases by ureas, amides, and amines. Chem Res Toxicol 14(4):409-415. PMID:11304129
Newman JW, Denton DL, Morisseau C, Koger CS, Wheelock CE, Hinton DE, Hammock BD. 2001. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environ Health Perspect 109(1):61-66. PMID:11171526 PMCID:PMC1242052
Newman JW, Hammock BD. 2001. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. J Chromatogr A 925(1-2):223-240. PMID:11519808
Shan G, Hammock BD. 2001. Development of sensitive esterase assays based on alpha-cyano-containing esters. Anal Biochem 299(1):54-62. PMID:11726184
Shan G, Leeman WR, Gee SJ, Sanborn JR, Jones AD, Chang DP, Hammock BD. 2001. Highly sensitive dioxin immunoassay and its application to soil and biota samples. Anal Chim Acta 444:169-178.
Sisemore MF, Zheng J, Yang JC, Thompson DA, Plopper CG, Cortopassi GA, Hammock BD. 2001. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction. Arch Biochem Biophys 392(1):32-37. PMID:11469791
Slim RM, Hammock BD, Toborek M, Robertson LW. 2001. The role of methyl linoleic acid epoxide and diol metabolites in the synergistic toxicity of linoleic acid and PCBs to vascular endothelial cells. Toxicol Sci 60:13.
Slim RM, Hammock BD, Toborek M, Robertson LW, Newman JW, Morisseau C, Watkins BA, Viswanathan S, Hennig B. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicol Appl Pharmacol 171(3):184-193. PMID:11243918
Staimer N, Gee SJ, Hammock BD. 2001. Development of a class-selective enzyme immunoassay for urinary phenolic glucuronides. Anal Chim Acta 444:27-36.
Staimer N, Gee SJ, Hammock BD. 2001. Development of a sensitive enzyme immunoassay for the detection of phenyl-b-D-thioglucuronide in human urine. Fresenius J Anal Chem 369(3-4):273-279. PMID:11293704
Viswanathan S, Narayan P, Hammock BD, Meerarani P, Toborek M, Hennig B. 2001. Linoleic acid-derived epoxides alter calcium and nitric oxide metabolism in endothelial cells. FASEB J 15:A190.
Watanabe T, Hammock BD. 2001. Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high performance liquid chromatography with electrospray tandem mass spectrometry. Anal Biochem 299(2):227-234. PMID:11730347
Watanabe T, Shan G, Stoutamire DW, Gee SJ, Hammock BD. 2001. Development of a class-specific immunoassay for the type I pyrethroid insecticides. Anal Chim Acta 444:119-129.
Watkins SM, Hammock BD, Newman JW, German JB. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. Am J Clin Nutr 74(3):283-286. PMID:11522549
Wheelock CE, Severson T, Hammock BD. 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chem Res Toxicol 14(12):1563-1572. PMID:11743738
Wudayagiri R, Inceoglu B, Herrmann R, Derbel M, Choudary P, Hammock BD. 2001. Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus. BMC Biochem 2:16. PMID:11782289
Zheng J, Plopper CG, Lakritz J, Storms DH, Hammock BD. 2001. Leukotoxin-diol - a putative toxic mediator involved in acute respiratory distress syndrome. Am J Respir Cell Mol Biol 25(4):434-438. PMID:11694448

2000

Argiriadi MA, Morisseau C, Goodrow MH, Dowdy DL, Hammock BD, Christianson DW. 2000. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. J Biol Chem 275(20):15265-15270. PMID:10747889
Draper AJ, Hammock BD. 2000. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. Arch Biochem Biophys 376(1):199-205. PMID:10729206
Fanucchi MV, Buckpitt AR, Murphy M, Storms DH, Hammock BD, Plopper CG. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicol Appl Pharmacol 168(3):253-267. PMID:11042098
Greene JF, Newman JW, Williamson K, Hammock BD. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chem Res Toxicol 13(4):217-226. PMID:10775319
Greene JF, Williamson K, Newman JW, Morisseau C, Hammock BD. 2000. Metabolism of monoepoxides of methyl linoleate: bioactivation and detoxification. Arch Biochem Biophys 376(2):420-432. PMID:10775430
Greene JF, Zheng J, Grant DF, Hammock BD. 2000. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicol Sci 53(2):352-360. PMID:10696783
Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC. 2000. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proc Natl Acad Sci U S A 97(4):1427-1432. PMID:10677478 PMCID:PMC26450
Kido H, Maquieira A, Hammock BD. 2000. Disc-based immunoassay microarrays. Anal Chim Acta 411(1-2):1-11.
Lakritz J, Winder BS, Noorouz-Zadeh J, Huang TL, Buckpitt AR, Hammock BD, Plopper CG. 2000. Hepatic and pulmonary enzyme activities in horses. American Journal of Veterinary Research 61(2):152-157. PMID:10685686
Lohse C, Jaeger LL, Staimer N, Sanborn JR, Jones AD, Lango J, Gee SJ, Hammock BD. 2000. Development of a class selective enzyme-linked immunosorbent assay for mercapturic acids in human urine. J Agric Food Chem 48(12):5913-5923. PMID:11312767
Morisseau C, Beetham JK, Pinot F, Debernard S, Newman JW, Hammock BD. 2000. Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes. Arch Biochem Biophys 378(2):321-332. PMID:10860549
Nakagawa Y, Wheelock CE, Morisseau C, Goodrow MH, Hammock BG, Hammock BD. 2000. 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues. Bioorg Med Chem 8(11):2663-2673. PMID:11092551
Shan G, Huang W, Gee SJ, Buchholz BA, Vogel JS, Hammock BD. 2000. Isotope-labeled immunoassays without radiation waste. Proc Natl Acad Sci U S A 97(6):2445-2449. PMID:10706612
Shan G, Leeman WR, Stoutamire DW, Gee SJ, Chang DP, Hammock BD. 2000. Enzyme-linked immunosorbent assay for the pyrethroid permethrin. J Agric Food Chem 48(9):4032-4040. PMID:10995309
Shan G, Sanborn JR, Gilman DS, Nagy SR, Gee SJ, Stoutamire DW, Mercer RS, Jones AD, Stanker LH, Denison MS, Hammock BD. 2000. Surrogates for dioxin analyses: analytical, ELISA and toxicological aspects. Organohalogen Compounds 45:188-191.
Williamson K, Morisseau C, Maxwell JE, Hammock BD. 2000. Regio- and enantioselective hydrolysis of phenyloxiranes catalyzed by soluble epoxide hydrolase. Tetrahedron: Asymmetry 11:4451-4462.
Yamada T, Morisseau C, Maxwell JE, Argiriadi MA, Christianson DW, Hammock BD. 2000. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. J Biol Chem 275(30):23082-23088. PMID:10806198
Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD, Zeldin DC, Kroetz DL. 2000. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res 87(11):992-998. PMID:11090543

1999

Argiriadi MA, Morisseau C, Hammock BD, Christianson DW. 1999. Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase. Proc Natl Acad Sci U S A 96:10637-10642. PMID:10485878
Buchholz BA, Fultz E, Haack KW, Vogel JS, Gilman DS, Gee SJ, Hammock BD, Hui X, Wester RC, Maibach HI. 1999. HPLC-accelerator MS measurement of atrazine metabolites in human urine after dermal exposure. Anal Chem 71(16):3519-3525. PMID:10464479
Draper AJ, Hammock BD. 1999. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol Sci 52:26-32. PMID:10568695
Draper AJ, Hammock BD. 1999. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Toxicol Sci 50:30-35. PMID:10445750
Kido H, Szurdoki F, Gustin MS, Hammock BD. 1999. Chelate sensor method for mercury. In: Metals and Genetics. Kluwer Academic/Plenum Press, NY. pp.235-259.
Morisseau C, Derbel M, Lane TR, Stoutamire DW, Hammock BD. 1999. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicol Sci 52(2):148-153. PMID:10630566
Morisseau C, Goodrow MH, Dowdy DL, Zheng J, Greene JF, Sanborn JR, Hammock BD. 1999. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proc Natl Acad Sci U S A 96(16):8849-8854. PMID:10430859
Morisseau C, Ward BL, Gilchrist DG, Hammock BD. 1999. Multiple epoxide hydrolases in Alternaria alternata f. sp. lycopersici and their relationship to medium composition and host-specific toxin production. Appl Environ Microbiol 65(6):2388-2395. PMID:10347018
Mullen RT, Trelease RN, Duerk H, Arand M, Hammock BD, Oesch F, Grant DF. 1999. Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants. FEBS Lett 445(2-3):301-305. PMID:10094477
Shan G, Stoutamire DW, Gee SJ, Wengatz I, Hammock BD. 1999. Development of an immunoassay for the pyrethroid insecticide esfenvalerate. J Agric Food Chem 47(5):2145-2155. PMID:10552511
Shan G, Wengatz I, Stoutamire DW, Gee SJ, Hammock BD. 1999. An enzyme-linked immunosorbent assay for the detection of esfenvalerate metabolites in human urine. Chem Res Toxicol 12(11):1033-1041. PMID:10563828
Thomas BA, Church WB, Lane TR, Hammock BD. 1999. Homology model of juvenile hormone esterase from the crop pest, Heliothis virescens. Proteins: Structure, Function, and Genetics 34(2):184-196. PMID:10022354
Yazynina EV, Zherdev AV, Dzantiev BB, Izumrudov VA, Gee SJ, Hammock BD. 1999. Immunoassay techniques for detection of the herbicide simazine based on use of oppositely charged water-soluble polyelectrolytes. Anal Chem 71(16):3538-3543. PMID:10464482
Yazynina EV, Zherdev AV, Dzantiev BB, Izumrudov VA, Gee SJ, Hammock BD. 1999. Microplate immunoassay technique using polyelectrolyte carriers: kinetic studies and application to detection of the herbicide atrazine. Anal Chim Acta 399(1-2):151-160.

1998

Gilman DS, Gee SJ, Hammock BD, Vogel JS, Haack KW, Buchholz BA, Freeman SP, Wester RC, Hui X, Maibach HI. 1998. Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of ¹⁴C-labeled atrazine metabolites in human urine. Anal Chem 70(16):3463-3469. PMID:9726169
Goodrow MH, Hammock BD. 1998. Hapten design for compound-selective antibodies: ELISA's for environmentally deleterious small molecules. Anal Chim Acta 376(1):83-91.
Harris AS, Wengatz I, Wortberg M, Kreissig SB, Gee SJ, Hammock BD. 1998. Development and application of immunoassays for biological and environmental monitoring. In: Effects of Multiple Impacts on Ecosystems. Lewis Publishers, Chelsea, MI. pp.135-153.
Jaeger LL, Jones AD, Hammock BD. 1998. Development of an enzyme-linked immunosorbent assay for atrazine mercapturic acid in human urine. Chem Res Toxicol 11(4):342-352. doi:10.1021/tx9701844 PMID:9548805
Marco M, Gee SJ, Hammock BD. 1998. Determination of 1-naphthol in well water samples by ELISA. In: Current Protocols in Field Analytical Chemistry. (V. Lopez-Avila, ed.) John Wiley & Sons, New York, NY. pp.2C.9.1-2C.9.11.
Marco M, Gee SJ, Hammock BD. 1998. Determination of carbaryl in well water samples by ELISA. In: Current Protocols in Field Analytical Chemistry. (V. Lopez-Avila, ed.) John Wiley & Sons, New York, NY. pp.2C8.1-2C8.15.
Mitchell AE, Zheng J, Hammock BD, Lo Bello M, Jones AD. 1998. Structural and functional consequences of haloenol lactone inactivation of murine and human glutathione S-transferase. Biochemistry 37(19):6752-6759. PMID:9578559
Reimer GJ, Gee SJ, Hammock BD. 1998. Comparison of a time-resolved fluorescence immunoassay and an enzyme-linked immunosorbent assay for the analysis of atrazine in water. J Agric Food Chem 46(8):3353-3358.
Sanborn JR, Gee SJ, Gilman DS, Sugawara Y, Jones AD, Rogers JM, Szurdoki F, Stanker LH, Stoutamire DW, Hammock BD. 1998. Hapten synthesis and antibody development for polychlorinated dibenzo-p-dioxin immunoassays. J Agric Food Chem 46:2407-2416.
Sugawara Y, Gee SJ, Sanborn JR, Gilman DS, Hammock BD. 1998. Development of a highly sensitive enzyme-linked immunosorbent assay based on polyclonal antibodies for the detection of polychlorinated dibenzo-p-dioxins. Anal Chem 70(6):1092-1099. PMID:9530001
Wengatz I, Stoutamire DW, Gee SJ, Hammock BD. 1998. Development of an enzymelinked immunosorbent assay for the detection of the pyrethroid insecticide fenpropathrin. J Agric Food Chem 46(6):2211-2221.

1997

Jones G, Wortberg M, Rocke DM, Hammock BD. 1997. Immunoassay of cross-reacting analytes. In: Immunochemical Technology for Environmental Applications (ACS Symposium Series No. 657). American Chemical Society, Washington, DC. pp.331-342.
Kido H, Goodrow MH, Griffeth V, Lucas AD, Gee SJ, Hammock BD. 1997. Development of an enzyme-linked immunosorbent assay for the detection of hydroxytriazines. J Agric Food Chem 45(2):414-424.
Moghaddam MF, Grant DF, Cheek JM, Greene JF, Williamson K, Hammock BD. 1997. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nat Med 3(5):562-566. PMID:9142128
Schutz S, Wengatz I, Goodrow MH, Gee SJ, Hummel HE, Hammock BD. 1997. Development of an enzyme-linked-immunosorbent assay for azadirachtins. J Agric Food Chem 45(6):2363-2368.
Swamy AR, Danesvar MI, Evans, III L, Strekowski L, Narayanan N, Szurdoki F, Wengatz I, Hammock BD, Patonay G. 1997. Near-infrared fluorescent immunoassays: A novel approach to environmental analysis. In: Immunochemical Technology for Environmental Applications (ACS Symposium Series No. 657). American Chemical Society, Washington, DC. pp.141-161.
Szurdoki F, Kido H, Hammock BD. 1997. Rapid mercury assays. In: Immunochemical Technology for Environmental Applications (ACS Symposium Series No. 657). American Chemical Society, Washington, DC. pp.38-48.
Zheng J, Cho M, Jones AD, Hammock BD. 1997. Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine clara cells after exposure to naphthalene. Chem Res Toxicol 10(9):1008-1014. PMID:9305583

1996

Grant DF, Greene JF, Pinot F, Borhan B, Moghaddam MF, Hammock BD, McCutchen B, Ohkawa H, Luo G, Guenthner TM. 1996. Development of an in situ toxicity assay system using recombinant baculoviruses. Biochem Pharmacol 51(4):503-515. PMID:8619897
Jones G, Wortberg M, Hammock BD, Rocke DM. 1996. A procedure for the immunoanalysis of samples containing one or more members of a group of cross-reacting analytes. Anal Chim Acta 336(1-3):175-183.
Jones G, Wortberg M, Kreissig SB, Hammock BD, Rocke DM. 1996. Application of the bootstrap to calibration experiments. Anal Chem 68(5):763-770. PMID:8779441
Linde CD, Gee SJ, Goh KS, Hsu JC, Hammock BD, Barry TA, Weaver DJ. 1996. Regulatory application of ELISA: compliance monitoring of bromacil in soil. Bull Environ Contam Toxicol 57(2):264-269. PMID:8661908
Szurdoki F, Jaeger LL, Harris AS, Kido H, Wengatz I, Goodrow MH, Szekacs A, Wortberg M, Zheng J, Stoutamire DW, Sanborn JR, Gilman DS, Jones AD, Gee SJ, Choudary P, Hammock BD. 1996. Rapid assays for environmental and biological monitoring. J Environ Sci Health B 31(3):451-458. PMID:8642182
Wengatz I, Harris AS, Gilman DS, Wortberg M, Kido H, Szurdoki F, Goodrow MH, Jaeger LL, Stoutamire DW, Sanborn JR, Gee SJ, Hammock BD. 1996. Recent developments in immunoassays and related methods for the detection of xenobiotics. In: Environmental Immunochemical Methods, Perspectives and Applications. ACS Symposium Series No. 646, American Chemical Society, Washington, DC. pp.110-126.
Wortberg M, Goodrow MH, Gee SJ, Hammock BD. 1996. Immunoassay for simazine and atrazine with low cross-reactivity for propazine. J Agric Food Chem 44(8):2210-2219.
Wortberg M, Jones G, Kreissig SB, Rocke DM, Gee SJ, Hammock BD. 1996. An approach to the construction of an immunoarray for differentiating and quantitating cross reacting analytes. Anal Chim Acta 319(3):291-303.
Zheng J, Hammock BD. 1996. Development of polyclonal antibodies for detection of protein modification by 1,2-naphthoquinone. Chem Res Toxicol 9(5):904-909. PMID:8828928
Zheng J, Mitchell AE, Jones AD, Hammock BD. 1996. Haloenol lactone is a new isozyme-selective and active site-directed inactivator of glutathione S-transferase. J Biol Chem 271(34):20421-20425. PMID:8702779

1995

Borhan B, Jones AD, Pinot F, Grant DF, Kurth M, Hammock BD. 1995. Mechanism of soluble epoxide hydrolase. Formation of An a-hydroxy ester-enzyme intermediate through Asp-333. J Biol Chem 270(45):26923-26930. PMID:7592938
Choudary P, Lee HA, Hammock BD, Morgan MR. 1995. Recombinant antibodies: New tools for immunoassays. Chapter 13 in: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.171-185.
Gee SJ, Hammock BD, Skerritt JH. 1995. Diagnostics for plant agrochemicals--a meeting of chemistry and immunoassay. In: New Diagnostics in Crop Sciences. CAB International, Oxon, United Kingdom. pp.243-276.
Gee SJ, Lucas AD, Hammock BD. 1995. Using immunochemical methods to analyze for biomarkers of exposure. In: Proceedings of the NATO (North Atlantic Treaty Organisation) Workshop on Methods of Pesticide Exposure Assessment. Ottawa, Canada.
Gee SJ, Lucas AD, Hammock BD. 1995. Using immunochemical methods to analyze for biomarkers of exposure. In: Methods of Pesticide Exposure Assessment. Plenum Press, NY. pp.143-155.
Goodrow MH, Sanborn JR, Stoutamire DW, Gee SJ, Hammock BD. 1995. Strategies for immunoassay hapten design. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.119-139.
Hammock BD, Gee SJ. 1995. Impact of emerging technologies on immunochemical methods for environmental analysis. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.1-19.
Harris AS, Lucas AD, Kramer PM, Marco M, Gee SJ, Hammock BD. 1995. Use of immunoassay for the detection of urinary biomarkers of exposure. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.217-235.
Jones G, Wortberg M, Kreissig SB, Hammock BD, Rocke DM. 1995. Sources of experimental variation in calibration curves for enzyme-linked immunosorbent assay. Anal Chim Acta 313:197-207.
Kreissig SB, Ward VK, Hammock BD, Choudary P. 1995. Nucleotide sequence of the variable region of the heavy and light chains of a monoclonal lgG antibody reactive to herbicides, terbutryn and prometryn. DNA Seq 6:51-54. PMID:8746462
Kreissig SB, Ward VK, Hammock BD, Choudary P. 1995. Sequence analysis of individual chains of antibodies to triazine herbicides. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.31-49.
Lucas AD, Gee SJ, Hammock BD, Seiber JN. 1995. Integration of immunochemical methods with other analytical techniques for pesticide residue determination. J AOAC Int 78(3):585-591. PMID:7756872
Lucas AD, Goodrow MH, Seiber JN, Hammock BD. 1995. Development of an ELISA for the N-dealkylated s-triazines: Application to environmental and biological samples. Anal Chim Acta 7:227-241.
Marco M, Chiron S, Gascon J, Hammock BD, Barcelo D. 1995. Validation of two immunoassay methods for environmental monitoring of carbaryl and 1-naphthol in ground water samples. Anal Chim Acta 311(3):319-329.
Schneider P, Gee SJ, Kreissig SB, Harris AS, Kramer PM, Marco M, Lucas AD, Hammock BD. 1995. Troubleshooting during the development and use of immunoassays for environmental monitoring. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.103-122.
Sundaram KM, Sundaram A, Gee SJ, Harrison RO, Hammock BD. 1995. Enzyme-linked immunosorb and assay for quantification of Bacillus thuringiensis var. kurstaki crystaline protein in commerical formulations, in relation to total protein content and insecticidal activity. In: Pesticide Formulations and Applicaiton Systems, 14^th Volume. American Society for Testing and Materials, Philadelphia, PA.
Szekacs A, Hammock BD. 1995. Development of an enzyme-linked immunosorbent assay for the detection of the triazole fungicide myclobutanil. J Agric Food Chem 43(8):2083-2091.
Szekacs A, Jung F, Hammock BD. 1995. Chemical modification of haptens: Selective amino group protection by chromophores for an immunoassay for aminotriazoles. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.65-75.
Szurdoki F, Bekheit HK, Marco M, Goodrow MH, Hammock BD. 1995. Important factors in hapten design and enzyme-linked immunosorbent assay development. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.39-63.
Szurdoki F, Kido H, Hammock BD. 1995. Development of assay for analysis of Hg²⁺ based on sulfur-containing ligands. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.248-264.
Szurdoki F, Kido H, Hammock BD. 1995. Development of rapid mercury assays. Synthesis of sulfur-and mercury-containing conjugates. Bioconjug Chem 6(2):145-149. PMID:7599258
Ward VK, Hammock BD, Maeda S, Choudary P. 1995. Development and application of recombinant antibodies to pesticide residue analysis. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.197-216.
Ward VK, Kreissig SB, Hammock BD, Choudary P. 1995. Generation of an expression library in the baculovirus expression vector system. J Virol Methods 53(2-3):263-272. PMID:7673393
Wengatz I, Szurdoki F, Swamy AR, Evans L, Patonay G, Stimman E, Delwiche M, Stoutamire DW, Gee SJ, Hammock BD. 1995. Immunoassays for pesticide monitoring. SPIE Proceedings, San Jose, CA 408-416.
Wortberg M, Kreissig SB, Jones G, Rocke DM, Hammock BD. 1995. An immunoarray for the simultaneous determination of multiple triazine herbicides. Anal Chim Acta 304:339-352.